Q60342 (CBID_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative cobalt-precorrin-6A synthase [deacetylating]
EC=2.1.1.-

Gene names

Name:	cbiD
Ordered Locus Names:	MJ0022

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May catalyze the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. HAMAP MF_00787
Pathway	Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10. HAMAP MF_00787
Sequence similarities	Belongs to the CbiD family.

Ontologies

Keywords
Biological process	Cobalamin biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Putative cobalt-precorrin-6A synthase [deacetylating] HAMAP MF_00787		PRO_0000141692

Sequences

	Sequence		Length	Mass (Da)
	Q60342 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 6AA2947C871906B7	FASTA	362	39,951
	10 20 30 40 50 60 MIYDFRKKSK FGYTTGSCAA AGAYSALYYL KFGKKLSYVE IENLNGDKLI IPIEKIEKCG 70 80 90 100 110 120 NKAKAVVIKD AGGDIDITNG IEIITEVELK KGKKDVIIKG GEGVGIVTKN GLQVKKGEPA 130 140 150 160 170 180 INPKPREMIR NNLLKLLNDD EVVEVTISIP KGKELAKKTL NPKLGIVGGL SILGTTGIVR 190 200 210 220 230 240 PMSNEAYMNS LAPQIDVALA NGYKRLIFVP GNIGTKYAKQ LLNANDDEII EVSNFWGFML 250 260 270 280 290 300 DKAKEKGVEE ILIFGHAGKI IKLAGGIYNT HSKVADCRNE ILAAYSSLFI DDKEAIKKIL 310 320 330 340 350 360 YSNTTEEVIK ILEEKGVLND VFNFIAKRVV ERLSERWKGI KFSCIIINMK GEVLGSYIWN KK

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98004.1.
PIR	F64302.
RefSeq	NP_246985.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q60342.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1450860.
GenomeReviews	Gene locus MJ0022 in contig L77117_GR.
KEGG	mja:MJ_0022.
NMPDR	fig|243232.1.peg.22.
TIGR	MJ0022.
Phylogenomic databases
HOGENOM	HBG705387.
OMA	GNASEDT.
ProtClustDB	PRK00075.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0022-MONOMER.
Family and domain databases
HAMAP	MF_00787. CbiD. [Tree]
InterPro	IPR002748. Cbl_biosynth_CbiD. [Graphical view]
KO	K02188.
Pfam	PF01888. CbiD. 1 hit. [Graphical view]
PIRSF	PIRSF026782. CbiD. 1 hit.
SUPFAM	SSF111342. Cbl_biosynth_CbiD. 1 hit.
TIGRFAMs	TIGR00312. CbiD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CBID_METJA

Accession

Primary (citable) accession number: Q60342

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 16, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program