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Q60614

- AA2BR_MOUSE

UniProt

Q60614 - AA2BR_MOUSE

Protein

Adenosine receptor A2b

Gene

Adora2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. G-protein coupled adenosine receptor activity Source: InterPro
    2. G-protein coupled receptor activity Source: MGI

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    2. cellular response to extracellular stimulus Source: MGI
    3. positive regulation of cAMP biosynthetic process Source: MGI
    4. positive regulation of cGMP biosynthetic process Source: MGI
    5. positive regulation of chemokine production Source: MGI
    6. positive regulation of chronic inflammatory response to non-antigenic stimulus Source: MGI
    7. positive regulation of guanylate cyclase activity Source: MGI
    8. positive regulation of interleukin-6 production Source: MGI
    9. positive regulation of mast cell degranulation Source: MGI
    10. positive regulation vascular endothelial growth factor production Source: MGI
    11. relaxation of vascular smooth muscle Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosine receptor A2b
    Gene namesi
    Name:Adora2b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:99403. Adora2b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332Adenosine receptor A2bPRO_0000069004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi78 ↔ 171PROSITE-ProRule annotation
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Lipidationi311 – 3111S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    PTM databases

    PhosphoSiteiQ60614.

    Expressioni

    Gene expression databases

    BgeeiQ60614.
    CleanExiMM_ADORA2B.
    GenevestigatoriQ60614.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ60614.
    SMRiQ60614. Positions 8-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88ExtracellularBy similarity
    Topological domaini34 – 4310CytoplasmicBy similarity
    Topological domaini68 – 7811ExtracellularBy similarityAdd
    BLAST
    Topological domaini102 – 12120CytoplasmicBy similarityAdd
    BLAST
    Topological domaini145 – 17834ExtracellularBy similarityAdd
    BLAST
    Topological domaini204 – 23532CytoplasmicBy similarityAdd
    BLAST
    Topological domaini260 – 2678ExtracellularBy similarity
    Topological domaini292 – 33241CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 3325Helical; Name=1By similarityAdd
    BLAST
    Transmembranei44 – 6724Helical; Name=2By similarityAdd
    BLAST
    Transmembranei79 – 10123Helical; Name=3By similarityAdd
    BLAST
    Transmembranei122 – 14423Helical; Name=4By similarityAdd
    BLAST
    Transmembranei179 – 20325Helical; Name=5By similarityAdd
    BLAST
    Transmembranei236 – 25924Helical; Name=6By similarityAdd
    BLAST
    Transmembranei268 – 29124Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni173 – 18210Agonist bindingBy similarity
    Regioni247 – 2548Agonist bindingBy similarity
    Regioni266 – 27611Agonist bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287824.
    GeneTreeiENSGT00550000074524.
    HOGENOMiHOG000015770.
    HOVERGENiHBG106962.
    InParanoidiQ8BXI2.
    KOiK04267.
    OMAiGWNSKDS.
    OrthoDBiEOG79SDXQ.
    TreeFamiTF325296.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001435. Adeno_A2B_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00554. ADENOSINA2BR.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60614-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA    50
    TADVAVGLFA IPFAITISLG FCTDFHGCLF LACFVLVLTQ SSIFSLLAVA 100
    VDRYLAIRVP LRYKGLVTGT RARGIIAVLW VLAFGIGLTP FLGWNSKDSA 150
    TSNCTELGDG IANKSCCPVT CLFENVVPMS YMVYFNFFGC VLPPLLIMLV 200
    IYIKIFMVAC KQLQRMELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV 250
    HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS 300
    FHKIISRYVL CQAETKGGSG QAGAQSTLSL GL 332
    Length:332
    Mass (Da):36,120
    Last modified:July 27, 2011 - v2
    Checksum:iBABE2C782001564A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti169 – 1691V → L in AAA19001. (PubMed:8157966)Curated
    Sequence conflicti215 – 2151R → S in AAA19001. (PubMed:8157966)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05673 mRNA. Translation: AAA19001.1.
    AK047002 mRNA. Translation: BAC32938.1.
    AL596110 Genomic DNA. Translation: CAI35330.1.
    BC116415 mRNA. Translation: AAI16416.1.
    BC116416 mRNA. Translation: AAI16417.1.
    CCDSiCCDS24822.1.
    PIRiI48933.
    RefSeqiNP_031439.2. NM_007413.4.
    UniGeneiMm.40740.

    Genome annotation databases

    EnsembliENSMUST00000018644; ENSMUSP00000018644; ENSMUSG00000018500.
    GeneIDi11541.
    KEGGimmu:11541.
    UCSCiuc007jio.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05673 mRNA. Translation: AAA19001.1 .
    AK047002 mRNA. Translation: BAC32938.1 .
    AL596110 Genomic DNA. Translation: CAI35330.1 .
    BC116415 mRNA. Translation: AAI16416.1 .
    BC116416 mRNA. Translation: AAI16417.1 .
    CCDSi CCDS24822.1.
    PIRi I48933.
    RefSeqi NP_031439.2. NM_007413.4.
    UniGenei Mm.40740.

    3D structure databases

    ProteinModelPortali Q60614.
    SMRi Q60614. Positions 8-314.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q60614.
    ChEMBLi CHEMBL2237.
    GuidetoPHARMACOLOGYi 20.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q60614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018644 ; ENSMUSP00000018644 ; ENSMUSG00000018500 .
    GeneIDi 11541.
    KEGGi mmu:11541.
    UCSCi uc007jio.1. mouse.

    Organism-specific databases

    CTDi 136.
    MGIi MGI:99403. Adora2b.

    Phylogenomic databases

    eggNOGi NOG287824.
    GeneTreei ENSGT00550000074524.
    HOGENOMi HOG000015770.
    HOVERGENi HBG106962.
    InParanoidi Q8BXI2.
    KOi K04267.
    OMAi GWNSKDS.
    OrthoDBi EOG79SDXQ.
    TreeFami TF325296.

    Miscellaneous databases

    NextBioi 279004.
    PROi Q60614.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q60614.
    CleanExi MM_ADORA2B.
    Genevestigatori Q60614.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001435. Adeno_A2B_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00554. ADENOSINA2BR.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells."
      Marquardt D.L., Walker L.L., Heinemann S.
      J. Immunol. 152:4508-4515(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Bone marrow.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiAA2BR_MOUSE
    AccessioniPrimary (citable) accession number: Q60614
    Secondary accession number(s): Q8BXI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3