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Q60603 (KCNH1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily H member 1
Alternative name(s):
Ether-a-go-go potassium channel 1
Short name=EAG channel 1
Short name=EAG1
Short name=m-eag
Voltage-gated potassium channel subunit Kv10.1
Gene names
Name:Kcnh1
Synonyms:Eag
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length989 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts By similarity.

Subunit structure

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. Interacts with ALG10B By similarity.

Subcellular location

Cell membrane By similarity; Multi-pass membrane protein. Nucleus inner membrane By similarity; Multi-pass membrane protein. Note: Perinuclear KCNH1 is located to NPC-free islands By similarity.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily. [View classification]

Contains 1 cyclic nucleotide-binding domain.

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 1 PAS (PER-ARNT-SIM) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 989989Potassium voltage-gated channel subfamily H member 1
PRO_0000053995

Regions

Topological domain1 – 220220Cytoplasmic Potential
Transmembrane221 – 24121Helical; Name=Segment S1; Potential
Topological domain242 – 2487Extracellular Potential
Transmembrane249 – 26921Helical; Name=Segment S2; Potential
Topological domain270 – 29425Cytoplasmic Potential
Transmembrane295 – 31521Helical; Name=Segment S3; Potential
Topological domain316 – 34934Extracellular Potential
Transmembrane350 – 37021Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain371 – 3766Cytoplasmic Potential
Transmembrane377 – 39721Helical; Name=Segment S5; Potential
Topological domain398 – 45053Extracellular Potential
Intramembrane451 – 47121Pore-forming; Name=Segment H5; Potential
Topological domain472 – 4776Extracellular Potential
Transmembrane478 – 49821Helical; Name=Segment S6; Potential
Topological domain499 – 989491Cytoplasmic Potential
Domain14 – 9481PAS
Domain93 – 14553PAC
Nucleotide binding581 – 698118cNMP
Region673 – 77098Calmodulin-binding By similarity
Region924 – 96441CAD (involved in subunit assembly) By similarity
Motif463 – 4686Selectivity filter By similarity

Amino acid modifications

Glycosylation4151N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential

Secondary structure

.......................................................... 989
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q60603 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BA9B8C30F958CDCA

FASTA989111,314
        10         20         30         40         50         60 
MTMAGGRRGL VAPQNTFLEN IVRRSNDTNF VLGNAQIVDW PIVYSNDGFC KLSGYHRAEV 

        70         80         90        100        110        120 
MQKSSACSFM YGELTDKDTV EKVRQTFENY EMNSFEILMY KKNRTPVWFF VKIAPIRNEQ 

       130        140        150        160        170        180 
DKVVLFLCTF SDITAFKQPI EDDSCKGWGK FARLTRALTS SRGVLQQLAP SVQKGENVHK 

       190        200        210        220        230        240 
HSRLAEVLQL GSDILPQYKQ EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS 

       250        260        270        280        290        300 
FKTRQNNVAW LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL 

       310        320        330        340        350        360 
LSCLPYDVIN AFENVDEVSA FMGDPGKIGF ADQIPPPLEG RESQGISSLF SSLKVVRLLR 

       370        380        390        400        410        420 
LGRVARKLDH YIEYGAAVLV LLVCVFGLAA HWMACIWYSI GDYEIFDEDT KTIRNNSWLY 

       430        440        450        460        470        480 
QLALDIGTPY QFNGSGSGKW EGGPSKNSVY ISSLYFTMTS LTSVGFGNIA PSTDIEKIFA 

       490        500        510        520        530        540 
VAIMMIGSLL YATIFGNVTT IFQQMYANTN RYHEMLNSVR DFLKLYQVPK GLSERVMDYI 

       550        560        570        580        590        600 
VSTWSMSRGI DTEKVLQICP KDMRADICVH LNRKVFKEHP AFRLASDGCL RALAMEFQTV 

       610        620        630        640        650        660 
HCAPGDLIYH AGESVDSLCF VVSGSLEVIQ DDEVVAILGK GDVFGDVFWK EATLAQSCAN 

       670        680        690        700        710        720 
VRALTYCDLH VIKRDALQKV LEFYTAFSHS FSRNLILTYN LRKRIVFRKI SDVKREEEER 

       730        740        750        760        770        780 
MKRKNEAPLI LPPDHPVRRL FQRFRQQKEA RLAAERGGRD LDDLDVEKGN ALTDHTSANH 

       790        800        810        820        830        840 
SLVKASVVTV RESPATPVSF QAATTSTMSD HAKLHAPGSE CLGPKAVSCD PAKRKGWARF 

       850        860        870        880        890        900 
KDACGKGEDW NKVSKAESME TLPERTKAPG EATLKKTDSC DSGITKSDLR LDNVGETRSP 

       910        920        930        940        950        960 
QDRSPILAEV KHSFYPIPEQ TLQATVLEVK YELKEDIKAL NAKMTSIEKQ LSEILRILMS 

       970        980 
RGSAQSPQET GEISRPQSPE SDRDIFGAS 

« Hide

References

[1]"A family of potassium channel genes related to eag in Drosophila and mammals."
Warmke J.W., Ganetzky B.
Proc. Natl. Acad. Sci. U.S.A. 91:3438-3442(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U04294 mRNA. Translation: AAA62474.1.
CCDSCCDS15627.1.
PIRI48912.
RefSeqNP_034730.1. NM_010600.2.
UniGeneMm.4489.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4F8AX-ray2.20A552-707[»]
4HOIX-ray1.85A/B/C/D28-137[»]
4LLOX-ray2.00A/C/E/G552-724[»]
B/D/F/H6-136[»]
ProteinModelPortalQ60603.
SMRQ60603. Positions 28-137, 449-503, 509-720.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ60603. 1 interaction.

PTM databases

PhosphoSiteQ60603.

Proteomic databases

PaxDbQ60603.
PRIDEQ60603.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000078470; ENSMUSP00000077563; ENSMUSG00000058248.
GeneID16510.
KEGGmmu:16510.
UCSCuc007edo.1. mouse.

Organism-specific databases

CTD3756.
MGIMGI:1341721. Kcnh1.

Phylogenomic databases

eggNOGCOG2202.
GeneTreeENSGT00680000099663.
HOGENOMHOG000230794.
HOVERGENHBG101348.
InParanoidQ60603.
KOK04904.
OMAHAKLHAP.
OrthoDBEOG7QG43V.
PhylomeDBQ60603.
TreeFamTF313130.

Gene expression databases

ArrayExpressQ60603.
BgeeQ60603.
GenevestigatorQ60603.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSPR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKCNH1. mouse.
NextBio289847.
PROQ60603.
SOURCESearch...

Entry information

Entry nameKCNH1_MOUSE
AccessionPrimary (citable) accession number: Q60603
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot