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Protein

COUP transcription factor 1

Gene

Nr2f1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi82 – 157Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri85 – 105NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri121 – 145NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • cerebral cortex regionalization Source: MGI
  • forebrain development Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neuron migration Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
COUP transcription factor 1
Short name:
COUP-TF1
Alternative name(s):
COUP transcription factor I
Short name:
COUP-TF I
Nuclear receptor subfamily 2 group F member 1
V-erbA-related protein 3
Short name:
EAR-3
Gene namesi
Name:Nr2f1
Synonyms:Erbal3, Tfcoup1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1352451. Nr2f1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536031 – 422COUP transcription factor 1Add BLAST422

Proteomic databases

MaxQBiQ60632.
PaxDbiQ60632.
PeptideAtlasiQ60632.
PRIDEiQ60632.

PTM databases

iPTMnetiQ60632.
PhosphoSitePlusiQ60632.

Expressioni

Developmental stagei

Expression begins in 8.5-day-old embryos, peaks at 14-15 days and declines before birth.

Gene expression databases

CleanExiMM_NR2F1.

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199495. 1 interactor.
STRINGi10090.ENSMUSP00000089036.

Structurei

3D structure databases

ProteinModelPortaliQ60632.
SMRiQ60632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni343 – 422Important for dimerizationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 38Poly-Gly7

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri85 – 105NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri121 – 145NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiQ60632.
KOiK08547.
PhylomeDBiQ60632.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQAGSGAPHT
60 70 80 90 100
PQTPGQPGAP ATPGTQGDKG QGPPGSGQSQ QHIECVVCGD KSSGKHYGQF
110 120 130 140 150
TCEGCKSFFK RSVRRNLTYT CRANRNCPID QHHRNQCQYC RLKKCLKVGM
160 170 180 190 200
RREAVQRGRM PPTQPNPGQY ALTNGDPLNG HCYLSGYISL LLRAEPYPTS
210 220 230 240 250
RYGSQCMQPN NIMGIENICE LAARLLFSAV EWARNIPFFP DLQITDQVSL
260 270 280 290 300
LRLTWSELFV LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI
310 320 330 340 350
FQEQVEKLKA LHVDSAEYSC LKAIVLFTSD ACGLSDAAHI ESLQEKSQCA
360 370 380 390 400
LEEYVRSQYP NQPSRFGKLL LRLPSLRTVS SSVIEQLFFV RLVGKTPIET
410 420
LIRDMLLSGS SFNWPYMSIQ CS
Length:422
Mass (Da):46,085
Last modified:May 1, 1997 - v2
Checksum:iC16591638E1E2500
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 37Missing in AAA19853 (PubMed:7947324).Curated2
Sequence conflicti66Q → A in AAA19853 (PubMed:7947324).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07625 mRNA. Translation: AAA19853.1.
X74134 mRNA. Translation: CAA52231.1.
PIRiI48305.
RefSeqiNP_034281.2. NM_010151.2.
UniGeneiMm.439653.

Genome annotation databases

GeneIDi13865.
KEGGimmu:13865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07625 mRNA. Translation: AAA19853.1.
X74134 mRNA. Translation: CAA52231.1.
PIRiI48305.
RefSeqiNP_034281.2. NM_010151.2.
UniGeneiMm.439653.

3D structure databases

ProteinModelPortaliQ60632.
SMRiQ60632.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199495. 1 interactor.
STRINGi10090.ENSMUSP00000089036.

PTM databases

iPTMnetiQ60632.
PhosphoSitePlusiQ60632.

Proteomic databases

MaxQBiQ60632.
PaxDbiQ60632.
PeptideAtlasiQ60632.
PRIDEiQ60632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13865.
KEGGimmu:13865.

Organism-specific databases

CTDi7025.
MGIiMGI:1352451. Nr2f1.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiQ60632.
KOiK08547.
PhylomeDBiQ60632.

Miscellaneous databases

ChiTaRSiNr2f1. mouse.
PROiQ60632.
SOURCEiSearch...

Gene expression databases

CleanExiMM_NR2F1.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOT1_MOUSE
AccessioniPrimary (citable) accession number: Q60632
Secondary accession number(s): Q61438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.