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Protein

Caseinolytic peptidase B protein homolog

Gene

Clpb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a regulatory ATPase and be related to secretion/protein trafficking process.

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi351 – 3588ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Caseinolytic peptidase B protein homolog (EC:3.6.1.3By similarity)
Alternative name(s):
Suppressor of potassium transport defect 3
Gene namesi
Name:Clpb
Synonyms:Skd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1100517. Clpb.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5050MitochondrionSequence analysisAdd
BLAST
Chaini51 – 677627Caseinolytic peptidase B protein homologPRO_0000191240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei559 – 5591N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ60649.
MaxQBiQ60649.
PaxDbiQ60649.
PRIDEiQ60649.

2D gel databases

REPRODUCTION-2DPAGEQ60649.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in testis. Also expressed in heart, skeletal muscle and kidney.

Gene expression databases

BgeeiQ60649.
CleanExiMM_CLPB.
ExpressionAtlasiQ60649. baseline and differential.
GenevisibleiQ60649. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001884.

Structurei

3D structure databases

ProteinModelPortaliQ60649.
SMRiQ60649. Positions 113-625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati133 – 16230ANK 1Add
BLAST
Repeati166 – 19530ANK 2Add
BLAST
Repeati235 – 26531ANK 3Add
BLAST
Repeati268 – 29730ANK 4Add
BLAST

Sequence similaritiesi

Belongs to the ClpA/ClpB family.Curated
Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1051. Eukaryota.
COG0542. LUCA.
GeneTreeiENSGT00390000012961.
HOGENOMiHOG000006543.
HOVERGENiHBG025978.
InParanoidiQ60649.
KOiK03695.
OrthoDBiEOG769ZJM.
TreeFamiTF328654.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR001270. ClpA/B.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF12796. Ank_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 1 hit.
SM00248. ANK. 3 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSAVLRRT TPAPRLFLGL IKSPSLQSRG GAYGRGVVTG DRGEPQRLRA
60 70 80 90 100
AAWVRPGASS TFVPGRGAAT WGRRGERTEI PYLTAASSER GPSPEETLPG
110 120 130 140 150
QDSWNGVPNK TGLGMWALAM ALVVQCYSKN PSNKDAALME AARANNVQEV
160 170 180 190 200
RRLLSEGADV NARHKLGWTA LMVASISHNE SVVQVLLAAG ADPNLGDEFS
210 220 230 240 250
SVYKTANEQG VHSLEVLVTR EDDFNNRLNH RASFKGCTAL HYAVLADDYS
260 270 280 290 300
IVKELLDRGA NPLQRNEMGH TPLDYAREGE VMKLLKTSET KYMEKQRKRE
310 320 330 340 350
AEERRRFPLE QRLKEHIIGQ ESAIATVGAA IRRKENGWYD EEHPLVFLFL
360 370 380 390 400
GSSGIGKTEL AKQTAKYMHK DAKKGFIRLD MSEFQERHEV AKFIGSPPGY
410 420 430 440 450
IGHEEGGQLT KKLKQCPNAV VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK
460 470 480 490 500
GKTIDCKDAI FIMTSNVASD EIAQHALQLR QEALEMSRNR IAENLGDVQM
510 520 530 540 550
SDKITISKNF KENVIRPILK AHFRRDEFLG RINEIVYFLP FCHSELIQLV
560 570 580 590 600
NKELNFWAKR AKQRHNITLL WDREVADVLV DGYNVHYGAR SIKHEVERRV
610 620 630 640 650
VNQLAAAYEQ DLLPGGCTLR ITVEDSDKHL LKSPELPSPQ AEKRPPTLRL
660 670
EIIDKDSKTR KLDIQAPLHP EKVCYTI
Length:677
Mass (Da):76,004
Last modified:November 1, 1996 - v1
Checksum:iF2E5921E44ECCEB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09874 mRNA. Translation: AAA62869.1.
BC048175 mRNA. Translation: AAH48175.1.
CCDSiCCDS21513.1.
PIRiI49045.
RefSeqiNP_033217.1. NM_009191.3.
UniGeneiMm.3990.

Genome annotation databases

EnsembliENSMUST00000001884; ENSMUSP00000001884; ENSMUSG00000001829.
GeneIDi20480.
KEGGimmu:20480.
UCSCiuc009ipb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09874 mRNA. Translation: AAA62869.1.
BC048175 mRNA. Translation: AAH48175.1.
CCDSiCCDS21513.1.
PIRiI49045.
RefSeqiNP_033217.1. NM_009191.3.
UniGeneiMm.3990.

3D structure databases

ProteinModelPortaliQ60649.
SMRiQ60649. Positions 113-625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001884.

2D gel databases

REPRODUCTION-2DPAGEQ60649.

Proteomic databases

EPDiQ60649.
MaxQBiQ60649.
PaxDbiQ60649.
PRIDEiQ60649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001884; ENSMUSP00000001884; ENSMUSG00000001829.
GeneIDi20480.
KEGGimmu:20480.
UCSCiuc009ipb.1. mouse.

Organism-specific databases

CTDi81570.
MGIiMGI:1100517. Clpb.

Phylogenomic databases

eggNOGiKOG1051. Eukaryota.
COG0542. LUCA.
GeneTreeiENSGT00390000012961.
HOGENOMiHOG000006543.
HOVERGENiHBG025978.
InParanoidiQ60649.
KOiK03695.
OrthoDBiEOG769ZJM.
TreeFamiTF328654.

Miscellaneous databases

ChiTaRSiClpb. mouse.
PROiQ60649.
SOURCEiSearch...

Gene expression databases

BgeeiQ60649.
CleanExiMM_CLPB.
ExpressionAtlasiQ60649. baseline and differential.
GenevisibleiQ60649. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR001270. ClpA/B.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF12796. Ank_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 1 hit.
SM00248. ANK. 3 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a putative ATPase suppresses the growth defect of a yeast potassium transport mutant: identification of a mammalian member of the Clp/HSP104 family."
    Perier F., Radeke C.M., Raab-Graham K.F., Vandenberg C.A.
    Gene 152:157-163(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 574-590, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney and Pancreas.

Entry informationi

Entry nameiCLPB_MOUSE
AccessioniPrimary (citable) accession number: Q60649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.