Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q60297

- T1MH_METJA

UniProt

Q60297 - T1MH_METJA

Protein

Putative type I restriction enzyme MjaXP M protein

Gene

MJECL42

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Methylation of specific adenine residues; required for both restriction and modification activities.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei283 – 2831S-adenosyl-L-methionineBy similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3910. M.MjaORFCL42P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative type I restriction enzyme MjaXP M protein (EC:2.1.1.72)
    Short name:
    M.MjaXP
    Gene namesi
    Ordered Locus Names:MJECL42
    Encoded oniPlasmid large ECE0 Publication
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Plasmid large ECE

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Putative type I restriction enzyme MjaXP M proteinPRO_0000088029Add
    BLAST

    Interactioni

    Subunit structurei

    The type I restriction/modification system is composed of three polypeptides R, M and S.

    Protein-protein interaction databases

    STRINGi243232.MJECL42.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni227 – 2326S-adenosyl-L-methionine bindingBy similarity
    Regioni256 – 2583S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0286.
    HOGENOMiHOG000239473.
    KOiK03427.
    OMAiDIAGFCK.
    PhylomeDBiQ60297.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR022749. D12N6_MeTrfase_N.
    IPR003356. DNA_methylase_A-5.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF12161. HsdM_N. 1 hit.
    PF02384. N6_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00507. N12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60297-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATLDKFLSI KENDEKTKKK ESKKKSSKSN KTSESLVSHD HFELTPEFEN    50
    QLWKVADKLR KKMEVHQYKY VVLGLIFLRA LTCRFYERRK EIEEELSNPN 100
    SELYTEDPEL RKMILEDEDF YLSEGVLYLP KETRWDYFVE NVMSPNIGEI 150
    IDTAIEILEE KYPDRLKDVI PKIYAQSPLD NHDYSYLINK FSEISFGKEH 200
    RVKDVFGRIY EYFLGKFTEV EGKLGGKFYT PRSLTKLIVD VLDVKGGSIF 250
    DPACGSGGFF VSALEKLERE GIDINELSIY GQDSDPMAYR LTKMNLIIRG 300
    AEGDIRIDDS YHDDKFMDMT FDYVVANPPF NDSEWDANRI KPDDPRLRIG 350
    NKKVPVPPNG NANYMWILHF IYHTAPNGKA GFVMANGALS AGNVEGEIRK 400
    AIIENDLVYG IVACPPKLFY NVSLPVSLWF IRKEKPDYMK GKVLFINAKN 450
    LYKQISRRQN ILTEEHIKKI VDKFRMFESG EDEDKINELG FAKVATIDEI 500
    AKNGYVLTPG RYVGVKIEDD GIPFEVKMKE YSEELKKLLD EEEKLRNKVK 550
    EILDALGF 558
    Length:558
    Mass (Da):64,552
    Last modified:November 1, 1997 - v1
    Checksum:i0DD8568C71C3AF37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77118 Genomic DNA. Translation: AAC37111.1.
    PIRiA64515.
    RefSeqiNP_044168.1. NC_001732.1.

    Genome annotation databases

    EnsemblBacteriaiAAC37111; AAC37111; MJ_ECL42.
    GeneIDi1450824.
    KEGGimja:MJECL42.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77118 Genomic DNA. Translation: AAC37111.1 .
    PIRi A64515.
    RefSeqi NP_044168.1. NC_001732.1.

    3D structure databases

    ProteinModelPortali Q60297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJECL42.

    Protein family/group databases

    REBASEi 3910. M.MjaORFCL42P.

    Protocols and materials databases

    DNASUi 1450824.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC37111 ; AAC37111 ; MJ_ECL42 .
    GeneIDi 1450824.
    KEGGi mja:MJECL42.

    Phylogenomic databases

    eggNOGi COG0286.
    HOGENOMi HOG000239473.
    KOi K03427.
    OMAi DIAGFCK.
    PhylomeDBi Q60297.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR022749. D12N6_MeTrfase_N.
    IPR003356. DNA_methylase_A-5.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF12161. HsdM_N. 1 hit.
    PF02384. N6_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00507. N12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiT1MH_METJA
    AccessioniPrimary (citable) accession number: Q60297
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3