true1997-11-012024-01-24182AA2AR_MOUSEAggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.Ledent C.Vaugeois J.M.Schiffmann S.N.Pedrazzini T.El-Yacoubi M.Vanderhaeghen J.J.Costentin J.Heath J.K.Vassart G.Parmentier M.doi:10.1038/417711997Nature388674-678NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]129/SvMural R.J.Adams M.D.Myers E.W.Smith H.O.Venter J.C.2005-09EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]JawCloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells.Marquardt D.L.Walker L.L.Heinemann S.1994J. Immunol.1524508-4515NUCLEOTIDE SEQUENCE [MRNA] OF 53-213BALB/cJBone marrowA novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.Wu Y.C.Lai H.L.Chang W.C.Lin J.T.Liu Y.J.Chern Y.doi:10.1016/j.bbamcr.2013.08.0092013Biochim. Biophys. Acta18333145-3154INTERACTION WITH GAS2L232 sites, No reported glycans2 sites493 antibodies from 41 providersmouseAdora2aEukaryotaAdenosine P1 receptorsG alpha (s) signalling eventsSurfactant metabolism1 hit in 80 CRISPR screensProteinExpressed in caudate-putamen and 135 other cell types or tissuesbaseline and differential7tmA_Adenosine_R_A2ARhodopsin 7-helix transmembrane proteinsAdeno_A2A_rcptAdenosn_rcptGPCR_RhodpsnGPCR_Rhodpsn_7TMADENOSINE RECEPTOR A2AOLFACTORY RECEPTOR AND ADENOSINE RECEPTOR7tm_1ADENOSINA2ARADENOSINERGPCRRHODOPSN7TM_GPCR_SrsxFamily A G protein-coupled receptor-likeG_PROTEIN_RECEP_F1_1G_PROTEIN_RECEP_F1_2MMAdenosine receptor A2aAdora2aReceptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (By similarity). May interact with DRD4 (By similarity). Interacts with NECAB2 (By similarity). Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (PubMed:23994616).Colocalizes with GAS2L2 at neuronal processes.The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).Belongs to the G-protein coupled receptor 1 family.Adenosine receptor A2a449711410Extracellular4Helical; Name=1529Cytoplasmic3039Helical; Name=24063Extracellular6474Helical; Name=37597Cytoplasmic98117Helical; Name=4118140Extracellular141168Helical; Name=5169193Cytoplasmic194229Helical; Name=6230253Extracellular254261Helical; Name=7262285Cytoplasmic286Interaction with GAS2L2322Disordered342Polar residues360374164248272273N-linked (GlcNAc...) asparagine142N-linked (GlcNAc...) asparagine1496815471143161257I77IKKTA137138T146TP204agonist2011-07-27344971d1369eff968eb50a0237511cad8f1f5cMGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGMRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDENSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCQHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFRAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSAPHSGRRPNGYTLGPGGGGSTQGSPGDVELLTQEHQEGQEHPGLGDHLAQGRVGTASWSSEFAPStruetruetruetruetruetruetruetruetruetruetruetrue