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Q60632

- COT1_MOUSE

UniProt

Q60632 - COT1_MOUSE

Protein

COUP transcription factor 1

Gene

Nr2f1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (01 May 1997)
      Previous versions | rss
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    Functioni

    Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi82 – 15776Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri85 – 10521NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri121 – 14525NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    2. sequence-specific DNA binding Source: MGI
    3. steroid hormone receptor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cerebral cortex regionalization Source: MGI
    2. forebrain development Source: MGI
    3. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    4. neuron migration Source: MGI

    Keywords - Molecular functioni

    Activator, Receptor, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COUP transcription factor 1
    Short name:
    COUP-TF1
    Alternative name(s):
    COUP transcription factor I
    Short name:
    COUP-TF I
    Nuclear receptor subfamily 2 group F member 1
    V-erbA-related protein 3
    Short name:
    EAR-3
    Gene namesi
    Name:Nr2f1
    Synonyms:Erbal3, Tfcoup1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1352451. Nr2f1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422COUP transcription factor 1PRO_0000053603Add
    BLAST

    Proteomic databases

    PaxDbiQ60632.
    PRIDEiQ60632.

    PTM databases

    PhosphoSiteiQ60632.

    Expressioni

    Developmental stagei

    Expression begins in 8.5-day-old embryos, peaks at 14-15 days and declines before birth.

    Gene expression databases

    CleanExiMM_NR2F1.
    GenevestigatoriQ60632.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199495. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60632.
    SMRiQ60632. Positions 81-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni343 – 42280Important for dimerizationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi32 – 387Poly-Gly

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri85 – 10521NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri121 – 14525NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG327099.
    HOGENOMiHOG000260820.
    HOVERGENiHBG005606.
    InParanoidiQ60632.
    KOiK08547.
    PhylomeDBiQ60632.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60632-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQAGSGAPHT    50
    PQTPGQPGAP ATPGTQGDKG QGPPGSGQSQ QHIECVVCGD KSSGKHYGQF 100
    TCEGCKSFFK RSVRRNLTYT CRANRNCPID QHHRNQCQYC RLKKCLKVGM 150
    RREAVQRGRM PPTQPNPGQY ALTNGDPLNG HCYLSGYISL LLRAEPYPTS 200
    RYGSQCMQPN NIMGIENICE LAARLLFSAV EWARNIPFFP DLQITDQVSL 250
    LRLTWSELFV LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI 300
    FQEQVEKLKA LHVDSAEYSC LKAIVLFTSD ACGLSDAAHI ESLQEKSQCA 350
    LEEYVRSQYP NQPSRFGKLL LRLPSLRTVS SSVIEQLFFV RLVGKTPIET 400
    LIRDMLLSGS SFNWPYMSIQ CS 422
    Length:422
    Mass (Da):46,085
    Last modified:May 1, 1997 - v2
    Checksum:iC16591638E1E2500
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 372Missing in AAA19853. (PubMed:7947324)Curated
    Sequence conflicti66 – 661Q → A in AAA19853. (PubMed:7947324)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07625 mRNA. Translation: AAA19853.1.
    X74134 mRNA. Translation: CAA52231.1.
    PIRiI48305.
    RefSeqiNP_034281.2. NM_010151.2.
    UniGeneiMm.439653.

    Genome annotation databases

    GeneIDi13865.
    KEGGimmu:13865.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07625 mRNA. Translation: AAA19853.1 .
    X74134 mRNA. Translation: CAA52231.1 .
    PIRi I48305.
    RefSeqi NP_034281.2. NM_010151.2.
    UniGenei Mm.439653.

    3D structure databases

    ProteinModelPortali Q60632.
    SMRi Q60632. Positions 81-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199495. 1 interaction.

    PTM databases

    PhosphoSitei Q60632.

    Proteomic databases

    PaxDbi Q60632.
    PRIDEi Q60632.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 13865.
    KEGGi mmu:13865.

    Organism-specific databases

    CTDi 7025.
    MGIi MGI:1352451. Nr2f1.

    Phylogenomic databases

    eggNOGi NOG327099.
    HOGENOMi HOG000260820.
    HOVERGENi HBG005606.
    InParanoidi Q60632.
    KOi K08547.
    PhylomeDBi Q60632.

    Miscellaneous databases

    ChiTaRSi NR2F1. mouse.
    NextBioi 284760.
    PROi Q60632.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_NR2F1.
    Genevestigatori Q60632.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon."
      Qiu Y., Cooney A.J., Kuratani S., DeMayo F.J., Tsai S.Y., Tsai M.J.
      Proc. Natl. Acad. Sci. U.S.A. 91:4451-4455(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors."
      Jonk L.J.C., de Jonge M.E.J., Pals C.E.G.M., Wissink S., Vervaart J.M.A., Schoorlemmer J., Kruijer W.
      Mech. Dev. 47:81-97(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCOT1_MOUSE
    AccessioniPrimary (citable) accession number: Q60632
    Secondary accession number(s): Q61438
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3