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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMCAP243233:G1G0X-2191-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:MCA2219
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
Proteomesi
  • UP000006821 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001993601 – 557Formate--tetrahydrofolate ligaseAdd BLAST557

Proteomic databases

PRIDEiQ605Q9

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA2219

Structurei

3D structure databases

ProteinModelPortaliQ605Q9
SMRiQ605Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q605Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIEIAQRA KMLPIIDLAR EKLGIPAASL DPYGHYKAKV ALDYIDGLKD
60 70 80 90 100
RPDGKLILVT AISPTPAGEG KTTTTVGLGD ALNRIGKKTV MCLREPSLGP
110 120 130 140 150
CFGVKGGAAG GGHAQVVPME DINLHFTGDF HAVGVAHNLL SALIDNHINH
160 170 180 190 200
GNALDIDPRR IQWKRVVDMN DRALRKIVVG MGGTANGYLR EDGFDIVVAS
210 220 230 240 250
EVMAILCLAT SMADLKERLG RIIVGYKSDG KTPVYARDLK AHGAMAALLK
260 270 280 290 300
DAIKPNLVQT LENNLAIIHG GPFANIAHGC NTVTATQTAL KLADYVVTEA
310 320 330 340 350
GFGADLGAEK FIDIKCRMAG LNPAAVVLVA TVRALKFHGG VKKEDLNQEN
360 370 380 390 400
LAALEAGFAN LERHVHNIRE HYGLPCVVSI NHFSFDTEAE IAWLMKKCEA
410 420 430 440 450
LGVKAVLARH WAEGGKGAEA LARTVADIVD HQPGRHTFVY GDEATLWNKI
460 470 480 490 500
ETIATKIYGA AGISADAKVK AQLEAWNADY GHYPVCMAKT QMSFSTDPNA
510 520 530 540 550
KGAPSGHTVA IREVRLANGA GFVVAIAGDM MTMPGLPKVP AAEHIDVDDD

GRISGLF
Length:557
Mass (Da):59,411
Last modified:November 23, 2004 - v1
Checksum:iF0655EC3CF7A38E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA Translation: AAU91814.1
RefSeqiWP_010961451.1, NC_002977.6

Genome annotation databases

EnsemblBacteriaiAAU91814; AAU91814; MCA2219
KEGGimca:MCA2219

Similar proteinsi

Entry informationi

Entry nameiFTHS_METCA
AccessioniPrimary (citable) accession number: Q605Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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