Reviewed,
UniProtKB/Swiss-Prot Q60487 (FGF2_CAVPO)
Last modified
December 15, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Heparin-binding growth factor 2 Short name=HBGF-2 Alternative name(s): Fibroblast growth factor 2 Short name=FGF-2 Basic fibroblast growth factor Short name=BFGF Prostatic growth factor | ||
| Gene names |
| ||
| Organism | Cavia porcellus (Guinea pig) | ||
| Taxonomic identifier | 10141 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia |
Protein attributes
| Sequence length | 170 AA. |
| Sequence status | Fragments. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. |
| Subunit structure | Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2 By similarity. |
| Post-translational modification | The N-terminus of isoform 2 is blocked Probable. |
| Miscellaneous | This protein binds heparin more strongly than does aFGF By similarity. |
| Sequence similarities | Belongs to the heparin-binding growth factors family. |
| Sequence caution | The sequence AAA85394.1 differs from that shown. Reason: Frameshift at positions 77, 88, 93 and 149. The correction of the frameshifts allows to extend the similarity to the human sequence and is based on partial amino-acid sequencing. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Angiogenesis Differentiation |
| Coding sequence diversity | Alternative initiation |
| Ligand | Heparin-binding |
| Molecular function | Developmental protein Growth factor Mitogen |
| PTM | Methylation |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell divisionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW heparin bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative initiation. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q60487-1) Also known as: 25 kDa; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q60487-2) Also known as: 18 kDa; The sequence of this isoform differs from the canonical sequence as follows: 1-21: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | ‹1 – 170 | ›170 | Heparin-binding growth factor 2 | PRO_0000008930 | |||||
Regions | |||||||||
| Region | 143 – 159 | 17 | Heparin-binding By similarity | ||||||
Sites | |||||||||
| Binding site | 51 | 1 | Heparin By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 4 | 1 | Omega-N-methylarginine; alternate Ref.3 | ||||||
| Modified residue | 4 | 1 | Symmetric dimethylarginine; alternate Ref.3 | ||||||
| Modified residue | 6 | 1 | Omega-N-methylarginine; alternate Ref.3 | ||||||
| Modified residue | 6 | 1 | Symmetric dimethylarginine; alternate Ref.3 | ||||||
| Modified residue | 8 | 1 | Omega-N-methylarginine; alternate Ref.3 | ||||||
| Modified residue | 8 | 1 | Symmetric dimethylarginine; alternate Ref.3 | ||||||
Natural variations | |||||||||
| Alternative sequence | ‹1 – 21 | ›21 | Missing in isoform 2. | VSP_018726 | |||||
Experimental info | |||||||||
| Non-adjacent residues | 15 – 16 | 2 | |||||||
| Non-adjacent residues | 50 – 51 | 2 | |||||||
| Non-terminal residue | 1 | 1 | |||||||
Sequences
| ||||||||||||||||||||||||
References
| [1] | "An amino-terminally extended and post-translationally modified form of a 25kD basic fibroblast growth factor." Sommer A., Moscatelli D., Rifkin D.B. Biochem. Biophys. Res. Commun. 160:1267-1274(1989) [PubMed: 2730645] [Abstract] Cited for: PROTEIN SEQUENCE OF N-TERMINUS, PARTIAL PROTEIN SEQUENCE, ALTERNATIVE INITIATION. |
| [2] | Ricciardelli C. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-170. Tissue: Prostate. |
| [3] | "Direct evidence for methylation of arginine residues in high molecular weight forms of basic fibroblast growth factor." Burgess W.H., Bizik J., Mehlman T., Quarto N., Rifkin D.B. Cell Regul. 2:87-93(1991) [PubMed: 1713785] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, METHYLATION AT ARG-4; ARG-6 AND ARG-8. |
| [4] | "Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor." Moscatelli D., Joseph-Silverstein J., Manejias R., Rifkin D.B. Proc. Natl. Acad. Sci. U.S.A. 84:5778-5782(1987) [PubMed: 3475702] [Abstract] Cited for: CHARACTERIZATION. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| L75974 mRNA. Translation: AAA85394.1. Frameshift. | |
3D structure databases | |
| SMR | Q60487. Positions 22-170. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSCPOT00000005443; ENSCPOP00000004847; ENSCPOG00000005386; Cavia porcellus. [Genome view] |
Phylogenomic databases | |
| HOVERGEN | Q60487. |
| InParanoid | Q60487. |
Family and domain databases | |
| InterPro | IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view] |
| PANTHER | PTHR11486. IL1_HBGF. 1 hit. |
| Pfam | PF00167. FGF. 1 hit. [Graphical view] |
| PRINTS | PR00263. HBGFFGF. PR00262. IL1HBGF. |
| SMART | SM00442. FGF. 1 hit. [Graphical view] |
| PROSITE | PS00247. HBGF_FGF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FGF2_CAVPO | ||||||||
| Accession | Primary (citable) accession number: Q60487 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


