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Protein

Corticotropin-releasing factor-binding protein

Gene

Crhbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

GO - Molecular functioni

  • corticotropin-releasing hormone binding Source: UniProtKB
  • peptide binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Corticotropin-releasing factor-binding protein
Short name:
CRF-BP
Short name:
CRF-binding protein
Alternative name(s):
Corticotropin-releasing hormone-binding protein
Short name:
CRH-BP
Gene namesi
Name:Crhbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:88497. Crhbp.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: UniProtKB
  • dendrite Source: UniProtKB
  • dense core granule Source: UniProtKB
  • extracellular space Source: UniProtKB
  • intracellular Source: UniProtKB
  • microtubule Source: UniProtKB
  • multivesicular body Source: UniProtKB
  • nucleus Source: UniProtKB
  • perikaryon Source: UniProtKB
  • secondary lysosome Source: UniProtKB
  • secretory granule Source: UniProtKB
  • varicosity Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 322298Corticotropin-releasing factor-binding proteinPRO_0000020995Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 81By similarity
Disulfide bondi104 ↔ 141By similarity
Disulfide bondi183 ↔ 205By similarity
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi237 ↔ 264By similarity
Disulfide bondi277 ↔ 318By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ60571.
PaxDbiQ60571.
PRIDEiQ60571.

PTM databases

PhosphoSiteiQ60571.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021680.
CleanExiMM_CRHBP.
ExpressionAtlasiQ60571. baseline and differential.
GenevisibleiQ60571. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042578.

Structurei

3D structure databases

ProteinModelPortaliQ60571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CRF-binding protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II3D. Eukaryota.
ENOG4111JUQ. LUCA.
GeneTreeiENSGT00390000001362.
HOGENOMiHOG000004819.
HOVERGENiHBG051117.
InParanoidiQ60571.
OMAiIHYDLVS.
OrthoDBiEOG091G094Q.
PhylomeDBiQ60571.
TreeFamiTF105383.

Family and domain databases

InterProiIPR008435. CRF-bd.
IPR000859. CUB_dom.
[Graphical view]
PANTHERiPTHR10278:SF0. PTHR10278:SF0. 1 hit.
PfamiPF05428. CRF-BP. 1 hit.
[Graphical view]
PIRSFiPIRSF009279. CRF_bd. 1 hit.
SUPFAMiSSF49854. SSF49854. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPNFKLQCH FILILLTALR GESRYLEVQE AAVYDPLLLF SANLKRDLAE
60 70 80 90 100
EQPYRRALRC LDMLSLPGQF TFTADRPQLH CAAFFIGEPE EFITIHYDLV
110 120 130 140 150
SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPTMKRYTDF CESGLTRRSI
160 170 180 190 200
RSSQNVAMVF FRVHEPGNGF TITIKTDPNL FPCNVISQTP SGRFTLVVPY
210 220 230 240 250
QHQNCSFSII YPVAIKISDL TLGHLHGLQL KKPAAGCGGT GDFVELLGGT
260 270 280 290 300
GLDPSKMMPL ADLCYPFLGP AQMKISCDNA VVRMVSSGKH INRVTFEYRQ
310 320
LEPFELETST GNSIPEYCLS SL
Length:322
Mass (Da):36,048
Last modified:November 1, 1996 - v1
Checksum:i2F8A5D80CD54C7BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33323 mRNA. Translation: AAC52253.1.
BC061247 mRNA. Translation: AAH61247.1.
CCDSiCCDS26698.1.
RefSeqiNP_940800.1. NM_198408.3.
UniGeneiMm.316614.

Genome annotation databases

EnsembliENSMUST00000045583; ENSMUSP00000042578; ENSMUSG00000021680.
GeneIDi12919.
KEGGimmu:12919.
UCSCiuc007rmk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33323 mRNA. Translation: AAC52253.1.
BC061247 mRNA. Translation: AAH61247.1.
CCDSiCCDS26698.1.
RefSeqiNP_940800.1. NM_198408.3.
UniGeneiMm.316614.

3D structure databases

ProteinModelPortaliQ60571.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042578.

PTM databases

PhosphoSiteiQ60571.

Proteomic databases

MaxQBiQ60571.
PaxDbiQ60571.
PRIDEiQ60571.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045583; ENSMUSP00000042578; ENSMUSG00000021680.
GeneIDi12919.
KEGGimmu:12919.
UCSCiuc007rmk.2. mouse.

Organism-specific databases

CTDi1393.
MGIiMGI:88497. Crhbp.

Phylogenomic databases

eggNOGiENOG410II3D. Eukaryota.
ENOG4111JUQ. LUCA.
GeneTreeiENSGT00390000001362.
HOGENOMiHOG000004819.
HOVERGENiHBG051117.
InParanoidiQ60571.
OMAiIHYDLVS.
OrthoDBiEOG091G094Q.
PhylomeDBiQ60571.
TreeFamiTF105383.

Miscellaneous databases

ChiTaRSiCrhbp. mouse.
PROiQ60571.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021680.
CleanExiMM_CRHBP.
ExpressionAtlasiQ60571. baseline and differential.
GenevisibleiQ60571. MM.

Family and domain databases

InterProiIPR008435. CRF-bd.
IPR000859. CUB_dom.
[Graphical view]
PANTHERiPTHR10278:SF0. PTHR10278:SF0. 1 hit.
PfamiPF05428. CRF-BP. 1 hit.
[Graphical view]
PIRSFiPIRSF009279. CRF_bd. 1 hit.
SUPFAMiSSF49854. SSF49854. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCRHBP_MOUSE
AccessioniPrimary (citable) accession number: Q60571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.