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Q60625

- ICAM5_MOUSE

UniProt

Q60625 - ICAM5_MOUSE

Protein

Intercellular adhesion molecule 5

Gene

Icam5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).1 Publication

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. phagocytosis Source: MGI
    2. single organismal cell-cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intercellular adhesion molecule 5
    Short name:
    ICAM-5
    Alternative name(s):
    Telencephalin
    Gene namesi
    Name:Icam5
    Synonyms:Icam3, Tlcn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:109430. Icam5.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi54 – 541N → Q: Fails to form disulfide bonds and to induce filopodia-like protrusions. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 917886Intercellular adhesion molecule 5PRO_0000014800Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi54 – 541N-linked (GlcNAc...) (high mannose)1 Publication
    Disulfide bondi55 ↔ 99PROSITE-ProRule annotation
    Disulfide bondi59 ↔ 103PROSITE-ProRule annotation
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi142 ↔ 198PROSITE-ProRule annotation
    Modified residuei182 – 1821PhosphothreonineBy similarity
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi249 ↔ 302PROSITE-ProRule annotation
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi344 ↔ 383PROSITE-ProRule annotation
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi415 ↔ 470PROSITE-ProRule annotation
    Disulfide bondi498 ↔ 551PROSITE-ProRule annotation
    Disulfide bondi579 ↔ 644PROSITE-ProRule annotation
    Glycosylationi582 – 5821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi645 – 6451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi672 ↔ 724PROSITE-ProRule annotation
    Glycosylationi762 – 7621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi767 ↔ 812PROSITE-ProRule annotation
    Glycosylationi793 – 7931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi794 – 7941N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylation at Asn-54 is critical for functional folding.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ60625.
    PRIDEiQ60625.

    PTM databases

    PhosphoSiteiQ60625.

    Expressioni

    Tissue specificityi

    Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.1 Publication

    Gene expression databases

    CleanExiMM_ICAM5.
    GenevestigatoriQ60625.

    Interactioni

    Protein-protein interaction databases

    IntActiQ60625. 3 interactions.
    MINTiMINT-4098408.
    STRINGi10090.ENSMUSP00000019616.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60625.
    SMRiQ60625. Positions 32-829.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 833802ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini855 – 91763CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei834 – 85421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 13083Ig-like C2-type 1Add
    BLAST
    Domaini135 – 235101Ig-like C2-type 2Add
    BLAST
    Domaini242 – 32988Ig-like C2-type 3Add
    BLAST
    Domaini337 – 40266Ig-like C2-type 4Add
    BLAST
    Domaini408 – 48679Ig-like C2-type 5Add
    BLAST
    Domaini491 – 56777Ig-like C2-type 6Add
    BLAST
    Domaini572 – 65180Ig-like C2-type 7Add
    BLAST
    Domaini665 – 73874Ig-like C2-type 8Add
    BLAST
    Domaini745 – 82884Ig-like C2-type 9Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. ICAM family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146347.
    GeneTreeiENSGT00530000063246.
    HOGENOMiHOG000168514.
    HOVERGENiHBG052077.
    InParanoidiQ60625.
    KOiK06769.
    OMAiVCNATNR.
    OrthoDBiEOG7MD4PS.
    TreeFamiTF333745.

    Family and domain databases

    Gene3Di2.60.40.10. 9 hits.
    InterProiIPR003988. ICAM.
    IPR013768. ICAM_N.
    IPR003987. ICAM_VCAM_N.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF03921. ICAM_N. 1 hit.
    [Graphical view]
    PRINTSiPR01473. ICAM.
    PR01472. ICAMVCAM1.
    SMARTiSM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60625-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGPSPGLRR ALLGLWAALG LGILGISAVA LEPFWADLQP RVALVERGGS    50
    LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF 100
    FRCARRTLQA RGLIRTFQRP DRVELVPLPS WQPVGENFTL SCRVPGAGPR 150
    ASLTLTLLRG GQELIRRSFV GEPPRARGAM LTARVLARRE DHRVNFSCLA 200
    ELDLRPHGLG LFANSSAPRQ LRTFAMPPHS PSLIAPRVLE VDSERPVTCT 250
    LDGLFPAPEA GVYLSLGDQR LNPNVTLDGD SLVATATATA SAEQEGTKQL 300
    MCVVTLGGES RETQENLTVY SFPTPLLTLS EPEAPEGKMV TISCWAGARA 350
    LVTLEGIPAA VPGQPAELQL NVTKNDDKRG FFCDAALDVD GETLRKNQSS 400
    ELRVLYAPRL DDLDCPRSWT WPEGPEQTLH CEARGNPEPS VHCARPEGGA 450
    VLALGLLGPV TRALAGTYRC TAVNGQGQAV KDVTLTVEYA PALDSVGCPE 500
    HITWLEGTEA SLSCVAHGVP PPSVSCVRSG KEEVMEGPLR VAREHAGTYR 550
    CEAINARGSA AKNVAVTVEY GPSFEELGCP SNWTWVEGSG KLFSCEVDGK 600
    PEPRVECVGS EGASEGIVLP LVSSNSGPRN SMTPGNLSPG IYLCNATNRH 650
    GSTVKTVVVS AESPPQMDES SCPSHQTWLE GAEATALACS ARGRPSPRVH 700
    CSREGAARLE RLQVSREDAG TYRCVATNAH GTDSRTVTVG VEYRPVVAEL 750
    AASPPSVRPG GNFTLTCRAE AWPPAQISWR APPGALNLGL SSNNSTLSVA 800
    GAMGSHGGEY ECAATNAHGR HARRITVRVA GPWLWVAVGG AAGGAALLAA 850
    GAGLAFYVQS TACKKGEYNV QEAESSGEAV CLNGAGGTPG AEGGAETPGT 900
    AESPADGEVF AIQLTSS 917
    Length:917
    Mass (Da):96,946
    Last modified:October 3, 2012 - v2
    Checksum:iC2E98892A190F59C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471R → P in AAA67204. (PubMed:7794412)Curated
    Sequence conflicti310 – 3101S → T in AAA67204. (PubMed:7794412)Curated
    Sequence conflicti517 – 5171H → P in AAA67204. (PubMed:7794412)Curated
    Sequence conflicti649 – 6491R → Q in BAE22394. (PubMed:16141072)Curated
    Sequence conflicti664 – 6641P → R in BAE22394. (PubMed:16141072)Curated
    Sequence conflicti859 – 8591Q → L in AAI13141. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06483 mRNA. Translation: AAA67204.1.
    AK135040 mRNA. Translation: BAE22394.1.
    AC159314 Genomic DNA. No translation available.
    CH466522 Genomic DNA. Translation: EDL25153.1.
    BC113140 mRNA. Translation: AAI13141.1.
    U89893 Genomic DNA. Translation: AAC53308.1.
    CCDSiCCDS22891.1.
    PIRiI48950.
    RefSeqiNP_032345.2. NM_008319.2.
    UniGeneiMm.4629.

    Genome annotation databases

    EnsembliENSMUST00000019616; ENSMUSP00000019616; ENSMUSG00000032174.
    GeneIDi15898.
    KEGGimmu:15898.
    UCSCiuc009oka.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06483 mRNA. Translation: AAA67204.1 .
    AK135040 mRNA. Translation: BAE22394.1 .
    AC159314 Genomic DNA. No translation available.
    CH466522 Genomic DNA. Translation: EDL25153.1 .
    BC113140 mRNA. Translation: AAI13141.1 .
    U89893 Genomic DNA. Translation: AAC53308.1 .
    CCDSi CCDS22891.1.
    PIRi I48950.
    RefSeqi NP_032345.2. NM_008319.2.
    UniGenei Mm.4629.

    3D structure databases

    ProteinModelPortali Q60625.
    SMRi Q60625. Positions 32-829.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q60625. 3 interactions.
    MINTi MINT-4098408.
    STRINGi 10090.ENSMUSP00000019616.

    PTM databases

    PhosphoSitei Q60625.

    Proteomic databases

    PaxDbi Q60625.
    PRIDEi Q60625.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019616 ; ENSMUSP00000019616 ; ENSMUSG00000032174 .
    GeneIDi 15898.
    KEGGi mmu:15898.
    UCSCi uc009oka.2. mouse.

    Organism-specific databases

    CTDi 7087.
    MGIi MGI:109430. Icam5.

    Phylogenomic databases

    eggNOGi NOG146347.
    GeneTreei ENSGT00530000063246.
    HOGENOMi HOG000168514.
    HOVERGENi HBG052077.
    InParanoidi Q60625.
    KOi K06769.
    OMAi VCNATNR.
    OrthoDBi EOG7MD4PS.
    TreeFami TF333745.

    Miscellaneous databases

    ChiTaRSi ICAM5. mouse.
    NextBioi 288612.
    PROi Q60625.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ICAM5.
    Genevestigatori Q60625.

    Family and domain databases

    Gene3Di 2.60.40.10. 9 hits.
    InterProi IPR003988. ICAM.
    IPR013768. ICAM_N.
    IPR003987. ICAM_VCAM_N.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF03921. ICAM_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01473. ICAM.
    PR01472. ICAMVCAM1.
    SMARTi SM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression."
      Yoshihara Y., Oka S., Nemoto Y., Watanabe Y., Nagata S., Kagamiyama H., Mori K.
      Neuron 12:541-553(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Olfactory bulb.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Genomic organization and chromosomal localization of the mouse telencephalin gene, a neuronal member of the ICAM family."
      Sugino H., Yoshihara Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Mori K.
      Genomics 43:209-215(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
      Strain: C57BL/CBA.
    7. "Asn54-linked glycan is critical for functional folding of intercellular adhesion molecule-5."
      Ohgomori T., Nanao T., Morita A., Ikekita M.
      Glycoconj. J. 29:47-55(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-54, MUTAGENESIS OF ASN-54.

    Entry informationi

    Entry nameiICAM5_MOUSE
    AccessioniPrimary (citable) accession number: Q60625
    Secondary accession number(s): G5E826, Q2KHL7, Q3UY19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3