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Q60340

- FRHG_METJA

UniProt

Q60340 - FRHG_METJA

Protein

Coenzyme F420 hydrogenase subunit gamma

Gene

frhG

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen.By similarity

    Catalytic activityi

    H2 + oxidized coenzyme F420 = reduced coenzyme F420.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi178 – 1781Iron-sulfur 1 (4Fe-4S)By similarity
    Metal bindingi181 – 1811Iron-sulfur 1 (4Fe-4S)By similarity
    Metal bindingi184 – 1841Iron-sulfur 1 (4Fe-4S)By similarity
    Metal bindingi188 – 1881Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi207 – 2071Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi210 – 2101Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi213 – 2131Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi217 – 2171Iron-sulfur 1 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. coenzyme F420 hydrogenase activity Source: UniProtKB-EC
    3. ferredoxin hydrogenase activity Source: InterPro
    4. flavin adenine dinucleotide binding Source: InterPro
    5. nickel cation binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coenzyme F420 hydrogenase subunit gamma (EC:1.12.98.1)
    Alternative name(s):
    8-hydroxy-5-deazaflavin-reducing hydrogenase subunit gamma
    Short name:
    FRH
    Gene namesi
    Name:frhG
    Ordered Locus Names:MJ0031
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ferredoxin hydrogenase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230Coenzyme F420 hydrogenase subunit gammaPRO_0000159232Add
    BLAST

    Interactioni

    Subunit structurei

    Heterocomplex of the form (alpha1beta1gamma1)8.By similarity

    Protein-protein interaction databases

    STRINGi243232.MJ0031.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini169 – 197294Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini198 – 228314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FrhG family.Curated
    Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1941.
    KOiK00443.
    OMAiCPPSPEI.
    PhylomeDBiQ60340.

    Family and domain databases

    Gene3Di3.40.50.700. 1 hit.
    InterProiIPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR017681. Coenz_F420_hydrogenase_gsu.
    IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR001821. NiFe_hydrogenase_ssu.
    [Graphical view]
    PfamiPF00037. Fer4. 1 hit.
    PF01058. Oxidored_q6. 1 hit.
    [Graphical view]
    PRINTSiPR00614. NIHGNASESMLL.
    TIGRFAMsiTIGR03294. FrhG. 1 hit.
    PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
    PS51379. 4FE4S_FER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60340-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKVVKVAHV QLCSCCGCLV SLADTYEKLL DVLNSIELVY CQTLADAREI    50
    PECDIALVEG SVCLDDHHSL EVAQEVRKKA KIVVALGACA ATGGVTRYCK 100
    GNQLSKPVHS SFSPLTEVIK VDLAIPGCPP SPEAIVGVIT AALNGDMEYL 150
    QPYAELAEKG SEACGCDVIY KVVNKSLCMG CGTCAAACPT RAIEMLDGRP 200
    NVLKELCIKC GACSVQCPRI RFPELIEKIE 230
    Length:230
    Mass (Da):24,534
    Last modified:November 1, 1997 - v1
    Checksum:i6C9936D3A20ED356
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98010.1.
    PIRiG64303.
    RefSeqiNP_246994.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB98010; AAB98010; MJ_0031.
    GeneIDi1450869.
    KEGGimja:MJ_0031.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98010.1 .
    PIRi G64303.
    RefSeqi NP_246994.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q60340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ0031.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB98010 ; AAB98010 ; MJ_0031 .
    GeneIDi 1450869.
    KEGGi mja:MJ_0031.

    Phylogenomic databases

    eggNOGi COG1941.
    KOi K00443.
    OMAi CPPSPEI.
    PhylomeDBi Q60340.

    Family and domain databases

    Gene3Di 3.40.50.700. 1 hit.
    InterProi IPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR017681. Coenz_F420_hydrogenase_gsu.
    IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR001821. NiFe_hydrogenase_ssu.
    [Graphical view ]
    Pfami PF00037. Fer4. 1 hit.
    PF01058. Oxidored_q6. 1 hit.
    [Graphical view ]
    PRINTSi PR00614. NIHGNASESMLL.
    TIGRFAMsi TIGR03294. FrhG. 1 hit.
    PROSITEi PS00198. 4FE4S_FER_1. 2 hits.
    PS51379. 4FE4S_FER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiFRHG_METJA
    AccessioniPrimary (citable) accession number: Q60340
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3