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Protein

Proenkephalin-B

Gene

PDYN

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).By similarity
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).By similarity
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndorphin, Neuropeptide, Neurotransmitter, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin
Cleaved into the following 9 chains:
Big dynorphin
Short name:
Big Dyn
Dynorphin A(1-17)
Short name:
Dyn-A17
Short name:
Dynorphin A
Alternative name(s):
Dynorphin B
Short name:
Dyn-B
Dynorphin B(1-13)
Alternative name(s):
Dynorphin B-29
Gene namesi
Name:PDYN
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000000816921 – 161Add BLAST141
PeptideiPRO_0000306341164 – 173Alpha-neoendorphin10
PeptideiPRO_0000008170164 – 172Beta-neoendorphin9
PeptideiPRO_0000306342164 – 168Leu-enkephalinBy similarity5
PropeptideiPRO_0000008171175 – 195Add BLAST21
PeptideiPRO_0000306343198 – 229Big dynorphinBy similarityAdd BLAST32
PeptideiPRO_0000008172198 – 214Dynorphin A(1-17)Add BLAST17
PeptideiPRO_0000306344198 – 210Dynorphin A(1-13)By similarityAdd BLAST13
PeptideiPRO_0000306345198 – 205Dynorphin A(1-8)8
PeptideiPRO_0000306346198 – 202Leu-enkephalinBy similarity5
PeptideiPRO_0000008173217 – 245LeumorphinAdd BLAST29
PeptideiPRO_0000008174217 – 229RimorphinBy similarityAdd BLAST13
PeptideiPRO_0000008175217 – 221Leu-enkephalin5

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Gene expression databases

BgeeiENSCPOG00000024291.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019436.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIMD. Eukaryota.
ENOG4111RTT. LUCA.
GeneTreeiENSGT00530000063761.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiQ60478.
OMAiWERCQGL.
OrthoDBiEOG091G0HV8.
TreeFamiTF332620.

Family and domain databases

InterProiView protein in InterPro
IPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF5. PTHR11438:SF5. 1 hit.
PfamiView protein in Pfam
PF01160. Opiods_neuropep. 1 hit.
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiView protein in PROSITE
PS01252. OPIOIDS_PRECURSOR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWPRLVLAA CLLAMPPAAA ECLSQCSLCA VRTQDGPKPI NPLICSLECQ
60 70 80 90 100
ETLLPSEEWE RCQGILSFFP SALRLRDQSG LDSRAALEEV YGELAKRARP
110 120 130 140 150
FLQELEKSRF LPSTPAEDKF RGLLGGLGEG LGSEAMGAPQ LNSGAVEAAA
160 170 180 190 200
LDFDEDPKEQ VKRYGGFLRK YPKRSSEVAR EGDRDGDNAG HEDLYKRYGG
210 220 230 240
FLRRIRPKLK WDNQKRYGGF LRRQFKVVTR SQEDPNAYSE EFFDV
Length:245
Mass (Da):27,509
Last modified:November 1, 1997 - v1
Checksum:i719B811A3683D19B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38912 mRNA. Translation: AAC18427.1.
PIRiA60410.
RefSeqiNP_001166468.1. NM_001172997.1.

Genome annotation databases

EnsembliENSCPOT00000022266; ENSCPOP00000019436; ENSCPOG00000024291.
GeneIDi100135596.

Similar proteinsi

Entry informationi

Entry nameiPDYN_CAVPO
AccessioniPrimary (citable) accession number: Q60478
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families