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Q60390 (MCRY_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methyl-coenzyme M reductase II subunit beta

Short name=MCR II beta
EC=2.8.4.1
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase beta
Gene names
Name:mrtB
Ordered Locus Names:MJ0081
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide By similarity.

Catalytic activity

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Cofactor

Binds 2 coenzyme F430 noncovalently per hexamer. Coenzyme F430 is a yellow nickel porphinoid By similarity.

Pathway

One-carbon metabolism; methyl-coenzyme M reduction; methane from methyl-coenzyme M: step 1/1.

Subunit structure

Hexamer of two alpha, two beta, and two gamma chains By similarity.

Ontologies

Keywords
   Biological processMethanogenesis
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmethanogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncoenzyme-B sulfoethylthiotransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Methyl-coenzyme M reductase II subunit beta
PRO_0000147466

Sequences

Sequence LengthMass (Da)Tools
Q60390 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: B9CAE1066BE977BC

FASTA44747,770
        10         20         30         40         50         60 
MLHYEDRIDL YDERGKLLEE NVPLEAISPL KNPTIEKIVN DIKRSVAINL AGIENALKTG 

        70         80         90        100        110        120 
AVGGKACFCP GRELDLPIVE NAEIIAEKIK RMVQIEEDDD TVVKLINGGK QLLLQLPSKR 

       130        140        150        160        170        180 
LRVAADYTVS ALIGGGATVQ AIVDAFDVDM FDAPVVKTAV MGRYPQTVDF HGANIATLLG 

       190        200        210        220        230        240 
PPVLLEGLGY GLRNIMANHI VAVTRKKTLN AVALASILEQ TAMFETGDAL GAFERLHLLG 

       250        260        270        280        290        300 
LAFQGLNANN LTYELVKENG KDGTVGTVVA SVVERALEDG VIRPLKTMPS GFTVYEPVDW 

       310        320        330        340        350        360 
ALWNAYAASG LVAAVIVNVG AARAAQGVAS TVLYYNDILE YETGLPSVDF GRAEGTAVGF 

       370        380        390        400        410        420 
SFFSHSIYGG GGPGTFHGNH VVTRHSKGFA IPCAAAAMCL DAGTQMFSVE RTSALVGTVY 

       430        440 
SAIDHLREPL KYVAEGAVEV KEKEKVI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98061.1.
RefSeqNP_247045.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ60390.
SMRQ60390. Positions 4-443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0081.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98061; AAB98061; MJ_0081.
GeneID1450920.
KEGGmja:MJ_0081.

Phylogenomic databases

eggNOGCOG4054.
KOK00401.
OMAWALWNAY.
ProtClustDBCLSK876059.

Enzyme and pathway databases

UniPathwayUPA00646; UER00699.

Family and domain databases

Gene3D1.20.840.10. 2 hits.
3.30.70.470. 1 hit.
InterProIPR022681. MCR_a/b_chain_a-bundle.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR003179. Me_CoM_Rdtase_bsu.
IPR022679. Me_CoM_Rdtase_bsu_C.
IPR022680. Me_CoM_Rdtase_bsu_N.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view]
PfamPF02241. MCR_beta. 1 hit.
PF02783. MCR_beta_N. 1 hit.
[Graphical view]
PIRSFPIRSF000263. Meth_CoM_rd_beta. 1 hit.
SUPFAMSSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsTIGR03257. met_CoM_red_bet. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMCRY_METJA
AccessionPrimary (citable) accession number: Q60390
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: October 16, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names