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Protein

Potassium voltage-gated channel subfamily E member 1

Gene

KCNE1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 1
Alternative name(s):
Delayed rectifier potassium channel subunit IsK
IKs producing slow voltage-gated potassium channel subunit beta Mink
Minimal potassium channel
Gene namesi
Name:KCNE1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Apical cell membrane By similarity
  • Membrane raft By similarity

  • Note: Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KNCQ1 (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6623HelicalSequence analysisAdd
BLAST
Topological domaini67 – 12559CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125Potassium voltage-gated channel subfamily E member 1PRO_0000144276Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylation inhibits the potassium current.By similarity
N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex KNCQ1-KCNE1 to the membrane raft (By similarity).By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000010090.

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY71. Eukaryota.
ENOG410Y1SF. LUCA.
GeneTreeiENSGT00510000048994.
HOGENOMiHOG000113207.
HOVERGENiHBG052226.
InParanoidiQ60409.
OMAiALYILMV.
OrthoDBiEOG7WMCMH.
TreeFamiTF335976.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
IPR005424. K_chnl_volt-dep_bsu_KCNE1.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01604. KCNE1CHANNEL.
PR00168. KCNECHANNEL.

Sequencei

Sequence statusi: Complete.

Q60409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILPNSTAVM PFLTTVWQGT VQPSSNASGL ARRSPLRDDG KLEALYILMV
60 70 80 90 100
LGFFGFFTLG IMLSYIRSKK LEHSHDPFNV YIESDTWQEK DKAFFQARVL
110 120
ENCRSCCVIE NQLTVEQPNT YLPEL
Length:125
Mass (Da):14,266
Last modified:November 1, 1996 - v1
Checksum:iE5CB6843D9AB5E76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 173TVW → SVM no nucleotide entry (PubMed:8265583).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20462 mRNA. Translation: AAA72394.1.
PIRiA49392.
I48146.
RefSeqiNP_001166443.1. NM_001172972.1.

Genome annotation databases

EnsembliENSCPOT00000011328; ENSCPOP00000010090; ENSCPOG00000011222.
GeneIDi100135562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20462 mRNA. Translation: AAA72394.1.
PIRiA49392.
I48146.
RefSeqiNP_001166443.1. NM_001172972.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000010090.

Chemistry

ChEMBLiCHEMBL5241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000011328; ENSCPOP00000010090; ENSCPOG00000011222.
GeneIDi100135562.

Organism-specific databases

CTDi3753.

Phylogenomic databases

eggNOGiENOG410IY71. Eukaryota.
ENOG410Y1SF. LUCA.
GeneTreeiENSGT00510000048994.
HOGENOMiHOG000113207.
HOVERGENiHBG052226.
InParanoidiQ60409.
OMAiALYILMV.
OrthoDBiEOG7WMCMH.
TreeFamiTF335976.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
IPR005424. K_chnl_volt-dep_bsu_KCNE1.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01604. KCNE1CHANNEL.
PR00168. KCNECHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "The min K channel underlies the cardiac potassium current IKs and mediates species-specific responses to protein kinase C."
    Varnum M.D., Busch A.E., Bond C.T., Maylie J., Adelman J.P.
    Proc. Natl. Acad. Sci. U.S.A. 90:11528-11532(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "K+ currents expressed from the guinea pig cardiac IsK protein are enhanced by activators of protein kinase C."
    Zhang J., Jurkiewicz N.K., Folander K., Lazarides E., Salata J.J., Swanson R.
    Proc. Natl. Acad. Sci. U.S.A. 91:1766-1770(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart muscle.

Entry informationi

Entry nameiKCNE1_CAVPO
AccessioniPrimary (citable) accession number: Q60409
Secondary accession number(s): Q9QVZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.