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Q60644

- NR1H2_MOUSE

UniProt

Q60644 - NR1H2_MOUSE

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Protein

Oxysterols receptor LXR-beta

Gene
Nr1h2, Lxrb, Rip15, Unr, Unr2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi75 – 15278Nuclear receptorAdd
BLAST
Zinc fingeri78 – 9821NR C4-typeAdd
BLAST
Zinc fingeri116 – 14025NR C4-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  3. protein binding Source: IntAct
  4. retinoid X receptor binding Source: MGI
  5. sequence-specific DNA binding Source: InterPro
  6. sequence-specific DNA binding transcription factor activity Source: MGI
  7. sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity Source: Ensembl
  8. steroid hormone receptor activity Source: InterPro
  9. zinc ion binding Source: InterPro

GO - Biological processi

  1. cellular lipid metabolic process Source: MGI
  2. cholesterol homeostasis Source: BHF-UCL
  3. lipid homeostasis Source: BHF-UCL
  4. negative regulation of cholesterol storage Source: Ensembl
  5. negative regulation of lipid transport Source: Ensembl
  6. negative regulation of pinocytosis Source: Ensembl
  7. negative regulation of proteolysis Source: BHF-UCL
  8. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  9. positive regulation of cellular protein metabolic process Source: Ensembl
  10. positive regulation of cholesterol efflux Source: BHF-UCL
  11. positive regulation of fatty acid biosynthetic process Source: Ensembl
  12. positive regulation of high-density lipoprotein particle assembly Source: BHF-UCL
  13. positive regulation of lipid storage Source: BHF-UCL
  14. positive regulation of lipoprotein lipase activity Source: Ensembl
  15. positive regulation of pancreatic juice secretion Source: BHF-UCL
  16. positive regulation of secretion of lysosomal enzymes Source: BHF-UCL
  17. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  18. positive regulation of triglyceride biosynthetic process Source: Ensembl
  19. regulation of cholesterol homeostasis Source: UniProtKB
  20. regulation of transcription, DNA-templated Source: MGI
  21. regulation of transcription from RNA polymerase II promoter Source: MGI
  22. retinoic acid receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterols receptor LXR-beta
Alternative name(s):
Liver X receptor beta
Nuclear receptor subfamily 1 group H member 2
Retinoid X receptor-interacting protein No.15
Ubiquitously-expressed nuclear receptor
Gene namesi
Name:Nr1h2
Synonyms:Lxrb, Rip15, Unr, Unr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1352463. Nr1h2.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Oxysterols receptor LXR-betaPRO_0000053533Add
BLAST

Proteomic databases

PRIDEiQ60644.

PTM databases

PhosphoSiteiQ60644.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ60644.
BgeeiQ60644.
CleanExiMM_NR1H2.
GenevestigatoriQ60644.

Interactioni

Subunit structurei

Forms a heterodimer with RXR.

Binary interactionsi

WithEntry#Exp.IntActNotes
SIRT1Q96EB62EBI-5276809,EBI-1802965From a different organism.

Protein-protein interaction databases

BioGridi204450. 1 interaction.
DIPiDIP-444N.
IntActiQ60644. 2 interactions.
STRINGi10090.ENSMUSP00000103545.

Structurei

3D structure databases

ProteinModelPortaliQ60644.
SMRiQ60644. Positions 66-445.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni216 – 446231Ligand-binding Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 1687Poly-Gln
Compositional biasi169 – 1724Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG285805.
GeneTreeiENSGT00720000108423.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
InParanoidiQ60644.
KOiK08535.
OMAiRRYACRG.
OrthoDBiEOG7DC25S.
PhylomeDBiQ60644.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60644-1 [UniParc]FASTAAdd to Basket

« Hide

MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI    50
VVILEPEDEP ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG 100
FFRRSVVHGG AGRYACRGSG TCQMDAFMRR KCQLCRLRKC KEAGMREQCV 150
LSEEQIRKKR IQKQQQQQPP PPSEPAASSS GRPAASPGTS EASSQGSGEG 200
EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG ADPQSRDARQ 250
QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE 300
TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL 350
DDAEYALLIA INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ 400
LRFPRMLMKL VSLRTLSSVH SEQVFALRLQ DKKLPPLLSE IWDVHE 446
Length:446
Mass (Da):49,720
Last modified:November 1, 1996 - v1
Checksum:i73153E635302C9DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09419 mRNA. Translation: AAC52164.1.
AJ132602 Genomic DNA. Translation: CAB51924.1.
BC066025 mRNA. Translation: AAH66025.1.
CCDSiCCDS21211.1.
PIRiI49021.
RefSeqiNP_001272446.1. NM_001285517.1.
NP_001272447.1. NM_001285518.1.
NP_001272448.1. NM_001285519.1.
NP_033499.1. NM_009473.3.
XP_006540867.1. XM_006540804.1.
UniGeneiMm.968.

Genome annotation databases

EnsembliENSMUST00000073488; ENSMUSP00000073188; ENSMUSG00000060601.
ENSMUST00000107912; ENSMUSP00000103545; ENSMUSG00000060601.
ENSMUST00000167197; ENSMUSP00000126788; ENSMUSG00000060601.
GeneIDi22260.
KEGGimmu:22260.
UCSCiuc009gpz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09419 mRNA. Translation: AAC52164.1 .
AJ132602 Genomic DNA. Translation: CAB51924.1 .
BC066025 mRNA. Translation: AAH66025.1 .
CCDSi CCDS21211.1.
PIRi I49021.
RefSeqi NP_001272446.1. NM_001285517.1.
NP_001272447.1. NM_001285518.1.
NP_001272448.1. NM_001285519.1.
NP_033499.1. NM_009473.3.
XP_006540867.1. XM_006540804.1.
UniGenei Mm.968.

3D structure databases

ProteinModelPortali Q60644.
SMRi Q60644. Positions 66-445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204450. 1 interaction.
DIPi DIP-444N.
IntActi Q60644. 2 interactions.
STRINGi 10090.ENSMUSP00000103545.

Chemistry

ChEMBLi CHEMBL2417346.

PTM databases

PhosphoSitei Q60644.

Proteomic databases

PRIDEi Q60644.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073488 ; ENSMUSP00000073188 ; ENSMUSG00000060601 .
ENSMUST00000107912 ; ENSMUSP00000103545 ; ENSMUSG00000060601 .
ENSMUST00000167197 ; ENSMUSP00000126788 ; ENSMUSG00000060601 .
GeneIDi 22260.
KEGGi mmu:22260.
UCSCi uc009gpz.1. mouse.

Organism-specific databases

CTDi 7376.
MGIi MGI:1352463. Nr1h2.

Phylogenomic databases

eggNOGi NOG285805.
GeneTreei ENSGT00720000108423.
HOGENOMi HOG000220845.
HOVERGENi HBG108655.
InParanoidi Q60644.
KOi K08535.
OMAi RRYACRG.
OrthoDBi EOG7DC25S.
PhylomeDBi Q60644.

Miscellaneous databases

ChiTaRSi NR1H2. mouse.
NextBioi 302353.
PROi Q60644.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q60644.
Bgeei Q60644.
CleanExi MM_NR1H2.
Genevestigatori Q60644.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors."
    Seol W., Choi H.S., Moore D.D.
    Mol. Endocrinol. 9:72-85(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta."
    Alberti S., Steffensen K.R., Gustafsson J.-A.
    Gene 243:93-103(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
    Wada T., Kang H.S., Angers M., Gong H., Bhatia S., Khadem S., Ren S., Ellis E., Strom S.C., Jetten A.M., Xie W.
    Mol. Pharmacol. 73:891-899(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN METABOLISM REGULATION.
  5. "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor."
    Zelcer N., Hong C., Boyadjian R., Tontonoz P.
    Science 325:100-104(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
    Hong C., Duit S., Jalonen P., Out R., Scheer L., Sorrentino V., Boyadjian R., Rodenburg K.W., Foley E., Korhonen L., Lindholm D., Nimpf J., van Berkel T.J., Tontonoz P., Zelcer N.
    J. Biol. Chem. 285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNR1H2_MOUSE
AccessioniPrimary (citable) accession number: Q60644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi