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Q605Q9

- FTHS_METCA

UniProt

Q605Q9 - FTHS_METCA

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, MCA2219
Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:MCA2219
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
ProteomesiUP000006821: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000199360Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA2219.

Structurei

3D structure databases

ProteinModelPortaliQ605Q9.
SMRiQ605Q9. Positions 3-555.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q605Q9-1 [UniParc]FASTAAdd to Basket

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MSDIEIAQRA KMLPIIDLAR EKLGIPAASL DPYGHYKAKV ALDYIDGLKD    50
RPDGKLILVT AISPTPAGEG KTTTTVGLGD ALNRIGKKTV MCLREPSLGP 100
CFGVKGGAAG GGHAQVVPME DINLHFTGDF HAVGVAHNLL SALIDNHINH 150
GNALDIDPRR IQWKRVVDMN DRALRKIVVG MGGTANGYLR EDGFDIVVAS 200
EVMAILCLAT SMADLKERLG RIIVGYKSDG KTPVYARDLK AHGAMAALLK 250
DAIKPNLVQT LENNLAIIHG GPFANIAHGC NTVTATQTAL KLADYVVTEA 300
GFGADLGAEK FIDIKCRMAG LNPAAVVLVA TVRALKFHGG VKKEDLNQEN 350
LAALEAGFAN LERHVHNIRE HYGLPCVVSI NHFSFDTEAE IAWLMKKCEA 400
LGVKAVLARH WAEGGKGAEA LARTVADIVD HQPGRHTFVY GDEATLWNKI 450
ETIATKIYGA AGISADAKVK AQLEAWNADY GHYPVCMAKT QMSFSTDPNA 500
KGAPSGHTVA IREVRLANGA GFVVAIAGDM MTMPGLPKVP AAEHIDVDDD 550
GRISGLF 557
Length:557
Mass (Da):59,411
Last modified:November 23, 2004 - v1
Checksum:iF0655EC3CF7A38E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU91814.1.
RefSeqiYP_114639.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU91814; AAU91814; MCA2219.
GeneIDi3102111.
KEGGimca:MCA2219.
PATRICi22608288. VBIMetCap22254_2248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU91814.1 .
RefSeqi YP_114639.1. NC_002977.6.

3D structure databases

ProteinModelPortali Q605Q9.
SMRi Q605Q9. Positions 3-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243233.MCA2219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU91814 ; AAU91814 ; MCA2219 .
GeneIDi 3102111.
KEGGi mca:MCA2219.
PATRICi 22608288. VBIMetCap22254_2248.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.

Entry informationi

Entry nameiFTHS_METCA
AccessioniPrimary (citable) accession number: Q605Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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