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Protein

Killer cell lectin-like receptor 7

Gene

Klra7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for class I MHC.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor 7
Alternative name(s):
Lymphocyte antigen 49g
Short name:
Ly-49g
T-cell surface glycoprotein Ly-49G
Gene namesi
Name:Klra7
Synonyms:Ly-49g, Ly49-g, Ly49g, Ly49g4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:101901. Klra7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
Transmembranei45 – 66Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST22
Topological domaini67 – 280ExtracellularSequence analysisAdd BLAST214

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466851 – 280Killer cell lectin-like receptor 7Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi163 ↔ 168PROSITE-ProRule annotation1 Publication
Disulfide bondi181 ↔ 269PROSITE-ProRule annotation1 Publication
Disulfide bondi185 ↔ 271PROSITE-ProRule annotation1 Publication
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi250 ↔ 263PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60654.
PRIDEiQ60654.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067599.
ExpressionAtlasiQ60654. baseline and differential.
GenevisibleiQ60654. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032286.

Structurei

Secondary structure

1280
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi160 – 164Combined sources5
Beta strandi167 – 176Combined sources10
Helixi178 – 186Combined sources9
Turni187 – 189Combined sources3
Helixi201 – 207Combined sources7
Beta strandi213 – 220Combined sources8
Turni221 – 224Combined sources4
Beta strandi225 – 228Combined sources4
Turni245 – 247Combined sources3
Beta strandi249 – 252Combined sources4
Beta strandi267 – 274Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CADX-ray2.60A/B156-280[»]
ProteinModelPortaliQ60654.
SMRiQ60654.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60654.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 275C-type lectinPROSITE-ProRule annotationAdd BLAST120

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00390000008117.
HOGENOMiHOG000113237.
HOVERGENiHBG053176.
InParanoidiQ60654.
PhylomeDBiQ60654.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR013600. Ly49_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF08391. Ly49. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Ly-49G.1 (identifier: Q60654-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEQEVTYST VRFHESSRLQ KLVRTEEPQR PREACYREYS VPWKLIVIAC
60 70 80 90 100
GILCFLLLVT VALLAITIFQ HSQQKHELQE TLNCHDNCSP TQSDVNLKDE
110 120 130 140 150
LLRNKSIECR PGNDLLESLS RDQNRWYSET KTFSDSSQHT GVHERPISKA
160 170 180 190 200
EGKGRGFEKY WFCYGIKCYY FNMDRKTWSG CKQTCQISSL SLLKIDNEDE
210 220 230 240 250
LKFLQNLAPS DISWIGLSYD NKKKDWVWID NGPSKLALNT TKYNIRDGLC
260 270 280
MSLSKTRLDN GDCDKSYICI CGKRLDKFPH
Length:280
Mass (Da):32,522
Last modified:November 1, 1996 - v1
Checksum:i4704A2D87D5E83FB
GO
Isoform Ly-49G.2 (identifier: Q60654-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-154: Missing.

Show »
Length:267
Mass (Da):31,132
Checksum:iD17A25C966398087
GO
Isoform Ly-49G.3 (identifier: Q60654-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-193: Missing.

Show »
Length:203
Mass (Da):23,466
Checksum:i5E7DC6721BF87673
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44K → Q in AAA58705 (PubMed:7964501).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003069117 – 193Missing in isoform Ly-49G.3. CuratedAdd BLAST77
Alternative sequenceiVSP_003070142 – 154Missing in isoform Ly-49G.2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10093 mRNA. Translation: AAA50221.1.
U10094 mRNA. Translation: AAA50222.1.
U10095 mRNA. Translation: AAA50223.1.
U12890 mRNA. Translation: AAA58705.1.
CCDSiCCDS39668.1. [Q60654-2]
CCDS51928.1. [Q60654-1]
PIRiI49052.
I49053.
I49054.
RefSeqiNP_001103793.1. NM_001110323.1.
NP_055009.5. NM_014194.5. [Q60654-2]
UniGeneiMm.441781.

Genome annotation databases

EnsembliENSMUST00000049304; ENSMUSP00000037917; ENSMUSG00000067599. [Q60654-2]
ENSMUST00000088011; ENSMUSP00000085326; ENSMUSG00000067599. [Q60654-2]
GeneIDi16638.
KEGGimmu:16638.
UCSCiuc009ehx.2. mouse. [Q60654-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10093 mRNA. Translation: AAA50221.1.
U10094 mRNA. Translation: AAA50222.1.
U10095 mRNA. Translation: AAA50223.1.
U12890 mRNA. Translation: AAA58705.1.
CCDSiCCDS39668.1. [Q60654-2]
CCDS51928.1. [Q60654-1]
PIRiI49052.
I49053.
I49054.
RefSeqiNP_001103793.1. NM_001110323.1.
NP_055009.5. NM_014194.5. [Q60654-2]
UniGeneiMm.441781.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CADX-ray2.60A/B156-280[»]
ProteinModelPortaliQ60654.
SMRiQ60654.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032286.

Proteomic databases

PaxDbiQ60654.
PRIDEiQ60654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049304; ENSMUSP00000037917; ENSMUSG00000067599. [Q60654-2]
ENSMUST00000088011; ENSMUSP00000085326; ENSMUSG00000067599. [Q60654-2]
GeneIDi16638.
KEGGimmu:16638.
UCSCiuc009ehx.2. mouse. [Q60654-2]

Organism-specific databases

CTDi16638.
MGIiMGI:101901. Klra7.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00390000008117.
HOGENOMiHOG000113237.
HOVERGENiHBG053176.
InParanoidiQ60654.
PhylomeDBiQ60654.

Miscellaneous databases

EvolutionaryTraceiQ60654.
PROiQ60654.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067599.
ExpressionAtlasiQ60654. baseline and differential.
GenevisibleiQ60654. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR013600. Ly49_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF08391. Ly49. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLRA7_MOUSE
AccessioniPrimary (citable) accession number: Q60654
Secondary accession number(s): Q60655, Q60656, Q60683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.