Putative type-1 restriction enzyme MjaXP R protein - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

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Q60295 (T1RH_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 93. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Putative type-1 restriction enzyme MjaXP R protein
EC=3.1.21.3

Alternative name(s):
Putative type I restriction enzyme MjaXP R protein

Gene names

Ordered Locus Names:

MJECL40

Encoded on

Plasmid large ECE

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus ›

Protein attributes

Sequence length	1042 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunit R is required for both nuclease and ATPase activities, but not for modification By similarity.
Catalytic activity	Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.
Subunit structure	The type I restriction/modification system is composed of three polypeptides R, M and S By similarity.
Sequence similarities	Belongs to the HsdR family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Biological process	Restriction system
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Plasmid Reference proteome
Gene Ontology (GO)
Biological_process	DNA restriction-modification system Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW Type I site-specific deoxyribonuclease activity Inferred from electronic annotation. Source: EC helicase activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1042

1042

Putative type-1 restriction enzyme MjaXP R protein

PRO_0000077273

Regions

Domain

323 – 487

165

Helicase ATP-binding

Domain

551 – 731

181

Helicase C-terminal

Sequences

Sequence

Length

Mass (Da)

Tools

Q60295 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 3C8E5A103E7B59D3
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FASTA

1,042

121,523

        10         20         30         40         50         60 
MPISANKYFL LVGVFIGDKM KKEAAKLNED YVVENAAIQR LKNLGYSYKH GSELTPEYNE 

        70         80         90        100        110        120 
RESYRDAILK NRFIKAIKNI NPWLTEELAL KVYKTVTNID NPDFNMRGKI FYEMLINGVK 

       130        140        150        160        170        180 
LEFKENGEKK TRFVKLIDFE NINKNEFLVA NQFEVEYYYE NGRFRRPDLV VFINGIPIAI 

       190        200        210        220        230        240 
FEFKSPKSNQ TAKDAFNDHK TKMKDIPQLY QYAQILVVSD GLETKYGSPT SDWDRFFVWE 

       250        260        270        280        290        300 
GVESDDDVEV IEVDNYGNTM YKYKGNPYTS LDILLMGLFK KEHLIEFLED FIIHDKKKII 

       310        320        330        340        350        360 
ATYYQFYTVK KAVDRTIKSV LYGETPEDRR IGIVWHAQGT GKSITMLFYA KKALKQKELN 

       370        380        390        400        410        420 
YPLLVFLTDR LELDEQLYNV FSSVFSEAER AESIAELQEL IKKTPGGIIF ATIQKFGRKS 

       430        440        450        460        470        480 
KDEHYPFLTD RNNIIIIADE AHRSHYGTLA QNLRKAIPNA SFLAFTATPI DYKDRSTFLV 

       490        500        510        520        530        540 
FGDYISAYPI DKAKRHGVVV PIYYEARLVE LHLTNEFIDL EFDEISERVA NDPETKESIK 

       550        560        570        580        590        600 
EVFAKLEKIM LTEDYLSKVS KDIIEHFNKR LQDFDGKAMV VTISRKVAVE LYKWITKQPN 

       610        620        630        640        650        660 
APKIAVVMSG NKSKDPEDFH PHIRTKKELE NLAKEFKDPE SDLKMVIVVD MWLTGFDVPC 

       670        680        690        700        710        720 
LHTMYFLKPM KNHSLAQAIA RVNRVFKDKP GGLIVDYIGI ADDLSKSLSK YSSEARKDLM 

       730        740        750        760        770        780 
TDIKVVIEEM KRRYEKVTSY FKNINYKDWK KLSSEDLSLL TVKAYQRVAK DDNTKKEFVR 

       790        800        810        820        830        840 
NVIALKKLYL LARPHPETIG IKDDLEFFEM IKKMIVKYST KKIREISQDL ENDIQSLISK 

       850        860        870        880        890        900 
SISAKELVDV FEMLKKEKPE LSVLSDEFLS EIAKIEYKDY VRDVLIKILN DDIRVRMAKN 

       910        920        930        940        950        960 
PIRFKKFSER LNEVIEKYRI KVITTAEMIE ELVNLAKEIR KAAEEGKELG LTEEELAFYD 

       970        980        990       1000       1010       1020 
LLLSYPNIPL TDKKRVEKIA KEIARMMSGY IKARDWKKKK NLQSKIRAKL KIILMKEGIK 

      1030       1040 
DYSLINKISD DLFEYAKNIY AI

« Hide

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77118 Genomic DNA. Translation: AAC37109.1.
PIR	G64514.
RefSeq	NP_044166.1. NC_001732.1.
3D structure databases
ProteinModelPortal	Q60295.
ModBase	Search...
Protein-protein interaction databases
STRING	243232.MJECL40.
Protein family/group databases
REBASE	3908. MjaORFCL42P.
Proteomic databases
PRIDE	Q60295.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC37109; AAC37109; MJ_ECL40.
GeneID	1450822.
KEGG	mja:MJECL40.
Phylogenomic databases
eggNOG	COG0610.
HOGENOM	HOG000240457.
KO	K01153.
OMA	LITRDDR.
ProtClustDB	CLSK2517091.
Family and domain databases
InterPro	IPR021810. DUF3387. IPR006935. Helicase/UvrB_dom. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR011254. Prismane-like. IPR007409. Restrct_endonuc_type1_HsdR_N. IPR004473. Restrct_endonuc_typeI_HsdR. [Graphical view]
Pfam	PF11867. DUF3387. 1 hit. PF04313. HSDR_N. 1 hit. PF04851. ResIII. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. [Graphical view]
SUPFAM	SSF56821. Prismane_like. 1 hit.
TIGRFAMs	TIGR00348. hsdR. 1 hit.
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T1RH_METJA

Accession

Primary (citable) accession number: Q60295

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents