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Protein

Killer cell lectin-like receptor 7

Gene

Klra7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for class I MHC.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor 7
Alternative name(s):
Lymphocyte antigen 49g
Short name:
Ly-49g
T-cell surface glycoprotein Ly-49G
Gene namesi
Name:Klra7
Synonyms:Ly-49g, Ly49-g, Ly49g, Ly49g4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:101901. Klra7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicSequence analysisAdd
BLAST
Transmembranei45 – 6622Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini67 – 280214ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Killer cell lectin-like receptor 7PRO_0000046685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi163 ↔ 168PROSITE-ProRule annotation1 Publication
Disulfide bondi181 ↔ 269PROSITE-ProRule annotation1 Publication
Disulfide bondi185 ↔ 271PROSITE-ProRule annotation1 Publication
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi250 ↔ 263PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60654.
PRIDEiQ60654.

Expressioni

Gene expression databases

BgeeiQ60654.
ExpressionAtlasiQ60654. baseline and differential.
GenevisibleiQ60654. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032286.

Structurei

Secondary structure

1
280
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi160 – 1645Combined sources
Beta strandi167 – 17610Combined sources
Helixi178 – 1869Combined sources
Turni187 – 1893Combined sources
Helixi201 – 2077Combined sources
Beta strandi213 – 2208Combined sources
Turni221 – 2244Combined sources
Beta strandi225 – 2284Combined sources
Turni245 – 2473Combined sources
Beta strandi249 – 2524Combined sources
Beta strandi267 – 2748Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CADX-ray2.60A/B156-280[»]
ProteinModelPortaliQ60654.
SMRiQ60654. Positions 107-280.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60654.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini156 – 275120C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00390000008117.
HOGENOMiHOG000113237.
HOVERGENiHBG053176.
InParanoidiQ60654.
OrthoDBiEOG7MSMQ9.
PhylomeDBiQ60654.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR013600. Ly49_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF08391. Ly49. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Ly-49G.1 (identifier: Q60654-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEQEVTYST VRFHESSRLQ KLVRTEEPQR PREACYREYS VPWKLIVIAC
60 70 80 90 100
GILCFLLLVT VALLAITIFQ HSQQKHELQE TLNCHDNCSP TQSDVNLKDE
110 120 130 140 150
LLRNKSIECR PGNDLLESLS RDQNRWYSET KTFSDSSQHT GVHERPISKA
160 170 180 190 200
EGKGRGFEKY WFCYGIKCYY FNMDRKTWSG CKQTCQISSL SLLKIDNEDE
210 220 230 240 250
LKFLQNLAPS DISWIGLSYD NKKKDWVWID NGPSKLALNT TKYNIRDGLC
260 270 280
MSLSKTRLDN GDCDKSYICI CGKRLDKFPH
Length:280
Mass (Da):32,522
Last modified:November 1, 1996 - v1
Checksum:i4704A2D87D5E83FB
GO
Isoform Ly-49G.2 (identifier: Q60654-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-154: Missing.

Show »
Length:267
Mass (Da):31,132
Checksum:iD17A25C966398087
GO
Isoform Ly-49G.3 (identifier: Q60654-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-193: Missing.

Show »
Length:203
Mass (Da):23,466
Checksum:i5E7DC6721BF87673
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441K → Q in AAA58705 (PubMed:7964501).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 19377Missing in isoform Ly-49G.3. CuratedVSP_003069Add
BLAST
Alternative sequencei142 – 15413Missing in isoform Ly-49G.2. 1 PublicationVSP_003070Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10093 mRNA. Translation: AAA50221.1.
U10094 mRNA. Translation: AAA50222.1.
U10095 mRNA. Translation: AAA50223.1.
U12890 mRNA. Translation: AAA58705.1.
CCDSiCCDS39668.1. [Q60654-2]
CCDS51928.1. [Q60654-1]
PIRiI49052.
I49053.
I49054.
RefSeqiNP_001103793.1. NM_001110323.1.
NP_055009.5. NM_014194.5. [Q60654-2]
UniGeneiMm.441781.

Genome annotation databases

EnsembliENSMUST00000049304; ENSMUSP00000037917; ENSMUSG00000067599. [Q60654-2]
ENSMUST00000088011; ENSMUSP00000085326; ENSMUSG00000067599. [Q60654-2]
GeneIDi16638.
KEGGimmu:16638.
UCSCiuc009ehx.2. mouse. [Q60654-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10093 mRNA. Translation: AAA50221.1.
U10094 mRNA. Translation: AAA50222.1.
U10095 mRNA. Translation: AAA50223.1.
U12890 mRNA. Translation: AAA58705.1.
CCDSiCCDS39668.1. [Q60654-2]
CCDS51928.1. [Q60654-1]
PIRiI49052.
I49053.
I49054.
RefSeqiNP_001103793.1. NM_001110323.1.
NP_055009.5. NM_014194.5. [Q60654-2]
UniGeneiMm.441781.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CADX-ray2.60A/B156-280[»]
ProteinModelPortaliQ60654.
SMRiQ60654. Positions 107-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032286.

Proteomic databases

PaxDbiQ60654.
PRIDEiQ60654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049304; ENSMUSP00000037917; ENSMUSG00000067599. [Q60654-2]
ENSMUST00000088011; ENSMUSP00000085326; ENSMUSG00000067599. [Q60654-2]
GeneIDi16638.
KEGGimmu:16638.
UCSCiuc009ehx.2. mouse. [Q60654-2]

Organism-specific databases

CTDi16638.
MGIiMGI:101901. Klra7.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00390000008117.
HOGENOMiHOG000113237.
HOVERGENiHBG053176.
InParanoidiQ60654.
OrthoDBiEOG7MSMQ9.
PhylomeDBiQ60654.

Miscellaneous databases

EvolutionaryTraceiQ60654.
NextBioi290287.
PROiQ60654.
SOURCEiSearch...

Gene expression databases

BgeeiQ60654.
ExpressionAtlasiQ60654. baseline and differential.
GenevisibleiQ60654. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR013600. Ly49_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF08391. Ly49. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ly-49 multigene family expressed by IL-2-activated NK cells."
    Smith H.R.C., Karlhofer F.M., Yokoyama W.M.
    J. Immunol. 153:1068-1079(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  2. "Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties."
    Brennan J., Mager D., Jefferies W., Takei F.
    J. Exp. Med. 180:2287-2295(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LY-49G.2).
    Strain: B10.A.
  3. "Molecular architecture of the major histocompatibility complex class I-binding site of Ly49 natural killer cell receptors."
    Deng L., Cho S., Malchiodi E.L., Kerzic M.C., Dam J., Mariuzza R.A.
    J. Biol. Chem. 283:16840-16849(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 156-280, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiKLRA7_MOUSE
AccessioniPrimary (citable) accession number: Q60654
Secondary accession number(s): Q60655, Q60656, Q60683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.