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Q605Q9

- FTHS_METCA

UniProt

Q605Q9 - FTHS_METCA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:MCA2219
    OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
    Taxonomic identifieri243233 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
    ProteomesiUP000006821: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000199360Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243233.MCA2219.

    Structurei

    3D structure databases

    ProteinModelPortaliQ605Q9.
    SMRiQ605Q9. Positions 3-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q605Q9-1 [UniParc]FASTAAdd to Basket

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    MSDIEIAQRA KMLPIIDLAR EKLGIPAASL DPYGHYKAKV ALDYIDGLKD    50
    RPDGKLILVT AISPTPAGEG KTTTTVGLGD ALNRIGKKTV MCLREPSLGP 100
    CFGVKGGAAG GGHAQVVPME DINLHFTGDF HAVGVAHNLL SALIDNHINH 150
    GNALDIDPRR IQWKRVVDMN DRALRKIVVG MGGTANGYLR EDGFDIVVAS 200
    EVMAILCLAT SMADLKERLG RIIVGYKSDG KTPVYARDLK AHGAMAALLK 250
    DAIKPNLVQT LENNLAIIHG GPFANIAHGC NTVTATQTAL KLADYVVTEA 300
    GFGADLGAEK FIDIKCRMAG LNPAAVVLVA TVRALKFHGG VKKEDLNQEN 350
    LAALEAGFAN LERHVHNIRE HYGLPCVVSI NHFSFDTEAE IAWLMKKCEA 400
    LGVKAVLARH WAEGGKGAEA LARTVADIVD HQPGRHTFVY GDEATLWNKI 450
    ETIATKIYGA AGISADAKVK AQLEAWNADY GHYPVCMAKT QMSFSTDPNA 500
    KGAPSGHTVA IREVRLANGA GFVVAIAGDM MTMPGLPKVP AAEHIDVDDD 550
    GRISGLF 557
    Length:557
    Mass (Da):59,411
    Last modified:November 23, 2004 - v1
    Checksum:iF0655EC3CF7A38E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017282 Genomic DNA. Translation: AAU91814.1.
    RefSeqiYP_114639.1. NC_002977.6.

    Genome annotation databases

    EnsemblBacteriaiAAU91814; AAU91814; MCA2219.
    GeneIDi3102111.
    KEGGimca:MCA2219.
    PATRICi22608288. VBIMetCap22254_2248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017282 Genomic DNA. Translation: AAU91814.1 .
    RefSeqi YP_114639.1. NC_002977.6.

    3D structure databases

    ProteinModelPortali Q605Q9.
    SMRi Q605Q9. Positions 3-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243233.MCA2219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU91814 ; AAU91814 ; MCA2219 .
    GeneIDi 3102111.
    KEGGi mca:MCA2219.
    PATRICi 22608288. VBIMetCap22254_2248.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33009 / NCIMB 11132 / Bath.

    Entry informationi

    Entry nameiFTHS_METCA
    AccessioniPrimary (citable) accession number: Q605Q9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3