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Protein

Intercellular adhesion molecule 5

Gene

Icam5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • cell-cell adhesion Source: InterPro
  • phagocytosis Source: MGI

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 5
Short name:
ICAM-5
Alternative name(s):
Telencephalin
Gene namesi
Name:Icam5
Synonyms:Icam3, Tlcn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109430 Icam5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 833ExtracellularSequence analysisAdd BLAST802
Transmembranei834 – 854HelicalSequence analysisAdd BLAST21
Topological domaini855 – 917CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54N → Q: Fails to form disulfide bonds and to induce filopodia-like protrusions. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001480032 – 917Intercellular adhesion molecule 5Add BLAST886

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Disulfide bondi55 ↔ 99PROSITE-ProRule annotation
Disulfide bondi59 ↔ 103PROSITE-ProRule annotation
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi142 ↔ 198PROSITE-ProRule annotation
Modified residuei182PhosphothreonineBy similarity1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 302PROSITE-ProRule annotation
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi344 ↔ 383PROSITE-ProRule annotation
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi415 ↔ 470PROSITE-ProRule annotation
Disulfide bondi498 ↔ 551PROSITE-ProRule annotation
Disulfide bondi579 ↔ 644PROSITE-ProRule annotation
Glycosylationi582N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi645N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi672 ↔ 724PROSITE-ProRule annotation
Glycosylationi762N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi767 ↔ 812PROSITE-ProRule annotation
Glycosylationi793N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi794N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylation at Asn-54 is critical for functional folding.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ60625
PeptideAtlasiQ60625
PRIDEiQ60625

PTM databases

CarbonylDBiQ60625
iPTMnetiQ60625
PhosphoSitePlusiQ60625

Expressioni

Tissue specificityi

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.1 Publication

Gene expression databases

BgeeiENSMUSG00000032174
CleanExiMM_ICAM5
GenevisibleiQ60625 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200503, 3 interactors
IntActiQ60625, 5 interactors
MINTiQ60625
STRINGi10090.ENSMUSP00000019616

Structurei

3D structure databases

ProteinModelPortaliQ60625
SMRiQ60625
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 130Ig-like C2-type 1Add BLAST83
Domaini135 – 235Ig-like C2-type 2Add BLAST101
Domaini242 – 329Ig-like C2-type 3Add BLAST88
Domaini337 – 402Ig-like C2-type 4Add BLAST66
Domaini408 – 486Ig-like C2-type 5Add BLAST79
Domaini491 – 567Ig-like C2-type 6Add BLAST77
Domaini572 – 651Ig-like C2-type 7Add BLAST80
Domaini665 – 738Ig-like C2-type 8Add BLAST74
Domaini745 – 828Ig-like C2-type 9Add BLAST84

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPHM Eukaryota
ENOG410YQ1Q LUCA
GeneTreeiENSGT00530000063246
HOGENOMiHOG000168514
HOVERGENiHBG052077
InParanoidiQ60625
KOiK06769
OMAiPSCPSNW
OrthoDBiEOG091G022Y
TreeFamiTF333745

Family and domain databases

Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SMARTiView protein in SMART
SM00409 IG, 6 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 9 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPSPGLRR ALLGLWAALG LGILGISAVA LEPFWADLQP RVALVERGGS
60 70 80 90 100
LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF
110 120 130 140 150
FRCARRTLQA RGLIRTFQRP DRVELVPLPS WQPVGENFTL SCRVPGAGPR
160 170 180 190 200
ASLTLTLLRG GQELIRRSFV GEPPRARGAM LTARVLARRE DHRVNFSCLA
210 220 230 240 250
ELDLRPHGLG LFANSSAPRQ LRTFAMPPHS PSLIAPRVLE VDSERPVTCT
260 270 280 290 300
LDGLFPAPEA GVYLSLGDQR LNPNVTLDGD SLVATATATA SAEQEGTKQL
310 320 330 340 350
MCVVTLGGES RETQENLTVY SFPTPLLTLS EPEAPEGKMV TISCWAGARA
360 370 380 390 400
LVTLEGIPAA VPGQPAELQL NVTKNDDKRG FFCDAALDVD GETLRKNQSS
410 420 430 440 450
ELRVLYAPRL DDLDCPRSWT WPEGPEQTLH CEARGNPEPS VHCARPEGGA
460 470 480 490 500
VLALGLLGPV TRALAGTYRC TAVNGQGQAV KDVTLTVEYA PALDSVGCPE
510 520 530 540 550
HITWLEGTEA SLSCVAHGVP PPSVSCVRSG KEEVMEGPLR VAREHAGTYR
560 570 580 590 600
CEAINARGSA AKNVAVTVEY GPSFEELGCP SNWTWVEGSG KLFSCEVDGK
610 620 630 640 650
PEPRVECVGS EGASEGIVLP LVSSNSGPRN SMTPGNLSPG IYLCNATNRH
660 670 680 690 700
GSTVKTVVVS AESPPQMDES SCPSHQTWLE GAEATALACS ARGRPSPRVH
710 720 730 740 750
CSREGAARLE RLQVSREDAG TYRCVATNAH GTDSRTVTVG VEYRPVVAEL
760 770 780 790 800
AASPPSVRPG GNFTLTCRAE AWPPAQISWR APPGALNLGL SSNNSTLSVA
810 820 830 840 850
GAMGSHGGEY ECAATNAHGR HARRITVRVA GPWLWVAVGG AAGGAALLAA
860 870 880 890 900
GAGLAFYVQS TACKKGEYNV QEAESSGEAV CLNGAGGTPG AEGGAETPGT
910
AESPADGEVF AIQLTSS
Length:917
Mass (Da):96,946
Last modified:October 3, 2012 - v2
Checksum:iC2E98892A190F59C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47R → P in AAA67204 (PubMed:7794412).Curated1
Sequence conflicti310S → T in AAA67204 (PubMed:7794412).Curated1
Sequence conflicti517H → P in AAA67204 (PubMed:7794412).Curated1
Sequence conflicti649R → Q in BAE22394 (PubMed:16141072).Curated1
Sequence conflicti664P → R in BAE22394 (PubMed:16141072).Curated1
Sequence conflicti859Q → L in AAI13141 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06483 mRNA Translation: AAA67204.1
AK135040 mRNA Translation: BAE22394.1
AC159314 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25153.1
BC113140 mRNA Translation: AAI13141.1
U89893 Genomic DNA Translation: AAC53308.1
CCDSiCCDS22891.1
PIRiI48950
RefSeqiNP_032345.2, NM_008319.2
UniGeneiMm.4629

Genome annotation databases

EnsembliENSMUST00000019616; ENSMUSP00000019616; ENSMUSG00000032174
GeneIDi15898
KEGGimmu:15898
UCSCiuc009oka.2 mouse

Similar proteinsi

Entry informationi

Entry nameiICAM5_MOUSE
AccessioniPrimary (citable) accession number: Q60625
Secondary accession number(s): G5E826, Q2KHL7, Q3UY19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health