Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosine receptor A2b

Gene

Adora2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • G-protein coupled adenosine receptor activity Source: InterPro
  • G-protein coupled receptor activity Source: MGI

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • cellular response to extracellular stimulus Source: MGI
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of cGMP biosynthetic process Source: MGI
  • positive regulation of chemokine production Source: MGI
  • positive regulation of chronic inflammatory response to non-antigenic stimulus Source: MGI
  • positive regulation of guanylate cyclase activity Source: MGI
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of mast cell degranulation Source: MGI
  • positive regulation of vascular endothelial growth factor production Source: MGI
  • relaxation of vascular smooth muscle Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-417973. Adenosine P1 receptors.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2b
Gene namesi
Name:Adora2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99403. Adora2b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8ExtracellularBy similarity8
Transmembranei9 – 33Helical; Name=1By similarityAdd BLAST25
Topological domaini34 – 43CytoplasmicBy similarity10
Transmembranei44 – 67Helical; Name=2By similarityAdd BLAST24
Topological domaini68 – 78ExtracellularBy similarityAdd BLAST11
Transmembranei79 – 101Helical; Name=3By similarityAdd BLAST23
Topological domaini102 – 121CytoplasmicBy similarityAdd BLAST20
Transmembranei122 – 144Helical; Name=4By similarityAdd BLAST23
Topological domaini145 – 178ExtracellularBy similarityAdd BLAST34
Transmembranei179 – 203Helical; Name=5By similarityAdd BLAST25
Topological domaini204 – 235CytoplasmicBy similarityAdd BLAST32
Transmembranei236 – 259Helical; Name=6By similarityAdd BLAST24
Topological domaini260 – 267ExtracellularBy similarity8
Transmembranei268 – 291Helical; Name=7By similarityAdd BLAST24
Topological domaini292 – 332CytoplasmicBy similarityAdd BLAST41

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2237.
GuidetoPHARMACOLOGYi20.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690041 – 332Adenosine receptor A2bAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 171PROSITE-ProRule annotation
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Lipidationi311S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ60614.
PRIDEiQ60614.

PTM databases

iPTMnetiQ60614.
PhosphoSitePlusiQ60614.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018500.
CleanExiMM_ADORA2B.
GenevisibleiQ60614. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018644.

Chemistry databases

BindingDBiQ60614.

Structurei

3D structure databases

ProteinModelPortaliQ60614.
SMRiQ60614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 182Agonist bindingBy similarity10
Regioni247 – 254Agonist bindingBy similarity8
Regioni266 – 276Agonist bindingBy similarityAdd BLAST11

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiQ60614.
KOiK04267.
OMAiCTDFYGC.
OrthoDBiEOG091G0I3U.
TreeFamiTF325296.

Family and domain databases

InterProiIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA
60 70 80 90 100
TADVAVGLFA IPFAITISLG FCTDFHGCLF LACFVLVLTQ SSIFSLLAVA
110 120 130 140 150
VDRYLAIRVP LRYKGLVTGT RARGIIAVLW VLAFGIGLTP FLGWNSKDSA
160 170 180 190 200
TSNCTELGDG IANKSCCPVT CLFENVVPMS YMVYFNFFGC VLPPLLIMLV
210 220 230 240 250
IYIKIFMVAC KQLQRMELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV
260 270 280 290 300
HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS
310 320 330
FHKIISRYVL CQAETKGGSG QAGAQSTLSL GL
Length:332
Mass (Da):36,120
Last modified:July 27, 2011 - v2
Checksum:iBABE2C782001564A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169V → L in AAA19001 (PubMed:8157966).Curated1
Sequence conflicti215R → S in AAA19001 (PubMed:8157966).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05673 mRNA. Translation: AAA19001.1.
AK047002 mRNA. Translation: BAC32938.1.
AL596110 Genomic DNA. Translation: CAI35330.1.
BC116415 mRNA. Translation: AAI16416.1.
BC116416 mRNA. Translation: AAI16417.1.
CCDSiCCDS24822.1.
PIRiI48933.
RefSeqiNP_031439.2. NM_007413.4.
UniGeneiMm.40740.

Genome annotation databases

EnsembliENSMUST00000018644; ENSMUSP00000018644; ENSMUSG00000018500.
GeneIDi11541.
KEGGimmu:11541.
UCSCiuc007jio.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05673 mRNA. Translation: AAA19001.1.
AK047002 mRNA. Translation: BAC32938.1.
AL596110 Genomic DNA. Translation: CAI35330.1.
BC116415 mRNA. Translation: AAI16416.1.
BC116416 mRNA. Translation: AAI16417.1.
CCDSiCCDS24822.1.
PIRiI48933.
RefSeqiNP_031439.2. NM_007413.4.
UniGeneiMm.40740.

3D structure databases

ProteinModelPortaliQ60614.
SMRiQ60614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018644.

Chemistry databases

BindingDBiQ60614.
ChEMBLiCHEMBL2237.
GuidetoPHARMACOLOGYi20.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ60614.
PhosphoSitePlusiQ60614.

Proteomic databases

PaxDbiQ60614.
PRIDEiQ60614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018644; ENSMUSP00000018644; ENSMUSG00000018500.
GeneIDi11541.
KEGGimmu:11541.
UCSCiuc007jio.1. mouse.

Organism-specific databases

CTDi136.
MGIiMGI:99403. Adora2b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiQ60614.
KOiK04267.
OMAiCTDFYGC.
OrthoDBiEOG091G0I3U.
TreeFamiTF325296.

Enzyme and pathway databases

ReactomeiR-MMU-417973. Adenosine P1 receptors.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-5683826. Surfactant metabolism.

Miscellaneous databases

PROiQ60614.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018500.
CleanExiMM_ADORA2B.
GenevisibleiQ60614. MM.

Family and domain databases

InterProiIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAA2BR_MOUSE
AccessioniPrimary (citable) accession number: Q60614
Secondary accession number(s): Q8BXI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.