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Q60603

- KCNH1_MOUSE

UniProt

Q60603 - KCNH1_MOUSE

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Protein
Potassium voltage-gated channel subfamily H member 1
Gene
Kcnh1, Eag
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi581 – 698118cNMP
Add
BLAST

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated potassium channel activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calmodulin-binding, Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 1
Alternative name(s):
Ether-a-go-go potassium channel 1
Short name:
EAG channel 1
Short name:
EAG1
Short name:
m-eag
Voltage-gated potassium channel subunit Kv10.1
Gene namesi
Name:Kcnh1
Synonyms:Eag
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1341721. Kcnh1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein. Nucleus inner membrane By similarity; Multi-pass membrane protein
Note: Perinuclear KCNH1 is located to NPC-free islands By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 220220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini242 – 2487Extracellular Reviewed prediction
Transmembranei249 – 26921Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini270 – 29425Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei295 – 31521Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini316 – 34934Extracellular Reviewed prediction
Add
BLAST
Transmembranei350 – 37021Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini371 – 3766Cytoplasmic Reviewed prediction
Transmembranei377 – 39721Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Topological domaini398 – 45053Extracellular Reviewed prediction
Add
BLAST
Intramembranei451 – 47121Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Topological domaini472 – 4776Extracellular Reviewed prediction
Transmembranei478 – 49821Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini499 – 989491Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
  2. nuclear inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 989989Potassium voltage-gated channel subfamily H member 1
PRO_0000053995Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi415 – 4151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ60603.
PRIDEiQ60603.

PTM databases

PhosphoSiteiQ60603.

Expressioni

Gene expression databases

ArrayExpressiQ60603.
BgeeiQ60603.
GenevestigatoriQ60603.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. Interacts with ALG10B By similarity.

Protein-protein interaction databases

IntActiQ60603. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 226
Beta strandi29 – 346
Beta strandi41 – 455
Helixi47 – 537
Helixi57 – 604
Helixi68 – 703
Helixi77 – 8812
Beta strandi93 – 1008
Beta strandi106 – 11712
Beta strandi123 – 13210
Turni134 – 1363
Beta strandi555 – 5595
Helixi565 – 5717
Helixi573 – 5764
Helixi580 – 5823
Helixi587 – 59610
Beta strandi598 – 6025
Beta strandi607 – 6093
Beta strandi613 – 6153
Beta strandi617 – 6248
Beta strandi626 – 6305
Beta strandi633 – 6386
Beta strandi643 – 6453
Turni647 – 6515
Beta strandi658 – 67316
Helixi674 – 68310
Helixi685 – 69410
Beta strandi698 – 7003
Helixi710 – 7189

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F8AX-ray2.20A552-707[»]
4HOIX-ray1.85A/B/C/D28-137[»]
4LLOX-ray2.00A/C/E/G552-724[»]
B/D/F/H6-136[»]
ProteinModelPortaliQ60603.
SMRiQ60603. Positions 28-137, 449-503, 509-720.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 9481PAS
Add
BLAST
Domaini93 – 14553PAC
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni673 – 77098Calmodulin-binding By similarity
Add
BLAST
Regioni924 – 96441CAD (involved in subunit assembly) By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi463 – 4686Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
GeneTreeiENSGT00680000099663.
HOGENOMiHOG000230794.
HOVERGENiHBG101348.
InParanoidiQ60603.
KOiK04904.
OMAiHAKLHAP.
OrthoDBiEOG7QG43V.
PhylomeDBiQ60603.
TreeFamiTF313130.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60603-1 [UniParc]FASTAAdd to Basket

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MTMAGGRRGL VAPQNTFLEN IVRRSNDTNF VLGNAQIVDW PIVYSNDGFC    50
KLSGYHRAEV MQKSSACSFM YGELTDKDTV EKVRQTFENY EMNSFEILMY 100
KKNRTPVWFF VKIAPIRNEQ DKVVLFLCTF SDITAFKQPI EDDSCKGWGK 150
FARLTRALTS SRGVLQQLAP SVQKGENVHK HSRLAEVLQL GSDILPQYKQ 200
EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS FKTRQNNVAW 250
LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL 300
LSCLPYDVIN AFENVDEVSA FMGDPGKIGF ADQIPPPLEG RESQGISSLF 350
SSLKVVRLLR LGRVARKLDH YIEYGAAVLV LLVCVFGLAA HWMACIWYSI 400
GDYEIFDEDT KTIRNNSWLY QLALDIGTPY QFNGSGSGKW EGGPSKNSVY 450
ISSLYFTMTS LTSVGFGNIA PSTDIEKIFA VAIMMIGSLL YATIFGNVTT 500
IFQQMYANTN RYHEMLNSVR DFLKLYQVPK GLSERVMDYI VSTWSMSRGI 550
DTEKVLQICP KDMRADICVH LNRKVFKEHP AFRLASDGCL RALAMEFQTV 600
HCAPGDLIYH AGESVDSLCF VVSGSLEVIQ DDEVVAILGK GDVFGDVFWK 650
EATLAQSCAN VRALTYCDLH VIKRDALQKV LEFYTAFSHS FSRNLILTYN 700
LRKRIVFRKI SDVKREEEER MKRKNEAPLI LPPDHPVRRL FQRFRQQKEA 750
RLAAERGGRD LDDLDVEKGN ALTDHTSANH SLVKASVVTV RESPATPVSF 800
QAATTSTMSD HAKLHAPGSE CLGPKAVSCD PAKRKGWARF KDACGKGEDW 850
NKVSKAESME TLPERTKAPG EATLKKTDSC DSGITKSDLR LDNVGETRSP 900
QDRSPILAEV KHSFYPIPEQ TLQATVLEVK YELKEDIKAL NAKMTSIEKQ 950
LSEILRILMS RGSAQSPQET GEISRPQSPE SDRDIFGAS 989
Length:989
Mass (Da):111,314
Last modified:November 1, 1996 - v1
Checksum:iBA9B8C30F958CDCA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04294 mRNA. Translation: AAA62474.1.
CCDSiCCDS15627.1.
PIRiI48912.
RefSeqiNP_034730.1. NM_010600.2.
UniGeneiMm.4489.

Genome annotation databases

EnsembliENSMUST00000078470; ENSMUSP00000077563; ENSMUSG00000058248.
GeneIDi16510.
KEGGimmu:16510.
UCSCiuc007edo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04294 mRNA. Translation: AAA62474.1 .
CCDSi CCDS15627.1.
PIRi I48912.
RefSeqi NP_034730.1. NM_010600.2.
UniGenei Mm.4489.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4F8A X-ray 2.20 A 552-707 [» ]
4HOI X-ray 1.85 A/B/C/D 28-137 [» ]
4LLO X-ray 2.00 A/C/E/G 552-724 [» ]
B/D/F/H 6-136 [» ]
ProteinModelPortali Q60603.
SMRi Q60603. Positions 28-137, 449-503, 509-720.
ModBasei Search...

Protein-protein interaction databases

IntActi Q60603. 1 interaction.

PTM databases

PhosphoSitei Q60603.

Proteomic databases

PaxDbi Q60603.
PRIDEi Q60603.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078470 ; ENSMUSP00000077563 ; ENSMUSG00000058248 .
GeneIDi 16510.
KEGGi mmu:16510.
UCSCi uc007edo.1. mouse.

Organism-specific databases

CTDi 3756.
MGIi MGI:1341721. Kcnh1.

Phylogenomic databases

eggNOGi COG2202.
GeneTreei ENSGT00680000099663.
HOGENOMi HOG000230794.
HOVERGENi HBG101348.
InParanoidi Q60603.
KOi K04904.
OMAi HAKLHAP.
OrthoDBi EOG7QG43V.
PhylomeDBi Q60603.
TreeFami TF313130.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

ChiTaRSi KCNH1. mouse.
NextBioi 289847.
PROi Q60603.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q60603.
Bgeei Q60603.
Genevestigatori Q60603.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A family of potassium channel genes related to eag in Drosophila and mammals."
    Warmke J.W., Ganetzky B.
    Proc. Natl. Acad. Sci. U.S.A. 91:3438-3442(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCNH1_MOUSE
AccessioniPrimary (citable) accession number: Q60603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi