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Protein

Glutamate-ammonia-ligase adenylyltransferase

Gene

glnE

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Adenylation and deadenylation of glutamate--ammonia ligase.UniRule annotation

Catalytic activityi

ATP + [glutamine synthetase]-L-tyrosine = diphosphate + [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  • [glutamate-ammonia-ligase] adenylyltransferase activity Source: JCVI
  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  • glutamine biosynthetic process Source: JCVI
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-ammonia-ligase adenylyltransferaseUniRule annotation (EC:2.7.7.42UniRule annotation)
Alternative name(s):
Glutamine-synthetase adenylyltransferase
Short name:
ATaseUniRule annotation
[Glutamate--ammonia-ligase] adenylyltransferaseUniRule annotation
Gene namesi
Name:glnEUniRule annotation
Ordered Locus Names:MCA2345
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
Proteomesi
  • UP000006821 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002092531 – 948Glutamate-ammonia-ligase adenylyltransferaseAdd BLAST948

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA2345.

Structurei

3D structure databases

ProteinModelPortaliQ605D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 307GlnE 1Add BLAST210
Regioni606 – 830GlnE 2Add BLAST225

Sequence similaritiesi

Belongs to the GlnE family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105CE6. Bacteria.
COG1391. LUCA.
HOGENOMiHOG000256491.
KOiK00982.
OMAiEFMVQYA.
OrthoDBiPOG091H0675.

Family and domain databases

HAMAPiMF_00802. GlnE. 1 hit.
InterProiIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q605D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPPDTSGS CSAFHECERI FAQWGYPFQD YSESFRQSLD TVCRCSRFFL
60 70 80 90 100
GVVKRDAHVI PLLASLFEGQ TPERNPSADL QQRVAEVADR NGLMRVLRQW
110 120 130 140 150
RNREMAIIAW QDICGLLDID SVLTRISETA ESAIRTALDW LFDDACRRWG
160 170 180 190 200
VPRRKDGSAQ SLVVLGMGKL GGYELNFSSD IDLVFAYVED GELPGRNGAT
210 220 230 240 250
YAEFYTRLAQ SLVHVLDAVT EDGFVFRVDV RLRPFGESGP LVVSFDSCER
260 270 280 290 300
YYQAQARDWE RYAMVKVRAV GGDAKDGREF ERFFHPFVYR RYLDYRVFGE
310 320 330 340 350
LRSLKARIMA ELRRKDRGDN IKLGAGGIRE IEFIGQAFQL IRGGRNVELQ
360 370 380 390 400
DRRILVVLER LGRLRLLEHG TASFLCAAYR FLRKVENRLQ QYEDKQTHEL
410 420 430 440 450
PVSEERRGLL AFSMGFESWE GFLHRLDEVR RRVHEIFTEV IAEPPQPARG
460 470 480 490 500
EPLLDGGEAE LSQALAGFDG AAEAMTGALV KFRASAPVRR LGAGARAELQ
510 520 530 540 550
RVIGKLLAEL AAFRVSDPVG VLGRILELFE SIAGRGVYFS LLAENPSALS
560 570 580 590 600
QLVRLAAASP WIVRLIAGAP ILLDELLDPR TLYSPLTRES LGREADILFS
610 620 630 640 650
SLAPDDDEQL MLRLRQFKAA HQLRIAAADI MNVIPVMVVS DYLTDLAEVV
660 670 680 690 700
IERVLRLAWK FAAARHGIPP VEAETSVDFP GFGIIAYGKL GGIELGYGSD
710 720 730 740 750
LDLVFLYDGV ASDAVTDGPR PISAAEFYAR VVQRMVSLLT ADMPGGALYE
760 770 780 790 800
VDLRLRPSGS SGLLVSKADA YENYQLHQAW TWERQALVRA RFVAGDPKVG
810 820 830 840 850
ARFDAIRRNV LCRERDSRQV RLDVRSMREK MREHLADRRP GVFDLKQGVG
860 870 880 890 900
GIADIEFIVQ FGVLISAAKH CEITRWTDTV RLLDSLRAIN FLELGQADRL
910 920 930 940
RCAYCDYRGR VHRLALQEMP ALAASSEFPG HRTAVEAVWK QIIEAPVF
Length:948
Mass (Da):106,527
Last modified:November 23, 2004 - v1
Checksum:i0EB7140FB6C9A957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA. Translation: AAU91502.1.
RefSeqiWP_010961573.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU91502; AAU91502; MCA2345.
KEGGimca:MCA2345.
PATRICi22608548. VBIMetCap22254_2377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA. Translation: AAU91502.1.
RefSeqiWP_010961573.1. NC_002977.6.

3D structure databases

ProteinModelPortaliQ605D9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243233.MCA2345.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU91502; AAU91502; MCA2345.
KEGGimca:MCA2345.
PATRICi22608548. VBIMetCap22254_2377.

Phylogenomic databases

eggNOGiENOG4105CE6. Bacteria.
COG1391. LUCA.
HOGENOMiHOG000256491.
KOiK00982.
OMAiEFMVQYA.
OrthoDBiPOG091H0675.

Family and domain databases

HAMAPiMF_00802. GlnE. 1 hit.
InterProiIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLNE_METCA
AccessioniPrimary (citable) accession number: Q605D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.