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Protein

Uncharacterized adenine-specific methylase MJECS02

Gene

MJECS02

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi6813. MjaORFECS2P.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized adenine-specific methylase MJECS02 (EC:2.1.1.72)
Gene namesi
Ordered Locus Names:MJECS02
Encoded oniPlasmid small ECE0 Publication
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Plasmid small ECE

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11811181Uncharacterized adenine-specific methylase MJECS02PRO_0000088002Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJECS02.

Structurei

3D structure databases

ProteinModelPortaliQ60301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG1002.
InParanoidiQ60301.
OMAiNIEYNVR.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
InterProiIPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR011639. RM_methylase_Eco57I.
IPR029063. SAM-dependent_MTases.
IPR025931. TaqI_C.
[Graphical view]
PfamiPF07669. Eco57I. 1 hit.
PF02384. N6_Mtase. 1 hit.
PF12950. TaqI_C. 1 hit.
[Graphical view]
PRINTSiPR00507. N12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60301-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVMAQTKLC SDIEIPKEVY NKWKDFIKLV GNIILSIKQI PELEGKFKEL
60 70 80 90 100
LKKGRYNFKS DDFGGQLPEP FTRQKVIEPI LEFLGYEFTS EISKKSPLGD
110 120 130 140 150
RKIPDYRVSV FNKEILIEAE PLGSDLNKKD SGIHQVKEWL IIKSYGVDTG
160 170 180 190 200
IATNGLEWVL LHYDDTIKEI RTLKELNLKS IFEYVLENKK DKDLENELKQ
210 220 230 240 250
VFSEFYYCFS KEYIEEYIEV ATKNIKHKKE EITNEFYKEF VKLVFGFEDV
260 270 280 290 300
KDVKKKDKSS SEKDKGTKKC LYNCIEAPPN TSELDKKKFA VLLMNRLIFI
310 320 330 340 350
KFLEDKGIVP RDLLRRTYED YKKSNVLINY YDAYLKPLFY EVLNTPEDER
360 370 380 390 400
KENIRTNPYY KDIPYLNGGL FRSNNVPNEL SFTIKDNEII GEVINFLERY
410 420 430 440 450
KFTLSTSEGS EEVELNPDIL GYVYEKLINI LAEKGQKGLG AYYTPDEITS
460 470 480 490 500
YIAKNTIEPI VVERFKEIIK NWKINDINFS TLDEILNEDS KIAENKHILR
510 520 530 540 550
AFLDELDKIR ILDPAVGSGH FLISALKELL QIKKRIYYLL REEMDIYKEK
560 570 580 590 600
LGIILNNLYG VDIDDIAVEI AKLRLWLALI ENLDVEALKR GEVLLPNIEY
610 620 630 640 650
NVRCGNSLVG WIDENLKQLS ISYLCDNVRI MCVLEGLIIN AHNSEERKKL
660 670 680 690 700
KKAKELLEKR DGYVLDNYVE AYHLLYEVYR TSHGLKANLL KELLDEIRDS
710 720 730 740 750
IYESVTPAYF AEIYQNGNNK KNNGKKSKKN RPRVEEFEKL KPFHWKIDFG
760 770 780 790 800
WIIKEEGFDV IIGNPPYGNL LSPTEKEIMK RRDTPEFDIF VTFIVHSSKL
810 820 830 840 850
LKNEGYLGFI IPSSFGTGVR YSNLRKELFT KMCLKKLIYL PFDVFSGAYV
860 870 880 890 900
DNCIIILHKK PPKSEDLVLI YAFPKKTKKI SFEFKNDLFI EYSKILNDPK
910 920 930 940 950
CRIFPKSPEI YIILDKIKQN CRESLTYLED LTESTIGILA SKYKFSDKKE
960 970 980 990 1000
NEYYLPYLEG NVYRYETKLK LKNYVDFSKH KNNEKLINLF MSPEKIFIRR
1010 1020 1030 1040 1050
IVNRQDRIMA SYGNIEGVVK KDLYVFVLKP DTPINYFYLL GILNSELISY
1060 1070 1080 1090 1100
IYIGKSAIAL KDDFRQTTLE ELRELPIVIP KNKNIINALT QLSKLRFELN
1110 1120 1130 1140 1150
DKLNENDRIF LENIIDSLVY GIYFQDLIPK EELNEICNEI NGIIKKYDEK
1160 1170 1180
SIDCLKYCQN IIKLLNTINT NELVRKIRNK N
Length:1,181
Mass (Da):138,439
Last modified:November 1, 1997 - v1
Checksum:i9F961D8F8C6A4BDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77119 Genomic DNA. Translation: AAC37060.1.
PIRiB64516.
RefSeqiNP_044172.1. NC_001733.1.
WP_010890095.1. NC_001733.1.

Genome annotation databases

EnsemblBacteriaiAAC37060; AAC37060; MJ_ECS02.
GeneIDi1450829.
KEGGimja:MJECS02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77119 Genomic DNA. Translation: AAC37060.1.
PIRiB64516.
RefSeqiNP_044172.1. NC_001733.1.
WP_010890095.1. NC_001733.1.

3D structure databases

ProteinModelPortaliQ60301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJECS02.

Protein family/group databases

REBASEi6813. MjaORFECS2P.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC37060; AAC37060; MJ_ECS02.
GeneIDi1450829.
KEGGimja:MJECS02.

Phylogenomic databases

eggNOGiCOG1002.
InParanoidiQ60301.
OMAiNIEYNVR.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
InterProiIPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR011639. RM_methylase_Eco57I.
IPR029063. SAM-dependent_MTases.
IPR025931. TaqI_C.
[Graphical view]
PfamiPF07669. Eco57I. 1 hit.
PF02384. N6_Mtase. 1 hit.
PF12950. TaqI_C. 1 hit.
[Graphical view]
PRINTSiPR00507. N12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiY3402_METJA
AccessioniPrimary (citable) accession number: Q60301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.