Q60387 (MCRZ_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methyl-coenzyme M reductase II subunit gamma
Short name=MCR II gamma
EC=2.8.4.1

Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma

Gene names

Name:	mrtG
Synonyms:	mtrG
Ordered Locus Names:	MJ0082

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and an heterodisulfide By similarity.
Catalytic activity	Methyl-CoM + CoB = CoM-S-S-CoB + methane.
Cofactor	Binds 2 coenzyme F430 noncovalently per hexamer. Coenzyme F430 is a yellow nickel porphinoid By similarity.
Pathway	One-carbon metabolism; methyl-coenzyme M reduction; methane from methyl-coenzyme M: step 1/1.
Subunit structure	Hexamer of two alpha, two beta, and two gamma chains By similarity.

Ontologies

Keywords
Biological process	Methanogenesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme-B sulfoethylthiotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Methyl-coenzyme M reductase II subunit gamma		PRO_0000147477

Sequences

	Sequence		Length	Mass (Da)
	Q60387 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 51E7B3C7F984157A	FASTA	266	30,764
	10 20 30 40 50 60 MAYKPQFYPG NTLIAENRRK HMNPEVELKK LRDIPDDEIV KILGHRNPGE SYKTVHPPLE 70 80 90 100 110 120 EMDFEEDPIK DIVEPIQGAK EGVRVRYIQF ADSMYNAPAQ PYDRARTYMW RFRGIDTGTL 130 140 150 160 170 180 SGRQVIEMRE LDLEKISKNF LIDTEFFDPA TCGIRGATVH GHSLRLDENG LMFDGLQRYI 190 200 210 220 230 240 YDEKTGHVLY VKDQVGRPLD EPVDVGEPLP HDYLAKITTI YRKDNIGMRE DKEALEVVQI 250 260 IHEARTKGGF GLEVFKKDLK KRLGEE

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98062.1.
PIR	B64310.
RefSeq	NP_247046.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q60387.
SMR	Q60387. Positions 6-252.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1450921.
GenomeReviews	Gene locus MJ0082 in contig L77117_GR.
KEGG	mja:MJ_0082.
NMPDR	fig|243232.1.peg.83.
TIGR	MJ0082.
Phylogenomic databases
HOGENOM	HBG540470.
OMA	EARERDM.
ProtClustDB	CLSK876060.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0082-MONOMER.
Family and domain databases
InterPro	IPR009024. Me_CoM_Rdtase_Fd-like_fold. IPR003178. Me_CoM_Rdtase_gsu. [Graphical view]
Gene3D	G3DSA:3.90.320.20. MCR_gamma. 1 hit.
KO	K00402.
Pfam	PF02240. MCR_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDom	PD005845. Me_CoM_Rdtase_gsu. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF55088. MCR_fer_like. 1 hit.
TIGRFAMs	TIGR03259. Met_CoM_red_gam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCRZ_METJA

Accession

Primary (citable) accession number: Q60387

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program