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Q60611

- SATB1_MOUSE

UniProt

Q60611 - SATB1_MOUSE

Protein

DNA-binding protein SATB1

Gene

Satb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis By similarity. Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.By similarity9 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei254 – 2552Cleavage; by caspases
    Binding sitei390 – 3901Matrix attachment region (MAR) DNABy similarity
    Binding sitei425 – 4251Matrix attachment region (MAR) DNABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi361 – 44888CUT 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi484 – 57188CUT 2PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi646 – 70560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. activated T cell proliferation Source: MGI
    2. CD4-positive, alpha-beta T cell differentiation Source: MGI
    3. CD8-positive, alpha-beta T cell differentiation Source: MGI
    4. chromatin organization Source: MGI
    5. chromatin remodeling Source: MGI
    6. epidermis development Source: MGI
    7. histone methylation Source: MGI
    8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    9. reflex Source: MGI
    10. regulation of transcription, DNA-templated Source: MGI
    11. T cell activation Source: MGI
    12. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_224460. Apoptotic cleavage of cellular proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-binding protein SATB1
    Alternative name(s):
    Special AT-rich sequence-binding protein 1
    Gene namesi
    Name:Satb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:105084. Satb1.

    Subcellular locationi

    Nucleus. NucleusPML body
    Note: Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs) By similarity.By similarity

    GO - Cellular componenti

    1. chromatin Source: MGI
    2. nuclear heterochromatin Source: MGI
    3. nuclear matrix Source: MGI
    4. PML body Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice are small in size, have disproportionately small thymi and spleens, and die at 3 weeks of age. Multiple defects in T-cell development are observed, including interrupted thymocytes differentiation and abnormal T-cell transcriptome.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764DNA-binding protein SATB1PRO_0000202399Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei136 – 1361N6-acetyllysineBy similarity
    Modified residuei185 – 1851PhosphoserineBy similarity
    Cross-linki745 – 745Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

    Post-translational modificationi

    Sumoylated. Sumoylation promotes cleavage by caspases.By similarity
    Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation By similarity.By similarity
    Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms can not dimerize and lose transcription regulation function because of impaired DNA and chromatin association.1 Publication

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ60611.
    PaxDbiQ60611.
    PRIDEiQ60611.

    PTM databases

    PhosphoSiteiQ60611.

    Expressioni

    Tissue specificityi

    Mainly expressed in thymus, spleen, and lymph nodes with a lower level observed in the brain.1 Publication

    Gene expression databases

    ArrayExpressiQ60611.
    BgeeiQ60611.
    CleanExiMM_SATB1.
    GenevestigatoriQ60611.

    Interactioni

    Subunit structurei

    Interacts with PCAF. Interacts with sumoylated PML and HDAC1 Tat via the PDZ-like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300 By similarity. Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least of SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts with CUX1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi203077. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60611.
    SMRiQ60611. Positions 71-171, 179-250, 370-452, 486-573, 647-705.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni90 – 204115PDZ-like dimerization domainAdd
    BLAST
    Regioni224 – 27855Nuclear matrix targeting sequence (NMTS)By similarityAdd
    BLAST
    Regioni400 – 41011Matrix attachment region (MAR) DNA-bindingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi20 – 4021Nuclear localization signalBy similarityAdd
    BLAST
    Motifi139 – 1435Protein interactionBy similarity
    Motifi224 – 27855Nuclear matrix targeting sequence (NMTS)Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi591 – 60717Poly-GlnAdd
    BLAST
    Compositional biasi608 – 61710Poly-Pro

    Sequence similaritiesi

    Belongs to the CUT homeobox family.Curated
    Contains 2 CUT DNA-binding domains.PROSITE-ProRule annotation
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, Repeat

    Phylogenomic databases

    eggNOGiNOG313826.
    GeneTreeiENSGT00390000008096.
    HOGENOMiHOG000004805.
    HOVERGENiHBG054240.
    InParanoidiQ91XB1.
    OrthoDBiEOG7FBRH5.
    PhylomeDBiQ60611.
    TreeFamiTF332714.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 2 hits.
    InterProiIPR003350. Hmoeo_CUT.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view]
    PfamiPF02376. CUT. 2 hits.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 2 hits.
    PROSITEiPS51042. CUT. 2 hits.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60611-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDHLNEATQG KEHSEMSNNV SDPKGPPAKI ARLEQNGSPL GRGRLGSTGG    50
    KMQGVPLKHS GHLMKTNLRK GTMLPVFCVV EHYENAIEYD CKEEHAEFVL 100
    VRKDMLFNQL IEMALLSLGY SHSSAAQAKG LIQVGKWNPV PLSYVTDAPD 150
    ATVADMLQDV YHVVTLKIQL HSCPKLEDLP PEQWSHTTVR NALKDLLKDM 200
    NQSSLAKECP LSQSMISSIV NSTYYANVSA AKCQEFGRWY KHFKKTKDMM 250
    VEMDSLSELS QQGANHVNFG QQPVPGNTAE QPPSPAQLSH GSQPSVRTPL 300
    PNLHPGLVST PISPQLVNQQ LVMAQLLNQQ YAVNRLLAQQ SLNQQYLNHP 350
    PPVSRSMNKP LEQQVSTNTE VSSEIYQWVR DELKRAGISQ AVFARVAFNR 400
    TQGLLSEILR KEEDPKTASQ SLLVNLRAMQ NFLQLPEAER DRIYQDERER 450
    SLNAASAMGP APLLSTPPSR PPQVKTATLA TERNGKPENN TMNINASIYD 500
    EIQQEMKRAK VSQALFAKVA ATKSQGWLCE LLRWKEDPSP ENRTLWENLS 550
    MIRRFLSLPQ PERDAIYEQE SNAVHHHGDR PPHIIHVPAE QIQQQQQQQQ 600
    QQQQQQQPPP PPPQPQPQPQ AGPRLPPRQP TVASSAESDE ENRQKTRPRT 650
    KISVEALGIL QSFIQDVGLY PDEEAIQTLS AQLDLPKYTI IKFFQNQRYY 700
    LKHHGKLKDN SGLEVDVAEY KDEELLKDLE ESVQDKNANT LFSVKLEEEL 750
    SVEGSTDVNA DLKD 764
    Length:764
    Mass (Da):85,880
    Last modified:July 27, 2011 - v2
    Checksum:i330ECCDBA8683B78
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti155 – 1551D → N in AAA17372. (PubMed:8114718)Curated
    Sequence conflicti515 – 5151L → P in AAA17372. (PubMed:8114718)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05252 mRNA. Translation: AAA17372.1.
    AK088563 mRNA. Translation: BAC40427.1.
    AK158518 mRNA. Translation: BAE34542.1.
    CT010371 mRNA. Translation: CAJ18578.1.
    BC011132 mRNA. Translation: AAH11132.1.
    CH466559 Genomic DNA. Translation: EDL23652.1.
    CCDSiCCDS28876.1.
    PIRiA56208.
    RefSeqiNP_001157102.1. NM_001163630.1.
    NP_001157103.1. NM_001163631.1.
    NP_001157104.1. NM_001163632.1.
    NP_033148.2. NM_009122.2.
    UniGeneiMm.311655.

    Genome annotation databases

    EnsembliENSMUST00000133574; ENSMUSP00000120536; ENSMUSG00000023927.
    ENSMUST00000144331; ENSMUSP00000116006; ENSMUSG00000023927.
    ENSMUST00000152830; ENSMUSP00000119842; ENSMUSG00000023927.
    ENSMUST00000169480; ENSMUSP00000128841; ENSMUSG00000023927.
    ENSMUST00000176669; ENSMUSP00000134957; ENSMUSG00000023927.
    GeneIDi20230.
    KEGGimmu:20230.
    UCSCiuc008czd.2. mouse.

    Keywords - Coding sequence diversityi

    Chromosomal rearrangement

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05252 mRNA. Translation: AAA17372.1 .
    AK088563 mRNA. Translation: BAC40427.1 .
    AK158518 mRNA. Translation: BAE34542.1 .
    CT010371 mRNA. Translation: CAJ18578.1 .
    BC011132 mRNA. Translation: AAH11132.1 .
    CH466559 Genomic DNA. Translation: EDL23652.1 .
    CCDSi CCDS28876.1.
    PIRi A56208.
    RefSeqi NP_001157102.1. NM_001163630.1.
    NP_001157103.1. NM_001163631.1.
    NP_001157104.1. NM_001163632.1.
    NP_033148.2. NM_009122.2.
    UniGenei Mm.311655.

    3D structure databases

    ProteinModelPortali Q60611.
    SMRi Q60611. Positions 71-171, 179-250, 370-452, 486-573, 647-705.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203077. 1 interaction.

    PTM databases

    PhosphoSitei Q60611.

    Proteomic databases

    MaxQBi Q60611.
    PaxDbi Q60611.
    PRIDEi Q60611.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000133574 ; ENSMUSP00000120536 ; ENSMUSG00000023927 .
    ENSMUST00000144331 ; ENSMUSP00000116006 ; ENSMUSG00000023927 .
    ENSMUST00000152830 ; ENSMUSP00000119842 ; ENSMUSG00000023927 .
    ENSMUST00000169480 ; ENSMUSP00000128841 ; ENSMUSG00000023927 .
    ENSMUST00000176669 ; ENSMUSP00000134957 ; ENSMUSG00000023927 .
    GeneIDi 20230.
    KEGGi mmu:20230.
    UCSCi uc008czd.2. mouse.

    Organism-specific databases

    CTDi 6304.
    MGIi MGI:105084. Satb1.

    Phylogenomic databases

    eggNOGi NOG313826.
    GeneTreei ENSGT00390000008096.
    HOGENOMi HOG000004805.
    HOVERGENi HBG054240.
    InParanoidi Q91XB1.
    OrthoDBi EOG7FBRH5.
    PhylomeDBi Q60611.
    TreeFami TF332714.

    Enzyme and pathway databases

    Reactomei REACT_224460. Apoptotic cleavage of cellular proteins.

    Miscellaneous databases

    ChiTaRSi SATB1. mouse.
    NextBioi 297861.
    PROi Q60611.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60611.
    Bgeei Q60611.
    CleanExi MM_SATB1.
    Genevestigatori Q60611.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 2 hits.
    InterProi IPR003350. Hmoeo_CUT.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02376. CUT. 2 hits.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 2 hits.
    PROSITEi PS51042. CUT. 2 hits.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1."
      Nakagomi K., Kohwi Y., Dickinson L.A., Kohwi-Shigematsu T.
      Mol. Cell. Biol. 14:1852-1860(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymus.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Thymus and Visual cortex.
    3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    6. "SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis."
      Galande S., Dickinson L.A., Mian I.S., Sikorska M., Kohwi-Shigematsu T.
      Mol. Cell. Biol. 21:5591-5604(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 255-259, FUNCTION, DIMERIZATION, CLEAVAGE BY CASP6.
    7. "The matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression."
      Liu J., Bramblett D., Zhu Q., Lozano M., Kobayashi R., Ross S.R., Dudley J.P.
      Mol. Cell. Biol. 17:5275-5287(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation."
      Liu J., Barnett A., Neufeld E.J., Dudley J.P.
      Mol. Cell. Biol. 19:4918-4926(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CUX1.
    9. "The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development."
      Alvarez J.D., Yasui D.H., Niida H., Joh T., Loh D.Y., Kohwi-Shigematsu T.
      Genes Dev. 14:521-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    10. "Tissue-specific nuclear architecture and gene expression regulated by SATB1."
      Cai S., Han H.-J., Kohwi-Shigematsu T.
      Nat. Genet. 34:42-51(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    11. "Nuclear matrix binding regulates SATB1-mediated transcriptional repression."
      Seo J., Lozano M.M., Dudley J.P.
      J. Biol. Chem. 280:24600-24609(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, NUCLEAR MATRIX TARGETING SEQUENCE.
    12. "A role for SATB1, a nuclear matrix association region-binding protein, in the development of CD8SP thymocytes and peripheral T lymphocytes."
      Nie H., Maika S.D., Tucker P.W., Gottlieb P.D.
      J. Immunol. 174:4745-4752(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
    13. "SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes."
      Cai S., Lee C.C., Kohwi-Shigematsu T.
      Nat. Genet. 38:1278-1288(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "SATB1 is required for CD8 coreceptor reversal."
      Nie H., Yao X., Maika S.D., Tucker P.W.
      Mol. Immunol. 46:207-211(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells."
      Agrelo R., Souabni A., Novatchkova M., Haslinger C., Leeb M., Komnenovic V., Kishimoto H., Gresh L., Kohwi-Shigematsu T., Kenner L., Wutz A.
      Dev. Cell 16:507-516(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    16. "Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1."
      Purbey P.K., Singh S., Notani D., Kumar P.P., Limaye A.S., Galande S.
      Mol. Cell. Biol. 29:1321-1337(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CTBP1.

    Entry informationi

    Entry nameiSATB1_MOUSE
    AccessioniPrimary (citable) accession number: Q60611
    Secondary accession number(s): Q91XB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3