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Protein

Inosose dehydratase

Gene

iolE

Organism
Mycoplasma hyopneumoniae (strain 232)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).UniRule annotation

Catalytic activityi

2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • glutathioneUniRule annotation
  • Co2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Cobalt, Manganese

Enzyme and pathway databases

BioCyciMHYO295358:GH8B-152-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosose dehydrataseUniRule annotation (EC:4.2.1.44UniRule annotation)
Alternative name(s):
2-keto-myo-inositol dehydrataseUniRule annotation
Short name:
2KMI dehydrataseUniRule annotation
Gene namesi
Name:iolEUniRule annotation
Ordered Locus Names:mhp148
OrganismiMycoplasma hyopneumoniae (strain 232)
Taxonomic identifieri295358 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000006822 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Inosose dehydratasePRO_0000352375Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ601Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IolE/MocC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239720.
KOiK03335.
OMAiHPLTYAT.
OrthoDBiEOG6HB9S9.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q601Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKIWKLKNV KVGVAPILWT NDDMPELGGD ISFDRAISEM AQAGYQGTEI
60 70 80 90 100
GNKFPKDAKI LLRELKKYNL EIASAWFSGY IISDFEKNFQ DFQKHCLFLK
110 120 130 140 150
ALGAKVVVFS EQTYSIQGQN KPLFKDKPYF TNQEFENLAQ GLNKFGKWSK
160 170 180 190 200
QHGIELVYHH HMGTGIQSLK ETEKILELTD PEFVSLIFDT GHFAHAGEDI
210 220 230 240 250
VFCLKRLISR IRHIHLKDIR KEKINELKAK NLSFLEGVKQ GIFTVPGDGD
260 270 280 290 300
IQNYPLFFEL LAKNNYQGWL IVEAEQDPRK ANPLEYAKKA MDYLRSLISW
Length:300
Mass (Da):34,579
Last modified:November 23, 2004 - v1
Checksum:iD2C46E22579A3524
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017332 Genomic DNA. Translation: AAV27740.1.
RefSeqiWP_011205986.1. NC_006360.1.

Genome annotation databases

EnsemblBacteriaiAAV27740; AAV27740; mhp148.
KEGGimhy:mhp148.
PATRICi20010853. VBIMycHyo77580_0152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017332 Genomic DNA. Translation: AAV27740.1.
RefSeqiWP_011205986.1. NC_006360.1.

3D structure databases

ProteinModelPortaliQ601Q3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV27740; AAV27740; mhp148.
KEGGimhy:mhp148.
PATRICi20010853. VBIMycHyo77580_0152.

Phylogenomic databases

HOGENOMiHOG000239720.
KOiK03335.
OMAiHPLTYAT.
OrthoDBiEOG6HB9S9.

Enzyme and pathway databases

BioCyciMHYO295358:GH8B-152-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis."
    Minion F.C., Lefkowitz E.J., Madsen M.L., Cleary B.J., Swartzell S.M., Mahairas G.G.
    J. Bacteriol. 186:7123-7133(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 232.

Entry informationi

Entry nameiIOLE_MYCH2
AccessioniPrimary (citable) accession number: Q601Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 23, 2004
Last modified: November 11, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.