Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kinesin-like protein KIFC1

Gene
N/A
Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:7744954). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi360 – 367ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC1
Alternative name(s):
CHO2 antigen
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003020881 – 622Kinesin-like protein KIFC1Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei309PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ60443

Interactioni

Subunit structurei

Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ60443
SMRiQ60443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 612Kinesin motorPROSITE-ProRule annotationAdd BLAST353

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili95 – 264Sequence analysisAdd BLAST170

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG001080

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q60443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEALEPAKK RTRGLGAVTK IDTSRSKGPL LSSLSQPQGP TAAQKGPKKT
60 70 80 90 100
GPRGCTAVGS VLKNQKLAPT APAQKPVRKR PGKRPDWDLK GQLCDLTEEL
110 120 130 140 150
KCYREKTQKL DQENQGLQEQ LKEAQEQAAA LGTERNTLEG ELASVRTQAE
160 170 180 190 200
QCQQKLEALC ARVLELEEWL GTKENLIQEL QKEQLELQEE RKALATRLEE
210 220 230 240 250
QERRLQASEA ALLSNESEVV CLRQKTAAQV TLLAEQGDRL HGLEMERRRL
260 270 280 290 300
HNQLQELKGN IRVFCRVRPV LAGEPTPSPG FLLFPHGPAG PSDPPTRLSL
310 320 330 340 350
SRSDDRRSTL TRAPAPTTRH DFSFDRVFPP GSKQEEVFEE ISMLVQSALD
360 370 380 390 400
GYPVCIFAYG QTGSGKTFTM EGRPGGDPQL EGLIPRRMRH LFSVAQEMSG
410 420 430 440 450
QGWTYSFVAS YVEIYNETVR DLLATGTRKG QGECEIRRAR PGSEELTVTN
460 470 480 490 500
ARYVPVSCER EVEALLHLAH QNRAVARTAQ NERSSRSHSV FQLQISGEHA
510 520 530 540 550
ARGLQCVAPL NLVDLAGSER LDPGLTLGPG ERDRLRETQS INSSLSTLGL
560 570 580 590 600
VIMALSNKES HVPYRNSKLT YLLQNSLGGS AKMLMFVNIS PLEENVSESL
610 620
NSLRFASKVN QCVIGTAQAN KK
Length:622
Mass (Da):68,821
Last modified:November 1, 1996 - v1
Checksum:iC40B01ECC79B6DBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83576 mRNA Translation: CAA58559.1
PIRiA57281

Similar proteinsi

Entry informationi

Entry nameiKIFC1_CRIGR
AccessioniPrimary (citable) accession number: Q60443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health