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Q60591

- NFAC2_MOUSE

UniProt

Q60591 - NFAC2_MOUSE

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Protein

Nuclear factor of activated T-cells, cytoplasmic 2

Gene
Nfatc2, Nfat1, Nfatp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi423 – 4308

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: MGI
  6. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. B cell receptor signaling pathway Source: Ensembl
  2. cell migration Source: UniProtKB
  3. cellular response to DNA damage stimulus Source: Ensembl
  4. cytokine production Source: MGI
  5. positive regulation of B cell proliferation Source: Ensembl
  6. positive regulation of gene expression Source: UniProtKB
  7. positive regulation of transcription, DNA-templated Source: MGI
  8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  9. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_188202. FCERI mediated Ca+2 mobilization.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor of activated T-cells, cytoplasmic 2
Short name:
NF-ATc2
Short name:
NFATc2
Alternative name(s):
NFAT pre-existing subunit
Short name:
NF-ATp
T-cell transcription factor NFAT1
Gene namesi
Name:Nfatc2
Synonyms:Nfat1, Nfatp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:102463. Nfatc2.

Subcellular locationi

Cytoplasm. Nucleus
Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.1 Publication

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. cytoplasm Source: MGI
  3. cytosol Source: MGI
  4. nuclear transcription factor complex Source: MGI
  5. nucleoplasm Source: Reactome
  6. nucleus Source: UniProtKB
  7. plasma membrane Source: Ensembl
  8. ribonucleoprotein complex Source: MGI
  9. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi112 – 1121R → A: Lowers dephosphorylation. 1 Publication
Mutagenesisi114 – 1141E → A: Lowers dephosphorylation. 1 Publication
Mutagenesisi116 – 1161T → A: No dephosphorylation. 1 Publication
Mutagenesisi164 – 1641R → A: Induces aberrant nuclear localization of the phosphorylated form. 1 Publication
Mutagenesisi423 – 4231R → A: Decrease in binding to DNA. 1 Publication
Mutagenesisi425 – 4251H → A: No change in binding to DNA. 1 Publication
Mutagenesisi426 – 4261Y → A: Decrease in binding to DNA. 1 Publication
Mutagenesisi428 – 4281T → A: No change in binding to DNA. 1 Publication
Mutagenesisi428 – 4281T → C: No change in binding to DNA and confers DNA-binding sensitivity to sulfhydryl modifications. 1 Publication
Mutagenesisi429 – 4291E → A: Decrease in binding to DNA. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 927927Nuclear factor of activated T-cells, cytoplasmic 2PRO_0000205179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531Phosphoserine Inferred
Modified residuei54 – 541Phosphoserine Inferred
Modified residuei56 – 561Phosphoserine Inferred
Modified residuei99 – 991Phosphoserine1 Publication
Modified residuei136 – 1361Phosphoserine1 Publication
Modified residuei150 – 1501Phosphoserine By similarity
Modified residuei170 – 1701Phosphoserine Inferred
Modified residuei173 – 1731Phosphoserine Inferred
Modified residuei174 – 1741Phosphoserine Inferred
Modified residuei176 – 1761Phosphoserine Inferred
Modified residuei177 – 1771Phosphoserine Inferred
Modified residuei179 – 1791Phosphoserine Inferred
Modified residuei182 – 1821Phosphoserine Inferred
Modified residuei215 – 2151Phosphoserine1 Publication
Modified residuei219 – 2191Phosphoserine1 Publication
Modified residuei223 – 2231Phosphoserine1 Publication
Modified residuei238 – 2381Phosphoserine1 Publication
Modified residuei245 – 2451Phosphoserine1 Publication
Modified residuei270 – 2701Phosphoserine1 Publication
Modified residuei276 – 2761Phosphoserine1 Publication
Modified residuei278 – 2781Phosphoserine1 Publication
Modified residuei282 – 2821Phosphoserine1 Publication
Modified residuei328 – 3281Phosphoserine1 Publication
Modified residuei365 – 3651Phosphoserine1 Publication
Modified residuei757 – 7571Phosphoserine By similarity
Modified residuei759 – 7591Phosphoserine By similarity
Modified residuei761 – 7611Phosphoserine By similarity

Post-translational modificationi

In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-365 region. Upon cell stimulation, all these sites except Ser-245 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, one site among Ser-53; Ser-54 and Ser-56 is phosphorylated; which is required for full transcriptional activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ60591.

PTM databases

PhosphoSiteiQ60591.

Expressioni

Tissue specificityi

Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas.1 Publication

Gene expression databases

ArrayExpressiQ60591.
BgeeiQ60591.
GenevestigatoriQ60591.

Interactioni

Subunit structurei

Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. The phosphorylated form specifically interacts with XPO1; which mediates nuclear export. NFATC proteins bind to DNA as monomers. Interacts with NFATC2IP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VRK2Q86Y07-12EBI-643104,EBI-1207633From a different organism.

Protein-protein interaction databases

BioGridi201739. 1 interaction.
DIPiDIP-49476N.
IntActiQ60591. 9 interactions.
MINTiMINT-1565857.

Structurei

3D structure databases

ProteinModelPortaliQ60591.
SMRiQ60591. Positions 398-680.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati186 – 202171Add
BLAST
Repeati215 – 231172Add
BLAST
Repeati274 – 290173; approximateAdd
BLAST
Domaini394 – 576183RHDAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 1166Calcineurin-binding
Regioni119 – 20183Trans-activation domain A (TAD-A)Add
BLAST
Regioni163 – 17715Required for cytoplasmic retention of the phosphorylated formAdd
BLAST
Regioni186 – 2921073 X approximate SP repeatsAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi253 – 2553Nuclear localization signal

Domaini

Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG84065.
GeneTreeiENSGT00550000074562.
HOVERGENiHBG069754.
InParanoidiB5B2Q3.
KOiK17332.
OMAiMWKTSPD.
OrthoDBiEOG79PJND.
TreeFamiTF326480.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PANTHERiPTHR12533. PTHR12533. 1 hit.
PfamiPF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PRINTSiPR01789. NUCFACTORATC.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50254. REL_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform C (identifier: Q60591-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDVPEPQPDP DGGDGPGHEP GGSPQDELDF SILFDYDYLN PIEEEPIAHK    50
AISSPSGLAY PDDVLDYGLK PCNPLASLSG EPPGRFGEPD SIGFQNFLSP 100
VKPAGASGPS PRIEITPSHE LMQAGGALRG RDAGLSPEQP ALALAGVAAS 150
PRFTLPVPGY EGYREPLCLS PASSGSSASF ISDTFSPYTS PCVSPNNAGP 200
DDLCPQFQNI PAHYSPRTSP IMSPRTSLAE DSCLGRHSPV PRPASRSSSP 250
GAKRRHSCAE ALVAPLPAAS PQRSRSPSPQ PSPHVALQDD SIPAGYPPTA 300
GSAVLMDALN TLATDSPCGI PSKIWKTSPD PTPVSTAPSK AGLARHIYPT 350
VEFLGPCEQE ERRNSAPESI LLVPPTWPKQ LVPAIPICSI PVTASLPPLE 400
WPLSNQSGSY ELRIEVQPKP HHRAHYETEG SRGAVKAPTG GHPVVQLHGY 450
MENKPLGLQI FIGTADERIL KPHAFYQVHR ITGKTVTTTS YEKIVGNTKV 500
LEIPLEPKNN MRATIDCAGI LKLRNADIEL RKGETDIGRK NTRVRLVFRV 550
HVPEPSGRIV SLQAASNPIE CSQRSAHELP MVERQDMDSC LVYGGQQMIL 600
TGQNFTAESK VVFMEKTTDG QQIWEMEATV DKDKSQPNML FVEIPEYRNK 650
HIRVPVKVNF YVINGKRKRS QPQHFTYHPV PAIKTEPSDE YEPSLICSPA 700
HGGLGSQPYY PQHPMLAESP SCLVATMAPC QQFRSGLSSP DARYQQQSPA 750
AALYQRSKSL SPGLLGYQQP SLLAAPLGLA DAHRSVLVHA GSQGQGQGST 800
LPHTSSASQQ ASPVIHYSPT NQQLRGGGHQ EFQHIMYCEN FGPSSARPGP 850
PPINQGQRLS PGAYPTVIQQ QTAPSQRAAK NGPSDQKEAL PTGVTVKQEQ 900
NLDQTYLDDV NEIIRKEFSG PPSRNQT 927
Length:927
Mass (Da):100,020
Last modified:July 27, 2011 - v3
Checksum:iF21E7BABE7DBB40F
GO
Isoform B (identifier: Q60591-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     910-927: VNEIIRKEFSGPPSRNQT → ELIDTHLSWIQNIL

Show »
Length:923
Mass (Da):99,642
Checksum:iA2B4B0476A75A83D
GO
Isoform D (identifier: Q60591-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     619-806: DGQQIWEMEA...QGSTLPHTSS → GPAGTCETRP...PGSSLVLLAL

Show »
Length:794
Mass (Da):85,181
Checksum:i1A8246FF98E219B8
GO
Isoform A (identifier: Q60591-1)

Sequence is not available

Note: Ref.2 (AAC52929) sequence is a chimeric cDNA.

Length:
Mass (Da):

Sequence cautioni

The sequence AAC52929.1 differs from that shown. Reason: Chimeric cDNA fused with Phyhd1 (Lrrc8a).

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei619 – 806188DGQQI…PHTSS → GPAGTCETRPLPISLISADR LSPWLSRLQRNPPGSVFRCS VLLPAPGSSLVLLAL in isoform D. VSP_005597Add
BLAST
Alternative sequencei910 – 92718VNEII…SRNQT → ELIDTHLSWIQNIL in isoform B. VSP_005596Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781L → P in AAK49895. 1 Publication
Sequence conflicti287 – 2871L → P in AAC52929. 1 Publication
Sequence conflicti287 – 2871L → P in AAC52930. 1 Publication
Sequence conflicti287 – 2871L → P in AAC52931. 1 Publication
Sequence conflicti802 – 8021P → R in AAC52929. 1 Publication
Sequence conflicti802 – 8021P → R in AAC52930. 1 Publication
Sequence conflicti802 – 8021P → R in AAC52931. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U02079 mRNA. Translation: AAC52929.1. Sequence problems.
U36575 mRNA. Translation: AAC52930.1.
U36576 mRNA. Translation: AAC52931.1.
AF289078 mRNA. Translation: AAK49895.1.
EU887588 mRNA. Translation: ACG55608.1.
AL840639, AL844575 Genomic DNA. Translation: CAM15662.1.
AL840639, AL844575 Genomic DNA. Translation: CAM15663.1.
AL844575 Genomic DNA. Translation: CAM15669.1.
AL844575, AL840639 Genomic DNA. Translation: CAM15670.1.
AL844575, AL840639 Genomic DNA. Translation: CAM15671.1.
CCDSiCCDS17112.1. [Q60591-3]
CCDS50803.1. [Q60591-2]
PIRiA48753.
RefSeqiNP_035029.2. NM_010899.3. [Q60591-3]
UniGeneiMm.116802.

Genome annotation databases

EnsembliENSMUST00000074618; ENSMUSP00000074198; ENSMUSG00000027544. [Q60591-3]
ENSMUST00000109184; ENSMUSP00000104812; ENSMUSG00000027544. [Q60591-2]
GeneIDi18019.
KEGGimmu:18019.
UCSCiuc008oau.1. mouse. [Q60591-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U02079 mRNA. Translation: AAC52929.1 . Sequence problems.
U36575 mRNA. Translation: AAC52930.1 .
U36576 mRNA. Translation: AAC52931.1 .
AF289078 mRNA. Translation: AAK49895.1 .
EU887588 mRNA. Translation: ACG55608.1 .
AL840639 , AL844575 Genomic DNA. Translation: CAM15662.1 .
AL840639 , AL844575 Genomic DNA. Translation: CAM15663.1 .
AL844575 Genomic DNA. Translation: CAM15669.1 .
AL844575 , AL840639 Genomic DNA. Translation: CAM15670.1 .
AL844575 , AL840639 Genomic DNA. Translation: CAM15671.1 .
CCDSi CCDS17112.1. [Q60591-3 ]
CCDS50803.1. [Q60591-2 ]
PIRi A48753.
RefSeqi NP_035029.2. NM_010899.3. [Q60591-3 ]
UniGenei Mm.116802.

3D structure databases

ProteinModelPortali Q60591.
SMRi Q60591. Positions 398-680.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201739. 1 interaction.
DIPi DIP-49476N.
IntActi Q60591. 9 interactions.
MINTi MINT-1565857.

PTM databases

PhosphoSitei Q60591.

Proteomic databases

PRIDEi Q60591.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074618 ; ENSMUSP00000074198 ; ENSMUSG00000027544 . [Q60591-3 ]
ENSMUST00000109184 ; ENSMUSP00000104812 ; ENSMUSG00000027544 . [Q60591-2 ]
GeneIDi 18019.
KEGGi mmu:18019.
UCSCi uc008oau.1. mouse. [Q60591-3 ]

Organism-specific databases

CTDi 4773.
MGIi MGI:102463. Nfatc2.

Phylogenomic databases

eggNOGi NOG84065.
GeneTreei ENSGT00550000074562.
HOVERGENi HBG069754.
InParanoidi B5B2Q3.
KOi K17332.
OMAi MWKTSPD.
OrthoDBi EOG79PJND.
TreeFami TF326480.

Enzyme and pathway databases

Reactomei REACT_188202. FCERI mediated Ca+2 mobilization.

Miscellaneous databases

ChiTaRSi NFATC2. mouse.
NextBioi 293063.
PROi Q60591.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q60591.
Bgeei Q60591.
Genevestigatori Q60591.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view ]
PANTHERi PTHR12533. PTHR12533. 1 hit.
Pfami PF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view ]
PRINTSi PR01789. NUCFACTORATC.
SMARTi SM00429. IPT. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS50254. REL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE (ISOFORM A).
  2. "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes."
    Luo C., Burgeon E., Carew J.A., McCaffrey P.G., Badalian T.M., Lane W.S., Hogan P.G., Rao A.
    Mol. Cell. Biol. 16:3955-3966(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
  3. "Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain."
    Plyte S., Boncristiano M., Fattori E., Galvagni F., Paccani S.R., Majolini M.B., Oliviero S., Ciliberto G., Telford J.L., Baldari C.T.
    J. Biol. Chem. 276:14350-14358(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Alternative splicing and expression of human and mouse NFAT genes."
    Vihma H., Pruunsild P., Timmusk T.
    Genomics 92:279-291(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Strain: C57BL/6.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "A similar DNA-binding motif in NFAT family proteins and the Rel homology region."
    Jain J., Burgeon E., Badalian T.M., Hogan P.G., Rao A.
    J. Biol. Chem. 270:4138-4145(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ARG-423; HIS-425; TYR-426; THR-428 AND GLU-429.
  7. "NF-AT-driven interleukin-4 transcription potentiated by NIP45."
    Hodge M.R., Chun H.J., Rengarajan J., Alt A., Lieberson R., Glimcher L.H.
    Science 274:1903-1905(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NFATC2IP.
  8. "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT."
    Aramburu J., Garcia-Cozar F., Raghavan A., Okamura H., Rao A., Hogan P.G.
    Mol. Cell 1:627-637(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ARG-112; GLU-114 AND THR-116.
  9. "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT."
    Crabtree G.R.
    Cell 96:611-614(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity."
    Okamura H., Aramburu J., Garcia-Rodriguez C., Viola J.P.B., Raghavan A., Tahiliani M., Zhang X., Qin J., Hogan P.G., Rao A.
    Mol. Cell 6:539-550(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-99; SER-136; SER-170; SER-173; SER-174; SER-176; SER-177; SER-179; SER-182; SER-215; SER-219; SER-223; SER-238; SER-245; SER-270; SER-276; SER-278; SER-282; SER-328 AND SER-365, SUBCELLULAR LOCATION, INTERACTION WITH XPO1, MUTAGENESIS OF ARG-164, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiNFAC2_MOUSE
AccessioniPrimary (citable) accession number: Q60591
Secondary accession number(s): A2APK2
, A2APK3, A2AQC5, A2AQC6, A2AQC7, B5B2Q3, Q60984, Q60985, Q91Y65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi