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Protein

Scavenger receptor class B member 1

Gene

SCARB1

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). Plays an important role in the uptake of HDL cholesteryl ester (By similarity).By similarity

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class B member 1
Short name:
SRB1
Alternative name(s):
HaSR-BI
SR-BI
Gene namesi
Name:SCARB1
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Topological domaini33 – 440408ExtracellularSequence analysisAdd
BLAST
Transmembranei441 – 46121HelicalSequence analysisAdd
BLAST
Topological domaini462 – 50948CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Scavenger receptor class B member 1PRO_0000144159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi251 ↔ 384By similarity
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity
The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106577.
KOiK13885.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

Q60417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGSARARWV AVGLGVVGLL CAVLGVVMIL VMPSLIKQQV LKNVRIDPSS
60 70 80 90 100
LSFAMWKEIP VPFYLSVYFF EVVNPSEILK GEKPVVRERG PYVYREFRHK
110 120 130 140 150
ANITFNDNDT VSFVEHRSLH FQPDRSHGSE SDYIILPNIL VLGGAVMMES
160 170 180 190 200
KSAGLKLMMT LGLATLGQRA FMNRTVGEIL WGYEDPFVNF INKYLPDMFP
210 220 230 240 250
IKGKFGLFVE MNNSDSGLFT VFTGVQNFSK IHLVDRWNGL SKVNYWHSEQ
260 270 280 290 300
CNMINGTSGQ MWAPFMTPQS SLEFFSPEAC RSMKLTYHDS GVFEGIPTYR
310 320 330 340 350
FTAPKTLFAN GSVYPPNEGF CPCLESGIQN VSTCRFGAPL FLSHPHFYNA
360 370 380 390 400
DPVLSEAVLG LNPDPREHSL FLDIHPVTGI PMNCSVKLQI SLYIKAVKGI
410 420 430 440 450
GQTGKIEPVV LPLLWFEQSG AMGGEPLNTF YTQLVLMPQV LQYVQYVLLG
460 470 480 490 500
LGGLLLLVPV IYQLRSQEKC FLFWSGSKKG SQDKEAIQAY SESLMSPAAK

GTVLQEAKL
Length:509
Mass (Da):56,735
Last modified:November 1, 1996 - v1
Checksum:i1A7C0F5F6CB61A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11453 mRNA. Translation: AAA61572.1.
PIRiA53920.
RefSeqiNP_001231777.1. NM_001244848.2.

Genome annotation databases

GeneIDi100736552.
KEGGicge:100736552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11453 mRNA. Translation: AAA61572.1.
PIRiA53920.
RefSeqiNP_001231777.1. NM_001244848.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100736552.
KEGGicge:100736552.

Organism-specific databases

CTDi949.

Phylogenomic databases

HOVERGENiHBG106577.
KOiK13885.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetiSearch...

Publicationsi

  1. "Expression cloning of SR-BI, a CD36-related class B scavenger receptor."
    Acton S.L., Scherer P.E., Lodish H.F., Krieger M.
    J. Biol. Chem. 269:21003-21009(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovarian carcinoma.

Entry informationi

Entry nameiSCRB1_CRIGR
AccessioniPrimary (citable) accession number: Q60417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.