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Protein

Zinc finger protein 30

Gene

Zfp30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 30
Short name:
Zfp-30
Gene namesi
Name:Zfp30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99178. Zfp30.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472921 – 533Zinc finger protein 30Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75Asymmetric dimethylarginineCombined sources1
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

PaxDbiQ60585.
PRIDEiQ60585.

PTM databases

iPTMnetiQ60585.
PhosphoSitePlusiQ60585.

Expressioni

Gene expression databases

CleanExiMM_ZFP30.

Interactioni

Protein-protein interaction databases

BioGridi204656. 1 interactor.
STRINGi10090.ENSMUSP00000032803.

Structurei

3D structure databases

ProteinModelPortaliQ60585.
SMRiQ60585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 78KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG018163.
InParanoidiQ60585.
KOiK09228.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequencei

Sequence statusi: Complete.

Q60585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSTVMFRD VAVGFSQEEW ECLSAYERDL YRDVMLENYS HLVSLAGCSI
60 70 80 90 100
SKPDVITLLE QGKEPWMIVR AEKRRWSRDL ESRYSSNGLL PEKNTYEINL
110 120 130 140 150
SPWEIMGRIQ RRGPEDSLLG KDFEYKIYEE QENSHRVYFR HVIKTTSGKR
160 170 180 190 200
PRYRKRTPVS LYQKTPNGEK PYECGECGKA FKVRQQLTFH QRIHTGEKPY
210 220 230 240 250
ECKECGKAFR QCAHLSRHQR IHASDKLYEC KKCAKIFTCS SDLRGHQRSH
260 270 280 290 300
VGEKPYDCKE CGKAFRVRGQ LMLHQRIHTG EKPYACTECG KSFRQVAHLT
310 320 330 340 350
RHQRLNSGSS RHECKECGRA FLCSTGLRLH HKLHTGEKPY DCKECGKAFR
360 370 380 390 400
VRQQLTLHER IHTGEKPFDC KECGKTFSRG YHLTLHQRIH TGEKPYECKE
410 420 430 440 450
CRKFFRRYSE LISHQGIHIG EKPYDCKECG KAFRLFSQLT QHQSIHFGEK
460 470 480 490 500
PYKCMECEKT FRLLSQLTQH QSIHTGEKPY DCKECGKAFR LHSSLIQHQR
510 520 530
IHSGEKPYKC TECKKAFRQH SHLTYHQRIH KNL
Length:533
Mass (Da):62,769
Last modified:May 24, 2005 - v2
Checksum:i0058748909A30CC3
GO

Sequence cautioni

The sequence CAA82913 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30174 mRNA. Translation: CAA82913.1. Different initiation.
AK014064 mRNA. Translation: BAB29138.2.
PIRiI48208. S42077.
RefSeqiNP_038733.1. NM_013705.1.
UniGeneiMm.292690.

Genome annotation databases

GeneIDi22693.
KEGGimmu:22693.
UCSCiuc009gcc.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiZFP30_MOUSE
AccessioniPrimary (citable) accession number: Q60585
Secondary accession number(s): Q9CRV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: May 24, 2005
Last modified: August 30, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families