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Protein

Translation initiation factor 6

Gene

eif6

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 6UniRule annotation
Short name:
aIF-6UniRule annotation
Gene namesi
Name:eif6UniRule annotation
Ordered Locus Names:MJ0048
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Translation initiation factor 6PRO_0000153746Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0048.

Structurei

Secondary structure

1
228
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Helixi15 – 184Combined sources
Beta strandi23 – 286Combined sources
Helixi34 – 4411Combined sources
Beta strandi47 – 504Combined sources
Helixi59 – 624Combined sources
Beta strandi67 – 737Combined sources
Helixi78 – 9013Combined sources
Beta strandi96 – 1005Combined sources
Helixi107 – 1104Combined sources
Beta strandi111 – 1133Combined sources
Beta strandi115 – 1206Combined sources
Helixi122 – 1276Combined sources
Helixi128 – 1358Combined sources
Beta strandi137 – 1415Combined sources
Turni150 – 1523Combined sources
Beta strandi153 – 1564Combined sources
Beta strandi158 – 1636Combined sources
Helixi169 – 17911Combined sources
Beta strandi182 – 1865Combined sources
Turni190 – 1923Combined sources
Helixi196 – 1983Combined sources
Beta strandi200 – 2023Combined sources
Beta strandi207 – 2104Combined sources
Helixi215 – 22511Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G61X-ray1.30A/B1-228[»]
ProteinModelPortaliQ60357.
SMRiQ60357. Positions 3-227.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60357.

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04176. Archaea.
COG1976. LUCA.
InParanoidiQ60357.
KOiK03264.
OMAiNDWCAFT.
PhylomeDBiQ60357.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMIIRKYFS GIPTIGVLAL TTEEITLLPI FLDKDDVNEV SEVLETKCLQ
60 70 80 90 100
TNIGGSSLVG SLSVANKYGL LLPKIVEDEE LDRIKNFLKE NNLDLNVEII
110 120 130 140 150
KSKNTALGNL ILTNDKGALI SPELKDFKKD IEDSLNVEVE IGTIAELPTV
160 170 180 190 200
GSNAVVTNKG CLTHPLVEDD ELEFLKSLFK VEYIGKGTAN KGTTSVGACI
210 220
IANSKGAVVG GDTTGPELLI IEDALGLI
Length:228
Mass (Da):24,459
Last modified:November 1, 1997 - v1
Checksum:i94DA7E11C10FCB47
GO

Mass spectrometryi

Molecular mass is 24948±6 Da from positions 1 - 228. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98029.1.
PIRiH64305.

Genome annotation databases

EnsemblBacteriaiAAB98029; AAB98029; MJ_0048.
KEGGimja:MJ_0048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98029.1.
PIRiH64305.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G61X-ray1.30A/B1-228[»]
ProteinModelPortaliQ60357.
SMRiQ60357. Positions 3-227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98029; AAB98029; MJ_0048.
KEGGimja:MJ_0048.

Phylogenomic databases

eggNOGiarCOG04176. Archaea.
COG1976. LUCA.
InParanoidiQ60357.
KOiK03264.
OMAiNDWCAFT.
PhylomeDBiQ60357.

Miscellaneous databases

EvolutionaryTraceiQ60357.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIF6_METJA
AccessioniPrimary (citable) accession number: Q60357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.