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Protein

Flotillin-2

Gene

Flot2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-8849932 Synaptic adhesion-like molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Flotillin-2
Alternative name(s):
Epidermal surface antigen
Short name:
ESA
Membrane component chromosome 17 surface marker 1 homolog
Gene namesi
Name:Flot2
Synonyms:Esa1, M17s1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103309 Flot2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000940502 – 428Flotillin-2Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi4S-palmitoyl cysteine; by ZDHHC5By similarity1
Lipidationi19S-palmitoyl cysteineBy similarity1
Lipidationi20S-palmitoyl cysteine; by ZDHHC5By similarity1
Modified residuei405PhosphoserineBy similarity1

Post-translational modificationi

ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ60634
PeptideAtlasiQ60634
PRIDEiQ60634

PTM databases

iPTMnetiQ60634
PhosphoSitePlusiQ60634
SwissPalmiQ60634

Expressioni

Tissue specificityi

Expressed in many tissues, including suprabasal epidermis, hair follicles, heart, lung, thymus, spleen, liver, kidney and brain. Not expressed in skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000061981
CleanExiMM_FLOT2
ExpressionAtlasiQ60634 baseline and differential
GenevisibleiQ60634 MM

Interactioni

Subunit structurei

Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199705, 57 interactors
IntActiQ60634, 61 interactors
MINTiQ60634
STRINGi10090.ENSMUSP00000072136

Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi50 – 52Combined sources3
Beta strandi56 – 60Combined sources5
Beta strandi62 – 64Combined sources3
Beta strandi66 – 69Combined sources4
Beta strandi72 – 77Combined sources6
Helixi85 – 91Combined sources7
Beta strandi92 – 94Combined sources3
Helixi96 – 117Combined sources22
Helixi120 – 125Combined sources6
Helixi127 – 142Combined sources16
Turni143 – 146Combined sources4
Beta strandi147 – 153Combined sources7
Helixi163 – 167Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WINNMR-A43-172[»]
ProteinModelPortaliQ60634
SMRiQ60634
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60634

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2668 Eukaryota
COG2268 LUCA
GeneTreeiENSGT00560000077232
HOGENOMiHOG000240804
HOVERGENiHBG051628
InParanoidiQ60634
KOiK07192
OMAiYICQPSE
TreeFamiTF324879

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR031905 Flotillin_C
IPR027705 Flotillin_fam
PANTHERiPTHR13806 PTHR13806, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PF15975 Flot, 1 hit
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q60634-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNCHTVGPN EALVVSGGCC GSDYKQYVFG GWAWAWWCIS DTQRISLEIM
60 70 80 90 100
TLQPRCEDVE TAEGVALTVT GVAQVKIMTE KELLAVACEQ FLGKNVQDIK
110 120 130 140 150
NVVLQTLEGH LRSILGTLTV EQIYQDRDQF AKLVREVAAP DVGRMGIEIL
160 170 180 190 200
SFTIKDVYDK VDYLSSLGKT QTAVVQRDAD IGVAEAERDA GIREAECKKE
210 220 230 240 250
MLDVKFMADT KIADSKRAFE LQKSAFSEEV NIKTAEAQLA YELQGAREQQ
260 270 280 290 300
KIRQEEIEIE VVQRKKQIAV EAQEILRTDK ELIATVRRPA EAEAHRIQQI
310 320 330 340 350
AEGEKVKQVL LAQAEAEKIR KIGEAEAAVI EAMGKAEAER MKLKAEAYQK
360 370 380 390 400
YGDAAKMALV LEALPQIAAK ISAPLTKVDE IVVLSGDNSK VTSEVNRLLA
410 420
ELPASVHALT GVDLSKIPLI KNATGAQV
Length:428
Mass (Da):47,038
Last modified:July 28, 2009 - v2
Checksum:iE482A0E2071D3CA7
GO
Isoform 2 (identifier: Q60634-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-68: MTLQPRCEDVETAEGVALT → MTILCRCENIETSEGVPLF

Show »
Length:428
Mass (Da):47,130
Checksum:i7CC8BF0665890E0F
GO
Isoform 3 (identifier: Q60634-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Show »
Length:379
Mass (Da):41,659
Checksum:i043869D46EFEE3DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87A → S in AAH70423 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0376921 – 49Missing in isoform 3. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_00050250 – 68MTLQP…GVALT → MTILCRCENIETSEGVPLF in isoform 2. CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07890 mRNA Translation: AAA93127.1
AK170557 mRNA Translation: BAE41879.1
AL669840 Genomic DNA Translation: CAI25705.1
CH466596 Genomic DNA Translation: EDL12906.1
BC070423 mRNA Translation: AAH70423.1
CCDSiCCDS25088.1 [Q60634-3]
CCDS36237.1 [Q60634-1]
RefSeqiNP_001035493.1, NM_001040403.1 [Q60634-1]
NP_001271156.1, NM_001284227.1
NP_001271157.1, NM_001284228.1 [Q60634-3]
NP_032054.1, NM_008028.2 [Q60634-3]
XP_006532255.1, XM_006532192.2 [Q60634-3]
XP_006532256.1, XM_006532193.3 [Q60634-3]
UniGeneiMm.130227

Genome annotation databases

EnsembliENSMUST00000072289; ENSMUSP00000072136; ENSMUSG00000061981 [Q60634-1]
ENSMUST00000100784; ENSMUSP00000098347; ENSMUSG00000061981 [Q60634-3]
GeneIDi14252
KEGGimmu:14252
UCSCiuc007khw.1 mouse [Q60634-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFLOT2_MOUSE
AccessioniPrimary (citable) accession number: Q60634
Secondary accession number(s): Q5SS82, Q6NS75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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