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Protein

Sodium/potassium-transporting ATPase subunit beta-3

Gene

ATP1B3

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name:
ATPB-3
CD_antigen: CD298
Gene namesi
Name:ATP1B3
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini57 – 279ExtracellularSequence analysisAdd BLAST223

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191071 – 279Sodium/potassium-transporting ATPase subunit beta-3Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi128 ↔ 144By similarity
Disulfide bondi154 ↔ 170By similarity
Disulfide bondi191 ↔ 250By similarity
Glycosylationi240N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000003376.

Structurei

3D structure databases

ProteinModelPortaliQ60489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 279immunoglobulin-likeBy similarityAdd BLAST94

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiQ60489.
OMAiQNINCTP.
OrthoDBiEOG091G0DJ4.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSEKKSLN ESLAQWKLFL YNPTTREFLG RTAKSWGLIL LFYLVFYGFL
60 70 80 90 100
AALFTFTMWA MLQTLNDEIP KYRDQIPSPG LMVFPKPVTA LEYTFSVSDP
110 120 130 140 150
SSYEGYIKDL KKFLKSYSLD EQKNLNKCTD GVLFEQTGPV YAACQFPDSL
160 170 180 190 200
LEACSGTDDP DFGYSQGQPC VLVKMNRIIG LKPEGSPRID CISKDENTAM
210 220 230 240 250
VSTYPNQGVI DLKYFPYYGK KLHVGYLQPL VAVQVSFGSN STKKEVTVEC
260 270
KIEGSKNLRN EDDRDKFLGR VAFKITARA
Length:279
Mass (Da):31,570
Last modified:November 1, 1996 - v1
Checksum:iEB87CB770D82DF7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84448 mRNA. Translation: BAA12665.1.
RefSeqiNP_001166389.1. NM_001172918.2.

Genome annotation databases

EnsembliENSCPOT00000003783; ENSCPOP00000003376; ENSCPOG00000003739.
GeneIDi100135484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84448 mRNA. Translation: BAA12665.1.
RefSeqiNP_001166389.1. NM_001172918.2.

3D structure databases

ProteinModelPortaliQ60489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000003376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000003783; ENSCPOP00000003376; ENSCPOG00000003739.
GeneIDi100135484.

Organism-specific databases

CTDi483.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiQ60489.
OMAiQNINCTP.
OrthoDBiEOG091G0DJ4.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1B3_CAVPO
AccessioniPrimary (citable) accession number: Q60489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.