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Q60644

- NR1H2_MOUSE

UniProt

Q60644 - NR1H2_MOUSE

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Protein

Oxysterols receptor LXR-beta

Gene

Nr1h2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi75 – 15278Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri78 – 9821NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri116 – 14025NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  3. retinoid X receptor binding Source: MGI
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: MGI
  6. steroid hormone receptor activity Source: InterPro
  7. zinc ion binding Source: InterPro

GO - Biological processi

  1. cellular lipid metabolic process Source: MGI
  2. cholesterol homeostasis Source: BHF-UCL
  3. intracellular receptor signaling pathway Source: GOC
  4. lipid homeostasis Source: BHF-UCL
  5. negative regulation of proteolysis Source: BHF-UCL
  6. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  7. positive regulation of cholesterol efflux Source: BHF-UCL
  8. positive regulation of high-density lipoprotein particle assembly Source: BHF-UCL
  9. positive regulation of lipid storage Source: BHF-UCL
  10. positive regulation of pancreatic juice secretion Source: BHF-UCL
  11. positive regulation of secretion of lysosomal enzymes Source: BHF-UCL
  12. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  13. regulation of cholesterol homeostasis Source: UniProtKB
  14. regulation of transcription, DNA-templated Source: MGI
  15. regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterols receptor LXR-beta
Alternative name(s):
Liver X receptor beta
Nuclear receptor subfamily 1 group H member 2
Retinoid X receptor-interacting protein No.15
Ubiquitously-expressed nuclear receptor
Gene namesi
Name:Nr1h2
Synonyms:Lxrb, Rip15, Unr, Unr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1352463. Nr1h2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Oxysterols receptor LXR-betaPRO_0000053533Add
BLAST

Proteomic databases

PRIDEiQ60644.

PTM databases

PhosphoSiteiQ60644.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ60644.
CleanExiMM_NR1H2.
ExpressionAtlasiQ60644. baseline.
GenevestigatoriQ60644.

Interactioni

Subunit structurei

Forms a heterodimer with RXR.

Binary interactionsi

WithEntry#Exp.IntActNotes
SIRT1Q96EB62EBI-5276809,EBI-1802965From a different organism.

Protein-protein interaction databases

BioGridi204450. 1 interaction.
DIPiDIP-444N.
IntActiQ60644. 4 interactions.
STRINGi10090.ENSMUSP00000103545.

Structurei

3D structure databases

ProteinModelPortaliQ60644.
SMRiQ60644. Positions 66-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni216 – 446231Ligand-bindingSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 1687Poly-Gln
Compositional biasi169 – 1724Poly-Pro

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri78 – 9821NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri116 – 14025NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG285805.
GeneTreeiENSGT00760000118837.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
InParanoidiQ60644.
KOiK08535.
OMAiRRYACRG.
OrthoDBiEOG7DC25S.
PhylomeDBiQ60644.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60644-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI
60 70 80 90 100
VVILEPEDEP ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG
110 120 130 140 150
FFRRSVVHGG AGRYACRGSG TCQMDAFMRR KCQLCRLRKC KEAGMREQCV
160 170 180 190 200
LSEEQIRKKR IQKQQQQQPP PPSEPAASSS GRPAASPGTS EASSQGSGEG
210 220 230 240 250
EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG ADPQSRDARQ
260 270 280 290 300
QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE
310 320 330 340 350
TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL
360 370 380 390 400
DDAEYALLIA INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ
410 420 430 440
LRFPRMLMKL VSLRTLSSVH SEQVFALRLQ DKKLPPLLSE IWDVHE
Length:446
Mass (Da):49,720
Last modified:November 1, 1996 - v1
Checksum:i73153E635302C9DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09419 mRNA. Translation: AAC52164.1.
AJ132602 Genomic DNA. Translation: CAB51924.1.
BC066025 mRNA. Translation: AAH66025.1.
CCDSiCCDS21211.1.
PIRiI49021.
RefSeqiNP_001272446.1. NM_001285517.1.
NP_001272447.1. NM_001285518.1.
NP_001272448.1. NM_001285519.1.
NP_033499.1. NM_009473.3.
XP_006540867.1. XM_006540804.1.
UniGeneiMm.968.

Genome annotation databases

EnsembliENSMUST00000073488; ENSMUSP00000073188; ENSMUSG00000060601.
ENSMUST00000107912; ENSMUSP00000103545; ENSMUSG00000060601.
ENSMUST00000167197; ENSMUSP00000126788; ENSMUSG00000060601.
GeneIDi22260.
KEGGimmu:22260.
UCSCiuc009gpz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09419 mRNA. Translation: AAC52164.1 .
AJ132602 Genomic DNA. Translation: CAB51924.1 .
BC066025 mRNA. Translation: AAH66025.1 .
CCDSi CCDS21211.1.
PIRi I49021.
RefSeqi NP_001272446.1. NM_001285517.1.
NP_001272447.1. NM_001285518.1.
NP_001272448.1. NM_001285519.1.
NP_033499.1. NM_009473.3.
XP_006540867.1. XM_006540804.1.
UniGenei Mm.968.

3D structure databases

ProteinModelPortali Q60644.
SMRi Q60644. Positions 66-445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204450. 1 interaction.
DIPi DIP-444N.
IntActi Q60644. 4 interactions.
STRINGi 10090.ENSMUSP00000103545.

Chemistry

ChEMBLi CHEMBL2417346.

PTM databases

PhosphoSitei Q60644.

Proteomic databases

PRIDEi Q60644.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073488 ; ENSMUSP00000073188 ; ENSMUSG00000060601 .
ENSMUST00000107912 ; ENSMUSP00000103545 ; ENSMUSG00000060601 .
ENSMUST00000167197 ; ENSMUSP00000126788 ; ENSMUSG00000060601 .
GeneIDi 22260.
KEGGi mmu:22260.
UCSCi uc009gpz.1. mouse.

Organism-specific databases

CTDi 7376.
MGIi MGI:1352463. Nr1h2.

Phylogenomic databases

eggNOGi NOG285805.
GeneTreei ENSGT00760000118837.
HOGENOMi HOG000220845.
HOVERGENi HBG108655.
InParanoidi Q60644.
KOi K08535.
OMAi RRYACRG.
OrthoDBi EOG7DC25S.
PhylomeDBi Q60644.

Miscellaneous databases

ChiTaRSi NR1H2. mouse.
NextBioi 302353.
PROi Q60644.
SOURCEi Search...

Gene expression databases

Bgeei Q60644.
CleanExi MM_NR1H2.
ExpressionAtlasi Q60644. baseline.
Genevestigatori Q60644.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors."
    Seol W., Choi H.S., Moore D.D.
    Mol. Endocrinol. 9:72-85(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta."
    Alberti S., Steffensen K.R., Gustafsson J.-A.
    Gene 243:93-103(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
    Wada T., Kang H.S., Angers M., Gong H., Bhatia S., Khadem S., Ren S., Ellis E., Strom S.C., Jetten A.M., Xie W.
    Mol. Pharmacol. 73:891-899(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN METABOLISM REGULATION.
  5. "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor."
    Zelcer N., Hong C., Boyadjian R., Tontonoz P.
    Science 325:100-104(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
    Hong C., Duit S., Jalonen P., Out R., Scheer L., Sorrentino V., Boyadjian R., Rodenburg K.W., Foley E., Korhonen L., Lindholm D., Nimpf J., van Berkel T.J., Tontonoz P., Zelcer N.
    J. Biol. Chem. 285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNR1H2_MOUSE
AccessioniPrimary (citable) accession number: Q60644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3