Q60489 (AT1B3_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3

Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name=ATPB-3
CD_antigen=CD298

Gene names

Name:

ATP1B3

Organism

Cavia porcellus (Guinea pig)

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known By similarity.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type II membrane protein. Melanosome By similarity.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium Sodium
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Sodium/potassium-transporting ATPase subunit beta-3		PRO_0000219107
Regions
	Topological domain	1 – 35	35	Cytoplasmic Potential
	Transmembrane	36 – 56	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	57 – 279	223	Extracellular Potential
Amino acid modifications
	Glycosylation	240	1	N-linked (GlcNAc...) Potential
	Disulfide bond	128 ↔ 144		By similarity
	Disulfide bond	154 ↔ 170		By similarity
	Disulfide bond	191 ↔ 250		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q60489 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EB87CB770D82DF7A	FASTA	279	31,570
	10 20 30 40 50 60 MTKSEKKSLN ESLAQWKLFL YNPTTREFLG RTAKSWGLIL LFYLVFYGFL AALFTFTMWA 70 80 90 100 110 120 MLQTLNDEIP KYRDQIPSPG LMVFPKPVTA LEYTFSVSDP SSYEGYIKDL KKFLKSYSLD 130 140 150 160 170 180 EQKNLNKCTD GVLFEQTGPV YAACQFPDSL LEACSGTDDP DFGYSQGQPC VLVKMNRIIG 190 200 210 220 230 240 LKPEGSPRID CISKDENTAM VSTYPNQGVI DLKYFPYYGK KLHVGYLQPL VAVQVSFGSN 250 260 270 STKKEVTVEC KIEGSKNLRN EDDRDKFLGR VAFKITARA

References

[1]	"Isolation of cDNA encoding the guinea pig Na+,K+-ATPase beta-3 subunit." Watanabe T., Sato M., Yoshida T., Suzuki Y. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Hartley. Tissue: Distal colon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D84448 mRNA. Translation: BAA12665.1.
RefSeq	NP_001166389.1. NM_001172918.1.
3D structure databases
ProteinModelPortal	Q60489.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCPOT00000003783; ENSCPOP00000003376; ENSCPOG00000003739.
GeneID	100135484.
Organism-specific databases
CTD	483.
Phylogenomic databases
eggNOG	roNOG06299.
GeneTree	ENSGT00550000074530.
HOVERGEN	HBG050603.
InParanoid	Q60489.
OMA	LMISPKP.
OrthoDB	EOG447FTQ.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view]
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AT1B3_CAVPO

Accession

Primary (citable) accession number: Q60489

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	September 21, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program