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Q60478 (PDYN_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin

Cleaved into the following 9 chains:

  1. Alpha-neoendorphin
  2. Beta-neoendorphin
  3. Big dynorphin
    Short name=Big Dyn
  4. Dynorphin A(1-17)
    Short name=Dyn-A17
    Short name=Dynorphin A
  5. Dynorphin A(1-13)
  6. Dynorphin A(1-8)
  7. Leu-enkephalin
  8. Rimorphin
    Alternative name(s):
    Dynorphin B
    Short name=Dyn-B
    Dynorphin B(1-13)
  9. Leumorphin
    Alternative name(s):
    Dynorphin B-29
Gene names
Name:PDYN
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress By similarity.

Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin By similarity.

Leumorphin has a typical opiod activity and may have anti-apoptotic effect By similarity.

Subcellular location

Secreted.

Post-translational modification

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Sequence similarities

Belongs to the opioid neuropeptide precursor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 161141
PRO_0000008169
Peptide164 – 17310Alpha-neoendorphin
PRO_0000306341
Peptide164 – 1729Beta-neoendorphin
PRO_0000008170
Peptide164 – 1685Leu-enkephalin By similarity
PRO_0000306342
Propeptide175 – 19521
PRO_0000008171
Peptide198 – 22932Big dynorphin By similarity
PRO_0000306343
Peptide198 – 21417Dynorphin A(1-17)
PRO_0000008172
Peptide198 – 21013Dynorphin A(1-13) By similarity
PRO_0000306344
Peptide198 – 2058Dynorphin A(1-8)
PRO_0000306345
Peptide198 – 2025Leu-enkephalin By similarity
PRO_0000306346
Peptide217 – 24529Leumorphin
PRO_0000008173
Peptide217 – 22913Rimorphin By similarity
PRO_0000008174
Peptide217 – 2215Leu-enkephalin
PRO_0000008175

Sequences

Sequence LengthMass (Da)Tools
Q60478 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 719B811A3683D19B

FASTA24527,509
        10         20         30         40         50         60 
MVWPRLVLAA CLLAMPPAAA ECLSQCSLCA VRTQDGPKPI NPLICSLECQ ETLLPSEEWE 

        70         80         90        100        110        120 
RCQGILSFFP SALRLRDQSG LDSRAALEEV YGELAKRARP FLQELEKSRF LPSTPAEDKF 

       130        140        150        160        170        180 
RGLLGGLGEG LGSEAMGAPQ LNSGAVEAAA LDFDEDPKEQ VKRYGGFLRK YPKRSSEVAR 

       190        200        210        220        230        240 
EGDRDGDNAG HEDLYKRYGG FLRRIRPKLK WDNQKRYGGF LRRQFKVVTR SQEDPNAYSE 


EFFDV 

« Hide

References

[1]"Guinea pig preprodynorphin mRNA: primary structure and regional quantitation in the brain."
Yuferov V.P., Laforge K.S., Spangler R., Maggos C.E., Kreek M.J.
DNA Cell Biol. 15:1105-1112(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hartley.
Tissue: Adrenal gland and Brain.
[2]"Measurement and chromatographic characterization of prodynorphin-derived peptides in the guinea-pig ileum."
Steele P.A., Turner C.A., Murphy R.
Neuropeptides 13:207-213(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF DYNORPHIN A(1-8); DYNORPHIN A(1-17) AND ALPHA-NEOENDORPHIN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U38912 mRNA. Translation: AAC18427.1.
PIRA60410.
RefSeqNP_001166468.1. NM_001172997.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000019436.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000022266; ENSCPOP00000019436; ENSCPOG00000024291.
GeneID100135596.

Organism-specific databases

CTD5173.

Phylogenomic databases

eggNOGNOG46156.
GeneTreeENSGT00530000063761.
HOGENOMHOG000013003.
HOVERGENHBG000063.
InParanoidQ60478.
OMAWERCQGL.
OrthoDBEOG7BW0K5.
TreeFamTF332620.

Family and domain databases

InterProIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDYN_CAVPO
AccessionPrimary (citable) accession number: Q60478
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families