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Protein

Alpha-1-acid glycoprotein 1

Gene

Orm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Acute phase, Transport

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein 1
Short name:
AGP 1
Alternative name(s):
Orosomucoid-1
Short name:
OMD 1
Gene namesi
Name:Orm1
Synonyms:Agp1, Orm-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97443. Orm1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 207189Alpha-1-acid glycoprotein 1PRO_0000017862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acidBy similarity
Glycosylationi25 – 251N-linked (GlcNAc...)1 Publication
Glycosylationi34 – 341N-linked (GlcNAc...)1 Publication
Glycosylationi76 – 761N-linked (GlcNAc...)1 Publication
Disulfide bondi91 ↔ 184By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)2 Publications
Glycosylationi104 – 1041N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiQ60590.
MaxQBiQ60590.
PaxDbiQ60590.
PeptideAtlasiQ60590.
PRIDEiQ60590.

PTM databases

iPTMnetiQ60590.

Expressioni

Gene expression databases

BgeeiQ60590.
CleanExiMM_ORM1.
GenevisibleiQ60590. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030044.

Structurei

3D structure databases

ProteinModelPortaliQ60590.
SMRiQ60590. Positions 31-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.By similarity

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
GeneTreeiENSGT00390000012130.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiQ60590.
KOiK17308.
OMAiEYQTRQD.
OrthoDBiEOG7B5WXT.
PhylomeDBiQ60590.
TreeFamiTF343791.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHTVLIIL SLLPMLEAQN PEHANFTIGE PITNETLSWL SDKWFFMGAA
60 70 80 90 100
FRKLEYRQAI QTMQSEFFYL TTNLINDTIE LRESQTIGDQ CVYNSTHLGF
110 120 130 140 150
QRENGTFSKY EGGVETFAHL IVLRKHGAFM LAFDLKDEKK RGLSLYAKRP
160 170 180 190 200
DITPELREVF QKAVTHVGMD ESEIIFVDWK KDRCGQQEKK QLELGKETKK

DPEEGQA
Length:207
Mass (Da):23,895
Last modified:November 1, 1996 - v1
Checksum:i34CA38BE40BC1863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27008 mRNA. Translation: AAA37194.1.
CCDSiCCDS18251.1.
PIRiA32476.
RefSeqiNP_032794.1. NM_008768.2.
UniGeneiMm.4777.

Genome annotation databases

EnsembliENSMUST00000030044; ENSMUSP00000030044; ENSMUSG00000039196.
GeneIDi18405.
KEGGimmu:18405.
UCSCiuc008tfx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27008 mRNA. Translation: AAA37194.1.
CCDSiCCDS18251.1.
PIRiA32476.
RefSeqiNP_032794.1. NM_008768.2.
UniGeneiMm.4777.

3D structure databases

ProteinModelPortaliQ60590.
SMRiQ60590. Positions 31-191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030044.

PTM databases

iPTMnetiQ60590.

Proteomic databases

EPDiQ60590.
MaxQBiQ60590.
PaxDbiQ60590.
PeptideAtlasiQ60590.
PRIDEiQ60590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030044; ENSMUSP00000030044; ENSMUSG00000039196.
GeneIDi18405.
KEGGimmu:18405.
UCSCiuc008tfx.1. mouse.

Organism-specific databases

CTDi5004.
MGIiMGI:97443. Orm1.

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
GeneTreeiENSGT00390000012130.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiQ60590.
KOiK17308.
OMAiEYQTRQD.
OrthoDBiEOG7B5WXT.
PhylomeDBiQ60590.
TreeFamiTF343791.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiOrm1. mouse.
PROiQ60590.
SOURCEiSearch...

Gene expression databases

BgeeiQ60590.
CleanExiMM_ORM1.
GenevisibleiQ60590. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of cDNAs corresponding to two genes of alpha 1-acid glycoprotein and characterization of two alleles of AGP-1 in the mouse."
    Lee S.C., Chang C.J., Lee Y.M., Lei H.Y., Lai M.Y., Chen D.S.
    DNA 8:245-251(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-25; ASN-34; ASN-76 AND ASN-94.
    Strain: C57BL/6J.
    Tissue: Plasma.
  3. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94 AND ASN-104.
    Strain: C57BL/6J.
    Tissue: Plasma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue.

Entry informationi

Entry nameiA1AG1_MOUSE
AccessioniPrimary (citable) accession number: Q60590
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.