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Q605G6 (GCH4_METCA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:MCA2318
OrganismMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) [Complete proteome] [HAMAP]
Taxonomic identifier243233 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Methylococcales › Methylococcaceae › Methylococcus ›

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268GTP cyclohydrolase folE2 HAMAP-Rule MF_01527
PRO_0000147713

Sites

Site1521May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q605G6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 9F9910A81B39B0B0

FASTA26830,505
        10         20         30         40         50         60 
MEEEGLAIDD VQGRADLRRI DIDRVGIKGI RHPVRVRDRS LGEQHTVARF DMAVSLPHHF 

        70         80         90        100        110        120 
KGTHMSRFVE IINGHDREID IASFEAMLAE MMQRLNAEAG RIEMRFPYFL EKRAPVTGVR 

       130        140        150        160        170        180 
SLMDYEVALI GEVSVATTTT WLGVTVPVTS LCPCSKAISE RGAHNQRSHV TTAVRMRDFV 

       190        200        210        220        230        240 
WIEELIEWVE AEASSPIYGL LKRPDEKYVT EYAYDHPRFV EDLVRGVAAR LDTEPRIAAY 

       250        260 
AVEVENFESI HNHSAYALIE RDKRTADA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017282 Genomic DNA. Translation: AAU91629.1.
RefSeqYP_114734.1. NC_002977.6.

3D structure databases

ProteinModelPortalQ605G6.
SMRQ605G6. Positions 20-263.
ModBaseSearch...

Protein-protein interaction databases

STRING243233.MCA2318.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU91629; AAU91629; MCA2318.
GeneID3102453.
KEGGmca:MCA2318.
PATRIC22608496. VBIMetCap22254_2351.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAINMYVDL.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR002042. Uricase.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_METCA
AccessionPrimary (citable) accession number: Q605G6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 23, 2004
Last modified: May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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