Reviewed, UniProtKB/Swiss-Prot Q60337 (THIL_METJA)

Names and origin

Protein names

Recommended name:
    Probable thiamine-monophosphate kinase
      Short name=Thiamine-phosphate kinase
    EC=2.7.4.16

Gene names

Name:	thiL
Ordered Locus Names:	MJ0028

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

2190 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + thiamine phosphate = ADP + thiamine diphosphate.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.
Sequence similarities	Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Probable thiamine-monophosphate kinase		PRO_0000096201

Sequences

	Sequence		Length	Mass (Da)
	Q60337-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 92607D5AD59A723F	FASTA	319	36,160
	10 20 30 40 50 60 MDEMKVIEII KKTLKFSNEN IVKGIDDDCA IIKIDENFYL VATTDMMVKK AHIPSILSPY 70 80 90 100 110 120 EIGGRILTAN VSDIASMGAK PLAFLVSISL SKEEANEKFI KELYSGLDDF SKLYDCPVVG 130 140 150 160 170 180 GDTNRGDELI LSGTAFGITD NPIYRRGKVG DDICVTNDLG RVYCALTLYY MLKENKISYK 190 200 210 220 230 240 EFERLCQKYP KIIEKLRKPI ARIKEGLLMN KLINGCCDIS DGLGKEITYF KNFEIYSDRI 250 260 270 280 290 300 FKLIPEDVIE FCDAFNLNPI KVALNSGEEF ELLFTTSKFN KVKDSLKGYS KIYKIGKIIE 310 DGQFIDGEEF YGGGYIHKW

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L77117 Genomic DNA. Translation: AAB98008.1.
PIR	D64303.
RefSeq	NP_246991.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1450866.
GenomeReviews	Gene locus MJ0028 in contig L77117_GR.
KEGG	mja:MJ0028.
NMPDR	fig|243232.1.peg.28.
TIGR	MJ0028.
Phylogenomic databases
HOGENOM	Q60337.
OMA	ANVSDIA.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0028-MON.
BRENDA	2.7.4.16. 256362.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR006283. ThiL. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. [Graphical view]
PIRSF	PIRSF005303. Thiam_monoph_kin. 1 hit.
TIGRFAMs	TIGR01379. thiL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIL_METJA

Accession

Primary (citable) accession number: Q60337

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)