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Protein

Growth factor receptor-bound protein 2

Gene

Grb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced. transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death (By similarity).By similarity

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB
  • epidermal growth factor receptor binding Source: MGI
  • identical protein binding Source: MGI
  • insulin receptor substrate binding Source: MGI
  • neurotrophin TRKA receptor binding Source: MGI
  • poly(A) RNA binding Source: MGI
  • protein domain specific binding Source: MGI
  • protein kinase binding Source: MGI
  • protein phosphatase binding Source: UniProtKB
  • SH3/SH2 adaptor activity Source: MGI
  • SH3 domain binding Source: UniProtKB

GO - Biological processi

  • aging Source: Ensembl
  • anatomical structure formation involved in morphogenesis Source: MGI
  • branching involved in labyrinthine layer morphogenesis Source: MGI
  • cell differentiation Source: MGI
  • cellular response to ionizing radiation Source: MGI
  • Fc-epsilon receptor signaling pathway Source: Reactome
  • insulin receptor signaling pathway Source: MGI
  • positive regulation of actin filament polymerization Source: MGI
  • positive regulation of reactive oxygen species metabolic process Source: MGI
  • protein heterooligomerization Source: Ensembl
  • Ras protein signal transduction Source: MGI
  • receptor internalization Source: MGI
  • regulation of MAPK cascade Source: MGI
  • signal transduction in response to DNA damage Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-112412. SOS-mediated signalling.
R-MMU-114604. GPVI-mediated activation cascade.
R-MMU-1250347. SHC1 events in ERBB4 signaling.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-1295596. Spry regulation of FGF signaling.
R-MMU-1433557. Signaling by SCF-KIT.
R-MMU-1433559. Regulation of KIT signaling.
R-MMU-167044. Signalling to RAS.
R-MMU-179812. GRB2 events in EGFR signaling.
R-MMU-180292. GAB1 signalosome.
R-MMU-180336. SHC1 events in EGFR signaling.
R-MMU-182971. EGFR downregulation.
R-MMU-186763. Downstream signal transduction.
R-MMU-1963640. GRB2 events in ERBB2 signaling.
R-MMU-1963642. PI3K events in ERBB2 signaling.
R-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-210993. Tie2 Signaling.
R-MMU-2179392. EGFR Transactivation by Gastrin.
R-MMU-2424491. DAP12 signaling.
R-MMU-2428933. SHC-related events triggered by IGF1R.
R-MMU-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-2871809. FCERI mediated Ca+2 mobilization.
R-MMU-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-388841. Costimulation by the CD28 family.
R-MMU-389359. CD28 dependent Vav1 pathway.
R-MMU-391160. Signal regulatory protein (SIRP) family interactions.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-512988. Interleukin-3, 5 and GM-CSF signaling.
R-MMU-5654688. SHC-mediated cascade:FGFR1.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654704. SHC-mediated cascade:FGFR3.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654710. PI-3K cascade:FGFR3.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654719. SHC-mediated cascade:FGFR4.
R-MMU-5654720. PI-3K cascade:FGFR4.
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5654732. Negative regulation of FGFR3 signaling.
R-MMU-5654733. Negative regulation of FGFR4 signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-74749. Signal attenuation.
R-MMU-74751. Insulin receptor signalling cascade.
R-MMU-912526. Interleukin receptor SHC signaling.
R-MMU-912631. Regulation of signaling by CBL.
R-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth factor receptor-bound protein 2
Alternative name(s):
Adapter protein GRB2
SH2/SH3 adapter GRB2
Gene namesi
Name:Grb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95805. Grb2.

Subcellular locationi

GO - Cellular componenti

  • cell-cell junction Source: MGI
  • COP9 signalosome Source: UniProtKB
  • cytoplasm Source: MGI
  • cytosol Source: Reactome
  • endosome Source: UniProtKB
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: UniProtKB-SubCell
  • Grb2-EGFR complex Source: MGI
  • membrane Source: MGI
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • plasma membrane Source: MGI
  • vesicle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Growth factor receptor-bound protein 2PRO_0000088199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei6 – 61N6-acetyllysineBy similarity
Modified residuei50 – 501N6-acetyllysineBy similarity
Modified residuei109 – 1091N6-acetyllysineBy similarity
Modified residuei211 – 2111PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ60631.
MaxQBiQ60631.
PaxDbiQ60631.
PeptideAtlasiQ60631.
PRIDEiQ60631.

PTM databases

iPTMnetiQ60631.
PhosphoSiteiQ60631.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059923.
CleanExiMM_GRB2.
ExpressionAtlasiQ60631. baseline and differential.
GenevisibleiQ60631. MM.

Interactioni

Subunit structurei

Associates (via SH2 domain) with activated EGF and PDGF receptors (tyrosine phosphorylated) (By similarity). Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (PubMed:8943348). Interacts with IRS4 (when Tyr-phosphorylated) (PubMed:11113178). Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains (By similarity). It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Interacts with SOS1 (By similarity). Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1 (By similarity). Interacts with phosphorylated MET (By similarity). Interacts with phosphorylated TOM1L1 (PubMed:11711534). Interacts with the phosphorylated C-terminus of SH2B2 (By similarity). Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation (By similarity) (PubMed:16249387, PubMed:14610044, PubMed:15477350, PubMed:15477348, PubMed:22561606). Interacts with NISCH, PTPNS1 and REPS2 (By similarity). Interacts with syntrophin SNTA1 (PubMed:11551227). Interacts (via SH3 domains) with REPS1 (PubMed:9395447). Interacts (via SH3 domains) with PIK3C2B (By similarity). Interacts with CBL and CBLB (By similarity). Interacts with AJUBA and CLNK (PubMed:10330178, PubMed:11463797). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (PubMed:10521483). Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2 (By similarity). Interacts with PTPN11 (PubMed:8943348). Interacts with PRNP (PubMed:11571277). Interacts with RALGPS1 (By similarity). Interacts also with HCST (PubMed:16582911). Interacts with KDR (PubMed:16966330). Interacts with FLT1 (tyrosine-phosphorylated) (PubMed:9722576). Interacts with GAPT and PTPRE (By similarity). Interacts (via SH2 domain) with KIF26A (By similarity). Interacts (via SH3 2) with GAB2 (PubMed:10068651). Interacts with ADAM15 (By similarity). Interacts with THEMIS2 (PubMed:20644716). Interacts (via SH2 domain) with AXL (phosphorylated) (By similarity). Interacts (via SH2 domain) with KIT (phosphorylated) (PubMed:10377264). Interacts with PTPRJ and BCR (By similarity). Interacts with PTPN23 (By similarity). Interacts with FLT4 (tyrosine phosphorylated) (By similarity). Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration (PubMed:12925710). Part of a complex including TNK2, GRB2 and one receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which GRB2 promotes RTK recruitment by TNK2 (By similarity). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (PubMed:9312046). Interacts with ERBB4 (By similarity). Interacts with NTRK1 (phosphorylated upon ligand-binding) (By similarity). Interacts with PTK2/FAK1 (tyrosine phosphorylated) (PubMed:7997267). Interacts with PTK2B/PYK2 (tyrosine phosphorylated) (By similarity). Interacts with SCIMP (PubMed:21930792). Interacts (via SH3 domains) with GAREM1 (via proline-rich domain and tyrosine phosphorylated); the interaction occurs upon EGF stimulation (By similarity). Interacts with DAB2 (PubMed:9569023). Interacts with TESPA1 (By similarity). Interacts with THEMIS (PubMed:19597498, PubMed:19597497, PubMed:19805304, PubMed:22561606). Interacts with PLCG1, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1 (PubMed:22561606). Interacts with CD28 (By similarity). Interacts with RAB13; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA (PubMed:21543326). Interacts with ASAP3 (phosphorylated form) (By similarity).By similarity29 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BlnkO547374EBI-1688,EBI-641814
BtkP359914EBI-1688,EBI-625119
CblbB9EKI53EBI-1688,EBI-682463
Cd22P353294EBI-1688,EBI-300059
Dab2P980784EBI-1688,EBI-1391846
Errfi1Q99JZ73EBI-1688,EBI-643375
Frs2Q8C1805EBI-1688,EBI-6880000
Gab1Q9QYY08EBI-1688,EBI-644784
Kif26aQ52KG52EBI-1688,EBI-2480646
LatO549572EBI-1688,EBI-6390034
Plcg1Q620772EBI-1688,EBI-300133
PrnpP049257EBI-1688,EBI-768613
Ptpn11P352353EBI-1688,EBI-397236
PtpraP180524EBI-1688,EBI-6597520
Rapgef1Q91ZZ23EBI-1688,EBI-644719
Shc1P980837EBI-1688,EBI-300201
Snta1Q612343EBI-1688,EBI-295952
Sos1Q622457EBI-1688,EBI-1693
Sos2Q023845EBI-1688,EBI-395573
TekQ028583EBI-1688,EBI-7099626
Uck2Q99PM93EBI-1688,EBI-644712

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB
  • epidermal growth factor receptor binding Source: MGI
  • identical protein binding Source: MGI
  • insulin receptor substrate binding Source: MGI
  • neurotrophin TRKA receptor binding Source: MGI
  • protein domain specific binding Source: MGI
  • protein kinase binding Source: MGI
  • protein phosphatase binding Source: UniProtKB
  • SH3/SH2 adaptor activity Source: MGI
  • SH3 domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi200046. 29 interactions.
DIPiDIP-259N.
IntActiQ60631. 67 interactions.
MINTiMINT-84889.
STRINGi10090.ENSMUSP00000021090.

Chemistry

BindingDBiQ60631.

Structurei

Secondary structure

1
217
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Beta strandi13 – 164Combined sources
Beta strandi24 – 263Combined sources
Beta strandi34 – 418Combined sources
Beta strandi44 – 496Combined sources
Helixi50 – 523Combined sources
Beta strandi53 – 564Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GBQNMR-A1-61[»]
1GBRNMR-A1-59[»]
2GBQNMR-A1-59[»]
3GBQNMR-A1-59[»]
4GBQNMR-A1-59[»]
ProteinModelPortaliQ60631.
SMRiQ60631. Positions 1-217.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60631.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5858SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 15293SH2PROSITE-ProRule annotationAdd
BLAST
Domaini156 – 21560SH3 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The SH3 domains mediate interaction with RALGPS1 and SHB.By similarity

Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG3601. Eukaryota.
ENOG410XR1G. LUCA.
GeneTreeiENSGT00820000126999.
HOGENOMiHOG000251625.
HOVERGENiHBG005404.
InParanoidiQ60631.
KOiK04364.
OMAiYDFTPQE.
OrthoDBiEOG091G0HWS.
PhylomeDBiQ60631.
TreeFamiTF354288.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q60631-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK
60 70 80 90 100
NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK
110 120 130 140 150
FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD
160 170 180 190 200
IEQMPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG
210
QTGMFPRNYV TPVNRNV
Length:217
Mass (Da):25,238
Last modified:November 1, 1996 - v1
Checksum:i97F4A4FE4B248DDF
GO
Isoform 2 (identifier: Q60631-2) [UniParc]FASTAAdd to basket
Also known as: GRB3-3

The sequence of this isoform differs from the canonical sequence as follows:
     60-100: Missing.

Show »
Length:176
Mass (Da):20,589
Checksum:i64323FA95FE940C5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei60 – 10041Missing in isoform 2. 1 PublicationVSP_001841Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07617 mRNA. Translation: AAB40022.1.
D85748 mRNA. Translation: BAA12862.1.
BC052377 mRNA. Translation: AAH52377.1.
BC085254 mRNA. Translation: AAH85254.1.
CCDSiCCDS25645.1. [Q60631-1]
PIRiA54688.
RefSeqiNP_001300865.1. NM_001313936.1. [Q60631-1]
NP_001300866.1. NM_001313937.1. [Q60631-1]
NP_032189.1. NM_008163.4. [Q60631-1]
UniGeneiMm.439649.
Mm.490413.

Genome annotation databases

EnsembliENSMUST00000021090; ENSMUSP00000021090; ENSMUSG00000059923. [Q60631-1]
ENSMUST00000106497; ENSMUSP00000102106; ENSMUSG00000059923. [Q60631-1]
ENSMUST00000106499; ENSMUSP00000102108; ENSMUSG00000059923. [Q60631-2]
GeneIDi14784.
KEGGimmu:14784.
UCSCiuc007mii.1. mouse. [Q60631-2]
uc007mij.1. mouse. [Q60631-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Grb2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07617 mRNA. Translation: AAB40022.1.
D85748 mRNA. Translation: BAA12862.1.
BC052377 mRNA. Translation: AAH52377.1.
BC085254 mRNA. Translation: AAH85254.1.
CCDSiCCDS25645.1. [Q60631-1]
PIRiA54688.
RefSeqiNP_001300865.1. NM_001313936.1. [Q60631-1]
NP_001300866.1. NM_001313937.1. [Q60631-1]
NP_032189.1. NM_008163.4. [Q60631-1]
UniGeneiMm.439649.
Mm.490413.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GBQNMR-A1-61[»]
1GBRNMR-A1-59[»]
2GBQNMR-A1-59[»]
3GBQNMR-A1-59[»]
4GBQNMR-A1-59[»]
ProteinModelPortaliQ60631.
SMRiQ60631. Positions 1-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200046. 29 interactions.
DIPiDIP-259N.
IntActiQ60631. 67 interactions.
MINTiMINT-84889.
STRINGi10090.ENSMUSP00000021090.

Chemistry

BindingDBiQ60631.
ChEMBLiCHEMBL4830.

PTM databases

iPTMnetiQ60631.
PhosphoSiteiQ60631.

Proteomic databases

EPDiQ60631.
MaxQBiQ60631.
PaxDbiQ60631.
PeptideAtlasiQ60631.
PRIDEiQ60631.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021090; ENSMUSP00000021090; ENSMUSG00000059923. [Q60631-1]
ENSMUST00000106497; ENSMUSP00000102106; ENSMUSG00000059923. [Q60631-1]
ENSMUST00000106499; ENSMUSP00000102108; ENSMUSG00000059923. [Q60631-2]
GeneIDi14784.
KEGGimmu:14784.
UCSCiuc007mii.1. mouse. [Q60631-2]
uc007mij.1. mouse. [Q60631-1]

Organism-specific databases

CTDi2885.
MGIiMGI:95805. Grb2.

Phylogenomic databases

eggNOGiKOG3601. Eukaryota.
ENOG410XR1G. LUCA.
GeneTreeiENSGT00820000126999.
HOGENOMiHOG000251625.
HOVERGENiHBG005404.
InParanoidiQ60631.
KOiK04364.
OMAiYDFTPQE.
OrthoDBiEOG091G0HWS.
PhylomeDBiQ60631.
TreeFamiTF354288.

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-112412. SOS-mediated signalling.
R-MMU-114604. GPVI-mediated activation cascade.
R-MMU-1250347. SHC1 events in ERBB4 signaling.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-1295596. Spry regulation of FGF signaling.
R-MMU-1433557. Signaling by SCF-KIT.
R-MMU-1433559. Regulation of KIT signaling.
R-MMU-167044. Signalling to RAS.
R-MMU-179812. GRB2 events in EGFR signaling.
R-MMU-180292. GAB1 signalosome.
R-MMU-180336. SHC1 events in EGFR signaling.
R-MMU-182971. EGFR downregulation.
R-MMU-186763. Downstream signal transduction.
R-MMU-1963640. GRB2 events in ERBB2 signaling.
R-MMU-1963642. PI3K events in ERBB2 signaling.
R-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-210993. Tie2 Signaling.
R-MMU-2179392. EGFR Transactivation by Gastrin.
R-MMU-2424491. DAP12 signaling.
R-MMU-2428933. SHC-related events triggered by IGF1R.
R-MMU-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-2871809. FCERI mediated Ca+2 mobilization.
R-MMU-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-388841. Costimulation by the CD28 family.
R-MMU-389359. CD28 dependent Vav1 pathway.
R-MMU-391160. Signal regulatory protein (SIRP) family interactions.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-512988. Interleukin-3, 5 and GM-CSF signaling.
R-MMU-5654688. SHC-mediated cascade:FGFR1.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654704. SHC-mediated cascade:FGFR3.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654710. PI-3K cascade:FGFR3.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654719. SHC-mediated cascade:FGFR4.
R-MMU-5654720. PI-3K cascade:FGFR4.
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5654732. Negative regulation of FGFR3 signaling.
R-MMU-5654733. Negative regulation of FGFR4 signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-74749. Signal attenuation.
R-MMU-74751. Insulin receptor signalling cascade.
R-MMU-912526. Interleukin receptor SHC signaling.
R-MMU-912631. Regulation of signaling by CBL.
R-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

ChiTaRSiGrb2. mouse.
EvolutionaryTraceiQ60631.
PROiQ60631.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059923.
CleanExiMM_GRB2.
ExpressionAtlasiQ60631. baseline and differential.
GenevisibleiQ60631. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
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Entry informationi

Entry nameiGRB2_MOUSE
AccessioniPrimary (citable) accession number: Q60631
Secondary accession number(s): Q61240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 180 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.