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Q60297 (T1MH_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative type I restriction enzyme MjaXP M protein

Short name=M.MjaXP
EC=2.1.1.72
Gene names
Ordered Locus Names:MJECL42
Encoded onPlasmid large ECE
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Methylation of specific adenine residues; required for both restriction and modification activities By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Subunit structure

The type I restriction/modification system is composed of three polypeptides R, M and S.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Putative type I restriction enzyme MjaXP M protein
PRO_0000088029

Regions

Region227 – 2326S-adenosyl-L-methionine binding By similarity
Region256 – 2583S-adenosyl-L-methionine binding By similarity

Sites

Binding site2831S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60297 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 0DD8568C71C3AF37

FASTA55864,552
        10         20         30         40         50         60 
MATLDKFLSI KENDEKTKKK ESKKKSSKSN KTSESLVSHD HFELTPEFEN QLWKVADKLR 

        70         80         90        100        110        120 
KKMEVHQYKY VVLGLIFLRA LTCRFYERRK EIEEELSNPN SELYTEDPEL RKMILEDEDF 

       130        140        150        160        170        180 
YLSEGVLYLP KETRWDYFVE NVMSPNIGEI IDTAIEILEE KYPDRLKDVI PKIYAQSPLD 

       190        200        210        220        230        240 
NHDYSYLINK FSEISFGKEH RVKDVFGRIY EYFLGKFTEV EGKLGGKFYT PRSLTKLIVD 

       250        260        270        280        290        300 
VLDVKGGSIF DPACGSGGFF VSALEKLERE GIDINELSIY GQDSDPMAYR LTKMNLIIRG 

       310        320        330        340        350        360 
AEGDIRIDDS YHDDKFMDMT FDYVVANPPF NDSEWDANRI KPDDPRLRIG NKKVPVPPNG 

       370        380        390        400        410        420 
NANYMWILHF IYHTAPNGKA GFVMANGALS AGNVEGEIRK AIIENDLVYG IVACPPKLFY 

       430        440        450        460        470        480 
NVSLPVSLWF IRKEKPDYMK GKVLFINAKN LYKQISRRQN ILTEEHIKKI VDKFRMFESG 

       490        500        510        520        530        540 
EDEDKINELG FAKVATIDEI AKNGYVLTPG RYVGVKIEDD GIPFEVKMKE YSEELKKLLD 

       550 
EEEKLRNKVK EILDALGF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77118 Genomic DNA. Translation: AAC37111.1.
PIRA64515.
RefSeqNP_044168.1. NC_001732.1.

3D structure databases

ProteinModelPortalQ60297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJECL42.

Protein family/group databases

REBASE3910. M.MjaORFCL42P.

Protocols and materials databases

DNASU1450824.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC37111; AAC37111; MJ_ECL42.
GeneID1450824.
KEGGmja:MJECL42.

Phylogenomic databases

eggNOGCOG0286.
HOGENOMHOG000239473.
KOK03427.
OMAIAVYGQE.
ProtClustDBCLSK2517092.

Family and domain databases

InterProIPR022749. D12N6_MeTrfase_N.
IPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
[Graphical view]
PfamPF12161. HsdM_N. 1 hit.
PF02384. N6_Mtase. 1 hit.
[Graphical view]
PRINTSPR00507. N12N6MTFRASE.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameT1MH_METJA
AccessionPrimary (citable) accession number: Q60297
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names