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Q60632

- COT1_MOUSE

UniProt

Q60632 - COT1_MOUSE

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Protein

COUP transcription factor 1

Gene

Nr2f1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi82 – 15776Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri85 – 10521NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 14525NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  2. sequence-specific DNA binding Source: MGI
  3. steroid hormone receptor activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. cerebral cortex regionalization Source: MGI
  2. forebrain development Source: MGI
  3. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  4. neuron migration Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
COUP transcription factor 1
Short name:
COUP-TF1
Alternative name(s):
COUP transcription factor I
Short name:
COUP-TF I
Nuclear receptor subfamily 2 group F member 1
V-erbA-related protein 3
Short name:
EAR-3
Gene namesi
Name:Nr2f1
Synonyms:Erbal3, Tfcoup1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1352451. Nr2f1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422COUP transcription factor 1PRO_0000053603Add
BLAST

Proteomic databases

MaxQBiQ60632.
PaxDbiQ60632.
PRIDEiQ60632.

PTM databases

PhosphoSiteiQ60632.

Expressioni

Developmental stagei

Expression begins in 8.5-day-old embryos, peaks at 14-15 days and declines before birth.

Gene expression databases

CleanExiMM_NR2F1.
GenevestigatoriQ60632.

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199495. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ60632.
SMRiQ60632. Positions 81-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni343 – 42280Important for dimerizationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 387Poly-Gly

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri85 – 10521NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 14525NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG327099.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiQ60632.
KOiK08547.
PhylomeDBiQ60632.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60632-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQAGSGAPHT
60 70 80 90 100
PQTPGQPGAP ATPGTQGDKG QGPPGSGQSQ QHIECVVCGD KSSGKHYGQF
110 120 130 140 150
TCEGCKSFFK RSVRRNLTYT CRANRNCPID QHHRNQCQYC RLKKCLKVGM
160 170 180 190 200
RREAVQRGRM PPTQPNPGQY ALTNGDPLNG HCYLSGYISL LLRAEPYPTS
210 220 230 240 250
RYGSQCMQPN NIMGIENICE LAARLLFSAV EWARNIPFFP DLQITDQVSL
260 270 280 290 300
LRLTWSELFV LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI
310 320 330 340 350
FQEQVEKLKA LHVDSAEYSC LKAIVLFTSD ACGLSDAAHI ESLQEKSQCA
360 370 380 390 400
LEEYVRSQYP NQPSRFGKLL LRLPSLRTVS SSVIEQLFFV RLVGKTPIET
410 420
LIRDMLLSGS SFNWPYMSIQ CS
Length:422
Mass (Da):46,085
Last modified:May 1, 1997 - v2
Checksum:iC16591638E1E2500
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 372Missing in AAA19853. (PubMed:7947324)Curated
Sequence conflicti66 – 661Q → A in AAA19853. (PubMed:7947324)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07625 mRNA. Translation: AAA19853.1.
X74134 mRNA. Translation: CAA52231.1.
PIRiI48305.
RefSeqiNP_034281.2. NM_010151.2.
UniGeneiMm.439653.

Genome annotation databases

GeneIDi13865.
KEGGimmu:13865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07625 mRNA. Translation: AAA19853.1 .
X74134 mRNA. Translation: CAA52231.1 .
PIRi I48305.
RefSeqi NP_034281.2. NM_010151.2.
UniGenei Mm.439653.

3D structure databases

ProteinModelPortali Q60632.
SMRi Q60632. Positions 81-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199495. 1 interaction.

PTM databases

PhosphoSitei Q60632.

Proteomic databases

MaxQBi Q60632.
PaxDbi Q60632.
PRIDEi Q60632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13865.
KEGGi mmu:13865.

Organism-specific databases

CTDi 7025.
MGIi MGI:1352451. Nr2f1.

Phylogenomic databases

eggNOGi NOG327099.
HOGENOMi HOG000260820.
HOVERGENi HBG005606.
InParanoidi Q60632.
KOi K08547.
PhylomeDBi Q60632.

Miscellaneous databases

ChiTaRSi Nr2f1. mouse.
NextBioi 284760.
PROi Q60632.
SOURCEi Search...

Gene expression databases

CleanExi MM_NR2F1.
Genevestigatori Q60632.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon."
    Qiu Y., Cooney A.J., Kuratani S., DeMayo F.J., Tsai S.Y., Tsai M.J.
    Proc. Natl. Acad. Sci. U.S.A. 91:4451-4455(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors."
    Jonk L.J.C., de Jonge M.E.J., Pals C.E.G.M., Wissink S., Vervaart J.M.A., Schoorlemmer J., Kruijer W.
    Mech. Dev. 47:81-97(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCOT1_MOUSE
AccessioniPrimary (citable) accession number: Q60632
Secondary accession number(s): Q61438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3