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Protein

Alpha-1-acid glycoprotein 1

Gene

Orm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.By similarity

GO - Biological processi

Keywordsi

Biological processAcute phase, Transport

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein 1
Short name:
AGP 1
Alternative name(s):
Orosomucoid-1
Short name:
OMD 1
Gene namesi
Name:Orm1
Synonyms:Agp1, Orm-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97443 Orm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001786219 – 207Alpha-1-acid glycoprotein 1Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1
Glycosylationi25N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi34N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi76N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi91 ↔ 184By similarity
Glycosylationi94N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi104N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiQ60590
PaxDbiQ60590
PeptideAtlasiQ60590
PRIDEiQ60590

PTM databases

GlyConnecti798
iPTMnetiQ60590
PhosphoSitePlusiQ60590

Expressioni

Gene expression databases

BgeeiENSMUSG00000039196
CleanExiMM_ORM1
GenevisibleiQ60590 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030044

Structurei

3D structure databases

ProteinModelPortaliQ60590
SMRiQ60590
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.By similarity

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI Eukaryota
ENOG4111C49 LUCA
GeneTreeiENSGT00390000012130
HOGENOMiHOG000125170
HOVERGENiHBG000035
InParanoidiQ60590
KOiK17308
OMAiQRENGTI
OrthoDBiEOG091G0NAQ
PhylomeDBiQ60590
TreeFamiTF343791

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR001500 A1A_glycop
IPR012674 Calycin
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11967 PTHR11967, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PIRSFiPIRSF036899 AGP, 1 hit
PRINTSiPR00708 A1AGLPROTEIN
SUPFAMiSSF50814 SSF50814, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHTVLIIL SLLPMLEAQN PEHANFTIGE PITNETLSWL SDKWFFMGAA
60 70 80 90 100
FRKLEYRQAI QTMQSEFFYL TTNLINDTIE LRESQTIGDQ CVYNSTHLGF
110 120 130 140 150
QRENGTFSKY EGGVETFAHL IVLRKHGAFM LAFDLKDEKK RGLSLYAKRP
160 170 180 190 200
DITPELREVF QKAVTHVGMD ESEIIFVDWK KDRCGQQEKK QLELGKETKK

DPEEGQA
Length:207
Mass (Da):23,895
Last modified:November 1, 1996 - v1
Checksum:i34CA38BE40BC1863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27008 mRNA Translation: AAA37194.1
CCDSiCCDS18251.1
PIRiA32476
RefSeqiNP_032794.1, NM_008768.2
UniGeneiMm.4777

Genome annotation databases

EnsembliENSMUST00000030044; ENSMUSP00000030044; ENSMUSG00000039196
GeneIDi18405
KEGGimmu:18405
UCSCiuc008tfx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiA1AG1_MOUSE
AccessioniPrimary (citable) accession number: Q60590
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health