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Q605G6

- GCH4_METCA

UniProt

Q605G6 - GCH4_METCA

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei152 – 1521May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:MCA2318
    OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
    Taxonomic identifieri243233 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
    ProteomesiUP000006821: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268GTP cyclohydrolase FolE2PRO_0000147713Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243233.MCA2318.

    Structurei

    3D structure databases

    ProteinModelPortaliQ605G6.
    SMRiQ605G6. Positions 20-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q605G6-1 [UniParc]FASTAAdd to Basket

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    MEEEGLAIDD VQGRADLRRI DIDRVGIKGI RHPVRVRDRS LGEQHTVARF    50
    DMAVSLPHHF KGTHMSRFVE IINGHDREID IASFEAMLAE MMQRLNAEAG 100
    RIEMRFPYFL EKRAPVTGVR SLMDYEVALI GEVSVATTTT WLGVTVPVTS 150
    LCPCSKAISE RGAHNQRSHV TTAVRMRDFV WIEELIEWVE AEASSPIYGL 200
    LKRPDEKYVT EYAYDHPRFV EDLVRGVAAR LDTEPRIAAY AVEVENFESI 250
    HNHSAYALIE RDKRTADA 268
    Length:268
    Mass (Da):30,505
    Last modified:November 23, 2004 - v1
    Checksum:i9F9910A81B39B0B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017282 Genomic DNA. Translation: AAU91629.1.
    RefSeqiWP_010961546.1. NC_002977.6.
    YP_114734.1. NC_002977.6.

    Genome annotation databases

    EnsemblBacteriaiAAU91629; AAU91629; MCA2318.
    GeneIDi3102453.
    KEGGimca:MCA2318.
    PATRICi22608496. VBIMetCap22254_2351.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017282 Genomic DNA. Translation: AAU91629.1 .
    RefSeqi WP_010961546.1. NC_002977.6.
    YP_114734.1. NC_002977.6.

    3D structure databases

    ProteinModelPortali Q605G6.
    SMRi Q605G6. Positions 20-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243233.MCA2318.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU91629 ; AAU91629 ; MCA2318 .
    GeneIDi 3102453.
    KEGGi mca:MCA2318.
    PATRICi 22608496. VBIMetCap22254_2351.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33009 / NCIMB 11132 / Bath.

    Entry informationi

    Entry nameiGCH4_METCA
    AccessioniPrimary (citable) accession number: Q605G6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3