LIM homeobox transcription factor 1-beta - Mesocricetus auratus (Golden hamster)

Preferred order of sections

Names and origin

Protein names

Recommended name:
LIM homeobox transcription factor 1-beta

Alternative name(s):
LIM/homeobox protein 1.2
Short name=LMX-1.2
LIM/homeobox protein LMX1B

Gene names

Name:	LMX1B
Synonyms:	LMX1.2

Organism

Mesocricetus auratus (Golden hamster)

Taxonomic identifier

10036 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Mesocricetus

Protein attributes

Sequence length	369 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function

Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Mediates physical interaction and transcriptional synergy with E47/PAN-1.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox LIM domain Repeat
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Developmental protein
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 369

›369

LIM homeobox transcription factor 1-beta

PRO_0000075829

Regions

Domain

23 – 73

51

LIM zinc-binding 1

Domain

82 – 135

54

LIM zinc-binding 2

DNA binding

186 – 245

60

Homeobox

Compositional bias

249 – 255

7

Poly-Gln

Experimental info

Non-terminal residue

1

Sequences

Sequence

Length

Mass (Da)

Tools

Q60564 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7C054910561C5054
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FASTA

369

41,161

        10         20         30         40         50         60 
PLRPGPATLG VLLGSDCPHP AVCEGCQRPI SDRFLMRVNE SSWHEECLQC AACQQALTTS 

        70         80         90        100        110        120 
CYFRDRKLYC KQDYQQLFAA KCSGCMEKIA PTEFVMRALE CVYHLGCFCC CVCERQLRKG 

       130        140        150        160        170        180 
DEFVLKEGQL LCKGDYEKEK DLLSSVSPDE SDSVKSEDED GDMKPAKGQG SQSKGGGDDG 

       190        200        210        220        230        240 
KDPRRPKRPR TILTTQQRRA FKASFEVSSK PCRKVRETLA AETGLSVRVV QVWFQNQRAK 

       250        260        270        280        290        300 
MKKLARRHQQ QQEQQNSQRL GQEVLSSRME GMMASYTPLA PPQQQIVAME QSPCGSSDPF 

       310        320        330        340        350        360 
QQGLTPPQMP GDHMNPYGND SIFHDIDSDT SLTSLSDCFL GSSDVGSLQA RVGNPIDRLY 


SMQSSYFAS

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References

[1]	Zhang W., Johnson J.D., Rudnick A., German M.S. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U61141 mRNA. Translation: AAB62320.1.
3D structure databases
ProteinModelPortal	Q60564.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG052335.
Family and domain databases
Gene3D	1.10.10.60. 1 hit. 2.10.110.10. 2 hits.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF00412. LIM. 2 hits. [Graphical view]
SMART	SM00389. HOX. 1 hit. SM00132. LIM. 2 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LMX1B_MESAU

Accession

Primary (citable) accession number: Q60564

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families