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Protein

Coenzyme F420 hydrogenase subunit gamma

Gene

frhG

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen.By similarity

Catalytic activityi

H2 + oxidized coenzyme F420 = reduced coenzyme F420.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi178 – 1781Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi181 – 1811Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi184 – 1841Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi188 – 1881Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi207 – 2071Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi210 – 2101Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi213 – 2131Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi217 – 2171Iron-sulfur 1 (4Fe-4S)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme F420 hydrogenase subunit gamma (EC:1.12.98.1)
Alternative name(s):
8-hydroxy-5-deazaflavin-reducing hydrogenase subunit gamma
Short name:
FRH
Gene namesi
Name:frhG
Ordered Locus Names:MJ0031
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Coenzyme F420 hydrogenase subunit gammaPRO_0000159232Add
BLAST

Interactioni

Subunit structurei

Heterocomplex of the form (alpha1beta1gamma1)8.By similarity

Protein-protein interaction databases

STRINGi243232.MJ_0031.

Structurei

3D structure databases

ProteinModelPortaliQ60340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 197294Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini198 – 228314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FrhG family.Curated
Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1941.
InParanoidiQ60340.
KOiK00443.
OMAiRDLCIKC.
PhylomeDBiQ60340.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
InterProiIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR017681. Coenz_F420_hydrogenase_gsu.
IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR001821. NiFe_hydrogenase_ssu.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF01058. Oxidored_q6. 1 hit.
[Graphical view]
PRINTSiPR00614. NIHGNASESMLL.
TIGRFAMsiTIGR03294. FrhG. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKVVKVAHV QLCSCCGCLV SLADTYEKLL DVLNSIELVY CQTLADAREI
60 70 80 90 100
PECDIALVEG SVCLDDHHSL EVAQEVRKKA KIVVALGACA ATGGVTRYCK
110 120 130 140 150
GNQLSKPVHS SFSPLTEVIK VDLAIPGCPP SPEAIVGVIT AALNGDMEYL
160 170 180 190 200
QPYAELAEKG SEACGCDVIY KVVNKSLCMG CGTCAAACPT RAIEMLDGRP
210 220 230
NVLKELCIKC GACSVQCPRI RFPELIEKIE
Length:230
Mass (Da):24,534
Last modified:November 1, 1997 - v1
Checksum:i6C9936D3A20ED356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98010.1.
PIRiG64303.
RefSeqiNP_246994.1. NC_000909.1.
WP_010869522.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98010; AAB98010; MJ_0031.
GeneIDi1450869.
KEGGimja:MJ_0031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98010.1.
PIRiG64303.
RefSeqiNP_246994.1. NC_000909.1.
WP_010869522.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ60340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0031.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98010; AAB98010; MJ_0031.
GeneIDi1450869.
KEGGimja:MJ_0031.

Phylogenomic databases

eggNOGiCOG1941.
InParanoidiQ60340.
KOiK00443.
OMAiRDLCIKC.
PhylomeDBiQ60340.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
InterProiIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR017681. Coenz_F420_hydrogenase_gsu.
IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR001821. NiFe_hydrogenase_ssu.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF01058. Oxidored_q6. 1 hit.
[Graphical view]
PRINTSiPR00614. NIHGNASESMLL.
TIGRFAMsiTIGR03294. FrhG. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiFRHG_METJA
AccessioniPrimary (citable) accession number: Q60340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.