Reviewed, UniProtKB/Swiss-Prot Q60326 (APGM2_METJA)

Names and origin

Protein names

Recommended name:
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2
      Short name=Phosphoglyceromutase 2
      Short name=BPG-independent PGAM 2
      Short name=aPGAM 2
    EC=5.4.2.1
Alternative name(s):
    aPGAM-Mj2

Gene names

Name:	apgM2
Ordered Locus Names:	MJ0010

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

2190 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. HAMAP MF_01402
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. Ref.2
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 HAMAP MF_01402		PRO_0000138135

Sequences

	Sequence		Length	Mass (Da)
	Q60326-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 7107678524B1C168	FASTA	428	49,350
	10 20 30 40 50 60 MRAILILLDG LGDRASEILN NKTPLQFAKT PNLDRLAENG MCGLMTTYKE GIPLGTEVAH 70 80 90 100 110 120 FLLWGYSLEE FPGRGVIEAL GEDIEIEKNA IYLRASLGFV KKDEKGFLVI DRRTKDISRE 130 140 150 160 170 180 EIEKLVDSLP TCVDGYKFEL FYSFDVHFIL KIKERNGWIS DKISDSDPFY KNRYVMKVKA 190 200 210 220 230 240 IRELCKSEVE YSKAKDTARA LNKYLLNVYK ILQNHKINRK RRKLEKMPAN FLLTKWASRY 250 260 270 280 290 300 KRVESFKEKW GMNAVILAES SLFKGLAKFL GMDFIKIESF EEGIDLIPEL DYDFIHLHTK 310 320 330 340 350 360 ETDEAAHTKN PLNKVKVIEK IDKLIGNLKL REDDLLIITA DHSTPSVGNL IHSGESVPIL 370 380 390 400 410 420 FYGKNVRVDN VKEFNEISCS NGHLRIRGEE LMHLILNYTD RALLYGLRSG DRLRYYIPKD DEIDLLEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"A divergent archaeal member of the alkaline phosphatase binuclear metalloenzyme superfamily has phosphoglycerate mutase activity." Graham D.E., Xu H., White R.H. FEBS Lett. 517:190-194(2002) [PubMed: 12062435] [Abstract] Cited for: CATALYTIC ACTIVITY. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB97991.1.
PIR	B64301.
RefSeq	NP_246973.1.
3D structure databases
SMR	Q60326. Positions 249-369.
ModBase	Search...
Genome annotation databases
GeneID	1450849.
GenomeReviews	Gene locus MJ0010 in contig L77117_GR.
KEGG	mja:MJ0010.
NMPDR	fig|243232.1.peg.10.
TIGR	MJ0010.
Phylogenomic databases
HOGENOM	HBG463247.
OMA	ISDSDPF.
Enzyme and pathway databases
BRENDA	5.4.2.1. 256362.
Family and domain databases
HAMAP	MF_01402_A. ApgM_A. [Tree]
InterPro	IPR017850. Alkaline_phosphatase_core. IPR004456. APGAM_arc. IPR019304. bisP-indep_Pglycerate_Mutase. IPR006124. Metalloenzyme. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
TIGRFAMs	TIGR00306. apgM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM2_METJA

Accession

Primary (citable) accession number: Q60326

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	February 9, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)