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Q60295 (T1RH_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative type-1 restriction enzyme MjaXP R protein

EC=3.1.21.3
Alternative name(s):
Putative type I restriction enzyme MjaXP R protein
Gene names
Ordered Locus Names:MJECL40
Encoded onPlasmid large ECE
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length1042 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunit R is required for both nuclease and ATPase activities, but not for modification By similarity.

Catalytic activity

Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.

Subunit structure

The type I restriction/modification system is composed of three polypeptides R, M and S By similarity.

Sequence similarities

Belongs to the HsdR family.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10421042Putative type-1 restriction enzyme MjaXP R protein
PRO_0000077273

Regions

Domain323 – 487165Helicase ATP-binding
Domain551 – 731181Helicase C-terminal

Sequences

Sequence LengthMass (Da)Tools
Q60295 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 3C8E5A103E7B59D3

FASTA1,042121,523
        10         20         30         40         50         60 
MPISANKYFL LVGVFIGDKM KKEAAKLNED YVVENAAIQR LKNLGYSYKH GSELTPEYNE 

        70         80         90        100        110        120 
RESYRDAILK NRFIKAIKNI NPWLTEELAL KVYKTVTNID NPDFNMRGKI FYEMLINGVK 

       130        140        150        160        170        180 
LEFKENGEKK TRFVKLIDFE NINKNEFLVA NQFEVEYYYE NGRFRRPDLV VFINGIPIAI 

       190        200        210        220        230        240 
FEFKSPKSNQ TAKDAFNDHK TKMKDIPQLY QYAQILVVSD GLETKYGSPT SDWDRFFVWE 

       250        260        270        280        290        300 
GVESDDDVEV IEVDNYGNTM YKYKGNPYTS LDILLMGLFK KEHLIEFLED FIIHDKKKII 

       310        320        330        340        350        360 
ATYYQFYTVK KAVDRTIKSV LYGETPEDRR IGIVWHAQGT GKSITMLFYA KKALKQKELN 

       370        380        390        400        410        420 
YPLLVFLTDR LELDEQLYNV FSSVFSEAER AESIAELQEL IKKTPGGIIF ATIQKFGRKS 

       430        440        450        460        470        480 
KDEHYPFLTD RNNIIIIADE AHRSHYGTLA QNLRKAIPNA SFLAFTATPI DYKDRSTFLV 

       490        500        510        520        530        540 
FGDYISAYPI DKAKRHGVVV PIYYEARLVE LHLTNEFIDL EFDEISERVA NDPETKESIK 

       550        560        570        580        590        600 
EVFAKLEKIM LTEDYLSKVS KDIIEHFNKR LQDFDGKAMV VTISRKVAVE LYKWITKQPN 

       610        620        630        640        650        660 
APKIAVVMSG NKSKDPEDFH PHIRTKKELE NLAKEFKDPE SDLKMVIVVD MWLTGFDVPC 

       670        680        690        700        710        720 
LHTMYFLKPM KNHSLAQAIA RVNRVFKDKP GGLIVDYIGI ADDLSKSLSK YSSEARKDLM 

       730        740        750        760        770        780 
TDIKVVIEEM KRRYEKVTSY FKNINYKDWK KLSSEDLSLL TVKAYQRVAK DDNTKKEFVR 

       790        800        810        820        830        840 
NVIALKKLYL LARPHPETIG IKDDLEFFEM IKKMIVKYST KKIREISQDL ENDIQSLISK 

       850        860        870        880        890        900 
SISAKELVDV FEMLKKEKPE LSVLSDEFLS EIAKIEYKDY VRDVLIKILN DDIRVRMAKN 

       910        920        930        940        950        960 
PIRFKKFSER LNEVIEKYRI KVITTAEMIE ELVNLAKEIR KAAEEGKELG LTEEELAFYD 

       970        980        990       1000       1010       1020 
LLLSYPNIPL TDKKRVEKIA KEIARMMSGY IKARDWKKKK NLQSKIRAKL KIILMKEGIK 

      1030       1040 
DYSLINKISD DLFEYAKNIY AI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77118 Genomic DNA. Translation: AAC37109.1.
PIRG64514.
RefSeqNP_044166.1. NC_001732.1.

3D structure databases

ProteinModelPortalQ60295.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJECL40.

Protein family/group databases

REBASE3908. MjaORFCL42P.

Proteomic databases

PRIDEQ60295.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC37109; AAC37109; MJ_ECL40.
GeneID1450822.
KEGGmja:MJECL40.

Phylogenomic databases

eggNOGCOG0610.
HOGENOMHOG000240457.
KOK01153.
OMAIRYFVLF.
PhylomeDBQ60295.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR021810. DUF3387.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR011254. Prismane-like.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
[Graphical view]
PfamPF11867. DUF3387. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
SSF56821. SSF56821. 1 hit.
TIGRFAMsTIGR00348. hsdR. 1 hit.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameT1RH_METJA
AccessionPrimary (citable) accession number: Q60295
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names