##gff-version 3 Q60603 UniProtKB Chain 1 989 . . . ID=PRO_0000053995;Note=Potassium voltage-gated channel subfamily H member 1 Q60603 UniProtKB Topological domain 1 220 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Transmembrane 221 241 . . . Note=Helical%3B Name%3DSegment S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Topological domain 242 248 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Transmembrane 249 269 . . . Note=Helical%3B Name%3DSegment S2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Topological domain 270 290 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Transmembrane 291 309 . . . Note=Helical%3B Name%3DSegment S3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Topological domain 310 345 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Transmembrane 346 368 . . . Note=Helical%3B Voltage-sensor%3B Name%3DSegment S4;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Topological domain 369 377 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Transmembrane 378 399 . . . Note=Helical%3B Name%3DSegment S5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Topological domain 400 448 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Intramembrane 449 470 . . . Note=Pore-forming%3B Name%3DSegment H5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Topological domain 471 477 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Transmembrane 478 498 . . . Note=Helical%3B Name%3DSegment S6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Topological domain 499 989 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Domain 14 94 . . . Note=PAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140 Q60603 UniProtKB Domain 93 145 . . . Note=PAC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00141 Q60603 UniProtKB Region 151 162 . . . Note=Required for phosphatidylinositol bisphosphate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O95259 Q60603 UniProtKB Region 673 770 . . . Note=Calmodulin-binding;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22732247,ECO:0000269|PubMed:27618660;Dbxref=PMID:22732247,PMID:27618660 Q60603 UniProtKB Region 699 701 . . . Note=Interaction with cyclic nucleotide-binding pocket;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22732247;Dbxref=PMID:22732247 Q60603 UniProtKB Region 857 905 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q60603 UniProtKB Region 924 964 . . . Note=CAD (involved in subunit assembly);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Region 961 989 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q60603 UniProtKB Motif 463 468 . . . Note=Selectivity filter;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472 Q60603 UniProtKB Compositional bias 857 874 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q60603 UniProtKB Compositional bias 881 897 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q60603 UniProtKB Compositional bias 961 975 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q60603 UniProtKB Modified residue 974 974 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q60603 UniProtKB Modified residue 978 978 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q60603 UniProtKB Modified residue 981 981 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q60603 UniProtKB Glycosylation 415 415 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q60603 UniProtKB Glycosylation 433 433 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q60603 UniProtKB Mutagenesis 7 8 . . . Note=Strongly shifts the voltage-dependent channel activation to more depolarized membrane potentials. RR->AA%2CEE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23975098;Dbxref=PMID:23975098 Q60603 UniProtKB Mutagenesis 57 57 . . . Note=Decreases the rate of channel opening. No effect%3B when associated with R-642. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23975098;Dbxref=PMID:23975098 Q60603 UniProtKB Mutagenesis 627 627 . . . Note=Strongly shifts the voltage-dependent channel activation to much more depolarized membrane potentials. E->A%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23975098;Dbxref=PMID:23975098 Q60603 UniProtKB Mutagenesis 628 628 . . . Note=Mildly increases the affinity for CALM. V->A%2CL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22732247;Dbxref=PMID:22732247 Q60603 UniProtKB Mutagenesis 642 642 . . . Note=Decreases the rate of channel opening. No effect%3B when associated with D-57. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23975098;Dbxref=PMID:23975098 Q60603 UniProtKB Mutagenesis 697 699 . . . Note=Increases the affinity for CALM. LTY->ATA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22732247;Dbxref=PMID:22732247 Q60603 UniProtKB Mutagenesis 699 701 . . . Note=Increases the affinity for CALM. YNL->ANA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22732247;Dbxref=PMID:22732247 Q60603 UniProtKB Mutagenesis 699 699 . . . Note=Mildly increases the affinity for CALM. Y->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22732247;Dbxref=PMID:22732247 Q60603 UniProtKB Mutagenesis 705 707 . . . Note=Decreases the affinity for CALM. IVF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22732247;Dbxref=PMID:22732247 Q60603 UniProtKB Mutagenesis 737 737 . . . Note=No effect on affinity for CALM%3B when associated with A-740. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27618660;Dbxref=PMID:27618660 Q60603 UniProtKB Mutagenesis 737 737 . . . Note=Decreases affinity for CALM 230-fold%3B when associated with S-740. V->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27618660;Dbxref=PMID:27618660 Q60603 UniProtKB Mutagenesis 740 740 . . . Note=No effect on affinity for CALM%3B when associated with A-737. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27618660;Dbxref=PMID:27618660 Q60603 UniProtKB Mutagenesis 740 740 . . . Note=Decreases affinity for CALM 230-fold%3B when associated with S-737. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27618660;Dbxref=PMID:27618660 Q60603 UniProtKB Mutagenesis 741 741 . . . Note=Decreases affinity for CALM about 30-fold. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27618660;Dbxref=PMID:27618660 Q60603 UniProtKB Sequence conflict 808 808 . . . Note=V->M Q60603 UniProtKB Helix 17 22 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Beta strand 29 34 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HOI Q60603 UniProtKB Beta strand 41 45 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HOI Q60603 UniProtKB Helix 47 53 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HOI Q60603 UniProtKB Helix 57 60 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HOI Q60603 UniProtKB Helix 68 70 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HOI Q60603 UniProtKB Helix 77 88 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HOI Q60603 UniProtKB Beta strand 93 100 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HOI Q60603 UniProtKB Beta strand 106 117 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HOI Q60603 UniProtKB Beta strand 123 132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HOI Q60603 UniProtKB Turn 134 136 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HOI Q60603 UniProtKB Beta strand 555 559 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Helix 565 571 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Helix 573 576 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Helix 580 582 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Helix 587 596 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Beta strand 598 602 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Beta strand 607 609 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Beta strand 613 615 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Beta strand 617 624 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Beta strand 626 630 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Beta strand 633 638 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Beta strand 643 645 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Turn 647 651 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Beta strand 658 673 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Helix 674 683 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Helix 685 694 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Beta strand 698 700 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Helix 710 718 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LLO Q60603 UniProtKB Helix 736 741 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIT