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Q605M0 (METE_METCA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:MCA2260
OrganismMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) [Complete proteome] [HAMAP]
Taxonomic identifier243233 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Methylococcales › Methylococcaceae › Methylococcus

Protein attributes

Sequence length762 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7627625-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_1000071613

Sites

Metal binding6421Zinc By similarity
Metal binding6441Zinc By similarity
Metal binding7271Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q605M0 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 40DCA76928287313

FASTA76284,237
        10         20         30         40         50         60 
MAVTHSLGFP RIGAGRELKR AVEACWAGRT GPAELAQTGR ELRERHWMIQ SGSGIDLVPV 

        70         80         90        100        110        120 
GDFAWYDQML NMTALLGAVP RRFGFQADAL SLDQYFQLAR GNAEQPAMEM TKWFDTNYHY 

       130        140        150        160        170        180 
IVPEFDRETG FGPGTEWLFD EVEEAKALRL NPKPVLIGPL TYLHLGKERQ AGFSRLELLP 

       190        200        210        220        230        240 
RLLPAYAAIL RRLHASGVPW VQMDEPILGM DLPPEWLEAF APAYAALAEA GPKLLLATYF 

       250        260        270        280        290        300 
ASVAEHAVWL KSSAVAGLHI DAVRAPEQVA DFLKDFPADK VLSLGLIDGR NVWRTDLRRA 

       310        320        330        340        350        360 
LEQAESAGAV LGERLWLAPS CSLLHVPQDL SLETSLNPEI KDWLAFAVQK LEELAVIDKG 

       370        380        390        400        410        420 
LRLGRQAVAA ELAERDRLLQ TRAQSPLIHD PGVKRRLEGL SDADFRRHSP FAERSPLQRE 

       430        440        450        460        470        480 
RLRLPPFPTT TIGSFPQTPK IRAARAAHRR GELNGDAYRD AMRAAIREAV YKQESLGLDL 

       490        500        510        520        530        540 
LVHGEAERND MVEYFGERLA GYAFTKHGWV QSYGSRCVKP PIIYGDVARP EPMTVEWIGY 

       550        560        570        580        590        600 
AQSLTKKPVK GMLTGPVTML QWSFARDDQP RAVTALQIAL AIRDEVADLE AAGVAAIQID 

       610        620        630        640        650        660 
EPAFREGLPL KAADRADYLD WAVKAFRLAS CGVADDTQIH THMCYSEFGD ILPAIAELDA 

       670        680        690        700        710        720 
DVITIETCRS AMDLLEAFGA FGYPNDIGPG VYDIHSPRVP AGAEIRALLE KAAAAVDPER 

       730        740        750        760 
LWVNPDCGLK TRQWPEAEQA LANMVEAARA MRRAESLAGS AA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017282 Genomic DNA. Translation: AAU91738.1.
RefSeqYP_114678.1. NC_002977.6.

3D structure databases

HSSPHSSP built from PDB template 1XDJ based on UniProtKB Q9X112.
ProteinModelPortalQ605M0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3102988.
GenomeReviewsGene locus MCA2260 in contig AE017282_GR.
KEGGmca:MCA2260.
NMPDRfig|243233.4.peg.2203.
PATRIC22608372. VBIMetCap22254_2290.
TIGRMCA2260.

Phylogenomic databases

HOGENOMHBG287495.
OMAMLDTAVM.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycMCAP243233:MCA_2260-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_METCA
AccessionPrimary (citable) accession number: Q605M0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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