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Protein

Potassium voltage-gated channel subfamily V member 1

Gene

KCNV1

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv8.1
Gene namesi
Name:KCNV1
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 214214CytoplasmicSequence analysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=Segment S1Sequence analysisAdd
BLAST
Topological domaini236 – 2427ExtracellularSequence analysis
Transmembranei243 – 26321Helical; Name=Segment S2Sequence analysisAdd
BLAST
Topological domaini264 – 28017CytoplasmicSequence analysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=Segment S3Sequence analysisAdd
BLAST
Topological domaini302 – 31312ExtracellularSequence analysisAdd
BLAST
Transmembranei314 – 33522Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd
BLAST
Topological domaini336 – 34914CytoplasmicSequence analysisAdd
BLAST
Transmembranei350 – 37021Helical; Name=Segment S5Sequence analysisAdd
BLAST
Transmembranei411 – 43121Helical; Name=Segment S6Sequence analysisAdd
BLAST
Topological domaini432 – 50473CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Potassium voltage-gated channel subfamily V member 1PRO_0000308352Add
BLAST

Expressioni

Tissue specificityi

Detected in brain, throughout layers II, IV and VI of the brain cortex. Detected in cerebellum and hippocampus, in the granule cell layer, Purkinje cell layer, pyramidal cell layer and dentate gyrus. Detected at lower levels in olfactory bulb, amygdala, thalamus, hypothalamus, midbrain and brainstem.1 Publication

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ60565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi396 – 4016Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052230.
OrthoDBiEOG091G0FP3.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 2 hits.
PTHR11537:SF38. PTHR11537:SF38. 2 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSPRNRPL LESSSLDSGG SLSSLDSSVF CSEGEGEPLA LGDCLTVNVG
60 70 80 90 100
GSRFVLSQQA LSCFPHTRLG KLAVVVASYR RLGALAAAPS PLELCDDANP
110 120 130 140 150
VDNEYFFDRS SQAFRYVLHY YRTGRLHVME QLCALSFLQE IQYWGIDELS
160 170 180 190 200
IDSCCRDRYF RRKELSETLD FKKDTDDQES QHESEQDFSQ GPCPTVRQKL
210 220 230 240 250
WDILEKPGSS TAARIFGVIS IIFVAVSIVN MALMSAELSW LNLQLLEILE
260 270 280 290 300
YVCISWFTGE FILRFLCVKD RCRFLRKVPN IIDLLAILPF YITLLVESLS
310 320 330 340 350
GSHTTQELEN VGRLVQVLRL LRALRMLKLG RHSTGLRSLG MTITQCYEEV
360 370 380 390 400
GLLLLFLSVG ISIFSTIEYF AEQSIPDTTF TSVPCAWWWA TTSMTTVGYG
410 420 430 440 450
DIRPDTTTGK IVAFMCILSG ILVLALPIAI INDRFSACYF TLKLKEAAVR
460 470 480 490 500
QREALKKLTK NIATDSYISV NLRDVYARSI MEMLRLKGRE RASTRSSGGD

DFWF
Length:504
Mass (Da):56,725
Last modified:November 1, 1996 - v1
Checksum:iBB667FB17E57A6F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62810 mRNA. Translation: AAC52727.1.
RefSeqiNP_001268571.1. NM_001281642.1.
XP_012970704.1. XM_013115250.1.

Genome annotation databases

GeneIDi101835683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62810 mRNA. Translation: AAC52727.1.
RefSeqiNP_001268571.1. NM_001281642.1.
XP_012970704.1. XM_013115250.1.

3D structure databases

ProteinModelPortaliQ60565.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101835683.

Organism-specific databases

CTDi27012.

Phylogenomic databases

HOVERGENiHBG052230.
OrthoDBiEOG091G0FP3.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 2 hits.
PTHR11537:SF38. PTHR11537:SF38. 2 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNV1_MESAU
AccessioniPrimary (citable) accession number: Q60565
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.