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Protein

Methyl-coenzyme M reductase II subunit beta

Gene

mrtB

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.By similarity

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathway: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase I subunit alpha (mcrA), Methyl-coenzyme M reductase I subunit gamma (mcrG), Methyl-coenzyme M reductase I subunit beta (mcrB), Methyl-coenzyme M reductase II subunit beta (mrtB), Methyl-coenzyme M reductase II subunit alpha (mrtA), Methyl-coenzyme M reductase II subunit gamma (mrtG)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Methanogenesis

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit beta (EC:2.8.4.1)
Short name:
MCR II beta
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase beta
Gene namesi
Name:mrtB
Ordered Locus Names:MJ0081
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Methyl-coenzyme M reductase II subunit betaPRO_0000147466Add
BLAST

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.By similarity

Protein-protein interaction databases

STRINGi243232.MJ_0081.

Structurei

3D structure databases

ProteinModelPortaliQ60390.
SMRiQ60390. Positions 4-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4054.
InParanoidiQ60390.
KOiK00401.
OMAiWALWNAY.
PhylomeDBiQ60390.

Family and domain databases

Gene3Di1.20.840.10. 2 hits.
3.30.70.470. 1 hit.
InterProiIPR022681. MCR_a/b_chain_a-bundle.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR003179. Me_CoM_Rdtase_bsu.
IPR022679. Me_CoM_Rdtase_bsu_C.
IPR022680. Me_CoM_Rdtase_bsu_N.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view]
PfamiPF02241. MCR_beta. 1 hit.
PF02783. MCR_beta_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000263. Meth_CoM_rd_beta. 1 hit.
SUPFAMiSSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03257. met_CoM_red_bet. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHYEDRIDL YDERGKLLEE NVPLEAISPL KNPTIEKIVN DIKRSVAINL
60 70 80 90 100
AGIENALKTG AVGGKACFCP GRELDLPIVE NAEIIAEKIK RMVQIEEDDD
110 120 130 140 150
TVVKLINGGK QLLLQLPSKR LRVAADYTVS ALIGGGATVQ AIVDAFDVDM
160 170 180 190 200
FDAPVVKTAV MGRYPQTVDF HGANIATLLG PPVLLEGLGY GLRNIMANHI
210 220 230 240 250
VAVTRKKTLN AVALASILEQ TAMFETGDAL GAFERLHLLG LAFQGLNANN
260 270 280 290 300
LTYELVKENG KDGTVGTVVA SVVERALEDG VIRPLKTMPS GFTVYEPVDW
310 320 330 340 350
ALWNAYAASG LVAAVIVNVG AARAAQGVAS TVLYYNDILE YETGLPSVDF
360 370 380 390 400
GRAEGTAVGF SFFSHSIYGG GGPGTFHGNH VVTRHSKGFA IPCAAAAMCL
410 420 430 440
DAGTQMFSVE RTSALVGTVY SAIDHLREPL KYVAEGAVEV KEKEKVI
Length:447
Mass (Da):47,770
Last modified:December 15, 1998 - v2
Checksum:iB9CAE1066BE977BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98061.1.
RefSeqiNP_247045.1. NC_000909.1.
WP_010869573.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98061; AAB98061; MJ_0081.
GeneIDi1450920.
KEGGimja:MJ_0081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98061.1.
RefSeqiNP_247045.1. NC_000909.1.
WP_010869573.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ60390.
SMRiQ60390. Positions 4-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98061; AAB98061; MJ_0081.
GeneIDi1450920.
KEGGimja:MJ_0081.

Phylogenomic databases

eggNOGiCOG4054.
InParanoidiQ60390.
KOiK00401.
OMAiWALWNAY.
PhylomeDBiQ60390.

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699.

Family and domain databases

Gene3Di1.20.840.10. 2 hits.
3.30.70.470. 1 hit.
InterProiIPR022681. MCR_a/b_chain_a-bundle.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR003179. Me_CoM_Rdtase_bsu.
IPR022679. Me_CoM_Rdtase_bsu_C.
IPR022680. Me_CoM_Rdtase_bsu_N.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view]
PfamiPF02241. MCR_beta. 1 hit.
PF02783. MCR_beta_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000263. Meth_CoM_rd_beta. 1 hit.
SUPFAMiSSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03257. met_CoM_red_bet. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiMCRY_METJA
AccessioniPrimary (citable) accession number: Q60390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: June 24, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.