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Q60625 (ICAM5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Intercellular adhesion molecule 5

Short name=ICAM-5
Alternative name(s):
Telencephalin
Gene names
Name:Icam5
Synonyms:Icam3, Tlcn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length917 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Ref.1

Subcellular location

Membrane; Single-pass type I membrane protein Ref.1.

Tissue specificity

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. Ref.1

Post-translational modification

Glycosylation at Asn-54 is critical for functional folding.

Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Contains 9 Ig-like C2-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 917886Intercellular adhesion molecule 5
PRO_0000014800

Regions

Topological domain32 – 833802Extracellular Potential
Transmembrane834 – 85421Helical; Potential
Topological domain855 – 91763Cytoplasmic Potential
Domain48 – 13083Ig-like C2-type 1
Domain135 – 235101Ig-like C2-type 2
Domain242 – 32988Ig-like C2-type 3
Domain337 – 40266Ig-like C2-type 4
Domain408 – 48679Ig-like C2-type 5
Domain491 – 56777Ig-like C2-type 6
Domain572 – 65180Ig-like C2-type 7
Domain665 – 73874Ig-like C2-type 8
Domain745 – 82884Ig-like C2-type 9

Amino acid modifications

Modified residue1821Phosphothreonine By similarity
Glycosylation541N-linked (GlcNAc...) (high mannose) Ref.7
Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation1371N-linked (GlcNAc...) Potential
Glycosylation1951N-linked (GlcNAc...) Potential
Glycosylation2141N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential
Glycosylation3161N-linked (GlcNAc...) Potential
Glycosylation3711N-linked (GlcNAc...) Potential
Glycosylation3971N-linked (GlcNAc...) Potential
Glycosylation5821N-linked (GlcNAc...) Potential
Glycosylation6451N-linked (GlcNAc...) Potential
Glycosylation7621N-linked (GlcNAc...) Potential
Glycosylation7931N-linked (GlcNAc...) Potential
Glycosylation7941N-linked (GlcNAc...) Potential
Disulfide bond55 ↔ 99 By similarity
Disulfide bond59 ↔ 103 By similarity
Disulfide bond142 ↔ 198 By similarity
Disulfide bond249 ↔ 302 By similarity
Disulfide bond344 ↔ 383 By similarity
Disulfide bond415 ↔ 470 By similarity
Disulfide bond498 ↔ 551 By similarity
Disulfide bond579 ↔ 644 By similarity
Disulfide bond672 ↔ 724 By similarity
Disulfide bond767 ↔ 812 By similarity

Experimental info

Mutagenesis541N → Q: Fails to form disulfide bonds and to induce filopodia-like protrusions. Ref.7
Sequence conflict471R → P in AAA67204. Ref.1
Sequence conflict3101S → T in AAA67204. Ref.1
Sequence conflict5171H → P in AAA67204. Ref.1
Sequence conflict6491R → Q in BAE22394. Ref.2
Sequence conflict6641P → R in BAE22394. Ref.2
Sequence conflict8591Q → L in AAI13141. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q60625 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: C2E98892A190F59C

FASTA91796,946
        10         20         30         40         50         60 
MPGPSPGLRR ALLGLWAALG LGILGISAVA LEPFWADLQP RVALVERGGS LWLNCSTNCP 

        70         80         90        100        110        120 
RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF FRCARRTLQA RGLIRTFQRP 

       130        140        150        160        170        180 
DRVELVPLPS WQPVGENFTL SCRVPGAGPR ASLTLTLLRG GQELIRRSFV GEPPRARGAM 

       190        200        210        220        230        240 
LTARVLARRE DHRVNFSCLA ELDLRPHGLG LFANSSAPRQ LRTFAMPPHS PSLIAPRVLE 

       250        260        270        280        290        300 
VDSERPVTCT LDGLFPAPEA GVYLSLGDQR LNPNVTLDGD SLVATATATA SAEQEGTKQL 

       310        320        330        340        350        360 
MCVVTLGGES RETQENLTVY SFPTPLLTLS EPEAPEGKMV TISCWAGARA LVTLEGIPAA 

       370        380        390        400        410        420 
VPGQPAELQL NVTKNDDKRG FFCDAALDVD GETLRKNQSS ELRVLYAPRL DDLDCPRSWT 

       430        440        450        460        470        480 
WPEGPEQTLH CEARGNPEPS VHCARPEGGA VLALGLLGPV TRALAGTYRC TAVNGQGQAV 

       490        500        510        520        530        540 
KDVTLTVEYA PALDSVGCPE HITWLEGTEA SLSCVAHGVP PPSVSCVRSG KEEVMEGPLR 

       550        560        570        580        590        600 
VAREHAGTYR CEAINARGSA AKNVAVTVEY GPSFEELGCP SNWTWVEGSG KLFSCEVDGK 

       610        620        630        640        650        660 
PEPRVECVGS EGASEGIVLP LVSSNSGPRN SMTPGNLSPG IYLCNATNRH GSTVKTVVVS 

       670        680        690        700        710        720 
AESPPQMDES SCPSHQTWLE GAEATALACS ARGRPSPRVH CSREGAARLE RLQVSREDAG 

       730        740        750        760        770        780 
TYRCVATNAH GTDSRTVTVG VEYRPVVAEL AASPPSVRPG GNFTLTCRAE AWPPAQISWR 

       790        800        810        820        830        840 
APPGALNLGL SSNNSTLSVA GAMGSHGGEY ECAATNAHGR HARRITVRVA GPWLWVAVGG 

       850        860        870        880        890        900 
AAGGAALLAA GAGLAFYVQS TACKKGEYNV QEAESSGEAV CLNGAGGTPG AEGGAETPGT 

       910 
AESPADGEVF AIQLTSS 

« Hide

References

« Hide 'large scale' references
[1]"An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression."
Yoshihara Y., Oka S., Nemoto Y., Watanabe Y., Nagata S., Kagamiyama H., Mori K.
Neuron 12:541-553(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Olfactory bulb.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Genomic organization and chromosomal localization of the mouse telencephalin gene, a neuronal member of the ICAM family."
Sugino H., Yoshihara Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Mori K.
Genomics 43:209-215(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
Strain: C57BL/CBA.
[7]"Asn54-linked glycan is critical for functional folding of intercellular adhesion molecule-5."
Ohgomori T., Nanao T., Morita A., Ikekita M.
Glycoconj. J. 29:47-55(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-54, MUTAGENESIS OF ASN-54.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06483 mRNA. Translation: AAA67204.1.
AK135040 mRNA. Translation: BAE22394.1.
AC159314 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25153.1.
BC113140 mRNA. Translation: AAI13141.1.
U89893 Genomic DNA. Translation: AAC53308.1.
PIRI48950.
RefSeqNP_032345.2. NM_008319.2.
UniGeneMm.4629.

3D structure databases

ProteinModelPortalQ60625.
SMRQ60625. Positions 32-836.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ60625. 3 interactions.
MINTMINT-4098408.
STRING10090.ENSMUSP00000019616.

PTM databases

PhosphoSiteQ60625.

Proteomic databases

PaxDbQ60625.
PRIDEQ60625.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019616; ENSMUSP00000019616; ENSMUSG00000032174.
GeneID15898.
KEGGmmu:15898.
UCSCuc009oka.2. mouse.

Organism-specific databases

CTD7087.
MGIMGI:109430. Icam5.

Phylogenomic databases

eggNOGNOG146347.
GeneTreeENSGT00530000063246.
HOGENOMHOG000168514.
HOVERGENHBG052077.
InParanoidQ60625.
KOK06769.
OMAPSVSCVR.
OrthoDBEOG7MD4PS.
TreeFamTF333745.

Gene expression databases

CleanExMM_ICAM5.
GenevestigatorQ60625.

Family and domain databases

Gene3D2.60.40.10. 9 hits.
InterProIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSICAM5. mouse.
NextBio288612.
PROQ60625.
SOURCESearch...

Entry information

Entry nameICAM5_MOUSE
AccessionPrimary (citable) accession number: Q60625
Secondary accession number(s): G5E826, Q2KHL7, Q3UY19
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 3, 2012
Last modified: March 19, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot