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Q605Q9 (FTHS_METCA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:MCA2219
OrganismMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) [Complete proteome] [HAMAP]
Taxonomic identifier243233 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199360

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q605Q9 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: F0655EC3CF7A38E8

FASTA55759,411
        10         20         30         40         50         60 
MSDIEIAQRA KMLPIIDLAR EKLGIPAASL DPYGHYKAKV ALDYIDGLKD RPDGKLILVT 

        70         80         90        100        110        120 
AISPTPAGEG KTTTTVGLGD ALNRIGKKTV MCLREPSLGP CFGVKGGAAG GGHAQVVPME 

       130        140        150        160        170        180 
DINLHFTGDF HAVGVAHNLL SALIDNHINH GNALDIDPRR IQWKRVVDMN DRALRKIVVG 

       190        200        210        220        230        240 
MGGTANGYLR EDGFDIVVAS EVMAILCLAT SMADLKERLG RIIVGYKSDG KTPVYARDLK 

       250        260        270        280        290        300 
AHGAMAALLK DAIKPNLVQT LENNLAIIHG GPFANIAHGC NTVTATQTAL KLADYVVTEA 

       310        320        330        340        350        360 
GFGADLGAEK FIDIKCRMAG LNPAAVVLVA TVRALKFHGG VKKEDLNQEN LAALEAGFAN 

       370        380        390        400        410        420 
LERHVHNIRE HYGLPCVVSI NHFSFDTEAE IAWLMKKCEA LGVKAVLARH WAEGGKGAEA 

       430        440        450        460        470        480 
LARTVADIVD HQPGRHTFVY GDEATLWNKI ETIATKIYGA AGISADAKVK AQLEAWNADY 

       490        500        510        520        530        540 
GHYPVCMAKT QMSFSTDPNA KGAPSGHTVA IREVRLANGA GFVVAIAGDM MTMPGLPKVP 

       550 
AAEHIDVDDD GRISGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017282 Genomic DNA. Translation: AAU91814.1.
RefSeqYP_114639.1. NC_002977.6.

3D structure databases

ProteinModelPortalQ605Q9.
SMRQ605Q9. Positions 3-555.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243233.MCA2219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU91814; AAU91814; MCA2219.
GeneID3102111.
KEGGmca:MCA2219.
PATRIC22608288. VBIMetCap22254_2248.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_METCA
AccessionPrimary (citable) accession number: Q605Q9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways