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Q60340

- FRHG_METJA

UniProt

Q60340 - FRHG_METJA

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Protein

Coenzyme F420 hydrogenase subunit gamma

Gene

frhG

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen.By similarity

Catalytic activityi

H2 + oxidized coenzyme F420 = reduced coenzyme F420.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi178 – 1781Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi181 – 1811Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi184 – 1841Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi188 – 1881Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi207 – 2071Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi210 – 2101Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi213 – 2131Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi217 – 2171Iron-sulfur 1 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. coenzyme F420 hydrogenase activity Source: UniProtKB-EC
  3. ferredoxin hydrogenase activity Source: InterPro
  4. flavin adenine dinucleotide binding Source: InterPro
  5. nickel cation binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme F420 hydrogenase subunit gamma (EC:1.12.98.1)
Alternative name(s):
8-hydroxy-5-deazaflavin-reducing hydrogenase subunit gamma
Short name:
FRH
Gene namesi
Name:frhG
Ordered Locus Names:MJ0031
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ferredoxin hydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Coenzyme F420 hydrogenase subunit gammaPRO_0000159232Add
BLAST

Interactioni

Subunit structurei

Heterocomplex of the form (alpha1beta1gamma1)8.By similarity

Protein-protein interaction databases

STRINGi243232.MJ0031.

Structurei

3D structure databases

ProteinModelPortaliQ60340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 197294Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini198 – 228314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FrhG family.Curated
Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1941.
InParanoidiQ60340.
KOiK00443.
OMAiCPPSPEI.
PhylomeDBiQ60340.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
InterProiIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR017681. Coenz_F420_hydrogenase_gsu.
IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR001821. NiFe_hydrogenase_ssu.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF01058. Oxidored_q6. 1 hit.
[Graphical view]
PRINTSiPR00614. NIHGNASESMLL.
TIGRFAMsiTIGR03294. FrhG. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60340-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKVVKVAHV QLCSCCGCLV SLADTYEKLL DVLNSIELVY CQTLADAREI
60 70 80 90 100
PECDIALVEG SVCLDDHHSL EVAQEVRKKA KIVVALGACA ATGGVTRYCK
110 120 130 140 150
GNQLSKPVHS SFSPLTEVIK VDLAIPGCPP SPEAIVGVIT AALNGDMEYL
160 170 180 190 200
QPYAELAEKG SEACGCDVIY KVVNKSLCMG CGTCAAACPT RAIEMLDGRP
210 220 230
NVLKELCIKC GACSVQCPRI RFPELIEKIE
Length:230
Mass (Da):24,534
Last modified:November 1, 1997 - v1
Checksum:i6C9936D3A20ED356
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98010.1.
PIRiG64303.
RefSeqiNP_246994.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98010; AAB98010; MJ_0031.
GeneIDi1450869.
KEGGimja:MJ_0031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98010.1 .
PIRi G64303.
RefSeqi NP_246994.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q60340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0031.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98010 ; AAB98010 ; MJ_0031 .
GeneIDi 1450869.
KEGGi mja:MJ_0031.

Phylogenomic databases

eggNOGi COG1941.
InParanoidi Q60340.
KOi K00443.
OMAi CPPSPEI.
PhylomeDBi Q60340.

Family and domain databases

Gene3Di 3.40.50.700. 1 hit.
InterProi IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR017681. Coenz_F420_hydrogenase_gsu.
IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR001821. NiFe_hydrogenase_ssu.
[Graphical view ]
Pfami PF00037. Fer4. 1 hit.
PF01058. Oxidored_q6. 1 hit.
[Graphical view ]
PRINTSi PR00614. NIHGNASESMLL.
TIGRFAMsi TIGR03294. FrhG. 1 hit.
PROSITEi PS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiFRHG_METJA
AccessioniPrimary (citable) accession number: Q60340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3