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Protein

Telomerase Cajal body protein 1

Gene

Wrap53

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase Cajal body protein 1
Alternative name(s):
Guanine nucleotide-binding protein beta 5
WD repeat-containing protein 79
WD repeat-containing protein WRAP53
WD40 repeat-containing protein antisense to TP53 gene
Gene namesi
Name:Wrap53
Synonyms:Gnb5, Tcab1, Wdr79
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003673171 – 538Telomerase Cajal body protein 1Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei478PhosphothreonineBy similarity1
Modified residuei480PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Preferentially expressed in testis.1 Publication

Interactioni

Subunit structurei

Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ60525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati154 – 194WD 1Add BLAST41
Repeati210 – 255WD 2Add BLAST46
Repeati260 – 301WD 3Add BLAST42
Repeati311 – 352WD 4Add BLAST42
Repeati353 – 393WD 5Add BLAST41
Repeati399 – 438WD 6Add BLAST40

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOVERGENiHBG098609.
OrthoDBiEOG091G0FP1.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSEERLVV PDSLSSDQAP APVPQGSPVD ENTDSEPVPQ PCGGDDRSQV
60 70 80 90 100
AADSVAGSVV FQEPQQGHPL PLSAPLEVEF NTPGELSPRI EEQELSENVS
110 120 130 140 150
LPVEDTNQPE LASGEDVEGV SEEPGPVDEG DAFWSYNFSQ VPRYLSGSWS
160 170 180 190 200
EFRAHSENFL KGCKWAPDGS CILTNSADNT LRIYNLPPEL YSATEQVDYA
210 220 230 240 250
EMVPVLRMVE GDTIYDYCWY SLMSSSQPDT SYVASSSREN PIHIWDAFTG
260 270 280 290 300
ELRASFRAYN HLDELTAAHS LCFSPDGSQL FCGFNRTVRV FSTSRPGRDC
310 320 330 340 350
EVRATFAKKQ GQSGIISCIA FSPSQPLYAC GSYGRTLGLY AWDDGSPLAL
360 370 380 390 400
LGGHQGGITH LCFHPDGNLF FSGARKDAEL LCWDLRQPGH LLWSLSREVT
410 420 430 440 450
TNQRIYFDLD PSGQFLVSGN TNGMVSVWDI SGAFGDSSKL GPVMTFLPQK
460 470 480 490 500
DCTNGVSLHP SLPLLATASG QRMFPEPTNS GDEGEPEGDL PLLSLCHAHP
510 520 530
EWQLQLWWCG GGPDPSSPND PQDEKGQGRA EGCGDGLI
Length:538
Mass (Da):58,501
Last modified:November 1, 1996 - v1
Checksum:iEEA6C6955693E04E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13152 mRNA. Translation: AAA85261.1.
RefSeqiNP_001268518.1. NM_001281589.1.

Genome annotation databases

GeneIDi101834343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13152 mRNA. Translation: AAA85261.1.
RefSeqiNP_001268518.1. NM_001281589.1.

3D structure databases

ProteinModelPortaliQ60525.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101834343.

Organism-specific databases

CTDi55135.

Phylogenomic databases

HOVERGENiHBG098609.
OrthoDBiEOG091G0FP1.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWAP53_MESAU
AccessioniPrimary (citable) accession number: Q60525
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.