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Q60603

- KCNH1_MOUSE

UniProt

Q60603 - KCNH1_MOUSE

Protein

Potassium voltage-gated channel subfamily H member 1

Gene

Kcnh1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi581 – 698118cNMPAdd
    BLAST

    GO - Molecular functioni

    1. phosphorelay sensor kinase activity Source: InterPro
    2. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome
    2. regulation of membrane potential Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Calmodulin-binding, Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily H member 1
    Alternative name(s):
    Ether-a-go-go potassium channel 1
    Short name:
    EAG channel 1
    Short name:
    EAG1
    Short name:
    m-eag
    Voltage-gated potassium channel subunit Kv10.1
    Gene namesi
    Name:Kcnh1
    Synonyms:Eag
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1341721. Kcnh1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein. Nucleus inner membrane By similarity; Multi-pass membrane protein
    Note: Perinuclear KCNH1 is located to NPC-free islands.By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RefGenome
    2. nuclear inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 989989Potassium voltage-gated channel subfamily H member 1PRO_0000053995Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ60603.
    PRIDEiQ60603.

    PTM databases

    PhosphoSiteiQ60603.

    Expressioni

    Gene expression databases

    ArrayExpressiQ60603.
    BgeeiQ60603.
    GenevestigatoriQ60603.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. Interacts with ALG10B By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ60603. 1 interaction.

    Structurei

    Secondary structure

    1
    989
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi17 – 226
    Beta strandi29 – 346
    Beta strandi41 – 455
    Helixi47 – 537
    Helixi57 – 604
    Helixi68 – 703
    Helixi77 – 8812
    Beta strandi93 – 1008
    Beta strandi106 – 11712
    Beta strandi123 – 13210
    Turni134 – 1363
    Beta strandi555 – 5595
    Helixi565 – 5717
    Helixi573 – 5764
    Helixi580 – 5823
    Helixi587 – 59610
    Beta strandi598 – 6025
    Beta strandi607 – 6093
    Beta strandi613 – 6153
    Beta strandi617 – 6248
    Beta strandi626 – 6305
    Beta strandi633 – 6386
    Beta strandi643 – 6453
    Turni647 – 6515
    Beta strandi658 – 67316
    Helixi674 – 68310
    Helixi685 – 69410
    Beta strandi698 – 7003
    Helixi710 – 7189

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4F8AX-ray2.20A552-707[»]
    4HOIX-ray1.85A/B/C/D28-137[»]
    4LLOX-ray2.00A/C/E/G552-724[»]
    B/D/F/H6-136[»]
    ProteinModelPortaliQ60603.
    SMRiQ60603. Positions 28-137, 449-503, 509-720.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 220220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini242 – 2487ExtracellularSequence Analysis
    Topological domaini270 – 29425CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini316 – 34934ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini371 – 3766CytoplasmicSequence Analysis
    Topological domaini398 – 45053ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini472 – 4776ExtracellularSequence Analysis
    Topological domaini499 – 989491CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei451 – 47121Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei221 – 24121Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 9481PASPROSITE-ProRule annotationAdd
    BLAST
    Domaini93 – 14553PACPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni673 – 77098Calmodulin-bindingBy similarityAdd
    BLAST
    Regioni924 – 96441CAD (involved in subunit assembly)By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi463 – 4686Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2202.
    GeneTreeiENSGT00680000099663.
    HOGENOMiHOG000230794.
    HOVERGENiHBG101348.
    InParanoidiQ60603.
    KOiK04904.
    OMAiHAKLHAP.
    OrthoDBiEOG7QG43V.
    PhylomeDBiQ60603.
    TreeFamiTF313130.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003949. K_chnl_volt-dep_EAG.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01464. EAGCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60603-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMAGGRRGL VAPQNTFLEN IVRRSNDTNF VLGNAQIVDW PIVYSNDGFC    50
    KLSGYHRAEV MQKSSACSFM YGELTDKDTV EKVRQTFENY EMNSFEILMY 100
    KKNRTPVWFF VKIAPIRNEQ DKVVLFLCTF SDITAFKQPI EDDSCKGWGK 150
    FARLTRALTS SRGVLQQLAP SVQKGENVHK HSRLAEVLQL GSDILPQYKQ 200
    EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS FKTRQNNVAW 250
    LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL 300
    LSCLPYDVIN AFENVDEVSA FMGDPGKIGF ADQIPPPLEG RESQGISSLF 350
    SSLKVVRLLR LGRVARKLDH YIEYGAAVLV LLVCVFGLAA HWMACIWYSI 400
    GDYEIFDEDT KTIRNNSWLY QLALDIGTPY QFNGSGSGKW EGGPSKNSVY 450
    ISSLYFTMTS LTSVGFGNIA PSTDIEKIFA VAIMMIGSLL YATIFGNVTT 500
    IFQQMYANTN RYHEMLNSVR DFLKLYQVPK GLSERVMDYI VSTWSMSRGI 550
    DTEKVLQICP KDMRADICVH LNRKVFKEHP AFRLASDGCL RALAMEFQTV 600
    HCAPGDLIYH AGESVDSLCF VVSGSLEVIQ DDEVVAILGK GDVFGDVFWK 650
    EATLAQSCAN VRALTYCDLH VIKRDALQKV LEFYTAFSHS FSRNLILTYN 700
    LRKRIVFRKI SDVKREEEER MKRKNEAPLI LPPDHPVRRL FQRFRQQKEA 750
    RLAAERGGRD LDDLDVEKGN ALTDHTSANH SLVKASVVTV RESPATPVSF 800
    QAATTSTMSD HAKLHAPGSE CLGPKAVSCD PAKRKGWARF KDACGKGEDW 850
    NKVSKAESME TLPERTKAPG EATLKKTDSC DSGITKSDLR LDNVGETRSP 900
    QDRSPILAEV KHSFYPIPEQ TLQATVLEVK YELKEDIKAL NAKMTSIEKQ 950
    LSEILRILMS RGSAQSPQET GEISRPQSPE SDRDIFGAS 989
    Length:989
    Mass (Da):111,314
    Last modified:November 1, 1996 - v1
    Checksum:iBA9B8C30F958CDCA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04294 mRNA. Translation: AAA62474.1.
    CCDSiCCDS15627.1.
    PIRiI48912.
    RefSeqiNP_034730.1. NM_010600.2.
    UniGeneiMm.4489.

    Genome annotation databases

    EnsembliENSMUST00000078470; ENSMUSP00000077563; ENSMUSG00000058248.
    GeneIDi16510.
    KEGGimmu:16510.
    UCSCiuc007edo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04294 mRNA. Translation: AAA62474.1 .
    CCDSi CCDS15627.1.
    PIRi I48912.
    RefSeqi NP_034730.1. NM_010600.2.
    UniGenei Mm.4489.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4F8A X-ray 2.20 A 552-707 [» ]
    4HOI X-ray 1.85 A/B/C/D 28-137 [» ]
    4LLO X-ray 2.00 A/C/E/G 552-724 [» ]
    B/D/F/H 6-136 [» ]
    ProteinModelPortali Q60603.
    SMRi Q60603. Positions 28-137, 449-503, 509-720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q60603. 1 interaction.

    PTM databases

    PhosphoSitei Q60603.

    Proteomic databases

    PaxDbi Q60603.
    PRIDEi Q60603.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078470 ; ENSMUSP00000077563 ; ENSMUSG00000058248 .
    GeneIDi 16510.
    KEGGi mmu:16510.
    UCSCi uc007edo.1. mouse.

    Organism-specific databases

    CTDi 3756.
    MGIi MGI:1341721. Kcnh1.

    Phylogenomic databases

    eggNOGi COG2202.
    GeneTreei ENSGT00680000099663.
    HOGENOMi HOG000230794.
    HOVERGENi HBG101348.
    InParanoidi Q60603.
    KOi K04904.
    OMAi HAKLHAP.
    OrthoDBi EOG7QG43V.
    PhylomeDBi Q60603.
    TreeFami TF313130.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    ChiTaRSi KCNH1. mouse.
    NextBioi 289847.
    PROi Q60603.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60603.
    Bgeei Q60603.
    Genevestigatori Q60603.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003949. K_chnl_volt-dep_EAG.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01464. EAGCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of potassium channel genes related to eag in Drosophila and mammals."
      Warmke J.W., Ganetzky B.
      Proc. Natl. Acad. Sci. U.S.A. 91:3438-3442(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNH1_MOUSE
    AccessioniPrimary (citable) accession number: Q60603
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3