Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q602D8 (SYR_MYCH2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:mhp012
OrganismMycoplasma hyopneumoniae (strain 232) [Complete proteome] [HAMAP]
Taxonomic identifier295358 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 534534Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242047

Regions

Motif120 – 13011"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q602D8 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 020AADFBF972D3C7

FASTA53461,651
        10         20         30         40         50         60 
MKKKISQAII KFFKNENLII DESKLIIEKS KNFGDYSSNV ALIFAKQNKI DSLKLAQTIK 

        70         80         90        100        110        120 
NQLLSENLNL EKIEIAPPGF INFFISKNEY ANIVSEIIQK GENFGRYSLQ KKINLEFVSA 

       130        140        150        160        170        180 
NPTGFLHLGH LRGAVIGDIL ANILEFSGNF VFREYYINDF GSQIDRLVGS VFSRYQQIFK 

       190        200        210        220        230        240 
KFPLPEEAYL GEDIIWCAQK FFQIYANKFE NSSLDDLEAY KIFREKSIEI FLDEIKADLA 

       250        260        270        280        290        300 
NLSIKFDVFS SESELFRTEK VQKNLANLPF VYKKEEAIWL KTSKFGDQKD RVLVKKNGEF 

       310        320        330        340        350        360 
TYFSSDIAYH FEKINSNFKP DFLINIWGAD HIGYVDRMKA ALKTVNLNQK LDILLYQLVK 

       370        380        390        400        410        420 
LFKNGQEFKM SKRMGKTFTI KDLLELVDQD AIRYFISERS YNSLVEFDIG LAAKISLQNP 

       430        440        450        460        470        480 
LFLIQYAHAR ASKLLANSTI APEKKLKFEA ENETILISKL KQFEEIVLKI TKNYKINLLN 

       490        500        510        520        530 
KYLLELANLF NSFYSNSKII GNQNQNSLLS LTKAVQIVLK NGLKLLGIKA KERI 

« Hide

References

[1]"The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis."
Minion F.C., Lefkowitz E.J., Madsen M.L., Cleary B.J., Swartzell S.M., Mahairas G.G.
J. Bacteriol. 186:7123-7133(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 232.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017332 Genomic DNA. Translation: AAV27355.1.
RefSeqYP_115527.1. NC_006360.1.

3D structure databases

ProteinModelPortalQ602D8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING295358.mhp012.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV27355; AAV27355; mhp012.
GeneID3105433.
KEGGmhy:mhp012.
PATRIC20010563. VBIMycHyo77580_0012.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMARFIMLTR.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycMHYO295358:GH8B-12-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_MYCH2
AccessionPrimary (citable) accession number: Q602D8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries