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Protein

Adenosine receptor A2a

Gene

Adora2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-417973. Adenosine P1 receptors.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2a
Gene namesi
Name:Adora2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:99402. Adora2a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4ExtracellularBy similarity4
Transmembranei5 – 29Helical; Name=1By similarityAdd BLAST25
Topological domaini30 – 39CytoplasmicBy similarity10
Transmembranei40 – 63Helical; Name=2By similarityAdd BLAST24
Topological domaini64 – 74ExtracellularBy similarityAdd BLAST11
Transmembranei75 – 97Helical; Name=3By similarityAdd BLAST23
Topological domaini98 – 117CytoplasmicBy similarityAdd BLAST20
Transmembranei118 – 140Helical; Name=4By similarityAdd BLAST23
Topological domaini141 – 168ExtracellularBy similarityAdd BLAST28
Transmembranei169 – 193Helical; Name=5By similarityAdd BLAST25
Topological domaini194 – 229CytoplasmicBy similarityAdd BLAST36
Transmembranei230 – 253Helical; Name=6By similarityAdd BLAST24
Topological domaini254 – 261ExtracellularBy similarity8
Transmembranei262 – 285Helical; Name=7By similarityAdd BLAST24
Topological domaini286 – 410CytoplasmicBy similarityAdd BLAST125

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2115.
GuidetoPHARMACOLOGYi19.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690001 – 410Adenosine receptor A2aAdd BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 154PROSITE-ProRule annotation
Disulfide bondi71 ↔ 143PROSITE-ProRule annotation
Disulfide bondi74 ↔ 161PROSITE-ProRule annotation
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi254 ↔ 257PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ60613.
PRIDEiQ60613.

PTM databases

PhosphoSitePlusiQ60613.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020178.
CleanExiMM_ADORA2A.
GenevisibleiQ60613. MM.

Interactioni

Subunit structurei

Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4. Interacts with NECAB2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ60613. 2 interactors.
MINTiMINT-4997181.
STRINGi10090.ENSMUSP00000101060.

Chemistry databases

BindingDBiQ60613.

Structurei

3D structure databases

ProteinModelPortaliQ60613.
SMRiQ60613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 172Agonist bindingBy similarity10
Regioni241 – 248Agonist bindingBy similarity8
Regioni259 – 269Agonist bindingBy similarityAdd BLAST11

Domaini

The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiQ60613.
KOiK04266.
OMAiMESQPLP.
OrthoDBiEOG091G0I3U.
TreeFamiTF325296.

Family and domain databases

CDDicd15068. 7tmA_Adenosine_R_A2A. 1 hit.
InterProiView protein in InterPro
IPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSVYIMVE LAIAVLAILG NVLVCWAVWI NSNLQNVTNF FVVSLAAADI
60 70 80 90 100
AVGVLAIPFA ITISTGFCAA CHGCLFFACF VLVLTQSSIF SLLAIAIDRY
110 120 130 140 150
IAIRIPLRYN GLVTGMRAKG IIAICWVLSF AIGLTPMLGW NNCSQKDENS
160 170 180 190 200
TKTCGEGRVT CLFEDVVPMN YMVYYNFFAF VLLPLLLMLA IYLRIFLAAR
210 220 230 240 250
RQLKQMESQP LPGERTRSTL QKEVHAAKSL AIIVGLFALC WLPLHIINCF
260 270 280 290 300
TFFCSTCQHA PPWLMYLAII LSHSNSVVNP FIYAYRIREF RQTFRKIIRT
310 320 330 340 350
HVLRRQEPFR AGGSSAWALA AHSTEGEQVS LRLNGHPLGV WANGSAPHSG
360 370 380 390 400
RRPNGYTLGP GGGGSTQGSP GDVELLTQEH QEGQEHPGLG DHLAQGRVGT
410
ASWSSEFAPS
Length:410
Mass (Da):44,971
Last modified:July 27, 2011 - v3
Checksum:iE5670F442D243E71
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77F → I in CAA73787 (PubMed:9262401).Curated1
Sequence conflicti77F → I in CAA73788 (PubMed:9262401).Curated1
Sequence conflicti117R → K in CAA73787 (PubMed:9262401).Curated1
Sequence conflicti117R → K in CAA73788 (PubMed:9262401).Curated1
Sequence conflicti137 – 138ML → TA in AAA19000 (PubMed:8157966).Curated2
Sequence conflicti146K → T in CAA73787 (PubMed:9262401).Curated1
Sequence conflicti146K → T in CAA73788 (PubMed:9262401).Curated1
Sequence conflicti204K → P in AAA19000 (PubMed:8157966).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13344, Y13345 Genomic DNA. Translation: CAA73787.1.
Y13346 mRNA. Translation: CAA73788.1.
BC110692 mRNA. Translation: AAI10693.1.
CH466553 Genomic DNA. Translation: EDL31926.1.
CH466553 Genomic DNA. Translation: EDL31927.1.
U05672 mRNA. Translation: AAA19000.1.
CCDSiCCDS23924.1.
PIRiI48932.
RefSeqiNP_001318024.1. NM_001331095.1.
NP_001318025.1. NM_001331096.1.
NP_033760.2. NM_009630.3.
XP_006513156.1. XM_006513093.3.
UniGeneiMm.333734.

Genome annotation databases

EnsembliENSMUST00000105420; ENSMUSP00000101060; ENSMUSG00000020178.
GeneIDi11540.
KEGGimmu:11540.
UCSCiuc007fqh.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiAA2AR_MOUSE
AccessioniPrimary (citable) accession number: Q60613
Secondary accession number(s): Q2NLC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 22, 2017
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families