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Q60565 (KCNV1_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv8.1
Gene names
Name:KCNV1
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Mesocricetus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes By similarity.

Subunit structure

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 By similarity.

Tissue specificity

Detected in brain, throughout layers II, IV and VI of the brain cortex. Detected in cerebellum and hippocampus, in the granule cell layer, Purkinje cell layer, pyramidal cell layer and dentate gyrus. Detected at lower levels in olfactory bulb, amygdala, thalamus, hypothalamus, midbrain and brainstem. Ref.1

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similarities

Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Potassium voltage-gated channel subfamily V member 1
PRO_0000308352

Regions

Topological domain1 – 214214Cytoplasmic Potential
Transmembrane215 – 23521Helical; Name=Segment S1; Potential
Topological domain236 – 2427Extracellular Potential
Transmembrane243 – 26321Helical; Name=Segment S2; Potential
Topological domain264 – 28017Cytoplasmic Potential
Transmembrane281 – 30121Helical; Name=Segment S3; Potential
Topological domain302 – 31312Extracellular Potential
Transmembrane314 – 33522Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain336 – 34914Cytoplasmic Potential
Transmembrane350 – 37021Helical; Name=Segment S5; Potential
Transmembrane411 – 43121Helical; Name=Segment S6; Potential
Topological domain432 – 50473Cytoplasmic Potential
Motif396 – 4016Selectivity filter By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60565 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BB667FB17E57A6F0

FASTA50456,725
        10         20         30         40         50         60 
MDLSPRNRPL LESSSLDSGG SLSSLDSSVF CSEGEGEPLA LGDCLTVNVG GSRFVLSQQA 

        70         80         90        100        110        120 
LSCFPHTRLG KLAVVVASYR RLGALAAAPS PLELCDDANP VDNEYFFDRS SQAFRYVLHY 

       130        140        150        160        170        180 
YRTGRLHVME QLCALSFLQE IQYWGIDELS IDSCCRDRYF RRKELSETLD FKKDTDDQES 

       190        200        210        220        230        240 
QHESEQDFSQ GPCPTVRQKL WDILEKPGSS TAARIFGVIS IIFVAVSIVN MALMSAELSW 

       250        260        270        280        290        300 
LNLQLLEILE YVCISWFTGE FILRFLCVKD RCRFLRKVPN IIDLLAILPF YITLLVESLS 

       310        320        330        340        350        360 
GSHTTQELEN VGRLVQVLRL LRALRMLKLG RHSTGLRSLG MTITQCYEEV GLLLLFLSVG 

       370        380        390        400        410        420 
ISIFSTIEYF AEQSIPDTTF TSVPCAWWWA TTSMTTVGYG DIRPDTTTGK IVAFMCILSG 

       430        440        450        460        470        480 
ILVLALPIAI INDRFSACYF TLKLKEAAVR QREALKKLTK NIATDSYISV NLRDVYARSI 

       490        500 
MEMLRLKGRE RASTRSSGGD DFWF

« Hide

References

[1]"Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels."
Hugnot J.-P., Salinas M., Lesage F., Guillemare E., de Weille J., Heurteaux C., Mattei M.-G., Lazdunski M.
EMBO J. 15:3322-3331(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U62810 mRNA. Translation: AAC52727.1.

3D structure databases

HSSPHSSP built from PDB template 2A79 based on UniProtKB P63142.
ProteinModelPortalQ60565.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG052230.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.
IPR003131. T1-type_BTB.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF02214. K_tetra. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKCNV1_MESAU
AccessionPrimary (citable) accession number: Q60565
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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