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Protein

Oxysterols receptor LXR-beta

Gene

Nr1h2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) (PubMed:18055760, PubMed:19520913, PubMed:20427281). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8 (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (PubMed:18055760, PubMed:19520913, PubMed:20427281). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi75 – 152Nuclear receptorPROSITE-ProRule annotationAdd BLAST78
Zinc fingeri78 – 98NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri116 – 140NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • cellular lipid metabolic process Source: MGI
  • cholesterol homeostasis Source: BHF-UCL
  • lipid homeostasis Source: BHF-UCL
  • negative regulation of cholesterol storage Source: MGI
  • negative regulation of lipid transport Source: MGI
  • negative regulation of pinocytosis Source: MGI
  • negative regulation of proteolysis Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of cellular protein metabolic process Source: MGI
  • positive regulation of cholesterol efflux Source: BHF-UCL
  • positive regulation of cholesterol transport Source: MGI
  • positive regulation of fatty acid biosynthetic process Source: MGI
  • positive regulation of high-density lipoprotein particle assembly Source: BHF-UCL
  • positive regulation of lipid storage Source: BHF-UCL
  • positive regulation of lipoprotein lipase activity Source: MGI
  • positive regulation of pancreatic juice secretion Source: BHF-UCL
  • positive regulation of secretion of lysosomal enzymes Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of triglyceride biosynthetic process Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • retinoic acid receptor signaling pathway Source: Ensembl

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-8866427 VLDLR internalisation and degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterols receptor LXR-beta
Alternative name(s):
Liver X receptor beta
Nuclear receptor subfamily 1 group H member 2
Retinoid X receptor-interacting protein No.15
Ubiquitously-expressed nuclear receptor
Gene namesi
Name:Nr1h2
Synonyms:Lxrb, Rip15, Unr, Unr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1352463 Nr1h2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2417346
GuidetoPHARMACOLOGYi601

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535331 – 446Oxysterols receptor LXR-betaAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki395Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki433Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Sumoylated by SUMO2 at Lys-395 and Lys-433 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ60644
MaxQBiQ60644
PaxDbiQ60644
PRIDEiQ60644

PTM databases

PhosphoSitePlusiQ60644

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000060601
CleanExiMM_NR1H2
ExpressionAtlasiQ60644 baseline and differential
GenevisibleiQ60644 MM

Interactioni

Subunit structurei

Forms a heterodimer with RXR. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts (when sumoylated) with GPS2; interaction with GPS2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SIRT1Q96EB62EBI-5276809,EBI-1802965From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204450, 1 interactor
DIPiDIP-444N
IntActiQ60644, 5 interactors
MINTiQ60644
STRINGi10090.ENSMUSP00000073188

Structurei

3D structure databases

ProteinModelPortaliQ60644
SMRiQ60644
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 446NR LBDPROSITE-ProRule annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 76Transactivation AF-1; required for ligand-independent transactivation functionBy similarityAdd BLAST76
Regioni205 – 446Transactivation AF-2; required for ligand-dependent transactivation function; mediates interaction with CCAR2By similarityAdd BLAST242

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 168Poly-Gln7
Compositional biasi169 – 172Poly-Pro4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri78 – 98NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri116 – 140NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000220845
HOVERGENiHBG108655
InParanoidiQ60644
KOiK08535
OMAiRRYACRG
OrthoDBiEOG091G0I4P
PhylomeDBiQ60644

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR023257 Liver_X_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR02034 LIVERXRECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q60644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI
60 70 80 90 100
VVILEPEDEP ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG
110 120 130 140 150
FFRRSVVHGG AGRYACRGSG TCQMDAFMRR KCQLCRLRKC KEAGMREQCV
160 170 180 190 200
LSEEQIRKKR IQKQQQQQPP PPSEPAASSS GRPAASPGTS EASSQGSGEG
210 220 230 240 250
EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG ADPQSRDARQ
260 270 280 290 300
QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE
310 320 330 340 350
TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL
360 370 380 390 400
DDAEYALLIA INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ
410 420 430 440
LRFPRMLMKL VSLRTLSSVH SEQVFALRLQ DKKLPPLLSE IWDVHE
Length:446
Mass (Da):49,720
Last modified:November 1, 1996 - v1
Checksum:i73153E635302C9DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09419 mRNA Translation: AAC52164.1
AJ132602 Genomic DNA Translation: CAB51924.1
BC066025 mRNA Translation: AAH66025.1
CCDSiCCDS21211.1
PIRiI49021
RefSeqiNP_001272446.1, NM_001285517.1
NP_001272447.1, NM_001285518.1
NP_001272448.1, NM_001285519.1
NP_033499.1, NM_009473.3
XP_006540867.1, XM_006540804.3
UniGeneiMm.968

Genome annotation databases

EnsembliENSMUST00000073488; ENSMUSP00000073188; ENSMUSG00000060601
ENSMUST00000107912; ENSMUSP00000103545; ENSMUSG00000060601
ENSMUST00000167197; ENSMUSP00000126788; ENSMUSG00000060601
GeneIDi22260
KEGGimmu:22260
UCSCiuc009gpz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNR1H2_MOUSE
AccessioniPrimary (citable) accession number: Q60644
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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