ID   PDYN_CAVPO              Reviewed;         245 AA.
AC   Q60478;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   24-JAN-2024, entry version 109.
DE   RecName: Full=Proenkephalin-B;
DE   AltName: Full=Beta-neoendorphin-dynorphin;
DE   AltName: Full=Preprodynorphin;
DE   Contains:
DE     RecName: Full=Alpha-neoendorphin;
DE   Contains:
DE     RecName: Full=Beta-neoendorphin;
DE   Contains:
DE     RecName: Full=Big dynorphin;
DE              Short=Big Dyn;
DE   Contains:
DE     RecName: Full=Dynorphin A(1-17);
DE              Short=Dyn-A17;
DE              Short=Dynorphin A;
DE   Contains:
DE     RecName: Full=Dynorphin A(1-13);
DE   Contains:
DE     RecName: Full=Dynorphin A(1-8);
DE   Contains:
DE     RecName: Full=Leu-enkephalin;
DE   Contains:
DE     RecName: Full=Rimorphin;
DE     AltName: Full=Dynorphin B;
DE              Short=Dyn-B;
DE     AltName: Full=Dynorphin B(1-13);
DE   Contains:
DE     RecName: Full=Leumorphin;
DE     AltName: Full=Dynorphin B-29;
DE   Flags: Precursor;
GN   Name=PDYN;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hartley; TISSUE=Adrenal gland, and Brain;
RX   PubMed=8985124; DOI=10.1089/dna.1996.15.1105;
RA   Yuferov V.P., Laforge K.S., Spangler R., Maggos C.E., Kreek M.J.;
RT   "Guinea pig preprodynorphin mRNA: primary structure and regional
RT   quantitation in the brain.";
RL   DNA Cell Biol. 15:1105-1112(1996).
RN   [2]
RP   IDENTIFICATION OF DYNORPHIN A(1-8); DYNORPHIN A(1-17) AND
RP   ALPHA-NEOENDORPHIN.
RX   PubMed=2565558; DOI=10.1016/0143-4179(89)90094-2;
RA   Steele P.A., Turner C.A., Murphy R.;
RT   "Measurement and chromatographic characterization of prodynorphin-derived
RT   peptides in the guinea-pig ileum.";
RL   Neuropeptides 13:207-213(1989).
CC   -!- FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate
CC       drugs. They play a role in a number of physiologic functions, including
CC       pain perception and responses to stress (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Dynorphin peptides differentially regulate the kappa opioid
CC       receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700
CC       times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Leumorphin has a typical opioid activity and may have anti-
CC       apoptotic effect. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: The N-terminal domain contains 6 conserved cysteines thought to be
CC       involved in disulfide bonding and/or processing.
CC   -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC       {ECO:0000305}.
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DR   EMBL; U38912; AAC18427.1; -; mRNA.
DR   PIR; A60410; A60410.
DR   RefSeq; NP_001166468.1; NM_001172997.1.
DR   AlphaFoldDB; Q60478; -.
DR   BMRB; Q60478; -.
DR   STRING; 10141.ENSCPOP00000019436; -.
DR   Ensembl; ENSCPOT00000022266.2; ENSCPOP00000019436.1; ENSCPOG00000024291.2.
DR   GeneID; 100135596; -.
DR   KEGG; cpoc:100135596; -.
DR   CTD; 5173; -.
DR   VEuPathDB; HostDB:ENSCPOG00000024291; -.
DR   eggNOG; ENOG502RXT4; Eukaryota.
DR   GeneTree; ENSGT00950000183149; -.
DR   HOGENOM; CLU_070973_1_0_1; -.
DR   InParanoid; Q60478; -.
DR   OMA; CSMCAVQ; -.
DR   OrthoDB; 5318835at2759; -.
DR   TreeFam; TF332620; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000024291; Expressed in hypothalamus and 4 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; IEA:Ensembl.
DR   GO; GO:0098992; C:neuronal dense core vesicle; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR006024; Opioid_neupept.
DR   InterPro; IPR000750; Proenkphlin_B.
DR   PANTHER; PTHR11438; PROENKEPHALIN; 1.
DR   PANTHER; PTHR11438:SF4; PROENKEPHALIN-B; 1.
DR   Pfam; PF01160; Opiods_neuropep; 1.
DR   PRINTS; PR01028; OPIOIDPRCRSR.
DR   PRINTS; PR01030; PENKBPRCRSR.
DR   PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Endorphin;
KW   Neuropeptide; Neurotransmitter; Opioid peptide; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..161
FT                   /id="PRO_0000008169"
FT   PEPTIDE         164..173
FT                   /note="Alpha-neoendorphin"
FT                   /id="PRO_0000306341"
FT   PEPTIDE         164..172
FT                   /note="Beta-neoendorphin"
FT                   /id="PRO_0000008170"
FT   PEPTIDE         164..168
FT                   /note="Leu-enkephalin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000306342"
FT   PROPEP          175..195
FT                   /id="PRO_0000008171"
FT   PEPTIDE         198..229
FT                   /note="Big dynorphin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000306343"
FT   PEPTIDE         198..214
FT                   /note="Dynorphin A(1-17)"
FT                   /id="PRO_0000008172"
FT   PEPTIDE         198..210
FT                   /note="Dynorphin A(1-13)"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000306344"
FT   PEPTIDE         198..205
FT                   /note="Dynorphin A(1-8)"
FT                   /id="PRO_0000306345"
FT   PEPTIDE         198..202
FT                   /note="Leu-enkephalin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000306346"
FT   PEPTIDE         217..245
FT                   /note="Leumorphin"
FT                   /id="PRO_0000008173"
FT   PEPTIDE         217..229
FT                   /note="Rimorphin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000008174"
FT   PEPTIDE         217..221
FT                   /note="Leu-enkephalin"
FT                   /id="PRO_0000008175"
SQ   SEQUENCE   245 AA;  27509 MW;  719B811A3683D19B CRC64;
     MVWPRLVLAA CLLAMPPAAA ECLSQCSLCA VRTQDGPKPI NPLICSLECQ ETLLPSEEWE
     RCQGILSFFP SALRLRDQSG LDSRAALEEV YGELAKRARP FLQELEKSRF LPSTPAEDKF
     RGLLGGLGEG LGSEAMGAPQ LNSGAVEAAA LDFDEDPKEQ VKRYGGFLRK YPKRSSEVAR
     EGDRDGDNAG HEDLYKRYGG FLRRIRPKLK WDNQKRYGGF LRRQFKVVTR SQEDPNAYSE
     EFFDV
//