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Q60316

- FDHB_METJA

UniProt

Q60316 - FDHB_METJA

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Protein

Formate dehydrogenase subunit beta

Gene

fdhB

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of formate.By similarity

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 2 [4Fe-4S] clusters.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi280 – 2801Iron-sulfur (4Fe-4S)By similarity
Metal bindingi283 – 2831Iron-sulfur (4Fe-4S)By similarity
Metal bindingi286 – 2861Iron-sulfur (4Fe-4S)By similarity
Metal bindingi290 – 2901Iron-sulfur (4Fe-4S)By similarity
Metal bindingi330 – 3301Iron-sulfur (4Fe-4S)By similarity
Metal bindingi333 – 3331Iron-sulfur (4Fe-4S)By similarity
Metal bindingi336 – 3361Iron-sulfur (4Fe-4S)By similarity
Metal bindingi340 – 3401Iron-sulfur (4Fe-4S)By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase subunit beta (EC:1.2.1.2)
Gene namesi
Name:fdhB
Ordered Locus Names:MJ0005
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Formate dehydrogenase subunit betaPRO_0000159224Add
BLAST

Interactioni

Subunit structurei

Dimer of an alpha and a beta subunit.By similarity

Protein-protein interaction databases

STRINGi243232.MJ0005.

Structurei

3D structure databases

ProteinModelPortaliQ60316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini271 – 301314Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini321 – 351314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FrhB family.Curated
Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1145.
InParanoidiQ60316.
KOiK00125.
OMAiCAPTMFG.
PhylomeDBiQ60316.

Family and domain databases

InterProiIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR007525. FrhB_FdhB_C.
IPR009051. Helical_ferredxn.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60316-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYVLIQATD NGILRRAECG GAVTALFKYL LDKKLVDGVL ALKRGEDVYD
60 70 80 90 100
GIPTFITNSN ELVETAGSLH CAPTNFGKLI AKYLADKKIA VPAKPCDAMA
110 120 130 140 150
IRELAKLNQI NLDNVYMIGL NCGGTISPIT AMKMIELFYE VNPLDVVKEE
160 170 180 190 200
IDKGKFIIEL KNGEHKAVKI EELEEKGFGR RKNCQRCEIM IPRMADLACG
210 220 230 240 250
NWGAEKGWTF VEICSERGRK LVEDAEKDGY IKIKQPSEKA IQVREKIESI
260 270 280 290 300
MIKLAKKFQK KHLEEEYPSL EKWKKYWNRC IKCYGCRDNC PLCFCVECSL
310 320 330 340 350
EKDYIEEKGK IPPNPLIFQG IRLSHISQSC INCGQCEDAC PMDIPLAYIF
360 370
HRMQLKIRDT LGYIPGVDNS LPPLFNIER
Length:379
Mass (Da):43,014
Last modified:November 1, 1997 - v1
Checksum:i9C257CCAD5547F5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB97986.1.
PIRiE64300.
RefSeqiNP_246968.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB97986; AAB97986; MJ_0005.
GeneIDi1450844.
KEGGimja:MJ_0005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB97986.1 .
PIRi E64300.
RefSeqi NP_246968.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q60316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB97986 ; AAB97986 ; MJ_0005 .
GeneIDi 1450844.
KEGGi mja:MJ_0005.

Phylogenomic databases

eggNOGi COG1145.
InParanoidi Q60316.
KOi K00125.
OMAi CAPTMFG.
PhylomeDBi Q60316.

Family and domain databases

InterProi IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR007525. FrhB_FdhB_C.
IPR009051. Helical_ferredxn.
[Graphical view ]
Pfami PF00037. Fer4. 1 hit.
PF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
PROSITEi PS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiFDHB_METJA
AccessioniPrimary (citable) accession number: Q60316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3