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Protein

Methyl-coenzyme M reductase II subunit gamma

Gene

mrtG

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.By similarity

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase I subunit alpha (mcrA), Methyl-coenzyme M reductase I subunit gamma (mcrG), Methyl-coenzyme M reductase I subunit beta (mcrB), Methyl-coenzyme M reductase II subunit beta (mrtB), Methyl-coenzyme M reductase II subunit alpha (mrtA), Methyl-coenzyme M reductase II subunit gamma (mrtG)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMethanogenesis

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-83-MONOMER
UniPathwayiUPA00646; UER00699

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit gamma (EC:2.8.4.1)
Short name:
MCR II gamma
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma
Gene namesi
Name:mrtG
Synonyms:mtrG
Ordered Locus Names:MJ0082
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001474771 – 266Methyl-coenzyme M reductase II subunit gammaAdd BLAST266

Proteomic databases

PRIDEiQ60387

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.By similarity

Protein-protein interaction databases

STRINGi243232.MJ_0082

Structurei

3D structure databases

ProteinModelPortaliQ60387
SMRiQ60387
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04858 Archaea
COG4057 LUCA
InParanoidiQ60387
KOiK00402
OMAiGHRNPGE
OrthoDBiPOG093Z08I2
PhylomeDBiQ60387

Family and domain databases

CDDicd00539 MCR_gamma, 1 hit
Gene3Di3.90.320.20, 1 hit
InterProiView protein in InterPro
IPR009024 Me_CoM_Rdtase_Fd-like_fold
IPR003178 Me_CoM_Rdtase_gsu
IPR036994 Me_CoM_Rdtase_gsu_sf
PfamiView protein in Pfam
PF02240 MCR_gamma, 1 hit
PIRSFiPIRSF000264 Meth_CoM_rd_gama, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005845 Me_CoM_Rdtase_gsu, 1 hit
SUPFAMiSSF55088 SSF55088, 1 hit
TIGRFAMsiTIGR03259 met_CoM_red_gam, 1 hit

Sequencei

Sequence statusi: Complete.

Q60387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYKPQFYPG NTLIAENRRK HMNPEVELKK LRDIPDDEIV KILGHRNPGE
60 70 80 90 100
SYKTVHPPLE EMDFEEDPIK DIVEPIQGAK EGVRVRYIQF ADSMYNAPAQ
110 120 130 140 150
PYDRARTYMW RFRGIDTGTL SGRQVIEMRE LDLEKISKNF LIDTEFFDPA
160 170 180 190 200
TCGIRGATVH GHSLRLDENG LMFDGLQRYI YDEKTGHVLY VKDQVGRPLD
210 220 230 240 250
EPVDVGEPLP HDYLAKITTI YRKDNIGMRE DKEALEVVQI IHEARTKGGF
260
GLEVFKKDLK KRLGEE
Length:266
Mass (Da):30,764
Last modified:November 1, 1997 - v1
Checksum:i51E7B3C7F984157A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98062.1
PIRiB64310
RefSeqiWP_010869574.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB98062; AAB98062; MJ_0082
GeneIDi1450921
KEGGimja:MJ_0082

Similar proteinsi

Entry informationi

Entry nameiMCRZ_METJA
AccessioniPrimary (citable) accession number: Q60387
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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