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Protein

NADPH--cytochrome P450 reductase

Gene

POR

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotationNote: Binds 1 FAD per monomer.UniRule annotation
  • FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197FMNUniRule annotation1
Binding sitei287NADPUniRule annotation1
Binding sitei413FADUniRule annotation1
Binding sitei467FADUniRule annotation1
Binding sitei524NADPUniRule annotation1
Binding sitei628NADPUniRule annotation1
Binding sitei666FADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 80FMNUniRule annotation6
Nucleotide bindingi127 – 130FMNUniRule annotation4
Nucleotide bindingi162 – 171FMNUniRule annotation10
Nucleotide bindingi443 – 446FADUniRule annotation4
Nucleotide bindingi461 – 463FADUniRule annotation3
Nucleotide bindingi477 – 480FADUniRule annotation4
Nucleotide bindingi585 – 586NADPUniRule annotation2
Nucleotide bindingi591 – 595NADPUniRule annotation5

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, FMNUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH--cytochrome P450 reductaseUniRule annotation (EC:1.6.2.4UniRule annotation)
Short name:
CPRUniRule annotation
Short name:
P450RUniRule annotation
Gene namesi
Name:PORUniRule annotation
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)Imported
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ60451

Structurei

3D structure databases

ProteinModelPortaliQ60451
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 213Flavodoxin-likeInterPro annotationAdd BLAST145
Domaini268 – 510FAD-binding FR-typeInterPro annotationAdd BLAST243

Sequence similaritiesi

Belongs to the NADPH--cytochrome P450 reductase family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOVERGENiHBG000432
KOiK00327

Family and domain databases

Gene3Di1.20.990.10, 4 hits
3.40.50.360, 1 hit
HAMAPiMF_03212 NCPR, 1 hit
InterProiView protein in InterPro
IPR003097 FAD-binding_1
IPR017927 Fd_Rdtase_FAD-bd
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR001433 OxRdtase_FAD/NAD-bd
IPR023208 P450R
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF00258 Flavodoxin_1, 1 hit
PF00175 NAD_binding_1, 1 hit
PIRSFiPIRSF000208 P450R, 1 hit
PRINTSiPR00369 FLAVODOXIN
PR00371 FPNCR
SUPFAMiSSF52218 SSF52218, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q60451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAVAEEVS LFSTTDVVLF SLIVGVLTYW FIFRKKKEEV PEFSKIQTAT
60 70 80 90 100
PSVKESSFVE KMKKTGRNII VFYGSQTGTA EEFANRLSKD AHRYGMRGMS
110 120 130 140 150
ADPEEYDLAD LSSLPEIDKS LVVFCMATYG EGDPTDNAQD FYDWLQETDV
160 170 180 190 200
DLTGVKFAVF GLGNKTYEHF NAMGKYVDQR LEQLGAQRIF ELGLGDDDGN
210 220 230 240 250
LEEDFITWRE QFWPAVCEFF GVEATGEESS IRQYELLVHE DIDAAKVYTG
260 270 280 290 300
EMGRLKSYEN QKPPFDAKNP FLAAVTTNRK LNQGTERHLM HLELDISDSK
310 320 330 340 350
IRYESGDHVA VYPANDSTLV NQIGEILGAD LDVVMSLNNL DEESNKKHPF
360 370 380 390 400
PCPTTYRTAL TYYLDITNPP RTNVLYELAQ YASEPSEQEQ LHKMASSSGE
410 420 430 440 450
GKELYLSWVV EARRHILAIL QDYPSLRPPI DHLCELLPRL QARYYSIASS
460 470 480 490 500
SKVHPNSVHI CAVAVEYEAK SGRVNKGVAT SWLRAKEPAG ENGRRALVPM
510 520 530 540 550
FVRKSQFRLP FKSVTPVIMV GPGTGIAPFM GFIQERAWLR EQGKEVGETL
560 570 580 590 600
LYYGCRRSDE DYLYREELAR FHKDGALTQL NVAFSREQAH KVYVQHLLKR
610 620 630 640 650
DREHLWKLIH EGGAHIYVCG DARNMAKDVQ NTFYDIVAEF GPMEHAQAVD
660
YVKKLMTKGR YSLDVWS
Length:667
Mass (Da):75,851
Last modified:November 1, 1996 - v1
Checksum:i2023F43DF4C1EF07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83230 mRNA Translation: BAA11856.1
RefSeqiNP_001231204.1, NM_001244275.1

Genome annotation databases

GeneIDi107976996
KEGGicge:100689241

Similar proteinsi

Entry informationi

Entry nameiQ60451_CRIGR
AccessioniPrimary (citable) accession number: Q60451
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health