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Protein

Guanylate kinase

Gene

gmk

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMCAP243233:G1G0X-2940-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:MCA2975
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
Proteomesi
  • UP000006821 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705601 – 204Guanylate kinaseAdd BLAST204

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA2975

Structurei

3D structure databases

ProteinModelPortaliQ602T6
SMRiQ602T6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 182Guanylate kinase-likeUniRule annotationAdd BLAST179

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037638
KOiK00942
OMAiAGNYYGT
OrthoDBiPOG091H01Q4

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q602T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQGLLYVIS APSGAGKTSL VSALCAGAPD LAVSVSHTTR PQRPGEVPGQ
60 70 80 90 100
DYWFVDKAEF EKMIANEAFL EYARVFDNYY GTAKTTVEEV LATGRDAVLE
110 120 130 140 150
IDWQGARQVR RLMPACVSVF ILPPSRQALE QRLRTRQQDS EAVIARRMEA
160 170 180 190 200
AISEMSHYAE YDYLIVNDDF NLALNQLRAI VQTQRLTVQR QAPRLGRLIA

DLLG
Length:204
Mass (Da):22,777
Last modified:November 23, 2004 - v1
Checksum:iA34A06FABECC6D0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA Translation: AAU90896.1
RefSeqiWP_010962165.1, NC_002977.6

Genome annotation databases

EnsemblBacteriaiAAU90896; AAU90896; MCA2975
KEGGimca:MCA2975

Similar proteinsi

Entry informationi

Entry nameiKGUA_METCA
AccessioniPrimary (citable) accession number: Q602T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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