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Q605G6

- GCH4_METCA

UniProt

Q605G6 - GCH4_METCA

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei152 – 1521May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:MCA2318
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
ProteomesiUP000006821: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268GTP cyclohydrolase FolE2PRO_0000147713Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA2318.

Structurei

3D structure databases

ProteinModelPortaliQ605G6.
SMRiQ605G6. Positions 20-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q605G6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEEGLAIDD VQGRADLRRI DIDRVGIKGI RHPVRVRDRS LGEQHTVARF
60 70 80 90 100
DMAVSLPHHF KGTHMSRFVE IINGHDREID IASFEAMLAE MMQRLNAEAG
110 120 130 140 150
RIEMRFPYFL EKRAPVTGVR SLMDYEVALI GEVSVATTTT WLGVTVPVTS
160 170 180 190 200
LCPCSKAISE RGAHNQRSHV TTAVRMRDFV WIEELIEWVE AEASSPIYGL
210 220 230 240 250
LKRPDEKYVT EYAYDHPRFV EDLVRGVAAR LDTEPRIAAY AVEVENFESI
260
HNHSAYALIE RDKRTADA
Length:268
Mass (Da):30,505
Last modified:November 23, 2004 - v1
Checksum:i9F9910A81B39B0B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA. Translation: AAU91629.1.
RefSeqiYP_114734.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU91629; AAU91629; MCA2318.
GeneIDi3102453.
KEGGimca:MCA2318.
PATRICi22608496. VBIMetCap22254_2351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA. Translation: AAU91629.1 .
RefSeqi YP_114734.1. NC_002977.6.

3D structure databases

ProteinModelPortali Q605G6.
SMRi Q605G6. Positions 20-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243233.MCA2318.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU91629 ; AAU91629 ; MCA2318 .
GeneIDi 3102453.
KEGGi mca:MCA2318.
PATRICi 22608496. VBIMetCap22254_2351.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.

Entry informationi

Entry nameiGCH4_METCA
AccessioniPrimary (citable) accession number: Q605G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3