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Protein

Adenosine receptor A1

Gene

Adora1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-417973. Adenosine P1 receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:Adora1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:99401. Adora1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010ExtracellularSequence analysis
Transmembranei11 – 3323Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini34 – 4613CytoplasmicSequence analysisAdd
BLAST
Transmembranei47 – 6923Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini70 – 8011ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10222Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini103 – 12321CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14623Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini147 – 17630ExtracellularSequence analysisAdd
BLAST
Transmembranei177 – 20125Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini202 – 23534CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25924Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 2678ExtracellularSequence analysis
Transmembranei268 – 29225Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 32634CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3688.
GuidetoPHARMACOLOGYi18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Adenosine receptor A1PRO_0000068992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis
Lipidationi309 – 3091S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ60612.
PRIDEiQ60612.

PTM databases

iPTMnetiQ60612.
PhosphoSiteiQ60612.

Expressioni

Gene expression databases

BgeeiQ60612.
CleanExiMM_ADORA1.
ExpressionAtlasiQ60612. baseline and differential.
GenevisibleiQ60612. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043522.

Chemistry

BindingDBiQ60612.

Structurei

3D structure databases

ProteinModelPortaliQ60612.
SMRiQ60612. Positions 10-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiQ60612.
KOiK04265.
OMAiVYAFRIH.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS
160 170 180 190 200
EVEQAWIANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL
310 320
KIWNDHFRCQ PKPPIEEDIP EEKADD
Length:326
Mass (Da):36,638
Last modified:July 27, 2011 - v4
Checksum:i6E5AC2D94447963C
GO

Sequence cautioni

The sequence AAA18999.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101A → G (PubMed:8157966).Curated
Sequence conflicti107 – 1071L → P in AAD31843 (PubMed:10318839).Curated
Sequence conflicti325 – 3251D → E in AAA18999 (PubMed:8157966).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05671 mRNA. Translation: AAA18999.1. Different initiation.
AK043954 mRNA. Translation: BAC31713.1.
AK045729 mRNA. Translation: BAC32474.1.
AK134553 mRNA. Translation: BAE22183.1.
CH466520 Genomic DNA. Translation: EDL39623.1.
AF133099 Genomic DNA. Translation: AAD31843.1.
CCDSiCCDS15305.1.
RefSeqiNP_001008533.1. NM_001008533.3.
NP_001034599.1. NM_001039510.2.
NP_001269874.1. NM_001282945.1.
NP_001278857.1. NM_001291928.1.
XP_006529142.1. XM_006529079.1.
UniGeneiMm.298908.

Genome annotation databases

EnsembliENSMUST00000038191; ENSMUSP00000043522; ENSMUSG00000042429.
ENSMUST00000086465; ENSMUSP00000083656; ENSMUSG00000042429.
ENSMUST00000169927; ENSMUSP00000132105; ENSMUSG00000042429.
GeneIDi11539.
KEGGimmu:11539.
UCSCiuc007crj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05671 mRNA. Translation: AAA18999.1. Different initiation.
AK043954 mRNA. Translation: BAC31713.1.
AK045729 mRNA. Translation: BAC32474.1.
AK134553 mRNA. Translation: BAE22183.1.
CH466520 Genomic DNA. Translation: EDL39623.1.
AF133099 Genomic DNA. Translation: AAD31843.1.
CCDSiCCDS15305.1.
RefSeqiNP_001008533.1. NM_001008533.3.
NP_001034599.1. NM_001039510.2.
NP_001269874.1. NM_001282945.1.
NP_001278857.1. NM_001291928.1.
XP_006529142.1. XM_006529079.1.
UniGeneiMm.298908.

3D structure databases

ProteinModelPortaliQ60612.
SMRiQ60612. Positions 10-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043522.

Chemistry

BindingDBiQ60612.
ChEMBLiCHEMBL3688.
GuidetoPHARMACOLOGYi18.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ60612.
PhosphoSiteiQ60612.

Proteomic databases

PaxDbiQ60612.
PRIDEiQ60612.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038191; ENSMUSP00000043522; ENSMUSG00000042429.
ENSMUST00000086465; ENSMUSP00000083656; ENSMUSG00000042429.
ENSMUST00000169927; ENSMUSP00000132105; ENSMUSG00000042429.
GeneIDi11539.
KEGGimmu:11539.
UCSCiuc007crj.2. mouse.

Organism-specific databases

CTDi134.
MGIiMGI:99401. Adora1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiQ60612.
KOiK04265.
OMAiVYAFRIH.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Enzyme and pathway databases

ReactomeiR-MMU-417973. Adenosine P1 receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiAdora1. mouse.
NextBioi278994.
PROiQ60612.
SOURCEiSearch...

Gene expression databases

BgeeiQ60612.
CleanExiMM_ADORA1.
ExpressionAtlasiQ60612. baseline and differential.
GenevisibleiQ60612. MM.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells."
    Marquardt D.L., Walker L.L., Heinemann S.
    J. Immunol. 152:4508-4515(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex, Corpora quadrigemina and Medulla oblongata.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Characterization of the murine A1 adenosine receptor promoter, potent regulation by GATA-4 and Nkx2.5."
    Rivkees S.A., Chen M., Kulkarni J., Browne J., Zhao Z.
    J. Biol. Chem. 274:14204-14209(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-107.

Entry informationi

Entry nameiAA1R_MOUSE
AccessioniPrimary (citable) accession number: Q60612
Secondary accession number(s): Q8BGU7, Q9WUF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.