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Q60478

- PDYN_CAVPO

UniProt

Q60478 - PDYN_CAVPO

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Protein

Proenkephalin-B

Gene

PDYN

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).By similarity
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).By similarity
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
  2. synaptic transmission Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin
Cleaved into the following 9 chains:
Big dynorphin
Short name:
Big Dyn
Dynorphin A(1-17)
Short name:
Dyn-A17
Short name:
Dynorphin A
Alternative name(s):
Dynorphin B
Short name:
Dyn-B
Dynorphin B(1-13)
Alternative name(s):
Dynorphin B-29
Gene namesi
Name:PDYN
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 161141PRO_0000008169Add
BLAST
Peptidei164 – 17310Alpha-neoendorphinPRO_0000306341
Peptidei164 – 1729Beta-neoendorphinPRO_0000008170
Peptidei164 – 1685Leu-enkephalinBy similarityPRO_0000306342
Propeptidei175 – 19521PRO_0000008171Add
BLAST
Peptidei198 – 22932Big dynorphinBy similarityPRO_0000306343Add
BLAST
Peptidei198 – 21417Dynorphin A(1-17)PRO_0000008172Add
BLAST
Peptidei198 – 21013Dynorphin A(1-13)By similarityPRO_0000306344Add
BLAST
Peptidei198 – 2058Dynorphin A(1-8)PRO_0000306345
Peptidei198 – 2025Leu-enkephalinBy similarityPRO_0000306346
Peptidei217 – 24529LeumorphinPRO_0000008173Add
BLAST
Peptidei217 – 22913RimorphinBy similarityPRO_0000008174Add
BLAST
Peptidei217 – 2215Leu-enkephalinPRO_0000008175

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019436.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46156.
GeneTreeiENSGT00530000063761.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiQ60478.
OMAiWERCQGL.
OrthoDBiEOG7BW0K5.
TreeFamiTF332620.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60478-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVWPRLVLAA CLLAMPPAAA ECLSQCSLCA VRTQDGPKPI NPLICSLECQ
60 70 80 90 100
ETLLPSEEWE RCQGILSFFP SALRLRDQSG LDSRAALEEV YGELAKRARP
110 120 130 140 150
FLQELEKSRF LPSTPAEDKF RGLLGGLGEG LGSEAMGAPQ LNSGAVEAAA
160 170 180 190 200
LDFDEDPKEQ VKRYGGFLRK YPKRSSEVAR EGDRDGDNAG HEDLYKRYGG
210 220 230 240
FLRRIRPKLK WDNQKRYGGF LRRQFKVVTR SQEDPNAYSE EFFDV
Length:245
Mass (Da):27,509
Last modified:November 1, 1997 - v1
Checksum:i719B811A3683D19B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38912 mRNA. Translation: AAC18427.1.
PIRiA60410.
RefSeqiNP_001166468.1. NM_001172997.1.

Genome annotation databases

EnsembliENSCPOT00000022266; ENSCPOP00000019436; ENSCPOG00000024291.
GeneIDi100135596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38912 mRNA. Translation: AAC18427.1 .
PIRi A60410.
RefSeqi NP_001166468.1. NM_001172997.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000019436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000022266 ; ENSCPOP00000019436 ; ENSCPOG00000024291 .
GeneIDi 100135596.

Organism-specific databases

CTDi 5173.

Phylogenomic databases

eggNOGi NOG46156.
GeneTreei ENSGT00530000063761.
HOGENOMi HOG000013003.
HOVERGENi HBG000063.
InParanoidi Q60478.
OMAi WERCQGL.
OrthoDBi EOG7BW0K5.
TreeFami TF332620.

Family and domain databases

InterProi IPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
Pfami PF01160. Opiods_neuropep. 1 hit.
[Graphical view ]
PRINTSi PR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Guinea pig preprodynorphin mRNA: primary structure and regional quantitation in the brain."
    Yuferov V.P., Laforge K.S., Spangler R., Maggos C.E., Kreek M.J.
    DNA Cell Biol. 15:1105-1112(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.
    Tissue: Adrenal gland and Brain.
  2. "Measurement and chromatographic characterization of prodynorphin-derived peptides in the guinea-pig ileum."
    Steele P.A., Turner C.A., Murphy R.
    Neuropeptides 13:207-213(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF DYNORPHIN A(1-8); DYNORPHIN A(1-17) AND ALPHA-NEOENDORPHIN.

Entry informationi

Entry nameiPDYN_CAVPO
AccessioniPrimary (citable) accession number: Q60478
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3