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Protein

Kinesin-like protein KIFC1

Gene
N/A
Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:7744954). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi360 – 3678ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC1
Alternative name(s):
CHO2 antigen
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: UniProtKB-SubCell
  • microtubule Source: UniProtKB-KW
  • microtubule organizing center Source: UniProtKB-SubCell
  • midbody Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Kinesin-like protein KIFC1PRO_0000302088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ60443.
SMRiQ60443. Positions 260-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini260 – 612353Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili95 – 264170Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG001080.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEALEPAKK RTRGLGAVTK IDTSRSKGPL LSSLSQPQGP TAAQKGPKKT
60 70 80 90 100
GPRGCTAVGS VLKNQKLAPT APAQKPVRKR PGKRPDWDLK GQLCDLTEEL
110 120 130 140 150
KCYREKTQKL DQENQGLQEQ LKEAQEQAAA LGTERNTLEG ELASVRTQAE
160 170 180 190 200
QCQQKLEALC ARVLELEEWL GTKENLIQEL QKEQLELQEE RKALATRLEE
210 220 230 240 250
QERRLQASEA ALLSNESEVV CLRQKTAAQV TLLAEQGDRL HGLEMERRRL
260 270 280 290 300
HNQLQELKGN IRVFCRVRPV LAGEPTPSPG FLLFPHGPAG PSDPPTRLSL
310 320 330 340 350
SRSDDRRSTL TRAPAPTTRH DFSFDRVFPP GSKQEEVFEE ISMLVQSALD
360 370 380 390 400
GYPVCIFAYG QTGSGKTFTM EGRPGGDPQL EGLIPRRMRH LFSVAQEMSG
410 420 430 440 450
QGWTYSFVAS YVEIYNETVR DLLATGTRKG QGECEIRRAR PGSEELTVTN
460 470 480 490 500
ARYVPVSCER EVEALLHLAH QNRAVARTAQ NERSSRSHSV FQLQISGEHA
510 520 530 540 550
ARGLQCVAPL NLVDLAGSER LDPGLTLGPG ERDRLRETQS INSSLSTLGL
560 570 580 590 600
VIMALSNKES HVPYRNSKLT YLLQNSLGGS AKMLMFVNIS PLEENVSESL
610 620
NSLRFASKVN QCVIGTAQAN KK
Length:622
Mass (Da):68,821
Last modified:November 1, 1996 - v1
Checksum:iC40B01ECC79B6DBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83576 mRNA. Translation: CAA58559.1.
PIRiA57281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83576 mRNA. Translation: CAA58559.1.
PIRiA57281.

3D structure databases

ProteinModelPortaliQ60443.
SMRiQ60443. Positions 260-610.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG001080.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a minus end-directed kinesin-like motor protein from cultured mammalian cells."
    Kuriyama R., Kofron M., Essner R., Kato T., Dragas-Granoic S., Omoto C.K., Khodjakov A.
    J. Cell Biol. 129:1049-1059(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiKIFC1_CRIGR
AccessioniPrimary (citable) accession number: Q60443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.