Q60597 (ODO1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial
EC=1.2.4.2

Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name=OGDC-E1
Alpha-ketoglutarate dehydrogenase

Gene names

Name:	Ogdh
Synonyms:	Kiaa4192

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1023 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.
Cofactor	Thiamine pyrophosphate.
Enzyme regulation	Catabolite repressed.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.
Sequence caution	The sequence AAH31165.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD90530.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
PTM	Acetylation Isopeptide bond Ubl conjugation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	2-oxoglutarate metabolic process Inferred from electronic annotation. Source: Compara NADH metabolic process Inferred from electronic annotation. Source: Compara cerebellar cortex development Inferred from expression pattern PubMed 16901643. Source: UniProtKB generation of precursor metabolites and energy Inferred from sequence or structural similarity. Source: UniProtKB glycolysis Inferred from electronic annotation. Source: UniProtKB-KW hippocampus development Inferred from expression pattern PubMed 16901643. Source: UniProtKB olfactory bulb mitral cell layer development Inferred from expression pattern PubMed 16901643. Source: UniProtKB pyramidal neuron development Inferred from expression pattern PubMed 16901643. Source: UniProtKB striatum development Inferred from expression pattern PubMed 16901643. Source: UniProtKB succinyl-CoA metabolic process Inferred from electronic annotation. Source: Compara tangential migration from the subventricular zone to the olfactory bulb Inferred from expression pattern PubMed 16901643. Source: UniProtKB thalamus development Inferred from expression pattern PubMed 16901643. Source: UniProtKB tricarboxylic acid cycle Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial membrane Inferred from sequence or structural similarity. Source: UniProtKB oxoglutarate dehydrogenase complex Inferred from electronic annotation. Source: Compara
Molecular_function	oxoglutarate dehydrogenase (NAD+) activity Inferred from direct assay PubMed 17322295. Source: MGI oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from sequence or structural similarity. Source: UniProtKB thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q60597-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q60597-2)

The sequence of this isoform differs from the canonical sequence as follows:
     139-172: IRGHHVAQLDPLGILDADLDSSVPADIISSTDKL → VRGHHIAKSCVNFDDAPVTVSSNV

Isoform 3 (identifier: Q60597-3)

The sequence of this isoform differs from the canonical sequence as follows:
     172-172: L → LDLAVFKERLRMLTVG

Note: No experimental confirmation available.

Isoform 4 (identifier: Q60597-4)

The sequence of this isoform differs from the canonical sequence as follows:
     139-172: IRGHHVAQLDPLGILDADLDSSVPADIISSTDKL → VRGHHIAKLD...KERLRMLTVG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 40	40	Mitochondrion By similarity
	Chain	41 – 1023	983	2-oxoglutarate dehydrogenase, mitochondrial		PRO_0000020434
Regions
	Region	933 – 939	7	Recognized by alloreactive CD8 cytotoxic T-lymphocytes in association with a class I MHC protein
Amino acid modifications
	Modified residue	970	1	N6-acetyllysine By similarity
	Cross-link	534		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Natural variations
	Alternative sequence	139 – 172	34	IRGHH…STDKL → VRGHHIAKSCVNFDDAPVTV SSNV in isoform 2.		VSP_024799
	Alternative sequence	139 – 172	34	IRGHH…STDKL → VRGHHIAKLDPLGISCVNFD DAPVTVSSNVDLAVFKERLR MLTVG in isoform 4.		VSP_024800
	Alternative sequence	172	1	L → LDLAVFKERLRMLTVG in isoform 3.		VSP_024801
Experimental info
	Sequence conflict	416	1	G → V in AAH49104. Ref.4
	Sequence conflict	549	1	V → F in AAH49104. Ref.4
	Sequence conflict	552	1	Q → E in AAH57354. Ref.4
	Sequence conflict	576	1	E → K in BAE29234. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2007. Version 3. Checksum: A0F3F8D36C7A76BC	FASTA	1,023	116,449
	10 20 30 40 50 60 MFHLRTCAAK LRPLTASQTV KTFSQNKPAA IRTFQQIRCY SAPVAAEPFL SGTSSNYVEE 70 80 90 100 110 120 MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RSSLATMAHA QSLVEAQPNV 130 140 150 160 170 180 DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL GILDADLDSS VPADIISSTD KLGFYGLHES 190 200 210 220 230 240 DLDKVFHLPT TTFIGGQEPA LPLREIIRRL EMAYCQHIGV EFMFINDLEQ CQWIRQKFET 250 260 270 280 290 300 PGIMQFTNEE KRTLLARLVR STRFEEFLQR KWSSEKRFGL EGCEVLIPAL KTIIDMSSAN 310 320 330 340 350 360 GVDYVIMGMP HRGRLNVLAN VIRKELEQIF CQFDSKLEAA DEGSGDMKYH LGMYHRRINR 370 380 390 400 410 420 VTDRNITLSL VANPSHLEAA DPVVMGKTKA EQFYCGDTEG KKVMSILLHG DAAFAGQGIV 430 440 450 460 470 480 YETFHLSDLP SYTTHGTVHV VVNNQIGFTT DPRMARSSPY PTDVARVVNA PIFHVNSDDP 490 500 510 520 530 540 EAVMYVCKVA AEWRNTFHKD VVVDLVCYRR NGHNEMDEPM FTQPLMYKQI RKQKPVLQKY 550 560 570 580 590 600 AELLVSQGVV NQPEYEEEIS KYDKICEEAF TRSKDEKILH IKHWLDSPWP GFFTLDGQPR 610 620 630 640 650 660 SMTCPSTGLE EDVLFHIGKV ASSVPVENFT IHGGLSRILK TRRELVTNRT VDWALAEYMA 670 680 690 700 710 720 FGSLLKEGIH VRLSGQDVER GTFSHRHHVL HDQNVDKRTC IPMNHLWPNQ APYTVCNSSL 730 740 750 760 770 780 SEYGVLGFEL GFAMASPNAL VLWEAQFGDF NNMAQCIIDQ FICPGQAKWV RQNGIVLLLP 790 800 810 820 830 840 HGMEGMGPEH SSARPERFLQ MCNDDPDVLP DLQEENFDIN QLYDCNWIVV NCSTPGNFFH 850 860 870 880 890 900 VLRRQILLPF RKPLIVFTPK SLLRHPEART SFDEMLPGTH FQRVIPENGP AAQDPHKVKR 910 920 930 940 950 960 LLFCTGKVYY DLTRERKARN MEEEVAITRI EQLSPFPFDL LLKEAQKYPN AELAWCQEEH 970 980 990 1000 1010 1020 KNQGYYDYVK PRLRTTIDRA KPVWYAGRDP AAAPATGNKK THLTELQRFL DTAFDLDAFK KFS
	Isoform 2 [UniParc]. Checksum: 64CBC6F0E46B5D5F	FASTA	1,013	115,419
	10 20 30 40 50 60 MFHLRTCAAK LRPLTASQTV KTFSQNKPAA IRTFQQIRCY SAPVAAEPFL SGTSSNYVEE 70 80 90 100 110 120 MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RSSLATMAHA QSLVEAQPNV 130 140 150 160 170 180 DKLVEDHLAV QSLIRAYQVR GHHIAKSCVN FDDAPVTVSS NVGFYGLHES DLDKVFHLPT 190 200 210 220 230 240 TTFIGGQEPA LPLREIIRRL EMAYCQHIGV EFMFINDLEQ CQWIRQKFET PGIMQFTNEE 250 260 270 280 290 300 KRTLLARLVR STRFEEFLQR KWSSEKRFGL EGCEVLIPAL KTIIDMSSAN GVDYVIMGMP 310 320 330 340 350 360 HRGRLNVLAN VIRKELEQIF CQFDSKLEAA DEGSGDMKYH LGMYHRRINR VTDRNITLSL 370 380 390 400 410 420 VANPSHLEAA DPVVMGKTKA EQFYCGDTEG KKVMSILLHG DAAFAGQGIV YETFHLSDLP 430 440 450 460 470 480 SYTTHGTVHV VVNNQIGFTT DPRMARSSPY PTDVARVVNA PIFHVNSDDP EAVMYVCKVA 490 500 510 520 530 540 AEWRNTFHKD VVVDLVCYRR NGHNEMDEPM FTQPLMYKQI RKQKPVLQKY AELLVSQGVV 550 560 570 580 590 600 NQPEYEEEIS KYDKICEEAF TRSKDEKILH IKHWLDSPWP GFFTLDGQPR SMTCPSTGLE 610 620 630 640 650 660 EDVLFHIGKV ASSVPVENFT IHGGLSRILK TRRELVTNRT VDWALAEYMA FGSLLKEGIH 670 680 690 700 710 720 VRLSGQDVER GTFSHRHHVL HDQNVDKRTC IPMNHLWPNQ APYTVCNSSL SEYGVLGFEL 730 740 750 760 770 780 GFAMASPNAL VLWEAQFGDF NNMAQCIIDQ FICPGQAKWV RQNGIVLLLP HGMEGMGPEH 790 800 810 820 830 840 SSARPERFLQ MCNDDPDVLP DLQEENFDIN QLYDCNWIVV NCSTPGNFFH VLRRQILLPF 850 860 870 880 890 900 RKPLIVFTPK SLLRHPEART SFDEMLPGTH FQRVIPENGP AAQDPHKVKR LLFCTGKVYY 910 920 930 940 950 960 DLTRERKARN MEEEVAITRI EQLSPFPFDL LLKEAQKYPN AELAWCQEEH KNQGYYDYVK 970 980 990 1000 1010 PRLRTTIDRA KPVWYAGRDP AAAPATGNKK THLTELQRFL DTAFDLDAFK KFS
	Isoform 3 [UniParc]. Checksum: 7DC3C47068B12D2C	FASTA	1,038	118,179
	10 20 30 40 50 60 MFHLRTCAAK LRPLTASQTV KTFSQNKPAA IRTFQQIRCY SAPVAAEPFL SGTSSNYVEE 70 80 90 100 110 120 MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RSSLATMAHA QSLVEAQPNV 130 140 150 160 170 180 DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL GILDADLDSS VPADIISSTD KLDLAVFKER 190 200 210 220 230 240 LRMLTVGGFY GLHESDLDKV FHLPTTTFIG GQEPALPLRE IIRRLEMAYC QHIGVEFMFI 250 260 270 280 290 300 NDLEQCQWIR QKFETPGIMQ FTNEEKRTLL ARLVRSTRFE EFLQRKWSSE KRFGLEGCEV 310 320 330 340 350 360 LIPALKTIID MSSANGVDYV IMGMPHRGRL NVLANVIRKE LEQIFCQFDS KLEAADEGSG 370 380 390 400 410 420 DMKYHLGMYH RRINRVTDRN ITLSLVANPS HLEAADPVVM GKTKAEQFYC GDTEGKKVMS 430 440 450 460 470 480 ILLHGDAAFA GQGIVYETFH LSDLPSYTTH GTVHVVVNNQ IGFTTDPRMA RSSPYPTDVA 490 500 510 520 530 540 RVVNAPIFHV NSDDPEAVMY VCKVAAEWRN TFHKDVVVDL VCYRRNGHNE MDEPMFTQPL 550 560 570 580 590 600 MYKQIRKQKP VLQKYAELLV SQGVVNQPEY EEEISKYDKI CEEAFTRSKD EKILHIKHWL 610 620 630 640 650 660 DSPWPGFFTL DGQPRSMTCP STGLEEDVLF HIGKVASSVP VENFTIHGGL SRILKTRREL 670 680 690 700 710 720 VTNRTVDWAL AEYMAFGSLL KEGIHVRLSG QDVERGTFSH RHHVLHDQNV DKRTCIPMNH 730 740 750 760 770 780 LWPNQAPYTV CNSSLSEYGV LGFELGFAMA SPNALVLWEA QFGDFNNMAQ CIIDQFICPG 790 800 810 820 830 840 QAKWVRQNGI VLLLPHGMEG MGPEHSSARP ERFLQMCNDD PDVLPDLQEE NFDINQLYDC 850 860 870 880 890 900 NWIVVNCSTP GNFFHVLRRQ ILLPFRKPLI VFTPKSLLRH PEARTSFDEM LPGTHFQRVI 910 920 930 940 950 960 PENGPAAQDP HKVKRLLFCT GKVYYDLTRE RKARNMEEEV AITRIEQLSP FPFDLLLKEA 970 980 990 1000 1010 1020 QKYPNAELAW CQEEHKNQGY YDYVKPRLRT TIDRAKPVWY AGRDPAAAPA TGNKKTHLTE 1030 LQRFLDTAFD LDAFKKFS
	Isoform 4 [UniParc]. Checksum: 7023215EEEE9516B	FASTA	1,034	117,758
	10 20 30 40 50 60 MFHLRTCAAK LRPLTASQTV KTFSQNKPAA IRTFQQIRCY SAPVAAEPFL SGTSSNYVEE 70 80 90 100 110 120 MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RSSLATMAHA QSLVEAQPNV 130 140 150 160 170 180 DKLVEDHLAV QSLIRAYQVR GHHIAKLDPL GISCVNFDDA PVTVSSNVDL AVFKERLRML 190 200 210 220 230 240 TVGGFYGLHE SDLDKVFHLP TTTFIGGQEP ALPLREIIRR LEMAYCQHIG VEFMFINDLE 250 260 270 280 290 300 QCQWIRQKFE TPGIMQFTNE EKRTLLARLV RSTRFEEFLQ RKWSSEKRFG LEGCEVLIPA 310 320 330 340 350 360 LKTIIDMSSA NGVDYVIMGM PHRGRLNVLA NVIRKELEQI FCQFDSKLEA ADEGSGDMKY 370 380 390 400 410 420 HLGMYHRRIN RVTDRNITLS LVANPSHLEA ADPVVMGKTK AEQFYCGDTE GKKVMSILLH 430 440 450 460 470 480 GDAAFAGQGI VYETFHLSDL PSYTTHGTVH VVVNNQIGFT TDPRMARSSP YPTDVARVVN 490 500 510 520 530 540 APIFHVNSDD PEAVMYVCKV AAEWRNTFHK DVVVDLVCYR RNGHNEMDEP MFTQPLMYKQ 550 560 570 580 590 600 IRKQKPVLQK YAELLVSQGV VNQPEYEEEI SKYDKICEEA FTRSKDEKIL HIKHWLDSPW 610 620 630 640 650 660 PGFFTLDGQP RSMTCPSTGL EEDVLFHIGK VASSVPVENF TIHGGLSRIL KTRRELVTNR 670 680 690 700 710 720 TVDWALAEYM AFGSLLKEGI HVRLSGQDVE RGTFSHRHHV LHDQNVDKRT CIPMNHLWPN 730 740 750 760 770 780 QAPYTVCNSS LSEYGVLGFE LGFAMASPNA LVLWEAQFGD FNNMAQCIID QFICPGQAKW 790 800 810 820 830 840 VRQNGIVLLL PHGMEGMGPE HSSARPERFL QMCNDDPDVL PDLQEENFDI NQLYDCNWIV 850 860 870 880 890 900 VNCSTPGNFF HVLRRQILLP FRKPLIVFTP KSLLRHPEAR TSFDEMLPGT HFQRVIPENG 910 920 930 940 950 960 PAAQDPHKVK RLLFCTGKVY YDLTRERKAR NMEEEVAITR IEQLSPFPFD LLLKEAQKYP 970 980 990 1000 1010 1020 NAELAWCQEE HKNQGYYDYV KPRLRTTIDR AKPVWYAGRD PAAAPATGNK KTHLTELQRF 1030 LDTAFDLDAF KKFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Bone marrow.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4). Strain: C57BL/6 and FVB/N. Tissue: Brain, Colon, Mammary tumor and Salivary gland.
[5]	Lubec G., Klug S., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 123-135; 185-204; 311-319; 561-568; 616-633 AND 916-925, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain and Hippocampus.
[6]	"A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone." Udaka K., Tsomides T.J., Walden P., Fukusen N., Eisen H.N. Proc. Natl. Acad. Sci. U.S.A. 90:11272-11276(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 829-958 (ISOFORMS 1/2/3/4). Strain: BALB/c.
[7]	"A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein." Udaka K., Tsomides T.J., Eisen H.N. Cell 69:989-998(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 933-939.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK147289 mRNA. Translation: BAE27824.1.
AK150009 mRNA. Translation: BAE29234.1.
AK169286 mRNA. Translation: BAE41044.1.
AK220536 mRNA. Translation: BAD90530.1. Different initiation.
AL607152 Genomic DNA. Translation: CAI24404.1.
AL607152 Genomic DNA. Translation: CAI24405.1.
AL607152 Genomic DNA. Translation: CAI24406.1.
BC025040 mRNA. Translation: AAH25040.1.
BC013670 mRNA. Translation: AAH13670.1.
BC029143 mRNA. Translation: AAH29143.1.
BC031165 mRNA. Translation: AAH31165.1. Different initiation.
BC049104 mRNA. Translation: AAH49104.1.
BC057354 mRNA. Translation: AAH57354.1.
U02971 mRNA. Translation: AAC52130.1.

IPI

IPI00420882.
IPI00626237.
IPI00719841.
IPI00845652.

PIR

A41911. I48884.

RefSeq

NP_001239211.1. NM_001252282.1.
NP_001239212.1. NM_001252283.1.
NP_001239216.1. NM_001252287.1.
NP_001239217.1. NM_001252288.1.
NP_035086.2. NM_010956.4.

UniGene

Mm.276348.
Mm.479411.
Mm.490272.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3TF7	X-ray	2.75	B/F	932-940	[»]

ProteinModelPortal

Q60597.

SMR

Q60597. Positions 124-1014.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q60597. 1 interaction.

MINT

MINT-1860288.

PTM databases

PhosphoSite

Q60597.

2D gel databases

REPRODUCTION-2DPAGE

Q60597.

Proteomic databases

PaxDb

Q60597.

PRIDE

Q60597.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000003461; ENSMUSP00000003461; ENSMUSG00000020456.
ENSMUST00000093350; ENSMUSP00000091041; ENSMUSG00000020456.
ENSMUST00000101554; ENSMUSP00000099090; ENSMUSG00000020456.

GeneID

18293.

KEGG

mmu:18293.

UCSC

uc007hyf.2. mouse.
uc007hyg.2. mouse.
uc007hyh.2. mouse.

Organism-specific databases

CTD

4967.

MGI

MGI:1098267. Ogdh.

Rouge

Search...

Phylogenomic databases

eggNOG

COG0567.

GeneTree

ENSGT00530000063092.

HOVERGEN

HBG001892.

KO

K00164.

OMA

QEVQKYP.

OrthoDB

EOG4VQ9NH.

Gene expression databases

ArrayExpress

Q60597.

Bgee

Q60597.

CleanEx

MM_OGDH.

Genevestigator

Q60597.

GermOnline

ENSMUSG00000020456. Mus musculus.

Family and domain databases

InterPro

IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]

PANTHER

PTHR23152. PTHR23152. 1 hit.

Pfam

PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]

PIRSF

PIRSF000157. Oxoglu_dh_E1. 1 hit.

SMART

SM00861. Transket_pyr. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00239. 2oxo_dh_E1. 1 hit.

ProtoNet

Search...

Other

ChiTaRS

OGDH. mouse.

NextBio

293740.

SOURCE

Search...

Entry information

Entry name

ODO1_MOUSE

Accession

Primary (citable) accession number: Q60597
Secondary accession number(s): Q3UDM7 , Q5DTI4, Q5SVX7, Q5SVX9, Q6PFZ2, Q80Y57, Q8K0K7, Q8K2Z3, Q8R3M2, Q91WP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 2007
Last modified:	May 29, 2013
This is version 124 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program