Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q60625

- ICAM5_MOUSE

UniProt

Q60625 - ICAM5_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Intercellular adhesion molecule 5

Gene

Icam5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).1 Publication

GO - Biological processi

  1. phagocytosis Source: MGI
  2. single organismal cell-cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 5
Short name:
ICAM-5
Alternative name(s):
Telencephalin
Gene namesi
Name:Icam5
Synonyms:Icam3, Tlcn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:109430. Icam5.

Subcellular locationi

Membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 833802ExtracellularSequence AnalysisAdd
BLAST
Transmembranei834 – 85421HelicalSequence AnalysisAdd
BLAST
Topological domaini855 – 91763CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi54 – 541N → Q: Fails to form disulfide bonds and to induce filopodia-like protrusions. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 917886Intercellular adhesion molecule 5PRO_0000014800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...) (high mannose)1 Publication
Disulfide bondi55 ↔ 99PROSITE-ProRule annotation
Disulfide bondi59 ↔ 103PROSITE-ProRule annotation
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi142 ↔ 198PROSITE-ProRule annotation
Modified residuei182 – 1821PhosphothreonineBy similarity
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi249 ↔ 302PROSITE-ProRule annotation
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi344 ↔ 383PROSITE-ProRule annotation
Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi415 ↔ 470PROSITE-ProRule annotation
Disulfide bondi498 ↔ 551PROSITE-ProRule annotation
Disulfide bondi579 ↔ 644PROSITE-ProRule annotation
Glycosylationi582 – 5821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi645 – 6451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi672 ↔ 724PROSITE-ProRule annotation
Glycosylationi762 – 7621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi767 ↔ 812PROSITE-ProRule annotation
Glycosylationi793 – 7931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi794 – 7941N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylation at Asn-54 is critical for functional folding.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ60625.
PRIDEiQ60625.

PTM databases

PhosphoSiteiQ60625.

Expressioni

Tissue specificityi

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.1 Publication

Gene expression databases

CleanExiMM_ICAM5.
GenevestigatoriQ60625.

Interactioni

Protein-protein interaction databases

IntActiQ60625. 3 interactions.
MINTiMINT-4098408.
STRINGi10090.ENSMUSP00000019616.

Structurei

3D structure databases

ProteinModelPortaliQ60625.
SMRiQ60625. Positions 32-836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 13083Ig-like C2-type 1Add
BLAST
Domaini135 – 235101Ig-like C2-type 2Add
BLAST
Domaini242 – 32988Ig-like C2-type 3Add
BLAST
Domaini337 – 40266Ig-like C2-type 4Add
BLAST
Domaini408 – 48679Ig-like C2-type 5Add
BLAST
Domaini491 – 56777Ig-like C2-type 6Add
BLAST
Domaini572 – 65180Ig-like C2-type 7Add
BLAST
Domaini665 – 73874Ig-like C2-type 8Add
BLAST
Domaini745 – 82884Ig-like C2-type 9Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146347.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000168514.
HOVERGENiHBG052077.
InParanoidiQ60625.
KOiK06769.
OMAiVCNATNR.
OrthoDBiEOG7MD4PS.
TreeFamiTF333745.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60625-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGPSPGLRR ALLGLWAALG LGILGISAVA LEPFWADLQP RVALVERGGS
60 70 80 90 100
LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF
110 120 130 140 150
FRCARRTLQA RGLIRTFQRP DRVELVPLPS WQPVGENFTL SCRVPGAGPR
160 170 180 190 200
ASLTLTLLRG GQELIRRSFV GEPPRARGAM LTARVLARRE DHRVNFSCLA
210 220 230 240 250
ELDLRPHGLG LFANSSAPRQ LRTFAMPPHS PSLIAPRVLE VDSERPVTCT
260 270 280 290 300
LDGLFPAPEA GVYLSLGDQR LNPNVTLDGD SLVATATATA SAEQEGTKQL
310 320 330 340 350
MCVVTLGGES RETQENLTVY SFPTPLLTLS EPEAPEGKMV TISCWAGARA
360 370 380 390 400
LVTLEGIPAA VPGQPAELQL NVTKNDDKRG FFCDAALDVD GETLRKNQSS
410 420 430 440 450
ELRVLYAPRL DDLDCPRSWT WPEGPEQTLH CEARGNPEPS VHCARPEGGA
460 470 480 490 500
VLALGLLGPV TRALAGTYRC TAVNGQGQAV KDVTLTVEYA PALDSVGCPE
510 520 530 540 550
HITWLEGTEA SLSCVAHGVP PPSVSCVRSG KEEVMEGPLR VAREHAGTYR
560 570 580 590 600
CEAINARGSA AKNVAVTVEY GPSFEELGCP SNWTWVEGSG KLFSCEVDGK
610 620 630 640 650
PEPRVECVGS EGASEGIVLP LVSSNSGPRN SMTPGNLSPG IYLCNATNRH
660 670 680 690 700
GSTVKTVVVS AESPPQMDES SCPSHQTWLE GAEATALACS ARGRPSPRVH
710 720 730 740 750
CSREGAARLE RLQVSREDAG TYRCVATNAH GTDSRTVTVG VEYRPVVAEL
760 770 780 790 800
AASPPSVRPG GNFTLTCRAE AWPPAQISWR APPGALNLGL SSNNSTLSVA
810 820 830 840 850
GAMGSHGGEY ECAATNAHGR HARRITVRVA GPWLWVAVGG AAGGAALLAA
860 870 880 890 900
GAGLAFYVQS TACKKGEYNV QEAESSGEAV CLNGAGGTPG AEGGAETPGT
910
AESPADGEVF AIQLTSS
Length:917
Mass (Da):96,946
Last modified:October 3, 2012 - v2
Checksum:iC2E98892A190F59C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471R → P in AAA67204. (PubMed:7794412)Curated
Sequence conflicti310 – 3101S → T in AAA67204. (PubMed:7794412)Curated
Sequence conflicti517 – 5171H → P in AAA67204. (PubMed:7794412)Curated
Sequence conflicti649 – 6491R → Q in BAE22394. (PubMed:16141072)Curated
Sequence conflicti664 – 6641P → R in BAE22394. (PubMed:16141072)Curated
Sequence conflicti859 – 8591Q → L in AAI13141. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06483 mRNA. Translation: AAA67204.1.
AK135040 mRNA. Translation: BAE22394.1.
AC159314 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25153.1.
BC113140 mRNA. Translation: AAI13141.1.
U89893 Genomic DNA. Translation: AAC53308.1.
CCDSiCCDS22891.1.
PIRiI48950.
RefSeqiNP_032345.2. NM_008319.2.
UniGeneiMm.4629.

Genome annotation databases

EnsembliENSMUST00000019616; ENSMUSP00000019616; ENSMUSG00000032174.
GeneIDi15898.
KEGGimmu:15898.
UCSCiuc009oka.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06483 mRNA. Translation: AAA67204.1 .
AK135040 mRNA. Translation: BAE22394.1 .
AC159314 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25153.1 .
BC113140 mRNA. Translation: AAI13141.1 .
U89893 Genomic DNA. Translation: AAC53308.1 .
CCDSi CCDS22891.1.
PIRi I48950.
RefSeqi NP_032345.2. NM_008319.2.
UniGenei Mm.4629.

3D structure databases

ProteinModelPortali Q60625.
SMRi Q60625. Positions 32-836.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q60625. 3 interactions.
MINTi MINT-4098408.
STRINGi 10090.ENSMUSP00000019616.

PTM databases

PhosphoSitei Q60625.

Proteomic databases

PaxDbi Q60625.
PRIDEi Q60625.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019616 ; ENSMUSP00000019616 ; ENSMUSG00000032174 .
GeneIDi 15898.
KEGGi mmu:15898.
UCSCi uc009oka.2. mouse.

Organism-specific databases

CTDi 7087.
MGIi MGI:109430. Icam5.

Phylogenomic databases

eggNOGi NOG146347.
GeneTreei ENSGT00530000063246.
HOGENOMi HOG000168514.
HOVERGENi HBG052077.
InParanoidi Q60625.
KOi K06769.
OMAi VCNATNR.
OrthoDBi EOG7MD4PS.
TreeFami TF333745.

Miscellaneous databases

ChiTaRSi Icam5. mouse.
NextBioi 288612.
PROi Q60625.
SOURCEi Search...

Gene expression databases

CleanExi MM_ICAM5.
Genevestigatori Q60625.

Family and domain databases

Gene3Di 2.60.40.10. 9 hits.
InterProi IPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF03921. ICAM_N. 1 hit.
[Graphical view ]
PRINTSi PR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTi SM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression."
    Yoshihara Y., Oka S., Nemoto Y., Watanabe Y., Nagata S., Kagamiyama H., Mori K.
    Neuron 12:541-553(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Genomic organization and chromosomal localization of the mouse telencephalin gene, a neuronal member of the ICAM family."
    Sugino H., Yoshihara Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Mori K.
    Genomics 43:209-215(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
    Strain: C57BL/CBA.
  7. "Asn54-linked glycan is critical for functional folding of intercellular adhesion molecule-5."
    Ohgomori T., Nanao T., Morita A., Ikekita M.
    Glycoconj. J. 29:47-55(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-54, MUTAGENESIS OF ASN-54.

Entry informationi

Entry nameiICAM5_MOUSE
AccessioniPrimary (citable) accession number: Q60625
Secondary accession number(s): G5E826, Q2KHL7, Q3UY19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3