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Q60478

- PDYN_CAVPO

UniProt

Q60478 - PDYN_CAVPO

Protein

Proenkephalin-B

Gene

PDYN

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress By similarity.By similarity
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin By similarity.By similarity
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW
    2. synaptic transmission Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proenkephalin-B
    Alternative name(s):
    Beta-neoendorphin-dynorphin
    Preprodynorphin
    Cleaved into the following 9 chains:
    Big dynorphin
    Short name:
    Big Dyn
    Dynorphin A(1-17)
    Short name:
    Dyn-A17
    Short name:
    Dynorphin A
    Alternative name(s):
    Dynorphin B
    Short name:
    Dyn-B
    Dynorphin B(1-13)
    Alternative name(s):
    Dynorphin B-29
    Gene namesi
    Name:PDYN
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 161141PRO_0000008169Add
    BLAST
    Peptidei164 – 17310Alpha-neoendorphinPRO_0000306341
    Peptidei164 – 1729Beta-neoendorphinPRO_0000008170
    Peptidei164 – 1685Leu-enkephalinBy similarityPRO_0000306342
    Propeptidei175 – 19521PRO_0000008171Add
    BLAST
    Peptidei198 – 22932Big dynorphinBy similarityPRO_0000306343Add
    BLAST
    Peptidei198 – 21417Dynorphin A(1-17)PRO_0000008172Add
    BLAST
    Peptidei198 – 21013Dynorphin A(1-13)By similarityPRO_0000306344Add
    BLAST
    Peptidei198 – 2058Dynorphin A(1-8)PRO_0000306345
    Peptidei198 – 2025Leu-enkephalinBy similarityPRO_0000306346
    Peptidei217 – 24529LeumorphinPRO_0000008173Add
    BLAST
    Peptidei217 – 22913RimorphinBy similarityPRO_0000008174Add
    BLAST
    Peptidei217 – 2215Leu-enkephalinPRO_0000008175

    Post-translational modificationi

    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000019436.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46156.
    GeneTreeiENSGT00530000063761.
    HOGENOMiHOG000013003.
    HOVERGENiHBG000063.
    InParanoidiQ60478.
    OMAiWERCQGL.
    OrthoDBiEOG7BW0K5.
    TreeFamiTF332620.

    Family and domain databases

    InterProiIPR006024. Opioid_neupept.
    IPR000750. Proenkphlin_B.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF4. PTHR11438:SF4. 1 hit.
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]
    PRINTSiPR01028. OPIOIDPRCRSR.
    PR01030. PENKBPRCRSR.
    PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60478-1 [UniParc]FASTAAdd to Basket

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    MVWPRLVLAA CLLAMPPAAA ECLSQCSLCA VRTQDGPKPI NPLICSLECQ    50
    ETLLPSEEWE RCQGILSFFP SALRLRDQSG LDSRAALEEV YGELAKRARP 100
    FLQELEKSRF LPSTPAEDKF RGLLGGLGEG LGSEAMGAPQ LNSGAVEAAA 150
    LDFDEDPKEQ VKRYGGFLRK YPKRSSEVAR EGDRDGDNAG HEDLYKRYGG 200
    FLRRIRPKLK WDNQKRYGGF LRRQFKVVTR SQEDPNAYSE EFFDV 245
    Length:245
    Mass (Da):27,509
    Last modified:November 1, 1997 - v1
    Checksum:i719B811A3683D19B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38912 mRNA. Translation: AAC18427.1.
    PIRiA60410.
    RefSeqiNP_001166468.1. NM_001172997.1.

    Genome annotation databases

    EnsembliENSCPOT00000022266; ENSCPOP00000019436; ENSCPOG00000024291.
    GeneIDi100135596.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38912 mRNA. Translation: AAC18427.1 .
    PIRi A60410.
    RefSeqi NP_001166468.1. NM_001172997.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000019436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000022266 ; ENSCPOP00000019436 ; ENSCPOG00000024291 .
    GeneIDi 100135596.

    Organism-specific databases

    CTDi 5173.

    Phylogenomic databases

    eggNOGi NOG46156.
    GeneTreei ENSGT00530000063761.
    HOGENOMi HOG000013003.
    HOVERGENi HBG000063.
    InParanoidi Q60478.
    OMAi WERCQGL.
    OrthoDBi EOG7BW0K5.
    TreeFami TF332620.

    Family and domain databases

    InterProi IPR006024. Opioid_neupept.
    IPR000750. Proenkphlin_B.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF4. PTHR11438:SF4. 1 hit.
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    PRINTSi PR01028. OPIOIDPRCRSR.
    PR01030. PENKBPRCRSR.
    PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Guinea pig preprodynorphin mRNA: primary structure and regional quantitation in the brain."
      Yuferov V.P., Laforge K.S., Spangler R., Maggos C.E., Kreek M.J.
      DNA Cell Biol. 15:1105-1112(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hartley.
      Tissue: Adrenal gland and Brain.
    2. "Measurement and chromatographic characterization of prodynorphin-derived peptides in the guinea-pig ileum."
      Steele P.A., Turner C.A., Murphy R.
      Neuropeptides 13:207-213(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF DYNORPHIN A(1-8); DYNORPHIN A(1-17) AND ALPHA-NEOENDORPHIN.

    Entry informationi

    Entry nameiPDYN_CAVPO
    AccessioniPrimary (citable) accession number: Q60478
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3