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Q60644

- NR1H2_MOUSE

UniProt

Q60644 - NR1H2_MOUSE

Protein

Oxysterols receptor LXR-beta

Gene

Nr1h2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi75 – 15278Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri78 – 9821NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri116 – 14025NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    3. protein binding Source: IntAct
    4. retinoid X receptor binding Source: MGI
    5. sequence-specific DNA binding Source: InterPro
    6. sequence-specific DNA binding transcription factor activity Source: MGI
    7. sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity Source: Ensembl
    8. steroid hormone receptor activity Source: InterPro
    9. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cellular lipid metabolic process Source: MGI
    2. cholesterol homeostasis Source: BHF-UCL
    3. lipid homeostasis Source: BHF-UCL
    4. negative regulation of cholesterol storage Source: Ensembl
    5. negative regulation of lipid transport Source: Ensembl
    6. negative regulation of pinocytosis Source: Ensembl
    7. negative regulation of proteolysis Source: BHF-UCL
    8. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    9. positive regulation of cellular protein metabolic process Source: Ensembl
    10. positive regulation of cholesterol efflux Source: BHF-UCL
    11. positive regulation of fatty acid biosynthetic process Source: Ensembl
    12. positive regulation of high-density lipoprotein particle assembly Source: BHF-UCL
    13. positive regulation of lipid storage Source: BHF-UCL
    14. positive regulation of lipoprotein lipase activity Source: Ensembl
    15. positive regulation of pancreatic juice secretion Source: BHF-UCL
    16. positive regulation of secretion of lysosomal enzymes Source: BHF-UCL
    17. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    18. positive regulation of triglyceride biosynthetic process Source: Ensembl
    19. regulation of cholesterol homeostasis Source: UniProtKB
    20. regulation of transcription, DNA-templated Source: MGI
    21. regulation of transcription from RNA polymerase II promoter Source: MGI
    22. retinoic acid receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxysterols receptor LXR-beta
    Alternative name(s):
    Liver X receptor beta
    Nuclear receptor subfamily 1 group H member 2
    Retinoid X receptor-interacting protein No.15
    Ubiquitously-expressed nuclear receptor
    Gene namesi
    Name:Nr1h2
    Synonyms:Lxrb, Rip15, Unr, Unr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1352463. Nr1h2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Oxysterols receptor LXR-betaPRO_0000053533Add
    BLAST

    Proteomic databases

    PRIDEiQ60644.

    PTM databases

    PhosphoSiteiQ60644.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ60644.
    BgeeiQ60644.
    CleanExiMM_NR1H2.
    GenevestigatoriQ60644.

    Interactioni

    Subunit structurei

    Forms a heterodimer with RXR.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SIRT1Q96EB62EBI-5276809,EBI-1802965From a different organism.

    Protein-protein interaction databases

    BioGridi204450. 1 interaction.
    DIPiDIP-444N.
    IntActiQ60644. 4 interactions.
    STRINGi10090.ENSMUSP00000103545.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60644.
    SMRiQ60644. Positions 66-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni216 – 446231Ligand-bindingSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi162 – 1687Poly-Gln
    Compositional biasi169 – 1724Poly-Pro

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri78 – 9821NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri116 – 14025NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG285805.
    GeneTreeiENSGT00720000108423.
    HOGENOMiHOG000220845.
    HOVERGENiHBG108655.
    InParanoidiQ60644.
    KOiK08535.
    OMAiRRYACRG.
    OrthoDBiEOG7DC25S.
    PhylomeDBiQ60644.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR023257. Liver_X_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR02034. LIVERXRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60644-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI    50
    VVILEPEDEP ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG 100
    FFRRSVVHGG AGRYACRGSG TCQMDAFMRR KCQLCRLRKC KEAGMREQCV 150
    LSEEQIRKKR IQKQQQQQPP PPSEPAASSS GRPAASPGTS EASSQGSGEG 200
    EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG ADPQSRDARQ 250
    QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE 300
    TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL 350
    DDAEYALLIA INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ 400
    LRFPRMLMKL VSLRTLSSVH SEQVFALRLQ DKKLPPLLSE IWDVHE 446
    Length:446
    Mass (Da):49,720
    Last modified:November 1, 1996 - v1
    Checksum:i73153E635302C9DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09419 mRNA. Translation: AAC52164.1.
    AJ132602 Genomic DNA. Translation: CAB51924.1.
    BC066025 mRNA. Translation: AAH66025.1.
    CCDSiCCDS21211.1.
    PIRiI49021.
    RefSeqiNP_001272446.1. NM_001285517.1.
    NP_001272447.1. NM_001285518.1.
    NP_001272448.1. NM_001285519.1.
    NP_033499.1. NM_009473.3.
    XP_006540867.1. XM_006540804.1.
    UniGeneiMm.968.

    Genome annotation databases

    EnsembliENSMUST00000073488; ENSMUSP00000073188; ENSMUSG00000060601.
    ENSMUST00000107912; ENSMUSP00000103545; ENSMUSG00000060601.
    ENSMUST00000167197; ENSMUSP00000126788; ENSMUSG00000060601.
    GeneIDi22260.
    KEGGimmu:22260.
    UCSCiuc009gpz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09419 mRNA. Translation: AAC52164.1 .
    AJ132602 Genomic DNA. Translation: CAB51924.1 .
    BC066025 mRNA. Translation: AAH66025.1 .
    CCDSi CCDS21211.1.
    PIRi I49021.
    RefSeqi NP_001272446.1. NM_001285517.1.
    NP_001272447.1. NM_001285518.1.
    NP_001272448.1. NM_001285519.1.
    NP_033499.1. NM_009473.3.
    XP_006540867.1. XM_006540804.1.
    UniGenei Mm.968.

    3D structure databases

    ProteinModelPortali Q60644.
    SMRi Q60644. Positions 66-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204450. 1 interaction.
    DIPi DIP-444N.
    IntActi Q60644. 4 interactions.
    STRINGi 10090.ENSMUSP00000103545.

    Chemistry

    ChEMBLi CHEMBL2417346.

    PTM databases

    PhosphoSitei Q60644.

    Proteomic databases

    PRIDEi Q60644.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073488 ; ENSMUSP00000073188 ; ENSMUSG00000060601 .
    ENSMUST00000107912 ; ENSMUSP00000103545 ; ENSMUSG00000060601 .
    ENSMUST00000167197 ; ENSMUSP00000126788 ; ENSMUSG00000060601 .
    GeneIDi 22260.
    KEGGi mmu:22260.
    UCSCi uc009gpz.1. mouse.

    Organism-specific databases

    CTDi 7376.
    MGIi MGI:1352463. Nr1h2.

    Phylogenomic databases

    eggNOGi NOG285805.
    GeneTreei ENSGT00720000108423.
    HOGENOMi HOG000220845.
    HOVERGENi HBG108655.
    InParanoidi Q60644.
    KOi K08535.
    OMAi RRYACRG.
    OrthoDBi EOG7DC25S.
    PhylomeDBi Q60644.

    Miscellaneous databases

    ChiTaRSi NR1H2. mouse.
    NextBioi 302353.
    PROi Q60644.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60644.
    Bgeei Q60644.
    CleanExi MM_NR1H2.
    Genevestigatori Q60644.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR023257. Liver_X_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR02034. LIVERXRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors."
      Seol W., Choi H.S., Moore D.D.
      Mol. Endocrinol. 9:72-85(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta."
      Alberti S., Steffensen K.R., Gustafsson J.-A.
      Gene 243:93-103(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
      Wada T., Kang H.S., Angers M., Gong H., Bhatia S., Khadem S., Ren S., Ellis E., Strom S.C., Jetten A.M., Xie W.
      Mol. Pharmacol. 73:891-899(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN METABOLISM REGULATION.
    5. "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor."
      Zelcer N., Hong C., Boyadjian R., Tontonoz P.
      Science 325:100-104(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
      Hong C., Duit S., Jalonen P., Out R., Scheer L., Sorrentino V., Boyadjian R., Rodenburg K.W., Foley E., Korhonen L., Lindholm D., Nimpf J., van Berkel T.J., Tontonoz P., Zelcer N.
      J. Biol. Chem. 285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNR1H2_MOUSE
    AccessioniPrimary (citable) accession number: Q60644
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3