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Q60437

- BAIP2_CRIGR

UniProt

Q60437 - BAIP2_CRIGR

Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2

Gene

BAIAP2

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions By similarity.By similarity

    GO - Molecular functioni

    1. proline-rich region binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. actin crosslink formation Source: UniProtKB
    2. actin filament bundle assembly Source: UniProtKB
    3. filopodium assembly Source: InterPro
    4. regulation of actin cytoskeleton organization Source: UniProtKB
    5. regulation of cell shape Source: UniProtKB
    6. response to bacterium Source: UniProtKB
    7. signal transduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-specific angiogenesis inhibitor 1-associated protein 2
    Short name:
    BAI-associated protein 2
    Short name:
    BAI1-associated protein 2
    Alternative name(s):
    Insulin receptor substrate protein of 53 kDa
    Short name:
    IRSp53
    Short name:
    Insulin receptor substrate p53
    Insulin receptor tyrosine kinase 53 kDa substrate
    p58/p53
    Gene namesi
    Name:BAIAP2
    OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
    Taxonomic identifieri10029 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity. Cell projectionfilopodium By similarity. Cell projectionruffle By similarity. Cytoplasmcytoskeleton By similarity
    Note: Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites By similarity.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. cytosol Source: UniProtKB
    3. filopodium Source: UniProtKB-SubCell
    4. membrane Source: UniProtKB-SubCell
    5. ruffle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Brain-specific angiogenesis inhibitor 1-associated protein 2PRO_0000064815Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei324 – 3241PhosphoserineBy similarity
    Modified residuei326 – 3261PhosphoserineBy similarity
    Modified residuei341 – 3411PhosphothreonineBy similarity
    Modified residuei347 – 3471PhosphoserineBy similarity
    Modified residuei367 – 3671PhosphoserineBy similarity
    Modified residuei455 – 4551PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine residues by INSR in response to insulin treatment.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ60437.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, DIAPH1, EPS8, SHANK1, SHANK2, SHANK3, TIAM1, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCKIPSDQ9NZQ33EBI-7010040,EBI-745080From a different organism.

    Protein-protein interaction databases

    IntActiQ60437. 1 interaction.
    MINTiMINT-5314315.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60437.
    SMRiQ60437. Positions 1-248, 379-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 250250IMDPROSITE-ProRule annotationAdd
    BLAST
    Domaini375 – 43864SH3PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili132 – 15322Sequence AnalysisAdd
    BLAST

    Domaini

    The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation By similarity.By similarity
    The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.By similarity

    Sequence similaritiesi

    Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    HOVERGENiHBG054462.

    Family and domain databases

    InterProiIPR027681. BAIAP2.
    IPR013606. IRSp53/MIM_homology_IMD.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR14206. PTHR14206. 1 hit.
    PfamiPF08397. IMD. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS51338. IMD. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60437-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTFAAK    50
    GYFDALVKMG ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE 100
    LLTQLEQKVE LDSRYLSAAL KKYQAEQRSK GDALDKCQAE LKKLRKKSQG 150
    SKNPQKYSDK ELQYIDAISN KQGELENYVS DGYKTALTEE RRRFCFLVEK 200
    QCAVAKNSAA YHSKGKELLA QKLPVWQQAC ADPNKIPDRA VQLMQQIASS 250
    NGSILPSTLS ASKSNLVISD PIPGAKPLPV PPELAPFVGR MSAQENVPVM 300
    NGVAGPDSED YNPWADRKAA QPKSLSPPQS QSKLSDSYSN TLPVRKSVTP 350
    KNSYATTENK TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG 400
    DLITLLVPEA RDGWHYGESE KTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ 450
    GKSSSTGNLL DKDDLAVPPP DYGTSSRAFP TQTAGTFKQR PYSVAVPAFS 500
    QGLDDYGARS VSSADVEVAR F 521
    Length:521
    Mass (Da):57,639
    Last modified:November 1, 1996 - v1
    Checksum:i58485BD6CAC15DC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41899 mRNA. Translation: AAC52436.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41899 mRNA. Translation: AAC52436.1 .

    3D structure databases

    ProteinModelPortali Q60437.
    SMRi Q60437. Positions 1-248, 379-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q60437. 1 interaction.
    MINTi MINT-5314315.

    Proteomic databases

    PRIDEi Q60437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG054462.

    Family and domain databases

    InterProi IPR027681. BAIAP2.
    IPR013606. IRSp53/MIM_homology_IMD.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR14206. PTHR14206. 1 hit.
    Pfami PF08397. IMD. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS51338. IMD. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase."
      Yeh T.C., Ogawa W., Danielsen A.G., Roth R.A.
      J. Biol. Chem. 271:2921-2928(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 71-84 AND 264-285, PHOSPHORYLATION AT TYROSINE RESIDUES.
      Tissue: Ovary.

    Entry informationi

    Entry nameiBAIP2_CRIGR
    AccessioniPrimary (citable) accession number: Q60437
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3