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Q605G6

- GCH4_METCA

UniProt

Q605G6 - GCH4_METCA

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, MCA2318
Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei152 – 1521May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:MCA2318
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
ProteomesiUP000006821: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268GTP cyclohydrolase FolE2UniRule annotationPRO_0000147713Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA2318.

Structurei

3D structure databases

ProteinModelPortaliQ605G6.
SMRiQ605G6. Positions 20-263.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q605G6-1 [UniParc]FASTAAdd to Basket

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MEEEGLAIDD VQGRADLRRI DIDRVGIKGI RHPVRVRDRS LGEQHTVARF    50
DMAVSLPHHF KGTHMSRFVE IINGHDREID IASFEAMLAE MMQRLNAEAG 100
RIEMRFPYFL EKRAPVTGVR SLMDYEVALI GEVSVATTTT WLGVTVPVTS 150
LCPCSKAISE RGAHNQRSHV TTAVRMRDFV WIEELIEWVE AEASSPIYGL 200
LKRPDEKYVT EYAYDHPRFV EDLVRGVAAR LDTEPRIAAY AVEVENFESI 250
HNHSAYALIE RDKRTADA 268
Length:268
Mass (Da):30,505
Last modified:November 23, 2004 - v1
Checksum:i9F9910A81B39B0B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU91629.1.
RefSeqiWP_010961546.1. NC_002977.6.
YP_114734.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU91629; AAU91629; MCA2318.
GeneIDi3102453.
KEGGimca:MCA2318.
PATRICi22608496. VBIMetCap22254_2351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU91629.1 .
RefSeqi WP_010961546.1. NC_002977.6.
YP_114734.1. NC_002977.6.

3D structure databases

ProteinModelPortali Q605G6.
SMRi Q605G6. Positions 20-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243233.MCA2318.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU91629 ; AAU91629 ; MCA2318 .
GeneIDi 3102453.
KEGGi mca:MCA2318.
PATRICi 22608496. VBIMetCap22254_2351.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.

Entry informationi

Entry nameiGCH4_METCA
AccessioniPrimary (citable) accession number: Q605G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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