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Q60632 (COT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
COUP transcription factor 1

Short name=COUP-TF1
Alternative name(s):
COUP transcription factor I
Short name=COUP-TF I
Nuclear receptor subfamily 2 group F member 1
V-erbA-related protein 3
Short name=EAR-3
Gene names
Name:Nr2f1
Synonyms:Erbal3, Tfcoup1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG By similarity.

Subunit structure

Binds DNA as a dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2 By similarity.

Subcellular location

Nucleus.

Developmental stage

Expression begins in 8.5-day-old embryos, peaks at 14-15 days and declines before birth.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR2 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422COUP transcription factor 1
PRO_0000053603

Regions

DNA binding82 – 15776Nuclear receptor
Zinc finger85 – 10521NR C4-type
Zinc finger121 – 14525NR C4-type
Region343 – 42280Important for dimerization
Compositional bias32 – 387Poly-Gly

Experimental info

Sequence conflict36 – 372Missing in AAA19853. Ref.2
Sequence conflict661Q → A in AAA19853. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q60632 [UniParc].

Last modified May 1, 1997. Version 2.
Checksum: C16591638E1E2500

FASTA42246,085
        10         20         30         40         50         60 
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQAGSGAPHT PQTPGQPGAP 

        70         80         90        100        110        120 
ATPGTQGDKG QGPPGSGQSQ QHIECVVCGD KSSGKHYGQF TCEGCKSFFK RSVRRNLTYT 

       130        140        150        160        170        180 
CRANRNCPID QHHRNQCQYC RLKKCLKVGM RREAVQRGRM PPTQPNPGQY ALTNGDPLNG 

       190        200        210        220        230        240 
HCYLSGYISL LLRAEPYPTS RYGSQCMQPN NIMGIENICE LAARLLFSAV EWARNIPFFP 

       250        260        270        280        290        300 
DLQITDQVSL LRLTWSELFV LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI 

       310        320        330        340        350        360 
FQEQVEKLKA LHVDSAEYSC LKAIVLFTSD ACGLSDAAHI ESLQEKSQCA LEEYVRSQYP 

       370        380        390        400        410        420 
NQPSRFGKLL LRLPSLRTVS SSVIEQLFFV RLVGKTPIET LIRDMLLSGS SFNWPYMSIQ 


CS 

« Hide

References

[1]"Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon."
Qiu Y., Cooney A.J., Kuratani S., DeMayo F.J., Tsai S.Y., Tsai M.J.
Proc. Natl. Acad. Sci. U.S.A. 91:4451-4455(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors."
Jonk L.J.C., de Jonge M.E.J., Pals C.E.G.M., Wissink S., Vervaart J.M.A., Schoorlemmer J., Kruijer W.
Mech. Dev. 47:81-97(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U07625 mRNA. Translation: AAA19853.1.
X74134 mRNA. Translation: CAA52231.1.
PIRI48305.
RefSeqNP_034281.2. NM_010151.2.
UniGeneMm.439653.

3D structure databases

ProteinModelPortalQ60632.
SMRQ60632. Positions 81-413.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199495. 1 interaction.

PTM databases

PhosphoSiteQ60632.

Proteomic databases

PaxDbQ60632.
PRIDEQ60632.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID13865.
KEGGmmu:13865.

Organism-specific databases

CTD7025.
MGIMGI:1352451. Nr2f1.

Phylogenomic databases

eggNOGNOG327099.
HOGENOMHOG000260820.
HOVERGENHBG005606.
InParanoidQ60632.
KOK08547.
PhylomeDBQ60632.

Gene expression databases

CleanExMM_NR2F1.
GenevestigatorQ60632.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNR2F1. mouse.
NextBio284760.
PROQ60632.
SOURCESearch...

Entry information

Entry nameCOT1_MOUSE
AccessionPrimary (citable) accession number: Q60632
Secondary accession number(s): Q61438
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot