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Q60613

- AA2AR_MOUSE

UniProt

Q60613 - AA2AR_MOUSE

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Protein

Adenosine receptor A2a

Gene
Adora2a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. G-protein coupled adenosine receptor activity Source: MGI

GO - Biological processi

  1. adenosine receptor signaling pathway Source: MGI
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  3. astrocyte activation Source: Ensembl
  4. eating behavior Source: MGI
  5. G-protein coupled receptor signaling pathway Source: MGI
  6. locomotory behavior Source: MGI
  7. negative regulation of alpha-beta T cell activation Source: MGI
  8. negative regulation of cell proliferation Source: Ensembl
  9. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  10. negative regulation of inflammatory response Source: MGI
  11. negative regulation of locomotion Source: Ensembl
  12. negative regulation of neuron apoptotic process Source: Ensembl
  13. negative regulation of protein kinase activity Source: Ensembl
  14. negative regulation of vascular permeability Source: Ensembl
  15. neuron projection morphogenesis Source: Ensembl
  16. positive regulation of acetylcholine secretion, neurotransmission Source: Ensembl
  17. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: Ensembl
  18. positive regulation of apoptotic signaling pathway Source: MGI
  19. positive regulation of cAMP biosynthetic process Source: MGI
  20. positive regulation of circadian sleep/wake cycle, sleep Source: Ensembl
  21. positive regulation of glutamate secretion Source: Ensembl
  22. positive regulation of protein secretion Source: Ensembl
  23. positive regulation of renal sodium excretion Source: Ensembl
  24. positive regulation of synaptic transmission, GABAergic Source: MGI
  25. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  26. positive regulation of urine volume Source: Ensembl
  27. prepulse inhibition Source: Ensembl
  28. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  29. regulation of calcium ion transport Source: Ensembl
  30. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  31. regulation of inhibitory postsynaptic membrane potential Source: MGI
  32. regulation of mitochondrial membrane potential Source: Ensembl
  33. regulation of norepinephrine secretion Source: Ensembl
  34. regulation of synaptic plasticity Source: Ensembl
  35. regulation of transcription, DNA-templated Source: Ensembl
  36. response to amphetamine Source: MGI
  37. response to caffeine Source: Ensembl
  38. response to drug Source: Ensembl
  39. synaptic transmission, cholinergic Source: Ensembl
  40. synaptic transmission, dopaminergic Source: MGI
  41. synaptic transmission, glutamatergic Source: Ensembl
  42. vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_209347. NGF-independant TRKA activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2a
Gene namesi
Name:Adora2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:99402. Adora2a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44Extracellular By similarity
Transmembranei5 – 2925Helical; Name=1; By similarityAdd
BLAST
Topological domaini30 – 3910Cytoplasmic By similarity
Transmembranei40 – 6324Helical; Name=2; By similarityAdd
BLAST
Topological domaini64 – 7411Extracellular By similarityAdd
BLAST
Transmembranei75 – 9723Helical; Name=3; By similarityAdd
BLAST
Topological domaini98 – 11720Cytoplasmic By similarityAdd
BLAST
Transmembranei118 – 14023Helical; Name=4; By similarityAdd
BLAST
Topological domaini141 – 16828Extracellular By similarityAdd
BLAST
Transmembranei169 – 19325Helical; Name=5; By similarityAdd
BLAST
Topological domaini194 – 22936Cytoplasmic By similarityAdd
BLAST
Transmembranei230 – 25324Helical; Name=6; By similarityAdd
BLAST
Topological domaini254 – 2618Extracellular By similarity
Transmembranei262 – 28524Helical; Name=7; By similarityAdd
BLAST
Topological domaini286 – 410125Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. asymmetric synapse Source: Ensembl
  2. axolemma Source: Ensembl
  3. dendrite Source: Ensembl
  4. endomembrane system Source: Ensembl
  5. integral component of plasma membrane Source: Ensembl
  6. membrane Source: MGI
  7. neuronal cell body Source: Ensembl
  8. plasma membrane Source: MGI
  9. postsynaptic density Source: Ensembl
  10. postsynaptic membrane Source: Ensembl
  11. presynaptic active zone Source: Ensembl
  12. presynaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Adenosine receptor A2aPRO_0000069000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 154 By similarity
Disulfide bondi71 ↔ 143 By similarity
Disulfide bondi74 ↔ 161 By similarity
Glycosylationi142 – 1421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi149 – 1491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi254 ↔ 257 By similarity

Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ60613.

PTM databases

PhosphoSiteiQ60613.

Expressioni

Gene expression databases

BgeeiQ60613.
CleanExiMM_ADORA2A.
GenevestigatoriQ60613.

Interactioni

Subunit structurei

Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct By similarity. May interact with DRD4 By similarity.

Protein-protein interaction databases

IntActiQ60613. 2 interactions.
MINTiMINT-4997181.
STRINGi10090.ENSMUSP00000020395.

Structurei

3D structure databases

ProteinModelPortaliQ60613.
SMRiQ60613. Positions 3-304.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 17210Agonist binding By similarity
Regioni241 – 2488Agonist binding By similarity
Regioni259 – 26911Agonist binding By similarityAdd
BLAST

Domaini

The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287824.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiQ2NLC1.
KOiK04266.
OMAiPGVWANG.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60613-1 [UniParc]FASTAAdd to Basket

« Hide

MGSSVYIMVE LAIAVLAILG NVLVCWAVWI NSNLQNVTNF FVVSLAAADI    50
AVGVLAIPFA ITISTGFCAA CHGCLFFACF VLVLTQSSIF SLLAIAIDRY 100
IAIRIPLRYN GLVTGMRAKG IIAICWVLSF AIGLTPMLGW NNCSQKDENS 150
TKTCGEGRVT CLFEDVVPMN YMVYYNFFAF VLLPLLLMLA IYLRIFLAAR 200
RQLKQMESQP LPGERTRSTL QKEVHAAKSL AIIVGLFALC WLPLHIINCF 250
TFFCSTCQHA PPWLMYLAII LSHSNSVVNP FIYAYRIREF RQTFRKIIRT 300
HVLRRQEPFR AGGSSAWALA AHSTEGEQVS LRLNGHPLGV WANGSAPHSG 350
RRPNGYTLGP GGGGSTQGSP GDVELLTQEH QEGQEHPGLG DHLAQGRVGT 400
ASWSSEFAPS 410
Length:410
Mass (Da):44,971
Last modified:July 27, 2011 - v3
Checksum:iE5670F442D243E71
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771F → I in CAA73787. 1 Publication
Sequence conflicti77 – 771F → I in CAA73788. 1 Publication
Sequence conflicti117 – 1171R → K in CAA73787. 1 Publication
Sequence conflicti117 – 1171R → K in CAA73788. 1 Publication
Sequence conflicti137 – 1382ML → TA in AAA19000. 1 Publication
Sequence conflicti146 – 1461K → T in CAA73787. 1 Publication
Sequence conflicti146 – 1461K → T in CAA73788. 1 Publication
Sequence conflicti204 – 2041K → P in AAA19000. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13344, Y13345 Genomic DNA. Translation: CAA73787.1.
Y13346 mRNA. Translation: CAA73788.1.
BC110692 mRNA. Translation: AAI10693.1.
CH466553 Genomic DNA. Translation: EDL31926.1.
CH466553 Genomic DNA. Translation: EDL31927.1.
U05672 mRNA. Translation: AAA19000.1.
CCDSiCCDS23924.1.
PIRiI48932.
RefSeqiNP_033760.2. NM_009630.3.
XP_006513155.1. XM_006513092.1.
XP_006513156.1. XM_006513093.1.
XP_006513157.1. XM_006513094.1.
XP_006513158.1. XM_006513095.1.
UniGeneiMm.333734.

Genome annotation databases

EnsembliENSMUST00000105420; ENSMUSP00000101060; ENSMUSG00000020178.
GeneIDi11540.
KEGGimmu:11540.
UCSCiuc007fqh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13344 , Y13345 Genomic DNA. Translation: CAA73787.1 .
Y13346 mRNA. Translation: CAA73788.1 .
BC110692 mRNA. Translation: AAI10693.1 .
CH466553 Genomic DNA. Translation: EDL31926.1 .
CH466553 Genomic DNA. Translation: EDL31927.1 .
U05672 mRNA. Translation: AAA19000.1 .
CCDSi CCDS23924.1.
PIRi I48932.
RefSeqi NP_033760.2. NM_009630.3.
XP_006513155.1. XM_006513092.1.
XP_006513156.1. XM_006513093.1.
XP_006513157.1. XM_006513094.1.
XP_006513158.1. XM_006513095.1.
UniGenei Mm.333734.

3D structure databases

ProteinModelPortali Q60613.
SMRi Q60613. Positions 3-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q60613. 2 interactions.
MINTi MINT-4997181.
STRINGi 10090.ENSMUSP00000020395.

Chemistry

ChEMBLi CHEMBL2115.
GuidetoPHARMACOLOGYi 19.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q60613.

Proteomic databases

PRIDEi Q60613.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105420 ; ENSMUSP00000101060 ; ENSMUSG00000020178 .
GeneIDi 11540.
KEGGi mmu:11540.
UCSCi uc007fqh.1. mouse.

Organism-specific databases

CTDi 135.
MGIi MGI:99402. Adora2a.

Phylogenomic databases

eggNOGi NOG287824.
GeneTreei ENSGT00550000074524.
HOGENOMi HOG000015770.
HOVERGENi HBG106962.
InParanoidi Q2NLC1.
KOi K04266.
OMAi PGVWANG.
OrthoDBi EOG79SDXQ.
TreeFami TF325296.

Enzyme and pathway databases

Reactomei REACT_209347. NGF-independant TRKA activation.

Miscellaneous databases

NextBioi 279000.
PROi Q60613.
SOURCEi Search...

Gene expression databases

Bgeei Q60613.
CleanExi MM_ADORA2A.
Genevestigatori Q60613.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor."
    Ledent C., Vaugeois J.M., Schiffmann S.N., Pedrazzini T., El-Yacoubi M., Vanderhaeghen J.J., Costentin J., Heath J.K., Vassart G., Parmentier M.
    Nature 388:674-678(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Jaw.
  4. "Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells."
    Marquardt D.L., Walker L.L., Heinemann S.
    J. Immunol. 152:4508-4515(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-213.
    Strain: BALB/c.
    Tissue: Bone marrow.

Entry informationi

Entry nameiAA2AR_MOUSE
AccessioniPrimary (citable) accession number: Q60613
Secondary accession number(s): Q2NLC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi