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Q60614

- AA2BR_MOUSE

UniProt

Q60614 - AA2BR_MOUSE

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Protein

Adenosine receptor A2b

Gene

Adora2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. G-protein coupled adenosine receptor activity Source: InterPro
  2. G-protein coupled receptor activity Source: MGI

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  2. cellular response to extracellular stimulus Source: MGI
  3. positive regulation of cAMP biosynthetic process Source: MGI
  4. positive regulation of cGMP biosynthetic process Source: MGI
  5. positive regulation of chemokine production Source: MGI
  6. positive regulation of chronic inflammatory response to non-antigenic stimulus Source: MGI
  7. positive regulation of guanylate cyclase activity Source: MGI
  8. positive regulation of interleukin-6 production Source: MGI
  9. positive regulation of mast cell degranulation Source: MGI
  10. positive regulation vascular endothelial growth factor production Source: MGI
  11. relaxation of vascular smooth muscle Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_253800. Adenosine P1 receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2b
Gene namesi
Name:Adora2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:99403. Adora2b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88ExtracellularBy similarity
Transmembranei9 – 3325Helical; Name=1By similarityAdd
BLAST
Topological domaini34 – 4310CytoplasmicBy similarity
Transmembranei44 – 6724Helical; Name=2By similarityAdd
BLAST
Topological domaini68 – 7811ExtracellularBy similarityAdd
BLAST
Transmembranei79 – 10123Helical; Name=3By similarityAdd
BLAST
Topological domaini102 – 12120CytoplasmicBy similarityAdd
BLAST
Transmembranei122 – 14423Helical; Name=4By similarityAdd
BLAST
Topological domaini145 – 17834ExtracellularBy similarityAdd
BLAST
Transmembranei179 – 20325Helical; Name=5By similarityAdd
BLAST
Topological domaini204 – 23532CytoplasmicBy similarityAdd
BLAST
Transmembranei236 – 25924Helical; Name=6By similarityAdd
BLAST
Topological domaini260 – 2678ExtracellularBy similarity
Transmembranei268 – 29124Helical; Name=7By similarityAdd
BLAST
Topological domaini292 – 33241CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Adenosine receptor A2bPRO_0000069004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 171PROSITE-ProRule annotation
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Lipidationi311 – 3111S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiQ60614.

Expressioni

Gene expression databases

BgeeiQ60614.
CleanExiMM_ADORA2B.
GenevestigatoriQ60614.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ60614.
SMRiQ60614. Positions 8-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni173 – 18210Agonist bindingBy similarity
Regioni247 – 2548Agonist bindingBy similarity
Regioni266 – 27611Agonist bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287824.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiQ60614.
KOiK04267.
OMAiGWNSKDS.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60614-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA
60 70 80 90 100
TADVAVGLFA IPFAITISLG FCTDFHGCLF LACFVLVLTQ SSIFSLLAVA
110 120 130 140 150
VDRYLAIRVP LRYKGLVTGT RARGIIAVLW VLAFGIGLTP FLGWNSKDSA
160 170 180 190 200
TSNCTELGDG IANKSCCPVT CLFENVVPMS YMVYFNFFGC VLPPLLIMLV
210 220 230 240 250
IYIKIFMVAC KQLQRMELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV
260 270 280 290 300
HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS
310 320 330
FHKIISRYVL CQAETKGGSG QAGAQSTLSL GL
Length:332
Mass (Da):36,120
Last modified:July 27, 2011 - v2
Checksum:iBABE2C782001564A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti169 – 1691V → L in AAA19001. (PubMed:8157966)Curated
Sequence conflicti215 – 2151R → S in AAA19001. (PubMed:8157966)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05673 mRNA. Translation: AAA19001.1.
AK047002 mRNA. Translation: BAC32938.1.
AL596110 Genomic DNA. Translation: CAI35330.1.
BC116415 mRNA. Translation: AAI16416.1.
BC116416 mRNA. Translation: AAI16417.1.
CCDSiCCDS24822.1.
PIRiI48933.
RefSeqiNP_031439.2. NM_007413.4.
UniGeneiMm.40740.

Genome annotation databases

EnsembliENSMUST00000018644; ENSMUSP00000018644; ENSMUSG00000018500.
GeneIDi11541.
KEGGimmu:11541.
UCSCiuc007jio.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05673 mRNA. Translation: AAA19001.1 .
AK047002 mRNA. Translation: BAC32938.1 .
AL596110 Genomic DNA. Translation: CAI35330.1 .
BC116415 mRNA. Translation: AAI16416.1 .
BC116416 mRNA. Translation: AAI16417.1 .
CCDSi CCDS24822.1.
PIRi I48933.
RefSeqi NP_031439.2. NM_007413.4.
UniGenei Mm.40740.

3D structure databases

ProteinModelPortali Q60614.
SMRi Q60614. Positions 8-314.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q60614.
ChEMBLi CHEMBL2237.
GuidetoPHARMACOLOGYi 20.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q60614.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018644 ; ENSMUSP00000018644 ; ENSMUSG00000018500 .
GeneIDi 11541.
KEGGi mmu:11541.
UCSCi uc007jio.1. mouse.

Organism-specific databases

CTDi 136.
MGIi MGI:99403. Adora2b.

Phylogenomic databases

eggNOGi NOG287824.
GeneTreei ENSGT00550000074524.
HOGENOMi HOG000015770.
HOVERGENi HBG106962.
InParanoidi Q60614.
KOi K04267.
OMAi GWNSKDS.
OrthoDBi EOG79SDXQ.
TreeFami TF325296.

Enzyme and pathway databases

Reactomei REACT_242871. G alpha (s) signalling events.
REACT_253800. Adenosine P1 receptors.

Miscellaneous databases

NextBioi 279004.
PROi Q60614.
SOURCEi Search...

Gene expression databases

Bgeei Q60614.
CleanExi MM_ADORA2B.
Genevestigatori Q60614.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells."
    Marquardt D.L., Walker L.L., Heinemann S.
    J. Immunol. 152:4508-4515(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Bone marrow.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiAA2BR_MOUSE
AccessioniPrimary (citable) accession number: Q60614
Secondary accession number(s): Q8BXI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3