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Protein

Protachykinin-1

Gene

TAC1

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide, Neurotransmitter

Names & Taxonomyi

Protein namesi
Recommended name:
Protachykinin-1
Alternative name(s):
PPT
Cleaved into the following 5 chains:
Neurokinin A
Short name:
NKA
Alternative name(s):
Neuromedin L
Substance K
Neuropeptide K
Short name:
NPK
Gene namesi
Name:TAC1
Synonyms:NKA, NKNA, TAC2
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003353620 – 56Sequence analysisAdd BLAST37
PeptideiPRO_000003353758 – 68Substance PAdd BLAST11
PeptideiPRO_000003353872 – 107Neuropeptide KAdd BLAST36
PeptideiPRO_000003353972 – 73Neuropeptide gamma, 1st part2
PeptideiPRO_000003354089 – 107Neuropeptide gamma, 2nd partAdd BLAST19
PeptideiPRO_000003354198 – 107Neurokinin A10
PeptideiPRO_0000033542111 – 126C-terminal-flanking peptideBy similarityAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68Methionine amideBy similarity1
Modified residuei107Methionine amideBy similarity1

Post-translational modificationi

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Cleavage; by FAPBy similarity2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Structurei

3D structure databases

ProteinModelPortaliQ60541.
SMRiQ60541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000127.

Family and domain databases

InterProiView protein in InterPro
IPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiView protein in SMART
SM00203. TK. 2 hits.
PROSITEiView protein in PROSITE
PS00267. TACHYKININ. 2 hits.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: Q60541-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILVAVAVF FLVSTQLSAE EIGANDDLNY WSDWSDSDQI KEALPEPFEH
60 70 80 90 100
ILQRIARRPK PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT
110 120 130
DSFVGLMGKR ALNSVAFERS AMQNYERRRK
Length:130
Mass (Da):14,907
Last modified:November 1, 1996 - v1
Checksum:iCC92E9371A646F2E
GO
Isoform Alpha (identifier: Q60541-3)
Sequence is not available
Length:
Mass (Da):
Isoform Gamma (identifier: Q60541-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.

Show »
Length:115
Mass (Da):13,247
Checksum:i31CFFBF27BACCF5A
GO
Isoform Delta (identifier: Q60541-4)
Sequence is not available
Length:
Mass (Da):

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00637874 – 88Missing in isoform Gamma. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80662 mRNA. Translation: CAA56691.1.
X80663 mRNA. Translation: CAA56692.1.
PIRiS47038.
S47039.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTKN1_MESAU
AccessioniPrimary (citable) accession number: Q60541
Secondary accession number(s): P49110
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families